• 성인간호학회지
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• 제18권3호
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• pp.345-356
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• 2006

Purpose: This study was conducted to compare the process of change, decisional balance, and self-efficacy according to the stages of change of exercise on the basis of the Transtheoretical Model in order to investigate factors associated with the change of exercise in adult diabetic patients. Method: Data were collected from January to April 2005. The subjects were 160 patients in the G university hospital and public health center in J city. Results: The entire process of change showed the significant difference depending on the stage of change(F=20.007, p=.000). For each process of change, the Consciousness Raising(F=14.602, p=.000), Dramatic Relief(F=7.751, p=.000), Environmental Re-evaluation(F=11.843, p=.000), Self Re-evaluation(F=16.035, p=.000), Social Liberation(F=10.968, p=.000), Counter-conditioning (F=24.090, p=.000), Helping Relationships(F= 7.625, p=.000), Reinforcement Management(F= 16.693, p=.000), Self Liberation(F=11.990, p= .000) and Stimulus Control(F=4.020, p=.002) demonstrated significant differences depending on the stages of change of exercise. For the decisional balance, the Pros showed the significant difference depending on the stage of change(F=14.121, p=.000). For the self efficacy showed significant difference depending on the stage of change(F=17.137, p=.000). Conclusion: In order to proceed the stage of change of exercise in patients with Diabetes Mellitus, intensive use of a specific process of change, a stage of change matching is needed.

• 대한화학회지
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• 제32권5호
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• pp.483-494
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• 1988

이온쌍크로마토그래피에서 방향족 유기산들의 머무름을 연구하기 위하여 Amberlite XAD-4 수지에 대한 분배계수 값을 측정하였다. 유기산들의 XAD-4 수지에 대한 흡착은 시료의 농도, 용액의 pH 그리고 이온쌍 형성시약의 농도에 따라 영향을 받는다. Tetraalkylammonium염과 같은 이온쌍 형성 시약에 의한 유기산의 XAD-4 수지에 대한 흡착 증가는 전기적 이중층에 의한 이온 상호작용에 기인됨을 알았으며, 유기산과 이온쌍 형성 시약과의 상호작용은 공존이온과 상대이온의 종류와 농도에 따라 영향을 받음을 알았다. 한편, 이온쌍 형성시약과 메탄올의 농도 변화에 따른 XAD-4수지에 대한 유기산의 뱃치법과 용리법에서 얻은 용량인자의 관계는 좋은 직선관계를 보여주었다. 따라서 뱃치법의 실험으로써 용리법의 머무름을 예측할 수 있는 가능성을 제시하였다.

• Bulletin of the Korean Chemical Society
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• 제31권9호
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• pp.2649-2655
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• 2010

$PKC{\delta}$-catalytic V5 Heptapeptide (FEQFLDI, FP7) interacts with heat shock protein 27 (HSP27) and inhibits HSP27-mediated resistance to cell death against various stimuli including radiation therapy. Here, we prepared radio-iodinated heptapeptide and further investigated its uptake properties in HSP27 expression cells. Peptide sequence of FP7 and a negative control peptide (WSLLEKR, QP7) was modified by substituting their C-terminus residue to tyrosine (FP6Y and QP6Y) to label radio-iodine. Iodinated peptides were confirmed by LC mass analysis with cold iodine reaction mixture. Accumulation of [$^{125}I$]iodo-FP6Y and [$^{125}I$]iodo-QP6Y in NCI-H1299 cell line, with higher level of HSP27, and NCI-H460 cell line, with lower level of HSP27, was measured by NaI(Tl) scintillation counter. The modification of substituting C-terminus residue of FP7 to tyrosine (FP6Y) did not affect its interaction with HSP27. Accumulation of [$^{125}I$]iodo-FP6Y in NCI-H1299 cells was 3 fold higher than in NCI-H460 cells. The novel radio-iodinated FP6Y would be used as a tracer for targeting HSP27 protein.

• 대한치과교정학회지
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• 제22권1호
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• pp.147-158
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• 1992

