• 한국인터넷방송통신학회논문지
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• 제18권2호
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• pp.133-139
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• 2018

온라인 예약서비스를 통한 e하늘장사정보시스템의 2011년도 이용건수는 37,784구이었으나, 2017년도는 56,945구로 50.7%가 증가한 것으로 나타났다. 이러한 이용 증가로 관련한 서울특별시의 공설화장시설 운영개선이 다음과 같은 정책들이 시행되어야 할 것이다. 첫째, 현재 공설화장시설의 입지 지역주민과의 원만한 협상을 통한 화장로 추가 설치, 둘째, 서울특별시와 인접한 경기도 관내 지방자치단체와 공동으로 공설화장시설 건립을 위한 협력사업추진, 셋째, 서울시립묘지 내 개장 전용 화장시설의 설치를 통한 화장수요의 분산, 끝으로 서울특별시 관내 주민을 제외한 기타 지역주민에 대한 공설화장시설 이용시간대 차별 운영 확대 및 화장요금 인상 등을 통한 화장수요를 억제하는 방안에 대한 시행이 이루어져야 한다.

• 한국컴퓨터정보학회논문지
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• 제16권4호
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• pp.83-91
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• 2011

본 논문의 목적은 정보통신윤리 교육을 위한 효과적인 블랜디드 문제중심학습 시스템을 구현하는데 있다. 교수-학습 목표 달성을 위해서 온라인 학습과 면대면 수업이 체계적으로 혼합되었고 온라인 학습을 위한 주요 모듈은 오픈소스 학습 관리시스템인 무들에서 운영되었다. 제안 시스템의 교육적인 효과를 검증하기 위해서 ${\bigcirc}{\bigcirc}$시 소재의 대학교 2학년 2개 반을 대상으로 논문에서 제시한 방법을 사용하여 실험연구를 하였다. 실험 대상의 학생 수는 60명(실험집단: 30명, 통제집단: 30명)이며 각 그룹에 6명의 학생으로 10개의 그룹으로 편성되었다. 연구 결과는 다음과 같다. 첫째, 제안한 블랜디드 PBL을 활용한 교육이 면대면 PBL 방법을 활용한 교육보다 정보통신윤리 의식 함양에 효과적이었다. 둘째, 제안한 블랜디드 PBL에 참여한 학습자들이 면대면 PBL에 참여한 학습자들보다 문제해결능력 향상, 협동학습의 이해와 같은 다양한 PBL 효과를 체험하였다.

• 한국융합학회논문지
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• 제9권10호
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• pp.533-540
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• 2018

본 연구는 협동동료교수학습이 간호대학생의 의사소통능력과 셀프리더십에 미치는 융합적 효과를 확인하기 위해 시도되었다. 10회의 협동동료교수학습 전후 의사소통능력과 셀프리더십 조사 결과를 SPSS/WIN 19.0으로 시행한 Mann-Whitney U와 Kruskal-Wallis 검정 결과, 의사소통능력은 실험 전후 성격유형, 토론선호 및 리더역량에서 유의한 차이가 있었고, 셀프리더십은 간호학과 입학동기, 리더역량 및 학교성적에서 유의한 차이를 보였다. 처치 전후 의사소통능력과 셀프리더십 간 양의 상관관계가 있었고, Wilcoxon 부호순위검정 결과, 협동동료교수학습은 의사소통능력과 셀프리더십을 각각 유의하게 증가시켰다(p=.008, p<.001). 본 연구 결과 협동동료교수학습은 간호대학생들의 의사소통능력과 셀프리더십 향상을 위한 중재프로그램을 개발을 위해 적용가능한 효과적인 학습법으로 볼 수 있고, 대상자 수를 확대하고 대조군을 둔 실험연구를 제언한다.

• BMB Reports
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• 제34권4호
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• pp.365-370
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• 2001

We constructed a comparative expression system in order to produce recombinant human ferritin homo- and heteropolymers in Escherichia coli. Human ferritin H-(hfH) and L-chain (hfL) genes were expressed without amino acid changes under the control of a tac promoter. Ferritin heteropolymers of varying subunit composition were also produced by combining two different expression systems, a bicistronic expression system and a coplasmid expression system. As a result, recombinant H-chain ferritin and ferritin heteropolymers were catalytically active in forming iron core in vivo. In particular, the ferritin heteropolymer that is composed of 7% H-subunit and 93% L-subunit was capable of forming an iron core of the protein, while the L-chain ferritin homopolymer was inactive in vivo. This result indicates that the two H-subunits (i.e., 7% H-subunit content) are important to keep ferritin active in the cells. In addition, human ferritins were identified as the major iron binding proteins in the transformed cells. Also, the amount of iron bound to the recombinant ferritins was proportional to the H-subunit content in ferritin heteropolymers in vivo.

