• 한국수정란이식학회지
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• 제25권4호
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• pp.291-295
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• 2010

Four estrus-induced Himalayan tahrs (Hemitragus jemlahicus) were inseminated with frozen-thawed semen by laparoscopic or transcervical insemination techniques with no regard to the site of ovulation in non-breeding season. In June and July, 2009, estrus was synchronized by Eazi-Breed $CIDR^{(R)}$ (Controlled internal drug release; Pfizer Animal Health, New Zealand) insertion for 16 days and PG 600 (PMSG 400IU, hCG 200 IU; Intervet, Netherlands) injection (IM) a day before removing $CIDR^{(R)}$. Forty eight hours later, laparoscopic or transcervical insemination was done to each of two tahrs under anesthetic condition inducted by ketamine (1.5 mg/kg) and medetomidine (0.09 mg/kg). For examination of estradiol and progesterone, blood was collected right before $CIDR^{(R)}$ insertion, PG 600 injection, $CIDR^{(R)}$ removal and insemination. Estradiol levels of four tahrs (No. 1, 2, 3, 4) before $CIDR^{(R)}$ insertion and insemination were 13.3, 8.8, 14.3, 12 pg/ml and 23.5, 25.5, 21.1, 11.5 pg/ml, respectively. Progesterone levels of four tahrs (No. 1, 2, 3, 4) before $CIDR^{(R)}$ insertion and insemination were 1.8, 0.05, 0.63, 0.61 ng/ml and 1.03, 0.37, 1.48, 2.12 ng/ml. Except for No. 4 tahr, cervices showed cervical mucus and opened enough to penetrate with embryo transfer gun sheet usually used for cows. Therefore, No.4 was laparoscopically inseminated together with No. 1. In conclusion, none of four Himalayan tahrs was pregnant. However, we proved that estrus could be induced by CIDR and PG 600 injection in non-breeding season, and laparoscopic or transcervical insemination with frozen-thawed semen could be one of assisted reproductive techniques in Himalayan Tahr.

• 한국추진공학회지
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• 제20권6호
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• pp.46-53
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• 2016

희박 예혼합 가스터빈의 연소 불안정 현상을 이해하기 위해서는, 선형 과정에 의하여 얻어지는 고유주파수 및 초기 성장률뿐만 아니라, 연소기 비선형 특성에 의존하는 한계진폭의 예측이 필요하다. 특히 현재의 연구에서는 비선형 거동에 의한 한계 진폭을 예측하기 위해서 유동 섭동과 열발생의 비율이 주파수와 속도 진폭을 정의할 수 있는 화염묘사함수를 적용하였다. 본 연구에서는 화염묘사함수를 얻기 위하여 CFD 기법이 적용되었으며, 이를 통하여 비선형 열음향 해석으로부터 불안정 한계 진폭을 예측할 수 있었다.

• Macromolecular Research
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• 제12권4호
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• pp.399-406
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• 2004

Glass-like carbon precursors shrink significantly during curing and carbonization, which leads to crack formation and bending. Cured furan resin powder and ethanol were added to furan resin to diminish the weight loss, to suppress the shrinkage and bending, and to readily release the gases evolved during polymerization and curing. Curing and carbonization were controlled by pressure and slow heating to avoid damage to the samples. The effect of the filler and ethanol on the fabrication process was examined by measuring the properties of the glass-like carbon, such as the specific gravity, bending strength, electrical resistivity, and microstructural change. The specific gravities of the filler-added glass-like carbons were higher than those of the ethanol-added samples because of the formation of macropores from the vaporization of ethanol during the curing and polymerization processes. Although the ethanol-added glass-like carbons exhibited lower bending strengths after carbonization than did the filler-added samples, the opposite result was observed after aging at 2,600$^{\circ}C$. We found that the macropores created from ethanol were contracted and removed upon heat treatment. The electrical resistivity of the glass-like carbon aged at 2,600$^{\circ}C$ was lower than those of the samples carbonized at 1,000$^{\circ}C$. We attribute this phenomenon to the fact that aging at high temperature led to well-developed microstructures, the removal of macropores, and the reduction of the surface area.