This study was aimed to compare the relative cytotoxicity of the five common orthodontic bonding materials (Concise. Mon-lok, Ortho-One, Super C, Transbond) using cell culture technique. DNA synthesis of the fibroblasts was assessed by $^3H$-thymidine uptake to evaluate the effect of the bonding materials on the growth of the cells. The human gingival fibroblasts were explanted from the buccal gingiva of 10 year-old girl and cultured in $\alpha$-MEM/10% FBS/1% antibiotics medium, $37^{\circ}C$, 5% $CO_2$ incuvator. The gingival fibroblasts were tested with the medium into which the bonding materials had been soaked for 1 week. Or the bonding materials were placed on the cells immediately or 2 weeks after polymerization. After 22 hours, $^3H$-thymidine was added into the microtest wells and after 24 hours, the uptake of $^3H$-thymidine was determined by liquid scintilation counter. The results of this study were as follows. 1. DNA synthesis was significantly decreased with Super C and Transbond than Ortho-One, when treated with medium into which the bonding materials had been soaked for 1 week. 2. DNA synthesis was significantly decreased with Concise, Super C and Transbond than control, when treated immediately after polymerization. 3. DNA syntehsis was significantly decreased with Concise, Super C and Transbond than Ortho-One, when immediately after polymerization. 4. There was no significant difference in DNA synthesis between the bonding materials, when treated 2 weeks after polymerization.

• 한국항공우주학회지
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• 제41권5호
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• pp.373-382
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• 2013

본 논문에서는 적외선 영상탐색기가 탑재된 대함유도탄에 대한 함정 방어용 기만 체계의 성능 분석을 위한 교전모의 프로그램을 소개한다. 대함유도탄에 탑재된 적외선 영상탐색기는 함정의 적외선 신호를 탐지하는 거리로부터, 비례항법 유도법칙 또는 입사각 제어유도법칙에 기반하여 접근한다. 그러므로 대함유도탄의 유도 수행 능력은 기본적으로 탐색기의 표적 추적 알고리듬뿐만 아니라 함정의 적외선 신호에 의존한다. 개발한 프로그램을 사용하여, 대함유도탄 적외선 영상탐색기의 다양한 추적 알고리듬으로 flare와 함정 표면을 냉각하기 위한 Counter-Measures Wash-Down System(CMWDS) 같은 함정 기만 체계의 영향을 살펴볼 수 있다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2011년도 학술발표회
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• pp.177-177
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• 2011

환형수조는 점착성 퇴적물의 침/퇴적실험을 위한 실험장치로서, 수조내부의 수면과 접하여 회전하는 상부링(top ring)의 마찰력에 의해 흐름이 생성되며, 시간의 제약없이 흐름조건을 동일하게 만들 수 있다는 큰 장점을 갖는다. 그러나 환형수조는 원주유속의 속도차이 및 원심력으로 인한 2차 순환류가 형성되어 바닥전단응력이 불균일해지는 단점을 가지고 있으며, 이러한 이유로 인하여 환형수조를 이용한 침/퇴적실험 수행시 수조의 외벽부근에서 더 큰 침식이 발생한다. 따라서, 2차 순환류의 발생을 줄이고 바닥전단응력의 분포를 균등하게 하기 위해 양방향 회전(환형수조의 몸체를 상부링의 회전방향과 반대방향으로 회전)이 가능한 환형수조가 고안되었는데, 이러한 방법으로 2차 순환류의 크기를 저감시키고, 바닥전단응력을 균일하게 만들 수 있다. 한편, 환형수조의 양방향 회전(counter-rotation)은 현장용 환형수조에는 적용될 수 없는 단점을 갖는다. 현장실험에서는 바닥면이 없는 현장용 환형수조를 해저면에 거치시켜 자연상태의 비교란 퇴적물 시료를 저면으로 형성시키는데, 바닥면이 존재하지 않는 환형수조 본체는 회전시킬 수 없으므로 양방향 회전을 통한 2차 순환류의 저감 및 바닥전단응력 균일화의 효과를 기대할 수 없다. 이러한 이유로 환형수조의 양방향 회전은 단지 실내실험용 환형수조에만 적용된다. 이에 본 연구에서는 환형수조 본체를 회전시키지 않고 수조의 측벽과 상부링의 각도 조절을 통해 수조단면의 형상을 변화시켜 2차 순환류를 저감시키고 바닥전단응력을 균등하게 하는 방법에 대한 연구가 수행되었다. 이 방법은 본체의 회전이 필요 없으므로 현장용 환형수조에 적용될 수 있을 뿐만 아니라, 실험장치의 구조가 단순해져 실험장치의 제작비가 절감될 수 있다. 또한 원주속도에 수직한 단면에서 속도구배가 감소되어 2차 순환류가 저감됨과 동시에 바닥전단응력이 균등하게 됨으로서 양방향 회전시와 동일한 효과가 얻어질 수 있을 것으로 예상된다.

