• 공학교육연구
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• 제20권6호
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• pp.12-21
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• 2017

The purpose of this study is to develop an educational program to enhance convergence competence of undergraduate engineering students and analyze its educational effects. Prior to the development of the convergence education program for engineering students, 13 experts in engineering education field surveyed the needs of the convergence education program and 829 students from four engineering colleges in the Seoul metropolitan area, Chungcheong area and Honam area were assessed for the level of convergence competency. The educational program was developed based on the needs analysis and the program consisted of four major themes: convergence lecture, convergence competence, convergence practice, and convergence vision. The validity of the program was confirmed through the two expert validation tests. A total of 40 students participated in the selection of 10 students from each of the four universities. As a result of pre-post comparison of students' convergence competencies, the average of all competencies increased, and it was found that there were statistically significant differences in convergence mindset, differentiation mind, commitment, communication, and social value competence. Implications for the improvement of education programs and convergence education were suggested.

• 대한방사성의약품학회지
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• 제7권2호
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• pp.79-84
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• 2021

Radiopharmaceuticals are important for tumor diagnosis and therapy. To deliver a radiotracer at the desired target excluding non-targeted tissues is difficult The development of a targeted tracer that has a good clearance profile while maintaining high biostability and biocompatibility is key to optimizing its biodistribution and transport across biological barriers. Improving the hydrophilicity of radiotracers by PEGylation can reduce serum binding, allowing the tracer to circulate without retention and reducing its affinity for non-targeted tissues. In this study, we synthesized a new benzamido tracer (SnBz-PEG₃₆) with the introduction of a low molecular weight polyethylene glycol unit (PEG₃₆, ~2,100 Da). The tumor targeting efficiency and biodistribution of [¹³¹I]-Bz-PEG₃₆ or radiotracer-loaded liposomes were evaluated after their administration to normal mice or mouse tumor models including CT26 (xenograft) and 4T1 (xenograft and orthotopic). Most of the radiotracer was cleared out rapidly (1-24 h post-administration) through the kidney and there was little tumor uptake.

• 한국실내디자인학회논문집
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• 제22권1호
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• pp.222-230
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• 2013

The convergence progress in science technology and ensuing changes in educational environments require another huge change in education programs in the 21st century defined as a knowledge-based information society. But nowadays, prospective college students are increasingly avoiding natural science and engineering. So, educational fields in korea need suitable convergence educational programs (STEAM: science, technology, engineering, arts, mathematics) for creative competent person who is training and experiencing. In addition, environmental design fields are predicting about spread of Kinetic architecture. Therefore the aim of this study is developing convergence hand-on educational program which is incorporate robot science into environmental design for children. The program and teaching materials were developed by mapping between robot science and environmental design process leading the Design Promote Committee in KIID(Korea Institute of Interior Design) supported research teams in Hansung University. And then, For utility of the program, we had a 3 times of demonstration of empirical education. First, graduate students of design and robot major, and small group of children who are selected, at last, 63 children who are applying the program randomly. For more high quality program, we were conducting survey of post-empirical education evaluation for children and their parents. In conclusion, we found out highly satisfaction of the program those two groups. Also they need more organized places, time, task and so on. And the convergence educational program would develop by systematic approach and empirical research. At last, various and series convergence programs and teaching materials would develop creative competency based for regular and irregular courses of whole educational period.

• 한국실내디자인학회논문집
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• 제25권6호
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• pp.15-22
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• 2016

Recent changes in the Korean education policies are promoting the advances in science and technology and cultivating people of convergence talent. STEAM (science, technology, engineering, art and math) educational program is Korean styled convergence program for creative competent human resources. Therefore, Therefore the aim of this study is developing convergence hand-on educational program coping with climate change for elementary school students. For development of the program, we investigated the curriculum of the elementary school about the climate change, and allocated in the creative learning standard frame. Also, we selected themes related the climate change in the curriculum and learning activity. For more effective program to build the convergence competency, we analyzed the program based on creative problem based learning process and 4 core competency(creativity, communication, convergence, caring) elements. In conclusion, the STEAM program needs to develop by school curriculum and leaner's ability. For elementary school students, the STEAM program consists with creative problem based learning process. And the convergence educational program would analyze by the creative PBL process and convergence competency elements. So, this developing program has brought the promotion of the creative convergence competent talented person for the future global environment.

• 대한방사성의약품학회지
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• 제6권2호
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• pp.155-164
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• 2020

Polyethylene glycol (PEG) has been the most commonly used polymer for the past few decades in the field of biomedical applications due to its gold standard stealth effect. PEGylation of antibody-drug conjugates, liposomes, peptides, nanoparticles, and proteins is done to improve their pharmaceutical efficacy and pharmacokinetic properties. PEGylation of antibodies with various PEG linkers improves targeting ability by increasing the blood circulation time and thus enhances the biodistribution profiles. It also assists in minimizing the immediate capture by the reticuloendothelial system. In this review, we summarize the effect of PEG linkers in an antibody conjugation and their pharmacokinetics in the field of biomedical imaging.