• Asian Pacific Journal of Cancer Prevention
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• 제14권5호
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• pp.3255-3261
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• 2013

Background: The efficacy of erlotinib is controversial in patients with unknown EGFR mutational status. The aim of this study was to identify the clinicopathological factors that are predictive of erlotinob treatment outcomes for NSCLC patients with unknown EGFR mutational status. Materials and Methods: A retrospective analysis of 109 patients with advanced NSCLC who had previously failed at least one line of chemotherapy and received subsequent treatment with erlotinib (150 mg/day orally) was performed. A Cox proportional hazard model for univariate and multivariate analyses was used to identify the baseline clinical parameters correlating with treatment outcome, expressed in terms of hazard ratios (HRs) and 95% confidence intervals. Results: The median treatment duration was 15 weeks (range, 4-184). The disease control rate was 55%, including disease stability for ${\geq}3$ months for 40% of the patients. Median progression-free survival and median overall survival (OS) were 4.2 and 8.5 months, respectively. The Cox model indicated that an Eastern Cooperative Oncology Group performance status (ECOG PS) ${\geq}2$ (HR 3.82; p<0.001), presence of intra-abdominal metastasis (HR 3.42; p=0.002), 2 or more prior chemotherapy regimens (HR 2.29; p=0.021), and weight loss >5% (HR 2.05; p=0.034) were independent adverse prognostic factors for OS in NSCLC patients treated with erlotinib. Conclusions: This study suggests that NSCLC patients should be enrolled in erlotinib treatment after a first round of unsuccessful chemotherapy to improve treatment success, during which they should be monitored for intra-abdominal metastasis and weight loss.

• 대한한의학방제학회지
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• 제11권1호
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• pp.129-149
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• 2003

Liver is an important target of the toxicity of drugs, xenobiotics and oxidative stress. Acetaminophen pverdose causes acute liver injury in both humans and animals. This study was performed to observe the effect of sachunwhan and its component groups on recovery of hepatoxicity in acetaminophen treated rats. The experimental group was divided into 4 groups: sachungwhan(SC), samultang group(SC-1: 當歸, 川芎), chungyul group(SC-2: 龍膽草, 大黃, 梔子), and haepyo group(SC-3:羌活, 防風). Under the same condition Normal group was fed basal diet and water; Control group was injected acetaminophen and fed basal diet for 2 weeks; Experimental groups were injected acetaminophen and fed each extracts for 2 weeks respectively. The results were obtained as follows: 1. In the study on antioxidative defense system in vivo, SC reduced the amount of lipid peroxide in both serum and liver and showed activity on antioxidative enzymes such as catalase, glutathion. Other groups had effect only on glutathion. 2. In the study on hepatotoxicity(GOT, GPT, ${\gamma}$-GTP, ALP, LDH, Bilirubin), SC had a significant effect on recovery of hepatoxicity in acetaminophen treated rats. Other groups had no effect except SC-1 having effect on ${\gamma}$-GTP. As results shown, only Sachungwhan(SC) has significant effects on recovery of hepatoxicity and antioxidative defense system in vivo. These results suggest that Sachungwhan(SC) made antioxidative defense system active and it seemed to be very important to its effect on recovery of hepatoxicity. In the other hand, Component groups had no effect on recoverv of hepatoxicity and antioxidative defense system in vivo. This was thought that component drugs' cooperative synergy effect would be important to Sachungwhan(SC)'s effects mentioned in this paper.

• 한국콘텐츠학회논문지
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• 제10권3호
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• pp.132-140
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• 2010

컴퓨터 화면과 키보드나 마우스에만 의지하고 또 그에 익숙해져있는 사용자들에게 RFID를 이용한 인터페이스는 기존의 컴퓨터 게임을 확장하고 향상시킬 수 있다. 본 논문에서는 초기 개발자가 RFID 칩과 리더기를 이용하여 손으로 조작하며 게임을 즐길 수 있는 새로운 RFID 디지털 보드게임 콘텐츠를 소개한다. 개발된 RFID 보드게임은 총 4가지로, 3개의 게임은 화면을 보면서 RFID 칩으로 게임을 제어하는 것이고, 다른 하나는 화면을 배제할 수 있는 게임을 시도하여 보드판에 보다 몰입하여 게임을 즐길 수 있도록 구성하였다. 초기 개발자들의 결과물들을 살펴보면, RFID를 사용한 단순한 사물인지 기술에 기반한 접근에서 확장하여 사물의 배치를 인지하는 것과 같이 RFID의 기능을 최대한 활용한 게임 콘텐츠를 개발하여야 한다. 초기개발자의 개발 과정을 통해, 게임 기술개발자와 콘텐츠개발자 간의 공동협력 체계의 구성이 필요함을 알 수 있다. 또한, 유아와 아동이 능동적으로 참여하고 조작할 수 있는 상호작용성이 최적화된 인터페이스의 설계가 필요하다.

