• 제목/요약/키워드: Controlled clinical trials, randomized

검색결과 783건 처리시간 0.026초

통풍성 관절염의 침 치료에 대한 최근 연구동향 분석: China National Knowledge Infrastructure (CNKI), PubMed 검색을 중심으로 (Acupuncture Treatment for Gouty Arthritis Using the Search Results of China National Knowledge Infrastructure (CNKI), PubMed: A Literature Review)

  • 금홍기;신병철
    • 한방재활의학과학회지
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    • 제33권1호
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    • pp.31-45
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    • 2023
  • Objectives The aim of this study is to find the future perspective through analyzing the trends of acupuncture treatment for gouty arthritis (GA) by searching the China National Knowledge Infrastructure (CNKI) and PubMed. Methods We searched clinical studies about acupuncture treatment for GA through the searching the electronic database of CNKI and PubMed. We analyzed the characteristics of selected studies according to research design, sample size, publication year, treatment methods, evaluation criteria and adverse events. Results Twenty-nine studies published from January 1, 2015 to July 1, 2022 were selected. They consisted of 25 randomized controlled trials, 3 non-randomized controlled trials, and 1 case reports. In these studies, several types of acupuncture treatments were performed and the most treatment was conventional acupuncture treatment with fine needles. The most commonly used evaluation outcome was effective rate. Conclusions Through this result, the Chinese literature positively reported the effect of acupuncture on GA. However, high-quality evaluation by rigorous research using well-designed and more objective outcomes is required.

안면마비의 테이핑 요법에 대한 임상 연구 동향 (Clinical Research Trend for Taping Therapy on Facial Palsy)

  • 이규영
    • 한방안이비인후피부과학회지
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    • 제36권4호
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    • pp.70-87
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    • 2023
  • Objectives : The purpose of this research is to review the efficacy and safety of taping therapy for facial palsy. Methods : Two foreign databases(Pubmed, CNKI) and one domestic database(OASIS) were used to search, and papers retrieved from the starting point of literature provision in each database until June 19, 2023 were included in the study. All studies in which other treatments were performed as a treatment intervention along with taping therapy were included, but cases where taping therapy was a comparative intervention were excluded. Results : 18 studies were selected. 14 studies were two-arm randomized controlled trials(RCT), and 4 studies were case reports. There was improvement in facial palsy in all 4 case reports, and in all 14 RCTs, the treatment effect in the observation group was significantly higher than in the control group. Conclusions : Taping therapy can be an effective and safe treatment method for facial palsy. However, the risk of bias in the selected studies was high, and there were many cases in which multiple interventions other than taping therapy were applied simultaneously. Therefore, well-designed studies with high quality are needed in the future.

안구건조증의 뜸 치료에 대한 체계적 문헌 고찰 (Systematic Review of Moxibution Treatment for Dry Eye Syndrome)

  • 이호찬;이유림;고홍제;최정화;정민영;박수연
    • 한방안이비인후피부과학회지
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    • 제32권1호
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    • pp.42-58
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    • 2019
  • Objectives : The aim of this study is to review the methodology of clinical trials conducted with the acupuncture and moxibustion treatment on Dry eye syndrome. Methods : Through four foreign online databases(PubMed, Cochrane library, EMBASE, CNKI) and two domestic online databases(NDSL, OASIS), we searched for clinical studies that performed moxibustion for dry eye syndrome from 2000 to December 2018. Only randomized controlled trials(RCT) were selected and anlyzed according to the research method. Results : A total 12 studies were reviewed and conducted in China. BL1, ST2, BL2 were most frequently used acupoints in moxibustion treatment. Among the evaluation indexes, Schirmer I Test(SIT), Tear break-up time(BUT) were used most. In most of the 12 studies, moxibustion treatment showed significant therapeutic effects. Conclusions : These results suggest that it is necessary to develop more detailed standards about moxibustion treatment method as the method of moxibustion is getting more diverse, and objective tools are needed in evaluating dry eye syndrome.

