• BMB Reports
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• 제45권10호
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• pp.571-576
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• 2012

Radiotherapy is considered to cause detrimental effects on bone tissue eventually increasing bone loss and fracture risk. However, there is a great controversy on the real effects of irradiation itself on osteoblasts, and the mechanisms by which irradiation affects osteoblast differentiation and mineralization are not completely understood. We explored how X-ray radiation influences differentiation and bone-specific gene expression in mouse calvarial osteoblasts. Irradiation at 2 Gy not only increased differentiation and mineralization of the cells, but also upregulated the expression of alkaline phosphatase, type I collagen, osteopontin, and osteocalcin at early stages of differentiation. However, irradiation at higher doses (>2 Gy) did not stimulate osteoblast differentiation, rather it suppressed DNA synthesis by the cells without a toxic effect. Additional experiments suggested that transforming growth factor-beta 1 and runt-transcription factor 2 play important roles in irradiation- stimulated bone differentiation by acting as upstream regulators of bone-specific markers.

• Parasites, Hosts and Diseases
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• 제45권3호
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• pp.239-243
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• 2007

Many allergists are currently focusing on the development of new diagnostic tools, and are attempting to improve both the sensitivity and specificity. A multiple allergen simultaneous test-chemiluminescent assay (MAST-CLA) is one of the most popular diagnostic tools used in the Republic of Korea. However, there remains controversy among allergists with regard to the cut-off point for a positive result. The present study was conducted in order to determine the validity of MAST-CLA as compared with that of the skin prick test, with particular emphasis on arthropod allergens, on the basis of percentage agreement rates and k-values, and also to suggest the optimal positive cutoff points using receiver operating characteristic (ROC) curves. The study was conducted with 97 subjects (54 men, 43 women). Optimal individual cut-off points were calculated as follows; class II for Dermatophagoides farinae, class I for Dermatophagoides pteronyssinus, and trace for a cockroach mix. These findings suggest that attempting to apply optimal individual cut-off points will be a good way of improving diagnostic tests, particularly MAST-CLA.

• 한방비만학회지
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• 제7권1호
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• pp.23-29
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• 2007

Background : Mahuang (Ephedra sinica) has been used widely to treat respiratory disease in traditional medicine for over thousands years. Mahuang preparations contain approximately $0.75{\sim}1%$ ephedrine alkaloids. Recently in North America, the Eephedra alkaloids has aroused a controversy due to its adverse effects in those using whole extracts as "dietary supplements" for weight loss or athletic performance enhancement. Objective : To discuss the need for clinical practice guidelines on the use of Mahuang. Results and Conclusion : It is widely assumed that Mahuang is one of the useful medicines and is safe for human body. Most of scientific literatures support that the safety of Mahuang prescription in common dosage. However, it has been claimed that there were some warnings and apprehensions about the harmfulness of Mahuang as dietary supplements. This article does not negate the fact that it is necessary to pay more attention for use of Mahuang in clinical situations. We assert that the establishment of clinical practice guideline on the use of Mahuang, which is based on scientific materials and consensus, is required in traditional medicine.

• 한국의류학회지
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• 제32권11호
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• pp.1680-1691
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• 2008

This study examines how the development and value of dresses shown in MBC historical dramas have changed with the overall change of the dramas. As for the research method, the second data analysis was done with literature study which was supplemented with interviews with the wardrobe team of MBC production design center. Historical dramas produced by MBC have gone through the developmental period, legitimate historical drama-oriented period, stagnant period, and historical dramas-modernized period. The value of costume in each period is as follows: Costume in the developmental period is considered only as part of drama setting. During legitimate historical drama-oriented period, it carries value as educational data and historical replica produced by historical research. Production design including costume obtains its own value in the stagnant period although the production of historical dramas decreases dramatically. And lastly, in the historical dramas-modernized period, costume starts to have commercial value as cultural contents. Historical drama costume may contain important value in terms of education and history, even though there has been controversy on TV historical dramas' role: they should focus on reproducing historical facts or they should support writers' creativity.

• 디지털산업정보학회논문지
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• 제10권3호
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• pp.151-159
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• 2014

Recently, spread of large amount Smartphones made users to download location-based service applications, which provided by application developers. These location-based service applications are convenient tool for users. Location-based service use technology to find location of user and provide information of user's location. Leakage of information of user's location and expose of privacy life raised new controversy. In this thesis, it will analyze relations of increase of Smartphone market, usage of Location-based service and severity of personal information leakage. Also, it will analyze examples of user's case of damage which caused by leakage personal information and find solutions to reduce damage of personal information leakage. In research, it will find cases of damage that cause by Location-based service. Also it will analyze and research cases of damage and present with graph and chart. In conclusion, to reduce and prevent from damage which caused by leakage personal information, it is important that users and application developers to realize danger of private and personal information leakage. Also, user's personal information must deal with cautiously and application developers have to research and develop the application with powerful security.

