• Journal of The Korean Society of Integrative Medicine
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• v.11 no.4
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• pp.147-155
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• 2023

Purpose: Headache is a very common disease experienced at least once in daily life, and tension-type headaches have a high and increasing prevalence. Chronic headaches can cause functional damage and huge socioeconomic impacts. This study aimed to compare the effects of myofascial release technique with manual therapy and self-myofascial release technique using a foam roller on the pain threshold and body schema in patients with chronic tension-type headaches. Methods: The study was conducted on 20 patients living in Busan with chronic tension headaches. Myofascial release technique with manual therapy was performed on the suboccipital, sternocleidomastoid, scalene, and upper trapezius muscles. The self -myofascial release technique using a foam roller was applied to the cervical and thoracic muscles. A laterality test was performed using a recognized neck application developed to evaluate body schema ability. A pressure-pain threshold test was performed using an electronic pressure algometer to compare the results before and after the myofascial release technique. Results: After applying myofascial release with manual therapy and a foam roller, the pressure-pain threshold values showed significant changes in both groups (p<.05). As a result of the laterality test, myofascial release with manual therapy and a foam roller were applied to the painful area. The values showed significant changes in both groups (p<.05), but only the group using the foam roller showed a significant difference (p<.05) in painless areas. Conclusion: The myofascial release technique with manual therapy can be the primary treatment technique for pain control in painful areas. The self-muscle release technique using a foam roller can be an effective method when there is no pain or when maintenance is needed after pain control.

• Proceedings of the KSME Conference
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• 2001.06b
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• pp.525-532
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• 2001

Experimental study has been conducted to clarify the pneumatic characteristics of brake system for freight train and enhance the performance of diaphragm valve. Empty-load and diaphragm brake systems are mainly used in the freight trains of KNR (Korean National Railroad). The train set is composed of thirty freight cars and diesel locomotive. From the experimental results, new quick release valve shortens release time after brake application. In case of normal brake application, the release time is short by 34% of that of original diaphragm control valve. It will be expected to assure brake-release application and reduce maintenance efforts.

• Journal of the Korean Society of Physical Medicine
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• v.15 no.1
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• pp.133-141
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• 2020

PURPOSE: This study examined the effects of active release technique on pain, Oswestry Disability Index, and pelvic asymmetry in chronic low back pain patients. METHODS: Thirty five outpatients diagnosed with chronic low back pain were enrolled in this study. The patients were divided randomly into an active release technique therapy group(experimental group; n=18) and myofascial release technique therapy group(control group; n=17). These groups performed their respective therapy for a 40-minute session occurring twice a week over six weeks. The Visual Analogue Scale(VAS) was used to measure the subjects' pain, and the Korean Oswestry Disability Index(KODI) was used to measure the subjects' dysfunction. To assess the patients' pelvic asymmetry, their pelvic tilt and pelvic rotation were measured using X-ray imaging. RESULTS: Both the experimental group and control group exhibited significant decreases in their VAS and KODI scores after the therapy(p<.05). The experimental group exhibited a significant decrease in their pelvic tilt and pelvic rotation after therapy(p<.05). A significant difference was observed between the experimental group and the control group (p<.05). CONCLUSION: These results suggest that active release technique is effective in decreasing the level of pain and dysfunction in chronic low back pain patients. In addition, the active release technique is considered to be more effective in improving the pelvic tilt and pelvic rotation than myofascial release technique. This can be an effective method for the non-pharmacological and non-surgical treatment of chronic low back pain.

• Archives of Pharmacal Research
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• v.28 no.4
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• pp.493-501
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• 2005

Effect of solvents on physical characteristics and release characteristics of monolithic acetaminophen (APAP) hydroxypropylmethylcellulose (HPMC) matrix granules and tablets were examined. Various types and amounts of solvents were employed for granulation and coating. APAP and other excipients were mixed and were then wet-granulated in a high-speed mixer. The dried granules were then directly compressed and film-coated with low viscosity grade HPMC. As the amount of water increased, the size of granules also increased, showing more spherical and regular shape. However, manufacturing problems such as capping and lamination in tableting occurred when water was used alone as a granulating solvent. The physical properties of HPMC matrix granules were not affected by the batch size. The initial release rate as well as the amount of APAP dissolved had a tendency to decrease as the water level increased. Addition of nonaqueous solvent like ethanol to water resulted in good physical properties of granules. When compared to water/ethanol as a coating solvent, the release rate of film-coated HPMC matrix tablets was more sensitive to the conditions of coating and drying in methylene chloride/ethanol. Most of all, monolithic HPMC matrix tablet when granulated in ethanol/water showed dual release with about $50\%$ drug release immediately within few minutes followed by extended release. It was evident that the type and amount of solvents (mainly water and ethanol) were very important for wet granulation and film-coating of monolithic HPMC matrix tablet, because the plastic deforming and fragmenting properties of material were changed by the different strengths of the different solvents.