Efficacy of Pericapsular Nerve Group Block for Pain Reduction and Opioid Consumption after Total Hip Arthroplasty: A Meta-Analysis of Randomized Controlled Trials

  • Eunsoo Kim;Won Chul Shin;Sang Min Lee;Min Jun Choi;Nam Hoon Moon
    • Hip & pelvis
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    • 제35권2호
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    • pp.63-72
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    • 2023
  • The aim of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) for comparison of the effectiveness of pericapsular nerve group (PENG) block with that of other analgesic techniques for reduction of postoperative pain and consumption of opioids after total hip arthroplasty (THA). A search of records in the PubMed, Embase, and Cochrane Library, and ClinicalTrials.gov databases was conducted in order to identify studies comparing the effect of the PENG block with that of other analgesics on reduction of postoperative pain and consumption of opioids after THA. Determination of eligibility was based on the PICOS (participants, intervention, comparator, outcomes, and study design) criteria as follows: (1) Participants: patients who underwent THA. (2) Intervention: patients who received a PENG block for management of postoperative pain. (3) Comparator: patients who received other analgesics. (4) Outcomes: numerical rating scale (NRS) score and opioid consumption during different periods. (5) Study design: clinical RCTs. Five RCTs were finally included in the current meta-analysis. Significantly lower postoperative opioid consumption at 24 hours after THA was observed in the group of patients who received the PENG block compared with the control group (standard mean difference=-0.36, 95% confidence interval -0.64 to -0.08). However, no significant reduction in NRS score at 12, 24, and 48 hours after surgery and opioid consumption at 48 hours after THA was observed. The PENG block showed better results for opioid consumption at 24 hours after THA compared with other analgesics.

Effect and stability of miniscrew-assisted rapid palatal expansion: A systematic review and meta-analysis

  • Huang, Xinyi;Han, Yu;Yang, Shuangyan
    • 대한치과교정학회지
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    • 제52권5호
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    • pp.334-344
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    • 2022
  • Objective: This study aimed to systematically analyze the effect and stability of miniscrew-assisted rapid palatal expansion (MARPE) to provide a reference for the clinical treatment of patients with maxillary transverse deficiency (MTD). Methods: We searched PubMed, Science Direct, Web of Science, Embase, Cochrane Library, CNKI, and Wanfang Database for relevant studies published before February 18, 2021 and selected them according to the eligibility criteria. The Cochrane Handbook for Systematic Reviews (version 5.1.0) criteria were used for the quality assessment of randomized controlled trials, while the scoring protocol of the methodological index for non-randomized studies was used for non-randomized controlled trials. Statistical analysis was performed using the RevMan5.3 software. Results: All the included studies showed a relatively high success rate of expansion. The changes in both the intermolar and alveolar widths after MARPE were statistically significant. MARPE exhibited greater skeletal expansion effects than did conventional RPE. The midpalatal suture was opened in parallel after MARPE. A small amount of relapse was observed 1 year after expansion. MARPE caused tooth inclination and a decrease in alveolar height, but it was less significant than in conventional RPE. Conclusions: MARPE may be an effective treatment modality for patients with MTD. It causes great transverse skeletal expansion in late adolescence. In comparison to conventional RPE, MARPE has lower detrimental periodontal effects and has certain clinical advantages.

봉독을 이용한 무작위배정 임상연구의 국내 현황 (The Review on the Randomized Controlled Clinical Trials of Bee Venom in the Journal of Korean Medicine)

  • 이용석;이영준;한창현
    • 한방재활의학과학회지
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    • 제23권3호
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    • pp.87-106
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    • 2013
  • Objectives We will provide basic information on bee venom clinical tests and aid the practical use of bee venom in such tests, through examination of RCT research related to bee venom that was reported domestically. Methods We collected 365 articles on Bee venom study result from the OASIS system using the Keyword 'bee venom, apitoxin, apitherapy, bee sting'. The initially selected theses were primarily screened for clinical research. Out of these, case studies and non randomized controlled trial (non-RCT) were ruled out. As a result, 39 studies of randomized controlled trial (RCT) research were chosen as the subjects of study. Results RCT research related to bee venom was first presented in 2003, and 39 studies have been published until 2012. 18 studies were tests to confirm the effectiveness of bee venom, 7 studies were comparisons between SBV and BV, and 13 studies were comparisons with other types of treatment. Research conducted through appropriate randomization methods were 20 studies, and inappropriate randomization methods were used in 19 studies. In therms of Jadad score, 12 studies received 4~5 points, 15 studies received 1-3 points, and 12 studies received zero point. Conclusions In order to assure good quality RCT research, appropriate guidelines should be provided, and proper evaluation standards should be established. In-depth study is needed concerning the difference of responses to treatment according to the types of treatment received. A standardization of treatment should be reached as a result.