• 한국수학사학회지
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• 제22권3호
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• pp.273-292
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• 2009

뉴턴과 아인슈타인의 시공간에 대한 표준적 해석에 의하면 독립적으로 존재하는 시공간이란 존재자가 물체의 운동을 인과적으로 설명한다. 이 논문은 뉴턴과 아인슈타인의 시공간을 해석하는 이 견해를 비판적으로 고찰한다. 이두 이론에서 시공간을 해석하는 최근 과학사와 과학철학의 연구를 중심으로 필자는 시공간 구조가 운동법칙의 부산물이지 그 반대가 아님을 주장한다. 이러한 시공간의 동역학적 견해를 통해 시공간이 가지는 인과적 속성이 뉴턴물리학에서 아인슈타인 물리학으로의 이론변화의 발전에 의미 있는 기능을 하지 못하였음을 주장할 것이다.

• 한국가구학회지
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• 제24권4호
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• pp.345-349
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• 2013

Yellow poplar is well known commercial hardwood species in the world because of its availability, rapid growth, large size, excellent form, early natural pruning, and the good working quality of the wood. Therefore, yellow poplar (Liriodendron tulipifera L.) has been adopted in South Korea for decades ago, and its cultivating the saplings and silvicultural system have been studied. However, yellow poplar is still embroiled in controversy for utilization of use and worth. This species has not only advantages such as lower weight, light color, and higher machinability and bending processing, but also has disadvantages which are bad smell and different colors on heartwood and sapwood. In this study, the objective was that use of yellow poplar board as furniture materials by drying and painting process. Thirty years old yellow poplar was cut and dried for 7 days by high-frequency dryness. Adjustment of color tone to walnut color was conducted with multiple colorants and various number of spread times. Uniform color of yellow poplar on heartwood and sapwood was accomplished by applying 1 time stain (green), 2 times transparent primer, 1 time middle-painting (walnut), and 2 times top-painting (walnut) in sequentially. The painted yellow poplar board was used to manufacture table and dressing table. During the furniture manufacture process, no critical issues were occurred on part of jointing and painting. This painting method may be useful data for future use of yellow poplar as furniture materials.

• 기술혁신연구
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• 제5권1호
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• pp.181-205
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• 1997

There has been considerable controversy over the impacts of the tax credit on R&D expenditures in many countries. Korea has adopted various kinds of tax credit system to stimulate private firm' R&D expenditures. Korean government, Recently, is trying to reform tax system to reduce tax credit programmes according to Uruguay Round agreement and in line with OECD policy standards. The purpose of this paper is to analyze the effectiveness of current tax credit system on technology innovation in Korea and derive some policy implications over tax reform. In this paper, firstly, I investigate the size of tax reduction effects from each program in theoretical models and simulate the actual rate of individual tax incentive to a unit of R&D expenditure. I find that theoretically the reserve fund for technology development program has given the largest tax reduction effects to private firms irrespective of the R&D incentive system reform. Tax credit on R&D expenditure also has been very effective instrument to firm's tax reduction. Secondly, I try to measure the effectiveness of tax credit through the estimation of effective margianl tax rate between with the system and without the system of credit on R&D expenditure during the tax credit reform periods. I find that the tax credit on R&D has lowered firm's investment cost since the system introduced. I also have strong results that there has been a positive relation between the fluctuation of firm's R&D expenditure and the change of effective marginal tax rate. I suggest that it is better to sustain the system of tax credit on R&D for a while to increase firm's R&D expenditure.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.398-399
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• 2008

Enhanced performances of high temperature superconducting (HTS) cable attract tremendous interests of the power utility. However, the reliability issue as the power system is still in controversy. To verify the reliability of HTS cable, 22.9 kV HTS cable system with the specification of 100 m length, 50 MVA capacity, and open refrigeration cooling system was laid on Gochang power testing center of KEPCO in 2006. During the test period, the current transport characteristics, the fundamental function of power cable, have been monitored and investigated precisely. In this paper, the heat loss and AC loss measured at various current load conditions are described and discussed.

• 대한불안의학회지
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• 제5권2호
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• pp.75-79
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• 2009

In this article, we review the efficacy of early interventions after traumatic incidents and during acute stress disorder (ASD). There are some evidences that psychopharmacological medications such as propronolol, morphine, and hydrocortisone are effective in the prevention of posttraumatic stress disorder (PTSD). Considering the role of selective serotonin reuptake inhibitors in hippocampal neurogenesis and an animal model of PTSD, early administration of selective serotonin reuptake inhibitors is also fairly promising. Other pharmacological treatments including benzodiazepines did not treat ASD nor prevent PTSD. There are good evidences that cognitive behavioral therapy including cognitive therapy and prolonged exposure is a valuable intervention for ASD and the most effective prevention for PTSD. No contolled researches on eye movement desensitization&reprocessing, psychodynamic psychotherapy and hypnotherapy have performed. Recent randomized controlled studies using psychological debriefing did not prove as a useful intervention for the prevention of PTSD until now, although the efficacy of debriefing has been at the centre of controversy.