• 한국토양비료학회지
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• 제39권6호
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• pp.345-350
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• 2006

본 시험은 벼 종이멀칭이앙 시 적정한 완효성비료의 시용량을 구명하고자 경기도 수원에 위치한 작물과학원 벼 연구 포장 강서통에서 대안벼를 2004년 5월 28일에 중묘를 멀칭기계 이앙하였다. 시험에 사용한 완효성비료는 LCU (Latex Coated Urea, 21-7-9) 복비를 시용하였다. 피복재료는 생분해성 폴리에스터 (PES $10{\mu}m$)+재생지를 이용하여 피복하였다. 처리내용은 관행질소시비량 ($110kg\;ha^{-1}$)을 기준으로 하여 완효성비료호 기준시비량의 60%, 80%구, 100%구와 관행 및 무질소구를 두고 시험을 수행하였다. 벼 멀칭이앙 시 모의 결주율은 무피복의 관행이앙과 차이가 없었다. 잡초발생 및 방제가는 시비량이 적을수록 잡초가 다양해지고 잡초방제가가 낮아지는 경향이었다. 벼 이앙 후 일수가 진전됨에 따라서 시비량이 많을수록 초장와 경수가 크거나 많아지는 경향이었고 완효성비료 80%구의 벼 생육이 관행시비구와 차이가 없는 경향이었다. 엽색도와 토양 중 $NH_4{^+}-N$도 유사한 경향을 보였다. 따라서 수량구성요소 중 $m^2$당 이삭수의 증가로 인하여 완효성비료 80%구가 관행과 수량 차이가 없었다. 농업적 질소이용 효율은 시비량이 적을수록 증가하였다. 벼 종이멀칭이앙 시 벼 수량 및 수량구성요소, 잡초발생 및 방제가, 시비효율 등을 종합적으로 고려하여 관행질소 시비량의 80%를 완효성비료로 이앙 전에 밑거름으로 전층시비 하는 것이 알맞을 것으로 생각된다.

• Journal of Pharmaceutical Investigation
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• 제41권6호
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• pp.347-354
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• 2011

Repeated oral administration of loxoprofen can induce many side effects such as gastric disturbances and acidosis. Therefore, we considered alternative routes of administration for loxoprofen to avoid such adverse effects. The aim of this study was to develop an ethylene-vinyl acetate (EVA) matrix system containing a permeation enhancer for enhanced transdermal delivery of loxoprofen. The EVA matrix containing loxoprofen was fabricated and the effects of drug concentration, temperature, enhancer and plasticizer on drug release were studied from the loxoprofen-EVA matrix. The solubility of loxoprofen was highest at 40% (v/v) PEG 400. The release rate of drug from drug-EVA matrix increased with increased loading dose and temperature. The release rate was proportional to the square root of loading dose. The activation energy (Ea), which was measured from the slope of log P versus 1000/T, was 5.67 kcal/mol for a 2.0% loaded drug dose from the EVA matrix. Among the plasticizer used, diethyl phthalate showed the highest release rate of loxoprofen. Among the enhancers used, polyoxyethylene 2-oleyl ether showed the greatest enhancing effect. In conclusion, for the enhanced controlled transdermal delivery of loxoprofen, the application of the EVA matrix containing plasticizer and penetration enhancer could be useful in the development of a controlled drug delivery system.

• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.1-10
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• 1991

Hydrogels containing ketoprofen were prepared by adding NaOH or $Ca(OH)_2$ solution to Eudragit L, S and Eudispert hv at various concentration. And xerogels were prepared by drying hydrogels. On the other hand, organogels containing ketoprofen were prepared by mixing Eudragit L or S and propylene glycol. Effects of polymer content and base on drug release were investigated using KP V dissolution method. The release rate of ketoprofen from Eudragit L & S hydrogel decreased with increasing in polymer content. And the drug release rate from cal. hydroxide based gels were more decreased than that from sod. hydroxide based gels. At pH 7.2 dissolution medium, e release of ketoprofen from Edispert hv hydrogel followed apparent zero order kinetics. The release of ketoprofen from xerogel involved in simultaneous absorption of water and desorption of ketoprofen via a pH-dependant swelling controlled mechanism. The release of ketoprofen from Eudragit S organogels followed apparent zero order kinetics, providing strong evidence for a surface erosion mechanism.

