• The Journal of Korean Physical Therapy
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• 제26권6호
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• pp.459-463
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• 2014

Purpose: The purpose of this study was to investigate the correlations between functional movement screen (FMS) and ankle dysfunctions in subjects with chronic ankle instability (CAI). Methods: This study was a cross-sectional study of 20 participants with CAI. The ankle dorsiflexion range of motion (ROM), Foot and Ankle Disability Index (FADI), center of pressure (COP) path length, and COP velocity for ankle dysfunction were measured in all the subjects. All the subjects underwent the FMS concerned with ankle functions consisted of deep squats, hurdle steps and in-line lunges. The Spearman rank-order correlation coefficient was used to determine relationship between the ankle ROM, FADI, COP and FMS. Results: The results of the deep squat and in-line lunge exercises revealed a significant correlation with the ankle dorsiflexion ROM, FADI, COP path length, and COP velocity. The hurdle step showed no correlation with the ankle dorsiflexion ROM and FADI but a significant relationship with the COP path length and COP velocity. Conclusion: The results of this study showed that relationship deep squat and in-line lunge and it is suggested that an assessment tool using ankle dorsiflexion ROM and ankle instability would be clinically effective.

• Journal of Microbiology and Biotechnology
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• 제22권1호
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• pp.156-158
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• 2012

A synthetic coprisin analog peptide, 9-mer dimer CopA3 (CopA3) was designed based on a defensin-like peptide, Coprisin, isolated from the bacteria-immunized dung beetle Copris tripartitus. Here, CopA3 was investigated for its antimicrobial activity and cancer cell growth inhibition. CopA3 showed antimicrobial activities against various pathogenic bacteria and yeast fungus with MIC values in 2~32 ${\mu}M$ ranges, and inhibited the cell viabilities of pancreatic and hepatocellular cancer cells, except MIA-Paca2, Hep3B, and HepG2 cells, in a dose-dependent manner. The average $IC_{50}$ values of CopA3 against pancreatic and hepatocellular cancer cells were 61.7 ${\mu}M$ and 67.8 ${\mu}M$, respectively. The results indicate that CopA3 has potential in the treatments of pancreatic and hepatocellular cancers as well as microorganism infection disease.

• 한국균학회지
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• 제35권1호
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• pp.1-10
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• 2007

세포벽은 진균류의 생존과 삼투안전성 유지에 필수적인 구조체로, 세포부착성 단백질이나 가수분해효소 등과 같은 생물학적 활성을 갖는 다양한 단백질이 결합하거나 그 속에 자리잡고 작용할 수 있게 한다. 최근 효모류인 Saccharomyces cerevisiae와 사상균인 Aspergillus nidulans에서 세포 내 단백질 분비 소낭의 하나인 COPI 소낭을 구성하는 ${\alpha}-COP$ 단백질에 돌연변이가 일어날 경우, 온도의존적 삼투감수성이 나타나는 것으로 밝혀졌다. 이러한 사실은 ${\alpha}-COP$이 베타-1,3-글루칸 합성효소 복합체를 구성하는 단백질과 세포벽 단백질의 이송과정에 중요한 역할을 함으로써 세포벽 안정성 유지에 기여함을 시사하는 것이다. 본 총설에서는 세포 내 단백질 이송기구 중에서도 COPI 소낭을 구성하는 ${\alpha}-COP$과 균류의 세포벽 형성과정과의 관계에 대하여 기술하는 한편, 단백질 분비기구에 결손이 생긴 돌연변 이주를 이용한 세포벽 합성기작에 대한 기초 및 응용연구의 가능성에 대하여 검토하여 보았다.

• 한국지열·수열에너지학회논문집
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• 제18권3호
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• pp.19-30
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• 2022

In this study, comparative analysis of energy performance in Taebaek city, a test area, by applying hydrothermal, geothermal source and hybrid heat pump system to office, school and smart farms with different internal heat loads. The conclusion is as follows. In the load characteristics by use of buildings, it was found that office had a large cooling load compared to heating load, school had a large heating load compared to cooling load, and smart farm had only cooling load year-round. Performance analysis of the heat pump system in office shows that the cooling COP of the hydrothermal source is 5.12% and the heating COP is 3.22% lower based on the geothermal source, the cooling COP of the hybrid is 0.41% higher, and the heating COP is the difference in performance appeared sparsely. The performance analysis of the heat pump system in school showed that the cooling COP of the hydrothermal source was 10.44% and the heating COP 3.22% lower based on the geothermal source, and the performance difference between the hybrid cooling and heating COP was insignificant. Heat pump system performance analysis in smart farm only occurred with cooling load. Based on geothermal sources, the cooling COP of the hydrothermal source was 46% and the cooling COP of the hybrid was 19.65%, respectively.

• BMB Reports
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• 제52권7호
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• pp.445-450
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• 2019

TTYH2 is a calcium-activated, inwardly rectifying anion channel that has been shown to be related to renal cancer and colon cancer. Based on the topological prediction, TTYH2 protein has five transmembrane domains with the extracellular N-terminus and the cytoplasmic C-terminus. In the present study, we identified a vesicle transport protein, ${\beta}$-COP, as a novel specific binding partner of TTYH2 by yeast two-hybrid screening using a human brain cDNA library with the C-terminal region of TTYH2 (TTYH2-C) as a bait. Using in vitro and in vivo binding assays, we confirmed the protein-protein interactions between TTYH2 and ${\beta}$-COP. We also found that the surface expression and activity of TTYH2 were decreased by co-expression with ${\beta}$-COP in the heterologous expression system. In addition, ${\beta}$-COP associated with TTYH2 in a native condition at a human colon cancer cell line, LoVo cells. The over-expression of ${\beta}$-COP in the LoVo cells led to a dramatic decrease in the surface expression and activity of endogenous TTYH2. Collectively, these data suggested that ${\beta}$-COP plays a critical role in the trafficking of the TTYH2 channel to the plasma membrane.

