• Genomics & Informatics
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• v.15 no.4
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• pp.136-141
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• 2017

Accurate detection of genomic alterations, especially druggable hotspot mutations in tumors, has become an essential part of precision medicine. With targeted sequencing, we can obtain deeper coverage of reads and handle data more easily with a relatively lower cost and less time than whole-exome or whole-genome sequencing. Recently, we designed a customized gene panel for targeted sequencing of major solid cancers. In this study, we aimed to validate its performance. The cancer panel targets 95 cancer-related genes. In terms of the limit of detection, more than 86% of target mutations with a mutant allele frequency (MAF) <1% can be identified, and any mutation with >3% MAF can be detected. When we applied this system for the analysis of Acrometrix Oncology Hotspot Control DNA, which contains more than 500 COSMIC mutations across 53 genes, 99% of the expected mutations were robustly detected. We also confirmed the high reproducibility of the detection of mutations in multiple independent analyses. When we explored copy number alterations (CNAs), the expected CNAs were successfully detected, and this result was confirmed by target-specific genomic quantitative polymerase chain reaction. Taken together, these results support the reliability and accuracy of our cancer panel in detecting mutations. This panel could be useful for key mutation profiling research in solid tumors and clinical translation.

• Journal of the Korean Solar Energy Society
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• v.26 no.3
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• pp.1-8
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• 2006

The objective of this research is to study on the analysis of long-term performance characteristics of various solar thermal system for heating protected horticulture system for reducing heating cost, increasing the value of product by environment control, and developing advanced culture technology by deploying solar thermal system. Long term field test for the demonstration was carried out in horticulture complex in Jeju Island. Reliability and economic aspect of the system which was operated complementary with thermal storage and solar hot water generation were analyzed by investigating collector efficiency, operation performance, and control features. Optimum operating condition and its characteristics were closely investigated by changing the control condition based on the temperature difference which is the most important operating parameter. However, it is expected that, in high-insolation areas where large-scale ground storage is adaptable, solar system demonstrated in the research could be economically competitive and promisingly disseminate over various application areas.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2009.06a
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• pp.394-394
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• 2009

Owing to the increasing number of intelligent homes(or called Smart home), the corresponding cost is much higher. Low voltage circuit breakers are widely used in the intelligent homes to interrupt fault current rapidly and to assure the reliability of the power supply. The distribution of magnetic field induced by arc current in the contact system of molded case circuit breaker(hereafter MCCB) depends on the shape, arrangement, and kinds of material of arc runner. This paper is focused on understanding the interrupting capability, more specifically of the arc runner, based on the shape of the contact system in the current MCCB. The magnetic driving force was calculated by using the flux densities induced by the arc current, which are obtained by three-dimensional finite element method. There is a need to assure that the optimum design required to analyze the electromagnetic forces of the contact system generated by current and the flux density be present. This is paper present our computational analysis on contact system in MCCB.

• 한국신재생에너지학회:학술대회논문집
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• 2005.06a
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• pp.403-407
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• 2005

Objective of the research is to demonstrate solar thermal space and ground heating system which is integrated to a greenhouse culture facility for reducing heating cost, increasing the value of product by environment control, and developing advanced culture technology by deploying solar thermal system. Field test for the demonstration was carried out in horticulture complex in Jeju Island. Medium scale solar hot water system was installed in a ground heating culture facility. Reliability and economic aspect of the system which was operated complementary with thermal storage and solar hot water generation were analyzed by investigating collector efficiency, operation performance, and control features. Short term day test on element performance and Long term test of the whole system were carried out. Optimum operating condition and its characteristics were closely investigated by changing the control condition based on the temperature difference which is the most important operating parameter. For establishing more reliable and optimal design data regarding system scale and operation condition, continuous operation and monitoring on the system need to be further carried out. However, it is expected that, in high-insolation areas where large-scale ground storage is adaptable, solar system demonstrated in the research could be economically competitive and promisingly disseminate over various application areas.

• Journal of Institute of Control, Robotics and Systems
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• v.5 no.3
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• pp.353-362
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• 1999

This paper presents a shape reconstruction method for automatic inspection of the solder joints on PCBs using X-ray. Shape reconstruction from X-ray radiographic image has been very important since X-ray equipment was used for improving the reliability of inspection result. For this purpose there have been lots of previous works using tomography, which reconstructs the correct shape, laminography or tomosynthesis, which are very fast algorithm. Latter two methods show outstanding performance in cross-sectional image reconstruction of lead type component, but they are also known to show some fatal limitations to some kinds of components such as BGA, because of shadow effect. Although conventional tomography does not have any shadow effect, the shape of PCB prohibits it from being applied to shape reconstruction of solder joints on PCB. This paper shows that tomography using Iterative Reconstruction Technique(IRT) can be applied to this difficult problem without any limitations. This makes conventional radiographic instrument used for shape reconstruction without shadow effect. This means that the new method makes cost down and shadow-free shape reconstruction. To verify the effectiveness of IRT, we develop three dimensional model of BGA solder ball, make projection model to obtain X-ray projection data. and perform a simulation study of shape reconstruction. To compare the performance of IRT with that of conventional laminography or tomosynthesis, reconstruction data are reorganized and error analysis between the original model are also performed.