• Archives of Pharmacal Research
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• 제14권4호
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• pp.298-304
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• 1991

Isoprinosine, an antiviral agent with a bitter taste, has been clinically used up to a maximum of 4 g daily in 4-8 doses. In this investigation, isoprinosine was microencapsulated with ethylcellulose 22 cps, 50 cps and 100 cps by means of polymer deposition from cyclohexane through temperature change. Complete removal of cyclohexane from the microcapsules was necessary, since ethylcellulose-coated microcapsules obtained from cyclohexane medium were heavily solvated with cyclohexane and formed lumps even after drying. The displacement of cyclohexane by n-hexane during isolation of microcapsules (Method III) or the freezing of the anal-washed microcapsules before drying (Mothod II) provided the dried products which were more discrete microcapsules than those which were simply dried in the air overnight (Method I). Method III was especially the most effective procedure in preparing finer and more discrete microcapsules. The drug-release from microcapsules was influenced by the ratio of core to wall, the viscosity grade of ethylcellulose and the overall microcapsule size. The release rate was adequately fitted to both the first-order and the diffusion-controlled processes. It is therefore possible to design the release-controlled microcapsules with ethylcellulose of different viscosity along with various core to wall ratio.

• Journal of Pharmaceutical Investigation
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• 제20권2호
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• pp.79-88
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• 1990

A numerical model for diffusion and dissolution controlled transport from dispersed matrix is presented. The rate controlling process for transport is considered to be diffusion of drug through a concentration gradient coupled with time-dependent surface change and/or disappearance of the dispersed drug in response to the dissolution. The transport behavior of drug was explained in terms of ${\nu}$ parameter: ${\nu}$ value means a ratio of diffusion time constant and dissolution time constant. This general model has wide range of application from where release is controlled by the diffusion rate to where release is governed by the dissolution rate. Based on this model, theoretical drug concentration, particle size distributions in the polymer matrix system and the resulting release rate were also investigated.

• Journal of Pharmaceutical Investigation
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• 제40권spc호
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• pp.103-112
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• 2010

Pellets, which are multiple-unit dosage systems, have the several therapeutic advantages over single-unit dosage systems in oral drug delivery. This review focuses on the current status and explores extrusion-spheronization technique with special attention to controlled-release application of pellets including coated pellets for delayed release formulations, coated pellets for colon delivery, coated pellets for sustained drug delivery, sustained-release matrix pellets, pellets compressed into tablets, bioadhesive pellets, floating pellets, and pelletization with solubilization techniques.

• 한국염색가공학회지
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• 제19권5호
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• pp.30-36
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• 2007

Cypermethrin-containing polyurea microcapsules were prepared by interfacial polymerization using aromatic 2,4-toluene diisocyanate(TDI) and Ethylene diamine(EDA) as wall forming materials. The effects of the protective colloids of polyvinylalcohol(PVA) and gelatin were investigated through experimentation. The mean size of the polyurea microcapsules was smaller and the surface morphology of the PVA was much smoother than gelatin. In addition the release behavior was much more controlled and better sustained. As the concentration of protective colloid increased, the wall membrane of the polyurea microcapsules became more stable, the thermal stability of the wall membrane increased, the mean particle size became smaller, and the particle distribution was more uniform. The release behavior of the core material changed according to the concentration. As the gelatin concentration was increased, a more controlled and sustained release behavior was observed. However, in the case of PVA, the increase of PVA concentration lead to a more rapid release rate.

