Release Profile of ¹⁴C-Butachlor from Controlled Release Formulation Prepared with Alginate-Kaoline Matrix

Alginate와 Kaoline을 이용(利用)한 방출조절제(放出調節劑)의 ¹⁴C-Butachlor 용출특성(溶出特性)

The herbicide $^{14}C$-butachlot[N-(butoxymethyl)-2-chloro-2', 6'-diethylacetanilide] labelled uniformly in benzene ring was incorporated in alginate-based granules to get controlled release properties. The influence of kaoline addition on the formulation characteristics and release profiles were evaluated under a closed dark and an opened sunlight condition. Incorporation efficiency of $^{14}C$-butachlor in alginate-kaoline matrices was over 91.8%. Formulation yield was decreased with increase of kaoline concentration. The release rate from all the granules prepared with alginate was slower than that from the commercial granule impregnated in zeolite. The release rate from the granule containing kaoline was decreased as the kaoline content was increased under both conditions. Losses of butachlor from the leacheate solution of the alginate-kaoline matrices under an opened sunlight condition was diminished by increasing the kaoline content.

Alginate와 Kaoline을 저장매체(貯藏媒體)로 사용(使用)하여 제제(製劑)한 Butachlor[N-(butoxymethyl)-2-chloro-2', 6'-diethylacetamlide] 방출조절제(放出調節劑)의 특성(特性) 및 주성분(主成分) 용출양상(溶出樣相)을 암조건(暗條件)과 일광노출(日光露出) 조건하(條件下)에서 zeolite 흡착형립제(吸着型粒劑)와 비교시험(比較試驗)하였다. Calcium alginate-Kaoline 저장체(貯藏體)에의 butachior제제율(製劑率)은 91.8%이상(以上)이었고 제품(製品)의 수율(收率)은 kaoline의 첨가량(添加量)이 증가(增加)할수록 감소(減少)하였다. 방출조절제(放出調節劑)의 수중(水中) 주성분(主成分) 용출속도(溶出速度)는 시험조건(試驗條件)에 관계(關係)없이 zeolite흡착형립체(吸着型粒劑)보다 완만(緩慢)하였고 kaoline의 함량(含量)이 증가(增加)할수록 그 속도(速度)는 현저(顯著)하게 감소(減少)하였다. 일광노출조건(日光露出條件)에서 수증기(水蒸氣)와의 공증류(共蒸溜)에 의(依)한 용출주성분(溶出主性成分)의 감소율(減少率)은 kaoline의 함량(含量)이 증가(增加)할수록 저하(低下)되는 경향(傾向)을 보였다.