• Nutrition Research and Practice
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• 제12권1호
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• pp.29-40
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• 2018

BACKGROUND/OBJECTIVES: Ultraviolet radiation (UV) is a major cause of skin photoaging. Previous studies reported that ethanol extract (PET) of Prunus persica (L.) Batsch flowers (PPF, peach flowers) and its subfractions, particularly the ethylacetate (PEA) and n-butanol extracts (PBT), have potent antioxidant activity and attenuate the UV-induced matrix metalloproteinase (MMP) expression in human skin cells. In this study, we investigated the protective activity of PPF extract against UV-induced photoaging in a mouse model. MATERIALS/METHODS: Hairless mice were treated with PET or a mixture of PEA and PBT either topically or orally along with UV irradiation. Histological changes and biochemical alterations of mouse skin were examined. Major phenolic compounds in PPF extract were analyzed using an ACQUITY UPLC system. RESULTS: The overall effects of topical and oral treatments with PPF extract on the UV-induced skin responses exhibited similar patterns. In both experiments, the mixture of PEA and PBT significantly inhibited the UV-induced skin and epidermal thickening, while PET inhibited only the UV-induced epidermal thickening. Treatment of PET or the mixture of PEA and PBT significantly inhibited the UV-induced MMP-13 expression, but not type I collagen expression. Topical treatment of the mixture of PEA and PBT with UV irradiation significantly elevated catalase, superoxide dismutase (SOD) and glutathione-peroxidase (GPx) activities in the skin compared to those in the UV irradiated control group, while oral treatment of the mixture of PEA and PBT or PET elevated only catalase and SOD activities, but not GPx. Thirteen phytochemical compounds including 4-O-caffeoylquinic acid, cimicifugic acid E and B, quercetin-3-O-rhamnoside and kaempferol glycoside derivatives were identified in the PPF extract. CONCLUSIONS: These results demonstrate that treatment with PET or the mixture of PEA and PBT, both topically or orally, attenuates UV-induced photoaging via the cooperative interactions of phenolic components having anti-oxidative and collagen-protective activities.

• Clinical and Experimental Pediatrics
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• 제50권7호
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• pp.606-612
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• 2007

Since the introduction of chemotherapy for the treatment of childhood leukemia more than 50 years ago, the results of childhood cancer have improved dramatically. The 5-year survival rate of disease, many of which were uniformly fatal in the prechemotherapy era, reached to more than 75%. This remarkable improvement in survival is a direct result of the incorporation of chemotherapeutics into treatment regimens that previously relied only on surgery or radiotherapy for the primary tumor. The multimodality approach, which integrates surgery and radiotherapy to control local disease with chemotherapy to eradicate systemic or metastatic disease, has become the standard approach to treating most childhood cancers. The overall improvement in outcomes in childhood solid tumors has been related to the development of multidisplinary cooperative studies that has permitted the development of well-designed tumor treatment protocols characterized by uniform staging criteria, sharing informations in pathologic classification, uniform methods for tumor markers, oncogenes, and other biologic and genetic factors. Important advances in the biologic study of cancer and its genetic basis led to a number of observations that impact directly on the management of childhood solid tumors. Identification of specific genes, oncogenes, tumor markers, and other biologic and pathologic factors plays an important role in both staging and clarifying the risk categorization of individual patients. Treatment of the patient is influenced by the recognition of specific risk factors. This knowledge has resulted in a change in the approach to care based not only on staging criteria, but also on risk-based management. This concept uses various risk factors of outcomes. Risk-based management allows for each patient to maximize survival, minimize long-term morbidity and improve the quality of life, especially for children's growth and development.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2010년도 제39회 하계학술대회 초록집
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• pp.316-316
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• 2010

Thin films spin-coated from solvent solutions are characterized by solution parameters and spin-coating process. In this study, performance characteristics of polymer solar cells were investigated with changing solution parameters such as solvent and additives. The phase-separation between polymer and fullerene is needed to make the percolation pathway for better transportation of hole and electron in polymer solar cells. For this reason, cooperative effects of solvent mixtures adding additives with distinct solubility have been studied recently. In this study, chlorobezene, 1, 2-dichlorbenzene, and chloroform were used as solvent. 1, 8-diiodoctaned and 1, 8-octanedithiol were used as additives and were added into poly(3-hexylthiophene-2, 5-diyl)/[6, 6]-phenyl C61 butyric acid methyl ester (P3HT/PCBM) blends. Pre-patterned ITO glass was cleaned using ultrasonication in mixed solvent with ethyl alcohol, isopropyl alcohol and acetone. PEDOT:PSS was spin-coated on to the ITO substrate at 3000rpm and was baked at $120^{\circ}C$ for 10min on the hotplate. The prepared solution was spin-coated at 1000rpm and the spin-coated thin film was dried in the Petri dishes. Al electrode was deposited on the thin film by thermal evaporation. The devices were annealed at $120^{\circ}C$ for 30min. By adding 2.5 volume percent of additives into the chlorobenzene from that bulk heterojunction films consisting of P3HT/PCBM, the power efficiency (AM 1.5G conditions) was increased from 2.16% to 2.69% and 3.12% respectively. We have investigated the effect of additives in P3HT/PCBM blends and the film characteristics and the film characteristics including J-V characteristics, absorption, photoluminescence, X-ray diffraction, and atomic force microscopy to mainly depict the morphology control by doping additives.