• Journal of the Korean Society for Precision Engineering
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• v.28 no.9
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• pp.1054-1061
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• 2011

GMA welding process is a production process to improve productivity for the provision of higher quality of material, These includs numerous process variables that could affect welding quality, productivity and cost savings. Recently, the welding part of construction equipment had frequent failure of major components in the welding part of each subsidiary material due to shock which is very poor according to the welding part. Therefore, the implementation of sound welding procedure is the most decisive factor for the reliability of construction machinery. The data generated through experimens conducted in this study has validated its effectiveness for the optimization of bead geometry and process variables is presented. The criteria to control the process parameters, to achieve a healthy bead geometry. This study has developed mathematical models and algorithms to predict or control the bead geometry in GMA fillet welding process.

• The Transactions of the Korean Institute of Electrical Engineers P
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• v.64 no.4
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• pp.212-219
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• 2015

Korea's first tram (so called "tram"), which was commenced the operation on May 4, 1899 of late Joseon Dynasty and run until 1968, played a pivotal role of public transportation. However, tram as new transportation mean is being recognized as traffic congestion problem becomes issue due to geometric automobile increase and reckless urban plan after stoppage of tram service. Tram has an advantage of inexpensive construction cost and eco-friendly means compared to existing and city railway, carrying more passengers rather than existing bus, excellent connectivity of existing transportation because of easy accessible to destination in the city center. Therefore, tram, what is called "Green Rvolution of Public Transportation", has a dreaming of revival and in the process of pushing. We suggest the accident type which might break out in the early stage of tram introduction and preventive measures by surveying the accident cases of tram advanced country, and study the crossing control measures.

• Proceedings of the KIEE Conference
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• 2009.07a
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• pp.1451_1452
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• 2009

Owing to the increasing number of intelligent homes(or called Smart home), the corresponding cost is much higher. Low voltage circuit breakers are widely used in the intelligent homes to interrupt fault current rapidly and to assure the reliability of the power supply. The distribution of magnetic field induced by arc current in the contact system of molded case circuit breaker depends on the shape, arrangement, and kinds of material of grids. This paper is focused on understanding the interrupting capability, more specifically of the grid and the arc runner, based on the shape of the contact system in the current MCCB. The magnetic driving force was calculated by using the flux densities induced by the arc current, which are obtained by three-dimensional finite element method. There is a need to assure that the optimum design required to analyze the electromagnetic forces of the contact system generated by current and the flux density be present. This is paper present our computational analysis on contact system in MCCB.

• New & Renewable Energy
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• v.1 no.2 s.2
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• pp.53-59
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• 2005

Objective of the research is to demonstrate solar thermal space and ground heating system which is integrated to a green-house culture facility for reducing healing cost, Increasing the value of product by environment control, and developing advanced culture technology by deploying solar thermal system. Field test for the demonstration was carried out in horticulture complex In Jeju Island. Medium scale solar hot water system was installed in a ground heating culture facility. Reliability and economic aspect of the system which was operated complementary with thermal storage and solar hot water generation were analyzed by investigating collector efficiency, operation performance, and control features. Short term day test on element performance and Long term test of the whole system were carried out. Optimum operating condition and its characteristics were closely Investigated by changing the control condition based on the temperature difference which Is the most important operating parameter For establishing more reliable and optimal design data regarding system scale and operation condition, continuous operation and monitoring on the system need to be further carried out. However, It is expected that, in high-insolation areas where large-scale ground storage is adaptable, solar system demonstrated in the research could be economically competitive and promisingly disseminate over various application areas.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.10
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• pp.1731-1737
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• 2007

The Korea electricity wholesale market is operated under the cost-based-pool system and the government regulation to the new generation capacities in order to insure the resource adequacy. The goal of government's regulation is the electricity market stability by attracting proper generation investment while keeping the reliability of system. Generation companies must mandatory observe that government plan by now. But if the restructuring is to be complete, generation companies should not bear any obligation to invest unless their profitability is guaranteed. Namely the investors' behavior will be affected by the market prices. In this paper, the system dynamics model for Korea wholesale electricity market to examine whether competitive market can help to stabilize is developed and analyzes the investors behavior. The simulation results show that market controlled by government will be operated stable without resulting in price spike but there is no lower price because of maintaining the reasonable reserve margin. However, if the competition is introduced and the new investment is determined by the investor's decision without government intervention, the benefits from lower wholesale price are expected. Nevertheless, the volatility in the wholesale market increases, which increases the investment risks.