• 대한방사성의약품학회지
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• 제6권2호
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• pp.146-154
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• 2020

Selective installation of proteins using chemical reagents is important for the development of potential biomaterials for the treatment of human diseases. However, modification in a chemo- and regioselective manner under physiological conditions is a great challenge due to the presence of multiple reactive centers in the protein. Currently, the majority of conjugations are limited to lysine (Lys)- and cysteine (Cys)-selective reagents. Thus, they have been extensively studied. Apart from Lys and Cys, widespread site selectivity has been recently achieved through most of the 20 naturally occurring amino acid-bearing reactive functional groups. Consequently, this review focused on several recent achievements in site-selective modification of the rarest amino acid backbones (e.g., methionine, serine, glutamic acid, and tyrosine).

• 한국융합학회논문지
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• 제5권4호
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• pp.107-112
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• 2014

대체에너지로 차량주행풍을 이용한 연구 목표들은 다음 세 가지로 정리되었다. 첫째 목표는 차량주행풍의 풍력 발전 시스템을 통하여 환경적으로 무해한 대체 에너지 원을 확보하였다. 둘째는 연계된 융합 전문가를 길러낼 수 있는 교육 프로그램을 개발했다는 점이다. 셋째는 대체 에너지 교육을 위한 풍력시스템을 구축했다는 점이다. 본 연구에는 6개월의 연구기간이 소요되었다. 그 결과 다음과 같은 세 가지 결론을 얻게 되었다. 차량주행풍을 사용하는 시스템이 모델링 되었다. 전기, 전자, 기계공학의 새로운 융합 교육 프로그램이 이 모델링 시스템 하에 개발되었다. 마지막으로, 차량주행풍이 대체에너지의 데모용으로 실제 교육을 할 수 있도록 제작되었다.

• 대한방사성의약품학회지
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• 제8권1호
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• pp.39-44
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• 2022

The development of methods for the inert and stable radiohalogenation of targeted radiopharmaceuticals is a prerequisite for real-time diagnosis and therapy using radiohalogenated radiopharmaceuticals. Radiohalogenated carboranes demonstrate superior stability in vivo and versatile applications compared with directly labeled tyrosine analogues or synthetically modified organic compounds. Herein, we focus on the most common approaches for the radioiodination (¹²³l, ¹²⁴l, ¹²⁵l, and ¹³¹l) of carborane derivatives.

• BMB Reports
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• 제54권5호
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• pp.266-271
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• 2021

Estrogen-related receptor γ (ERRγ), a member of the orphan nuclear receptor family, is a key mediator in cellular metabolic processes and energy homeostasis. Therefore, ERRγ has become an attractive target for treating diverse metabolic disorders. We recently reported that ERRγ acts as a negative regulator of osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand (RANKL). In the present study, we explored the effects of an ERRγ-specific modulator, GSK5182, on ERRγ-regulated osteoclast differentiation and survival. Interestingly, GSK5182 increased ERRγ protein levels much as does GSK4716, which is an ERRγ agonist. GSK5182 inhibited osteoclast generation from bone-marrow-derived macrophages without affecting cytotoxicity. GSK5182 also attenuated RANKL-mediated expression of cFos and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), pivotal transcription factors for osteoclastogenesis. Arrested osteoclast differentiation was associated with reduced RANK expression, but not with the M-CSF receptor, c-Fms. GSK5182 strongly blocked the phosphorylation of IκBα, c-Jun N-terminal kinase, and extracellular signal-regulated kinase in response to RANKL. GSK5182 also suppressed NF-κB promoter activity in a dose-dependent manner. In addition to osteoclastogenesis, GSK5182 accelerated osteoclast apoptosis by caspase-3 activation. Together, these results suggest that GSK5182, a synthetic ERRγ modulator, may have potential in treating disorders related to bone resorption.

• 공학교육연구
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• 제17권1호
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• pp.42-49
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• 2014

The main purposes of this study was to develop evaluation model, which provides program educational objectives(PEO) evaluation research with guidances on how to evaluate the program educational objectives and procedures in order to enhance the quality of engineering education. Educational objective evaluation is reciprocal processes that depend on and affect one another. Thus, the evaluation component deals with how to identify members' strengths, weakness, and needs, how to assess and improve the effectiveness of curriculum programs, and how to provide data that assist in decision making. After literature reviews about the case studies on the program educational objectives evaluation, this study, to understand the meaning of education evaluation and the engineering accreditation, and then, examined the evaluation model for program educational objectives. This study suggested evaluation components of program educational objectives. In particular, the distinctions between diagnostic, formative, and summative evaluation are discussed. The result of this study is significant in terms of guiding the future evaluation model development for program educational objectives.