• Experimental and Molecular Medicine
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• 제50권12호
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• pp.7.1-7.14
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• 2018

Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development of various diseases. Recently, an emerging body of evidence has indicated that lncRNAs play important roles in the pathogenesis of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative Colitis (UC). In IBD, lncRNAs have been shown to be involved in diverse processes, including the regulation of intestinal epithelial cell apoptosis, association with lipid metabolism, and cell-cell interactions, thereby enhancing inflammation and the functional regulation of regulatory T cells. In this review, we aim to summarize the current knowledge regarding the role of lncRNAs in IBD and highlight potential avenues for future investigation. We also collate potentially immune-relevant, IBD-associated lncRNAs identified through a built-by association analysis with respect to their neighboring protein-coding genes within IBD-susceptible loci. We further underscore their importance by highlighting their enrichment for various aspects of immune system regulation, including antigen processing/presentation, immune cell proliferation and differentiation, and chronic inflammatory responses. Finally, we summarize the potential of lncRNAs as diagnostic biomarkers in IBD.

• 건축사
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• 통권596호
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• pp.102-107
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• 2018

• 건축사
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• 통권653호
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• pp.124-129
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• 2023

• Agribusiness and Information Management
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• 제5권1호
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• pp.20-30
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• 2013

This paper presents a model explaining industrywide information systems (IS) integration in the agri-industry. Using a theoretical frame of value configuration analysis and IS integration extent we study 15 organizations. We find that product sensitivity, continuous production, value chain captains, and value creation logic explain the industry-wide IS integration. Incompatible value creation logic among stakeholders and the lack of presence of "value chain captains" - powerful actors dominating the entire industry - has and negative impact on industry-wide integration. On the other hand, product sensitivity and continuous production process led to higher levels of integration.

• International Journal of Quality Innovation
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• 제6권3호
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• pp.19-37
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• 2005

It is generally accepted that leadership is the foundation for creation of a company's business results. However, empirical evidence is lacking. This paper examines the relationship between leadership and key performance results based on a Return on Leadership Model. The model links Denison's four leadership traits to people results, customer results, and ultimately key performance results. Further specified, the model is a structural equation model with nine latent variables, each measured by a set of indicators, observed by survey questions. To validate the model, an empirical study was conducted, and 379 managers from medium-sized and large companies in Denmark participated. The estimation of the model shows that the model structure explains return on leadership very well, and the findings support the developed model. We are able to quantify the relationships from leadership to people results, customer results and key performance results and, in this way, the data presented here provide evidence that leadership is linked to key performance results. Several results and applications of the model are shown. The findings provide new knowledge about how leadership can be linked to performance, and how excellent leadership creates key performance results.

• Molecules and Cells
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• 제43권7호
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• pp.591-599
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• 2020

Complex cell-to-cell communication underlies the basic processes essential for homeostasis in the given tissue architecture. Obtaining quantitative gene-expression of cells in their native context has significantly advanced through single-cell RNA sequencing technologies along with mechanical and enzymatic tissue manipulation. This approach, however, is largely reliant on the physical dissociation of individual cells from the tissue, thus, resulting in a library with unaccounted positional information. To overcome this, positional information can be obtained by integrating imaging and positional barcoding. Collectively, spatial transcriptomics strategies provide tissue architecture-dependent as well as position-dependent cellular functions. This review discusses the current technologies for spatial transcriptomics ranging from the methods combining mechanical dissociation and single-cell RNA sequencing to computational spatial re-mapping.

• International Journal of Quality Innovation
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• 제4권2호
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• pp.73-100
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• 2003

The most successful companies today are said to have strong brands. But what is a strong brand\ulcorner What makes a brand strong\ulcorner How do we build a strong brand\ulcorner This paper develops a customer-based brand equity model to help address these important questions. The developed model is a cause-and-effect model linking customer-brand relationships to rational and emotional brand associations, as well as rational and emotional brand evaluations. The customer-brand relationships are characterized by loyalty, based on both behaviour and attitude. As branding is a very complex concept, it is important to determine which of the many branding elements should be included in the model. This paper discusses why a given aspect is important for a brand's equity and which relations exist between the included variables from a theoretical perspective. The model provides insight into the creation of a brand's equity and can thus be used in the brand management process to achieve brand excellence.