• 한국철도학회논문집
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• 제11권3호
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• pp.294-299
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• 2008

본 연구는 구난역을 갖는 철도 터널 내에서 화재가 발생하였을 때 연기 전파 특성에 미치는 배연효과를 다루고 있다. 터널 화재 실험은 4cm의 정사각형 형태의 n-heptane$(C_7H_{16})$ 풀화재(pool fires)에 대해서 수행되었고 다양한 화재 발생위치에 따른 발열량을 측정하였다. 또한, 본 연구에서는 상용코드인 Fluent(Ver.6.3)를 사용하여 구난역을 갖는 철도 터널 내의 연층 전파 특성을 분석하였으며, MVHS(Modified Volumetric Heat Source) 모델을 사용하여 화재에 의한 연소생성물의 농도 및 거동을 예측하였다. 해석 조건은 다양한 화재 발생 위치에 따라서 측정 된 발열량을 이용하였다. 본 연구를 통해 교행로 내에 위치한 방화문에 의해 비사고터널로의 확산을 막을 수 있음을 보였고 특히, 배연시스템의 가동을 통해 유동방향을 변화시킴으로써 사고터널내의 연기 확산을 제어할 수 있음을 확인하였다.

• 대한임상독성학회지
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• 제5권2호
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• pp.126-130
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• 2007

Metformin is antihyperglycemic, not hypoglycemic. It causes neither insulin release from the pancreas nor hypo glycemia, even when taken in large doses. But, there are several reports of metformin-associated lactic acidosis (MALT). We present a case report of severe lactic acidosis most probably resulting from high doses of metformin in a patient with no known contraindications for metformin. A 43-year-old female was admitted to the emergency department due to a metformin overdose. She had diabetes for 6 years, well-controlled with metformin and novolet. One hour before admission, she impulsively took 50g metformin (100 mg or 100 tablets). Physical examination for symptoms revealed only irritability, and laboratory evaluation revealed only mild leukocytosis. After one hour the patient was drowsy, and arterial blood gas analysis showed severe lactic acidemia Seven hours after ED arrival, she commenced hemofiltration treatment and was admitted to the intensive care unit. Continuous venovenous hemodiafiltration was initiated. Forty-eight hours later, full clinical recovery was observed, with return to a normal serum lactate level. The patient was discharged from the intensive care unit on the third day. A progressive recovery was observed and she was discharged from the general word on the thirteenth day.

• 대한조선학회논문집
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• 제53권5호
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• pp.400-409
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• 2016

In recent, shipping companies have made an enormous effort to improve the operation of vessel in various approaches, due to recession of shipping market and increasing competition among shipping companies. One of important parameters for improving the efficiency of vessel is the resistance performance that consist of friction and residual resistance. Especially, it is recognized that the friction resistance tends to be affected by conditions of vessel’s surface and occupies approximately 70~90% of the total resistance for slow speed ships. In general, the surface of vessel is covered with various type of paint to reduce fouling and corrosion. As time goes by, however, it is so hull roughness would be increased by fouling over the wetted surface that anti-fouling paints, such as CDP(Controlled Depletion Paint), Tin-Free SPC(Self Polishing Co-polymer) or Foul Release, are applied evenly on the hull surface. Nevertheless, these anti-fouling paints could not prevent fouling absolutely. A fundamental study on evaluating ship resistance performance variation due to hull roughness has been performed using a commercial software, Star-CCM+, which solves the continuity and Navier-Stokes equations for incompressible and viscous flow. The results of present simulation for plate are compared with some experimental data available and the effect of surface roughness to ship resistance performance is discussed.

• 근관절건강학회지
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• 제18권2호
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• pp.257-269
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• 2011

Purpose: The purpose of this study was to analyze the effect of aquatic exercise and to identify directions for future research. Methods: Twenty one articles from 2 sites of article database (1990-2010) and 6 from Korean nursing journals were reviewed. Results: There were 20 quasi experimental design and 1 randomized controlled design. Major subjects of research were older women with arthritis. The most common type of exercise was Kim (1994)'s form. The most frequent duration of exercise was over 6 weeks. Outcome measurement was classified to physical and psychosocial variables. For physical outcomes, pain release was found in 13 articles among 15 articles, muscle strength improvement in 5 articles among 10 articles, flexibility improvement in 5 articles among 9 articles, and balance improvement in 3 articles among 6 articles. For psychosocial outcomes, improvement of quality of life was found in 3 articles among 7 articles and self-efficacy improvement in 5 articles among 7 articles. Conclusion : The effect of aquatic exercise over 6 weeks improves the physical and psychosocial functions. It is suggested that meta analysis needs to be done to integrate the various results.