경추증성 척수증의 한의학적 치료에 대한 국내외 연구 동향 (A Review of the Korean Traditional Medicine for Cervical Spondylotic Myelopathy)

  • 변다영;이기언;노지애;김효준;허석원;한시훈
    • 한방재활의학과학회지
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    • 제29권2호
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    • pp.149-158
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    • 2019
  • Objectives This study was performed to research the trends of Korean traditional medicine treatment for cervical spondylotic myelopathy (CSM). Methods Clinical studies about Korean traditional medicine of CSM were searched in 7 online databases. We extracted the characteristics of selected studies according to author, publication year, country, research design, treatment methods, evaluation tools, and adverse events. Results Nineteen studies were selected in online databases. The included studies consist of 8 uncontrolled trial, 7 case reports, 3 randomized controlled trials and 1 non-randomized controlled trials. In these studies, various Korean traditional medicine treatments were performed, and herbal medicine was the most common. The most commonly used outcomes was effective rate. Conclusions This study showed that Korean traditional medicine could be an effective treatment for CSM. It was suggested that various studies should be conducted to provide objective evidence of the therapeutic effects of Korean traditional medicine treatment for CSM.

Overview of RCT for Non-Alcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

  • Son, Chang-Gue
    • 대한한의학회지
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    • 제32권3호
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    • pp.44-49
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    • 2011
  • Objective: This study aimed to get information on the current status of therapies to date for non-alcoholic fatty liver disease (NAFLD), including non-alcoholic steatohepatitis (NASH). Methods: All randomized clinical controlled trial (RCT)-derived papers for NAFLD or NASH were reviewed via PubMed Database. Results: 39 RCTs met the review criteria, of which 15 and 24 papers were for NAFLD and NASH, respectively. 83% of the papers were released since 2006, and 30 studies were conducted for western medicines, antioxidants and lifestyle intervention whereas nine trials were done using herbal medicine or acupuncture which showed positive outcome. Conclusions: NAFLD and NASH are new epidemic disorders which can be a target of traditional Oriental medicine. This study will be helpful for the Oriental medicine-based strategies or therapeutic development for them.

소아 천식 치료의 국외 보완대체의학 임상 연구 동향 (The Trends in Foreign Clinical Trials for Pediatric Asthma in Complementary and Alternative Medicine)

  • 방미란;김장현;민상연
    • 대한한방소아과학회지
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    • 제29권3호
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    • pp.1-11
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    • 2015
  • Objectives : The purpose of this study is to analyze the trends in foreign clinical trials for pediatric asthma in complementary and alternative medicine (CAM). Methods : We reviewed 31 randomized controlled trials (RCT) for pediatric asthma treatment in CAM published from 2005 to 2015 in PubMed and analyzed their treatments, compounds of herbal medicines, acupoints, methods of assessment, and treatment results. Results : The treatments used in the studies were herbal medicines, acupuncture, acupoint application, breathing training, supplement, normocaloric diet, yoga, massage therapy, and art therapy. The frequently used herbs were Asari Herba Cum Radix (細辛). Ephedrae Herba (麻黃), Astragali Radix. The most common acupoints were Feishu (肺兪, BL13). The methods of assessment in pediatric asthma were symptom scale, questionnaire of Quality of Life, lung function test, laboratory studies, and medication usage. In 28 out of 31 studies, treatment group gets better than non-treated group. Conclusions : This study shows that CAM is effective in treating pediatric asthma. More clinical studies using objective outcome measures are needed to prove its efficacy clearly.

얼굴마비의 임상연구병행 경제성평가 프로토콜 개발을 위한 체계적 문헌고찰연구 (Systematic Review for the Development of the Clinical Study with Economical Assessment Protocol on Facial palsy)

  • 공나경;서은성;선지혜;김남권
    • 대한한의학회지
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    • 제38권1호
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    • pp.46-55
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    • 2017
  • Objectives: The aim of this study is reviewing the literature to extract the key parameter, study design, perspective, cost-effectiveness index and find the calibration parameter for the clinical study with economical evaluation protocol on facial palsy. Methods: Literature search is performed using PUBMED for literature published from January 2000 to December 2016. We included randomized controlled trials(RCTs) and modelling study with economic assessment in which human participated. Results: As a result of literature search, the 198 articles were found. After reviewing the title, abstract and full text, the 5 articles were selected. Selected articles are classified into 4 RCT studies dealing with quality of life and 1 CEA(cost-effectiveness analysis) study. Conclusions: We found reliable key parameters, calibration parameters and elements of economical assessment study, which might be necessary factors for developing research protocol of clinical trial with economic evaluation about facial palsy patients.