• 천문학논총
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• 제27권4호
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• pp.347-352
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• 2012

Understanding infrared (IR) luminosity is fundamental to understanding the cosmic star formation history and AGN evolution, since their most intense stages are often obscured by dust. Japanese infrared satellite, AKARI, provided unique data sets to probe this both at low and high redshifts. The AKARI performed an all sky survey in 6 IR bands (9, 18, 65, 90, 140, and $160{\mu}m$) with 3-10 times better sensitivity than IRAS, covering the crucial far-IR wavelengths across the peak of the dust emission. Combined with a better spatial resolution, AKARI can measure the total infrared luminosity ($L_{TIR}$) of individual galaxies much more precisely, and thus, the total infrared luminosity density of the local Universe. In the AKARI NEP deep field, we construct restframe $8{\mu}m$, $12{\mu}m$, and total infrared (TIR) luminosity functions (LFs) at 0.15 < z < 2.2 using 4,128 infrared sources. A continuous filter coverage in the mid-IR wavelength (2.4, 3.2, 4.1, 7, 9, 11, 15, 18, and $24{\mu}m$) by the AKARI satellite allows us to estimate restframe $8{\mu}m$ and $12{\mu}m$ luminosities without using a large extrapolation based on a SED fit, which was the largest uncertainty in previous work. By combining these two results, we reveal dust-hidden cosmic star formation history and AGN evolution from z = 0 to z = 2.2, all probed by the AKARI satellite.

• Safety and Health at Work
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• 제11권3호
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• pp.291-300
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• 2020

Background: The study aimed to determine the association of individual cognitive ability in late midlife with labor market participation among older workers. Methods: This prospective cohort study estimates the risk of long-term sickness absence, disability pension, early retirement, and unemployment from scores on the Intelligenz-Struktur-Test 2000R by combining data from 5076 workers from the Copenhagen Aging and Midlife Biobank with a register on social transfer payments. Analyses were stepwise adjusted for age, gender, physical and psychosocial work environment, health behaviors, occupational social class, education, and chronic diseases. Results: In the fully adjusted model, low cognitive ability (≥1 standard deviation below the mean for each gender) and high cognitive ability (≥1 standard deviation above the mean for each gender) were not associated with risk of any of the four labor market outcomes. Conclusion: Individual cognitive ability in late midlife was not associated with risk of long-term sickness absence, disability pension, early retirement, and unemployment in the fully adjusted model. Thus, no direct effect of individual cognitive ability in late midlife was observed on the risk of permanently or temporarily leaving the labor market.

• 대한수의학회지
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• 제30권2호
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• pp.203-214
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• 1990

A total of 166 strains of Salmonella (S) typhimurium var copenhagen isolated from pigeons (164 strains) and aquatic birds (2 strains) were examined for the biochemical characteristics and plasmid profiles. All the strains were sensitive to ampicillin, chloramphenicol, gentamicin, kanamycin and sulfadimethoxine. But 13 strains(7.8%) were resistant to streptomycin (Sm), 2 (1.2%) to tetracycline, 2 (1.2%) to rifampicin, and 1 (0.6%) to nalidixic acid. Among drug resistant strains, only one strain resistant to Sm contained conjugative R plasmid which was fertility inhibition and incompatibility group $I_{\alpha}$. All the strains were sensitive to cobalt chloride, cupric sulfate, lead nitrate, mercuric chloride and silver nitrate. Of 166 isolates, 6 (3.6%) were resistant to sodium arsenate and 1 (0.6%) to potassium tellurite. Among 166 isolates, 1 (0.6%) was colicinogenic, 12 (7.2%) sucrose fermenters, and 166 (100%) maltose fermenters. Plasmid profiles were confirmed as being 4 or 5 plasmids, and their molecular weight ranged 3.2 to 60 megadalton (MD). All the strains harbored 60 Md plasmid. There are three patterns by the plasmid profile, 150 isolates (90.4%) were pattern I (3.2, 3.5, 33, 60Md), 14 (8.4%) pattern II (3.2, 3.5, 29, 60Md), and 2 (1.2%) pattern III (4.2, 7.8, 8.5, 15, 60Md). S typhimurium var copenhagen strains containing 60Md plasmid were resistant to killing by 90% normal guinea pig serum.