• Genomics & Informatics
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• v.13 no.4
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• pp.152-155
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• 2015

Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in promoter regions. Here, we publish a frequency profile of the three ChromHMM promoter states, at 200-bp intervals, with particular reference to the existence of sequence patterns of promoter elements, GC-richness, and transcription starting sites. Through detailed and diligent analysis of promoter regions, researchers will be able to uncover new and significant information about transcription initiation and gene function.

• Korean Journal of Computational Design and Engineering
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• v.6 no.4
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• pp.271-276
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• 2001

A geometric kernel is the library of core mathematical functions that defines and stores 3D shapes in response to users'commands. We developed a light geometric kernel suitable to develop CAD/CAM application systems. The kernel contains geometric objects, such as points, curves and surfaces and a minimal set of functions for each type but does not contain lots of modeling and handling functions that are useful to create and maintain complex shapes from an idea sketch. The kernel was developed on MS-Windows NT using C++ with STL(Standard Template Library) but it is compatible with UNIX environments. This paper describes the structure of the kernel including several components: base, math, point sequence curve, geometry, translators. The base kernel gives portability to applications and the math kernel contains basic arithmetic and their classes, such as vector and matrix. The geometry kernel contains points, parametric curves, and parametric surfaces. A neutral fie format and programming and document styles are also presented in this paper.

• The Transactions of the Korean Institute of Power Electronics
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• v.25 no.3
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• pp.171-180
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• 2020

This paper presents the implementation and control methods of a battery simulator. The proposed battery simulator can emulate the dynamic characteristics of any actual battery using the second RC ladder model of the equivalent circuit. Moreover, it can emulate the variation of impedance, which is the result of the change of battery characteristics due to the aging effect. The parameters of the battery simulator can be derived from the sequence of tests of the actual battery or only from the data supplied by the battery manufacturer. Proposed methods for the battery simulator are tested by extensive experiments. Test results show that the proposed battery simulator can emulate not only the dynamic characteristics but also the aging effects of the actual battery in real time.

• Journal of the Korea Safety Management & Science
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• v.14 no.4
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• pp.117-123
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• 2012

For an effective energy management in intelligent buildings it is necessary to gather information about position/absence of people and the level of population. In this paper the smart occupancy detection system using the active RFID is developed to satisfy such a demand based on the results of previous research. First of all the design considerations and functions of the system are introduced. In sequence the functions of the system is presented, and then the performance of the developed system is tested and verified through various field tests. The developed core technology can be also applied to other fields such as security, healthcare, smart home, etc.

• Nuclear Engineering and Technology
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• v.34 no.2
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• pp.176-185
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• 2002

A 4-bundle shift refuelling method of CANDU6 F/H (Fuel Handling) System is analyzed to assess the operational flexibility and capacity of F/H system. The current 8-bundle shift refuelling scheme requires to refuel eight fuel bundles from a single fuel channel, and to refuel 14 fuel channels in a week on average assuming that the reactor is in a steady state. The analysis showed that the 4-bundle shift refuelling method increases F/M (Fuelling Machine) duty cycle and operator load. However, the fuellin’g method change from the 8- to 4-bundle shift refuelling ill not require additional team of operators. A marginal increase in the maintenance cost may be resulted in by the change of fuelling method and the increase of fatigue usage factors requires some components to be replaced during the FM lifetime.

• Molecules and Cells
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• v.46 no.12
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• pp.736-742
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• 2023

NifB, a radical S-adenosylmethionine (SAM) enzyme, is pivotal in the biosynthesis of the iron-molybdenum cofactor (FeMo-co), commonly referred to as the M-cluster. This cofactor, located within the active site of nitrogenase, is essential for the conversion of dinitrogen (N₂) to NH₃. Recognized as the most intricate metallocluster in nature, FeMo-co biosynthesis involves multiple proteins and a sequence of steps. Of particular significance, NifB directs the fusion of two [Fe₄S₄] clusters to assemble the 8Fe core, while also incorporating an interstitial carbide. Although NifB has been extensively studied, its molecular mechanisms remain elusive. In this review, we explore recent structural analyses of NifB and provide a comprehensive overview of the established catalytic mechanisms. We propose prospective directions for future research, emphasizing the relevance to biochemistry, agriculture, and environmental science. The goal of this review is to lay a solid foundation for future endeavors aimed at elucidating the atomic details of FeMo-co biosynthesis.