• 한국정보처리학회논문지
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• 제4권2호
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• pp.409-429
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• 1997

소프트웨어를 개발하고 운영하는 동안 직면하는 문제들은 소프트웨어나 하드웨어 또는 운영의 결함에 기인한다. 이들의 다양성 문제, 문제들을 조정하고 체계적으로 원인을 규명하기 위한 문제 발생의 규명 및 수정 작업을 중심적으로 관리하는 시스템이 요구 되고 있다.본 논문에서는 소프트웨어 개발 수명 주기(Softwate Development Life Cycle :SDIC)에서 획득할 수 있는 결함 데이터(Fault Data) 프로세스 데이터(Precess Data) 프로덕트 데이터(Preduct Data)를 수집하고 분석하기 위한 소프트웨어 문제 보고서 (Software Change Report:SCR)를 처리하는 SPR/SCR 관리시스를 개발하고 적용하였다. SPR/SCR 관리 시스템의 목적은 4가지가 있다. 첫째로 모든 소프트웨어 결함들을 문서 화하고, 수정하며 무시않는다. 둘째로 SPR의 타당성에 대해 평가된다. 셋째로 SPR의 진행 상태를 개발자 또는 사용자에게 피드백한다., 넷째로 소프트웨어 품질과 신뢰성을 예측하고 측정하기 위한 기본 자료를 제공한다. 이들 목표는 SRE/SCR 관리시스템의 적용에 의해 충족시킬 수 있다. 또한 소프트웨어 신뢰성의 달성 비욜, 테스트의 종료기준, 릴 리 즈 시기의 예측, 효율적인 개발 관리에 반영될 수 있다.

• Animal cells and systems
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• 제16권4호
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• pp.280-288
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• 2012

Targeted degradation of proteins through ubiquitin-mediated proteolysis is an important control mechanism in various cellular processes. The process of ubiquitin conjugation is achieved by three enzyme complexes, among which the ubiquitin ligase complex (E3) is in charge of substrate specificity. The SCF (SKP1-CUL1-F-box) family portrays the largest and the most characterized member of the E3 ligases. For each SCF complex, the ubiquitination target is recognized by the F-box protein subunit, which interacts with the substrate through a unique C-terminal domain. We have characterized a novel F-box protein CFL-1 that represents a single LRR-type F-box (FBXL) in the Caenorhabditis elegans genome. CFL-1 is highly homologous to FBXL20 and FBXL2 of mammals, which are known to regulate synaptic vesicle release and cell cycle, respectively. A green fluorescence protein (GFP)-reporter gene fused to the cfl-1 promoter showed restricted expression around the amphid and the anus. Modulation of CFL-1 activity by RNAi affected the time interval between defecations. RNAi-treated worms also exhibited reduced tendency to form dauer when exposed to daumone. The potential involvement of CFL-1 in the control of defecation and pheromone response adds to the ever expanding list of cellular processes controlled by ubiquitin-mediated proteolysis in C. elegans. We suggest that CFL-1, as a single LRR-type F-box protein in C. elegans, may portray a prototype gene exerting diverse functions that are allocated among multiple FBXLs in higher organisms.

• Molecules and Cells
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• 제38권12호
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• pp.1079-1085
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• 2015

Originally, activins were identified as stimulators of FSH release in reproduction. Other activities, including secondary axis formation in development, have since been revealed. Here, we investigated the influence of activin ${\beta}_A$ on the body, including the gastro-intestinal (GI) tract. Initially, the activin ${\beta}_A$ protein was detected in the serum proportional to the amount of pCMV-rAct plasmid injected. The induced level of activin ${\beta}_A$ in muscle was higher in female than male mice. Subsequent results revealed that stomach and intestine were severely damaged in pCMV-rAct-injected mice. At the cellular level, loss of parietal cells was observed, resulting in increased pH within the stomach. This phenomenon was more severe in male than female mice. Consistent with damage of the stomach and intestine, activin ${\beta}_A$ often led to necrosis in the tip of the tail or foot, and loss of body weight was observed in pCMV-rAct-injected male but not female mice. Finally, in pCMV-rAct-injected mice, circulating activin ${\beta}_A$ led to death at supraphysiological doses, and this was dependent on the strain of mice used. Taken together, these results indicate that activin ${\beta}_A$ has an important role outside of reproduction and development, specifically in digestion. These data also indicate that activin ${\beta}_A$ must be controlled within a narrow range because of latent lethal activity. In addition, our approach can be used effectively for functional analysis of secreted proteins.