• 대한설비공학회:학술대회논문집
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• 대한설비공학회 2008년도 하계학술발표대회 논문집
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• pp.163-170
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• 2008

Auxiliary port which had been known to be used to reduce the expansion loss of a refrigeration system was applied to a R134a reciprocating compressor in a household refrigerator cycle with an intention of improving the compressor performance. Effects of the auxiliary port on the compressor performance was investigated by a computer simulation program. When a simple hole was made on the side wall of the cylinder as an auxiliary port and surrounding gas inside the compressor shell was assumed to be drawn into the cylinder through the hole, maximum COP improvement of 1.66% was obtained. With auxiliary port equipped with a plate type of check valve, maximum COP was raised to be 1.99%. COP improvement was more distinctive with decreasing the discharge pressure; COP improvement was 5% with discharge pressure of 7 bar.

• 설비공학논문집
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• 제20권10호
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• pp.637-644
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• 2008

Auxiliary port which had been known to be used to reduce the expansion loss of a refrigeration system was applied to a R134a reciprocating compressor in a household refrigerator cycle with an intention of improving the compressor performance. Effects of the auxiliary port on the compressor performance was investigated by a computer simulation program. When a simple hole was made on the side wall of the cylinder as an auxiliary port and surrounding gas inside the compressor shell was assumed to be drawn into the cylinder through the hole, maximum COP improvement of 1.66% was obtained. With auxiliary port equipped with a plate type of check valve, maximum COP was raised to be 1.99%. COP improvement was more distinctive with decreasing the discharge pressure; COP improvement was 5% with discharge pressure of 7 bar.

• The Journal of Korean Physical Therapy
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• 제22권5호
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• pp.77-82
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• 2010

Purpose: The purpose of this study was to compare the pathway of COP and plantar foot pressure and to determine the correlation between plantar regions during the ascending and descending of a ramp. Methods: Fifteen healthy adults who had no musculoskeletal problems participated in our study. They were asked to walk on a level surface and on an ascending and descending ramp in their bare feet. Pathway of COP and plantar foot pressures were recorded using the Matscan system (Tekscan, Boston, USA). For pressure measurements, the plantar foot surface was divided into seven regions: two toe regions, three forefoot regions, a midfoot region, and a heel region. To determine whether there was a statistically significant difference between pathway of COP and plantar foot pressures during walking, we used repeated measuremes ANOVA. Results: In comparison to results for a level walking, pathway of COP while ascending a ramp had a tendency to be shifted medially in the forefoot and became longer till the big toe. Pathway of COP while descending a ramp also was shifted medially, but ended in the forefoot. Plantar foot pressure of the second and third metatarsal head and the fourth and fifth metatarsal heads was significantly decreased while descending the ramp. Conclusion: These results indicated that plantar foot pressure is changed while ascending and descending a ramp and demonstrated that ramp walking can affect the structure and function of the foot. Therefore, gait environment is associated with significant changes in foot characteristics, which contribute to altered plantar loading patterns during gait.

• The Journal of Korean Physical Therapy
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• 제21권3호
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• pp.75-80
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• 2009

Purpose: The purpose of this study was to examine the effect of an obstacle height on the balance control of older adults while stepping over an obstacle from a position of quiet stance. Methods: Fifteen community-dwelling healthy older adults (mean age, $74.4\pm4.27$ yrs; age range, 67-82 yrs) volunteered to participate in this study. The subjects performed gait initiation (GI) and they stepped over obstacles of two different heights (10 cm and 18 cm) at a self-paced speed from a position of quiet stance. Their performance was assessed by recording the changes in the displacement of the COP in the anteroposterior (A-P) and mediolateral (M-L) directions using a force platform. Results: The M-L displacement of the COP significantly increased for an 18 cm obstacle height condition as compared to the GI and a 10 cm obstacle height condition (p<0.01). Furthermore, the M-L displacement of the COP for a 10 cm high obstacle was significantly greater for that for the GI (p<0.01). However, the mean of the A-P displacement of the COP was similar between the stepping conditions for the A-P displacement of the COP (p>0.05). Conclusion: This study suggests that the M-L COP displacement could be a better parameter to identify the dynamic balance control in older adults when negotiating obstacles.

• International Journal of Air-Conditioning and Refrigeration
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• 제7권
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• pp.55-68
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• 1999

In this study, computer simulation programs were developed for single-stage, two-stage, and three-stage condensation heat pumps and their performance with CFC11, HCFC123, HCFC141b was examined under the same external conditions. The results showed that the coefficient of performance(COP) of an optimized 'non-split type' three-stage condensation heat pump is 25-42% higher than that of a conventional single-stage heat pump. The increase in COP, however, differed among the fluids tested. The improvement in COP is largely due to the decrease in average LMTDs in condensers, which results in the decrease in thermodynamic irreversibility in heat exchange process. For the three-stage heat pump, the highest COP is achieved when the total condenser area is evenly distributed among the three condensers. For the two-stage heat pump, however, the optimum distribution of the total condenser area varies with an individual working fluid. For the three-stage system, 'splitting the condenser cooling water'for the use of intermediate and high pressure subcoolers helps increase the COP further. When the individual cooling water entering the intermediate and high pressure subcoolers is roughly 10% of the total condenser cooling water, the maximum COP is achieved showing roughly an 11% increase in COP as compared to that of the 'non-split type' heat pump.