• 한국조경학회지
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• 제31권4호
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• pp.1-12
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• 2003

The urban park provides a safe rest and leisure area, and offers the beauty of nature to counter the drearyness of urban space. It can provide benefits such as the reduction of environmental pollution, the regulation of the local climate, and it can also provide a safe area during times of disaster. However, there was no interest in urban park development and control in Korea during the economic boom of the mid 1960s. Furthermore, during the industrialization process, the population grew significantly in the cities and the cities' scales were noticeably extended; as a result of this, the living environment and the natural environment in the cities worsened. With rapid urbanization and industrialization, urban green area diminished, and it became necessary to organize the urban park system to improve quality of life. 45% of south korea's population lives in 6 cities, which is only 4% of Korea's land size. The Urban park system has to be considered in the urban planning process. Paris' urban green system can be a role-model for Korea's urban green development plan to function organically. Urban public park concepts have been used in Paris's urban planning since 1850. There were hardly any parks, gardens and squares for the public before the middle of the 19th century. For improving life-styles for the poor, Napoleon III strongly supported the development of green space systems in Paris by G.E. Haussmann. Napoleon III and Haussmann established and applied the urban green regulation within Paris urban planning. The purpose of this study is to investigate the green regulations Haussmann's Paris urban plan and urban green space system: and as a result of this, it can be an indicator for urban green space development in Korea.

• Restorative Dentistry and Endodontics
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• 제20권1호
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• pp.275-288
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• 1995

The inhibitory effect of cell wall extracts of streptococci, have been investigated to know host-parasite relationship or pathogenesis of abscess formation. Streptococci isolated from the infected root canals were sonicated to get cell wall extracts which have been known as one of the factors of pyogenesis. Lymphocytes separated by density gradient were stimulated with phytohemagglutinin and exposed to cell wall extracts of Streptococcus sanguis, S. mitis, S. uberis, S. mutans (ATCC 10449), and S. faecalis (ATCC 19433). [$^3H$]-thymidine uptake of lymphocytes was analyzed with scintillation counter and lactate dehyrogenase (LD) activity was measured with autochemistry analyzer. S. faeealis had the strongest inhibitory effect. beginning at $100\;{\mu}g/ml$ concentration of sonic extracts. S. sanguis and S. mitis had inhibitory effect at $300\;{\mu}g/ml$, while S. uberis and S. mutans showed no inhibitory, effect on DNA syntheis even at $300\;{\mu}g/ml$. Each streptococci showed different inhibitory effect on the DNA synthesis of lymphocytes, which finding indicated wide spectrum of susceptibility of lymphocytes according to streptococcus spp. There were no significant difference of LD activities between control and each streptococcal extracts. Streptococcal sonic extracts did not affect the morphological findings or number of colonies activated lymphocytes. These finding suggested the inhibitory effect of sonic extract of streptococci to lymphocytes could be detected by DNA synthesis inhibition, not by cellular membrane damage.

• 대한한의학방제학회지
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• 제17권2호
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• pp.123-132
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• 2009

Acetaminophen (AP) is widely used as an over-the-counter analgesic and antipyretic drug. AP-induced hepatotoxicity is a common consequence of AP overdose and may lead to acute liver failure. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of AP and the possible protective effects of administration (50-200 mg/kg body weight) of Joo-Juk on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of Joo-Juk on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase ($\sigma$-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. AP caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were statistically significant losses in the activities of SOD, catalase, $\sigma$-ALA-D, and GPx and an increase in TBARS in the liver of AP-treated group compared with the control group. However, Joo-Juk was able to counteract these effects. These results suggest that Joo-juk can act as hepato-protectant against AP toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.

• 대한한의학방제학회지
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• 제16권2호
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• pp.183-191
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• 2008

Acetaminophen (N-acety1-p-aminophenol, paracetamol) is widely used as an over-the-counter analgesic and antipyretic drug. Intake of a over dose of acetaminophen may result in severe hepatic necrosis. In this study, we investigated the liver damage in mice using single dose (300 mg/kg) of acetaminophen and the possible protective effects of administration (50-200 mg/kg body weight) of SB-Ex on acetaminophen-induced liver damage in mice. The alanine aminotransferase (ALT), and aspartate aminotransferase (AST) activities were determined in the plasma of mice. The effect of SB-Ex on lipid peroxidation product thiobarbituric reacting substances (TBARS) and some antioxidant enzymes superoxide dismutase (SOD), catalase, d-aminolevulinate dehydratase (${\sigma}$-ALA-D) activities, and gluthathione peroxidase (GPx), were also evaluated in the mouse liver homogenate. Acetaminophen caused liver damage as evident by statistically significant increased in plasma activities of AST and ALT. There were general statistically significant losses in the activities of SOD, catalase, ${\sigma}$-ALA-D, and GPx and an increase in TBARS in the liver of acetaminophen-treated group compared with the control group. However, SB-Ex was able to counteract these effects. These results suggest that SB-Ex can act as hepatoprotectives against acetaminophen toxicity and is a good candidate for further evaluation as an effective chemotherapeutic agent.