• 약학회지
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• 제40권4호
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• pp.400-410
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• 1996

In oder to develop the controlled release of drugs from the suppositories, in vitro drug release and in vivo absorption in rabbits were investigated. Various suppo sitory forms with hollow cavities, into which drugs in the form of fine powder or solid dispersion system(SDS) could be placed, were utilized. The oleaginous Witepsol H-15 (WH-15) as a base, and indomethacin (IDM) of a very slightly soluble drug and propranolol-HCL (PPH) of a very soluble drug were employed as model drugs. The in vitro drug release showed that the cumulative release amount of PPH from PPH-(methylcellulose) MC-SDS and PPH-(ethylcellulose) EC-SDS hollow type suppositories reached 40% and 12% in 6 hrs,respectively. On the other hand, the drug release for a conventional suppository was 80% in 6 hrs. For the IDM suppositories,the cumulative drug release from IDM-(polyvinylpyrrolidone) PVP-SDS hollow type suppositories reached 99% in 24 hrs, whereas that from a conventional suppository reached 85%. An in vivo experiment with rabbits showed that IDM-PVP-SDS hollow type suppository delayed the absorption of IDM, significantly. The $t_{max},\;C_{max}\;and\;AUC_{0{\to}8}$ of IDM-PVP-SDS suppository were 60 min, 12.12${\mu}g$/ml and 2657${\mu}g$/ml/min, respectively. The $t_{max},\;C_{max}\;and\;AUC_{0{\to}8}$ of controlled group were 20 min, 15.49${\mu}g$/ml and 2190${\mu}g$/ml/min, respectively.

• Biotechnology and Bioprocess Engineering:BBE
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• 제6권5호
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• pp.326-331
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• 2001

With the aim of developing of pH-sensitive controlled drug release system, a poly(Llysine) (PLL) based cationic semi-interpenetrating polymer network (semi-IPN) has been synthesized. This cationic hydrogel was designed to swell at lower pH and de-swell at higher pH and therefore be applicable for achieving regulated drug release at a specific pH range. In addition to the pH sensitivity, this hydrogel was anticipated to interact with an ionic drug, providing another means to regulate the release rate of ionic drugs. This semi-IPN hydrogel was prepared using a free-radical polymerization method and by crosslinking of the polyethylene glycol (PEG)-methacrylate polymer through the PLL network. The two polymers were penetrated with each other via interpolymer complexation to yield the semi-IPN structures. The PLL hydrogel thus prepared showed dynamic swelling/de-swelling behavior in response to pH change, and such a behavior was influenced by both the concentrations of PLL and PEG-methacrylate. Drug release from this semi-IPN hydrogel was also investigated using a model protein drug, streptokinase. Streptokinase release was found to be dependent on its ionic interaction with the PLL backbones as well as on the swelling of the semi-IPN hydrogel. These results suggest that a PLL semi-IPN hydrogel could potentially be used as a drug delivery platform to modulate drug release by pH-sensitivity and ionic interaction.

• 한국잡초학회지
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• 제10권2호
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• pp.122-129
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• 1990

Alginate와 Kaoline을 저장매체(貯藏媒體)로 사용(使用)하여 제제(製劑)한 Butachlor[N-(butoxymethyl)-2-chloro-2', 6'-diethylacetamlide] 방출조절제(放出調節劑)의 특성(特性) 및 주성분(主成分) 용출양상(溶出樣相)을 암조건(暗條件)과 일광노출(日光露出) 조건하(條件下)에서 zeolite 흡착형립제(吸着型粒劑)와 비교시험(比較試驗)하였다. Calcium alginate-Kaoline 저장체(貯藏體)에의 butachior제제율(製劑率)은 91.8%이상(以上)이었고 제품(製品)의 수율(收率)은 kaoline의 첨가량(添加量)이 증가(增加)할수록 감소(減少)하였다. 방출조절제(放出調節劑)의 수중(水中) 주성분(主成分) 용출속도(溶出速度)는 시험조건(試驗條件)에 관계(關係)없이 zeolite흡착형립체(吸着型粒劑)보다 완만(緩慢)하였고 kaoline의 함량(含量)이 증가(增加)할수록 그 속도(速度)는 현저(顯著)하게 감소(減少)하였다. 일광노출조건(日光露出條件)에서 수증기(水蒸氣)와의 공증류(共蒸溜)에 의(依)한 용출주성분(溶出主性成分)의 감소율(減少率)은 kaoline의 함량(含量)이 증가(增加)할수록 저하(低下)되는 경향(傾向)을 보였다.