• Interdisciplinary Bio Central
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• v.1 no.3
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• pp.9.1-9.6
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• 2009

Introduction: In the mass spectrometry-based proteomics, biological samples are analyzed to identify proteins by mass spectrometer and database search. Database search is the process to select the best matches to the experimental mass spectra among the amino acid sequence database and we identify the protein as the matched sequence. The match score is defined to find the matches from the database and declare the highest scored hit as the most probable protein. According to the score definition, search result varies. In this study, the difference among search results of different search engines or different databases was investigated, in order to suggest a better way to identify more proteins with higher reliability. Materials and Methods: The protein extract of human mesenchymal stem cell was separated by several bands by one-dimensional electrophorysis. One-dimensional gel was excised one by one, digested by trypsin and analyzed by a mass spectrometer, FT LTQ. The tandem mass (MS/MS) spectra of peptide ions were applied to the database search of X!Tandem, Mascot and Sequest search engines with IPI human database and SwissProt database. The search result was filtered by several threshold probability values of the Trans-Proteomic Pipeline (TPP) of the Institute for Systems Biology. The analysis of the output which was generated from TPP was performed. Results and Discussion: For each MS/MS spectrum, the peptide sequences which were identified from different conditions such as search engines, threshold probability, and sequence database were compared. The main difference of peptide identification at high threshold probability was caused by not the difference of sequence database but the difference of the score. As the threshold probability decreases, the missed peptides appeared. Conversely, in the extremely high threshold level, we missed many true assignments. Conclusion and Prospects: The different identification result of the search engines was mainly caused by the different scoring algorithms. Usually in proteomics high-scored peptides are selected and low-scored peptides are discarded. Many of them are true negatives. By integrating the search results from different parameter and different search engines, the protein identification process can be improved.

• Korean Journal of Construction Engineering and Management
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• v.14 no.4
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• pp.140-151
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• 2013

In 2011 and 2012, Korean construction firms awarded around $ 64.5. Billion each year from the overseas market in 2011. This contract value accounted for overwhelming portion of total overseas construction contract values, and this growth is expected to continue for the next decade. However, contract scopes awarded to the Korean construction firms mainly involve detailed design and construction phases due to their competitiveness for the construction techniques. In other words, front-end-engineering-design and construction project management are not considered part of core business due to the lack of project management skills and experience. The researchers focused on development of construction sequence model required to improve construction planning and scheduling skills for the Korean construction firms. The model identifies critical work items and the sequence throughout project execution process. In addition, the researchers developed a risk evaluation method by applying fuzzy theory to the critical construction activities for the industrial plant construction projects. Developed methodology will help project practitioners to develop project schedule in a timely and effe ctive manner and evaluate project risks associated with scheduling process for the industrial plant construction projects.

• Ocean and Polar Research
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• v.36 no.1
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• pp.13-24
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• 2014

We established the first complete ice core processing method and analytical procedures for fundamental proxies, using a 40.2 m long ice core drilled on the Mt. Tsambagarav glacier in the Mongolian Altai mountains in July 2008. The whole core was first divided into two sub ice core sections and the measurements of the visual stratigraphy and electrical conductivity were performed on the surface of these sub core sections. A continuous sequence of samples was then prepared for chemical analyses (stable isotope ratios of oxygen ($^{18}O/^{16}O$) and hydrogen ($^2H/^1H$), soluble ions and trace elements). A total of 29 insoluble dust layers were identified from the measurement of visual stratigraphy. The electrical conductivity measurement (ECM) shows 11 peaks with the current more than 0.8 ${\mu}A$ Comparing the profiles of $SO_4{^{2-}}$ and $Cl^-$ concentrations to correlate with known volcanic eruptions, the first two ECM peaks appear to be linked to the eruptions (January and June 2007) of Kliuchevskoi volcano on the Kamchatka Peninsula of Russia, which supports the reliability of our ECM data. Finally, the composition of stable isotopes (${\delta}^{18}O$ and ${\delta}D$) shows a well-defined seasonal variation, suggesting that various chemical proxies may have been well preserved in the successive ice layers of Tsambagarav ice core. Our ice core processing method and analytical procedures for fundamental proxies are expected to be used for paleoclimate and paleoenvironmental studies from polar and alpine ice cores.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.38 no.1
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• pp.67-76
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• 2020

This study aims to elicit criteria regarding reassessment and designation of linear scenic sites henceforth. The results are as follows; First, based on the documents from the Cultural Properties Protection Committee of Korea, 23 out of 113 scenic sites in Korea were drawn, and their linear characteristics were categorized into four types including valleys, paths, rivers, and ridges. The linear scenic sites provide certain features in terms of sequence and direction, which results in the similar utilization among the sites which share the linear similarity. Second, the 23 sites mentioned above were intensely examined on the basis of six criteria for linear scenic sites through FGI, focus group interview. The criteria consist of six elements involving core resource(12), lot number(8), unclear(8), management path(5), ridge(4), basin(3). Third, the Cultural Heritage Administration has prioritized core resource since 2010, when designating a scenic site, whereas it tended to consider lot number as priority prior to 2010. It is thought that the authority gave consideration to issues related to private ownership of property in the scenic sites and the purpose of designation. Fourth, scenic sites are generally designated in accordance with the boundary of core resource, and in most cases, there are buffer zones alongside the core resource.