• Journal of Pharmaceutical Investigation
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• v.31 no.2
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• pp.101-106
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• 2001

Alginate-chitosan (anion-cationic polymeric complex) was prepared to control the release rate of silver sulfadiazine (AgSD). Na-alginate (2%) solution containing AgSD was gelled in $CaCl_2$ solution. The gel beads formed were immediately encapsulated with chitosan (CS). The gel matrix and membrane were then reinforced with chondroitin-6-sulfate (Ch6S). Release rate of AgSD from the gel matrix was investigated by placing alginate beads in the sac of cellulose membrane simmered in HEPES-buffer solution. The concentration of AgSD released was analyzed by UV at 264 nm. Incorporation capacity of AgSD in Ca-alginate gel was more than 90%. Alginate-Ch6S-CS could control the release rate of AgSD. The amount of AgSD release was dependent on the AgSD loading dose. Incorporation of tripolyphosphate (polyanionic crosslinker) onto the alginate-Ch6S-CS bead increased the release rate of AgSD. Collagen-coating had no influence on the AgSD release rate. Alginate-Ch6S-CS beads with a sufficiently high AgSD encapsulation were capable of controlling the release of the drug over 10 days. In summary, alginate-Ch6S-CS beads could be used as a sustained delivery for AgSD and provide local targeting with low silver toxicity and patient discomfort.

• Journal of Pharmaceutical Investigation
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• v.37 no.2
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• pp.95-99
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• 2007

To develop topical nitroglycerin (NTG) preparation far chronic anal fissure treatment, the release rate of NTG should be controlled carefully. For this, microemulsion was prepared from the phase diagram construction with Cremophor ELP, ethanol and Labrafil $M1944CS^{(R)}$ and the topical gel was prepared by dispersing NTG containing microemulsion into hydrophilic polymers. in viかo release characteristics were evaluated with Franz diffusion cell using cellulose membrane and compared with control hydrogels. The release rate of NTG was followed $1^{st}$ order kinetics and, when comparing the NTG release from control hydrogel with that from the microemulsion-based hydrogel, the NTG release rate was controlled by the content of polymers within continuous phase and the concentration of dispersed phase.

• YAKHAK HOEJI
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• v.35 no.6
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• pp.509-514
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• 1991

The effect of diacylglycerol on glucose release was studied by using 1,2-dioctanoyl-sn-glycerol ($diC_8$), a cell permeable diacylglycerol, in perfused rat liver. The glucose release was increased by $diC_8(50\;{\mu}M$), and the effect was depended on calcium ions. The increment of glucose release by $diC_8(50\;{\mu}M$) was inhibited by indomethacin ($50\;{\mu}M$); the amount of glucose release was almost the same with that of control group. Arachidonic acid($200\;{\mu}M$) also increased glucose release and the release was inhibited by indomethacin. There was no synergistic effect on glucose release by the combination of $diC_8(50\;{\mu}M$) and phenylephrine($10\;{\mu}M$).

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.211-211
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• 1996

Changes in glutamate release and uptake on cerebellar cells after the chronic exposure to lead were investigated. Rats were received 0.25% lead acetate in drinking water from the beginning of the pregnancy. The control group was given 0.125% sodium acetate in drinking water. The cerebellar cells from 7 or 8 day-old pups were cultured. Amino acid release from cerebellar granule cells and the glutamate uptake into cerebellar glial cells were measured using HPLC-ECD. Basal glutamate release and NMDA-induced glutamate release didn't show significant difference. However, the other amino acids in the granule cells obtained from lead exposed pups were less released than the control after the stimulation by NMDA (50$\mu$M). SNAP-induced (50$\mu$M) glutamate release was significantly reduced in granule cells prepared from lead exposed pups. The basal glutamate uptake in glial cells didn't show any difference. However, the uptake in glial cells prepared from lead exposed pups was significantly less blocked by PDC (24$\mu$M) compared to the control group. These results indicate that lead exposure to the mother might affect the Excitatory amino acid system during the development of the offspring.

• Water for future
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• v.29 no.1
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• pp.235-248
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• 1996

Apreliminary release scheme (PRS) is suggested for the operating rules during flood period to deal with conflicts between flood control and water conservation purposes. PRS can be used to decide the optimum releases, based on the forecast of an oncoming flood and flow rate at the control point downstream when comparing the variable restricted water level (VRWL) for flood control with the minimum required water level (MRWL) for conservation use. The model is applied to Chungju and Daechung reservoirs through simulations of the technique. This study illustrates the procedure to decide the time and size for preliminary releases. Also, effects of duration and magnitude of preliminary release are reviewed based on historicqal flood records. The simulation results indicate that the proposed PRS is effective for the managers to find optimal operating policies during flood period. The proposed scheme can be used with main release scheme using real-time operation on hour-to-hour basis to decide the release for a flood.

• Journal of the Korean Society of Physical Medicine
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• v.16 no.1
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• pp.93-101
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• 2021

PURPOSE: This study examined the effects of a myofascial release technique with preservation physical therapy on low back pain, range of motion, and physical function of patients in acute traffic accidents METHODS: Twelve patients with traffic accidents were divided randomly into two groups of six patients each who met the selection criteria. The training was conducted for 45 minutes each time, for two weeks and four times per week. The experimental group received four myofascial release techniques and with preservation physical therapy. The control group received only preservation physical therapy. RESULTS: The VAS test result was statistically significant after the intervention in both groups (p < .05). After the intervention, there was no significant difference between the experimental group and control group. The Schober test result was statistically significant after the intervention in both the experimental and control groups (p < .05), and there was a significant difference between the experimental group and control group after the intervention (p < .05). The KODI assessment result was significant after the intervention in both the experimental and control groups (p < .05), and there was a significant difference between the experimental group and control group after the intervention (p < .05). CONCLUSION: The myofascial release technique with preservation physical therapy had a positive effect on low back pain, range of motion, and body function in acute traffic accident patients.