• Journal of Integrative Natural Science
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• v.7 no.4
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• pp.253-259
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• 2014

Protein kinase C theta (PKC-${\theta}$) is a serine/threonine specific protein kinase. It is largely expressed in the T-cells and CD28 signaling. PKC-${\theta}$ phosphorylates diverse proteins that are involved in the various cellular signaling pathways. Activated PKC-${\theta}$ in turn activates other transcription factors that control the proliferation and differentiation of T- cells. PKC-${\theta}$ is considered to be an interesting therapeutic target due to its crucial role in the proliferation, differentiation and survival of T-cells. In the present study, we have performed ligand-based CoMFA study on a series of pyridylpyrazolopyridine derivatives as PKC-${\theta}$ inhibitors. An acceptable CoMFA model ($q^2$=0.544; ONC=4; $r^2$=0.876) was developed and validated by Bootsrapping and progressive sampling. The CoMFA contour map suggested the regions to increase the activity. Bulky substitutions in R2 position of the piperizine ring could increase the activity. Similarly positive, small substitution in the R1 position of the Pyridine ring could considerably increase the activity. Our work could assist in designing more potent PKC-${\theta}$ inhibitors of pyridylpyrazolopyridine derivatives.

• Journal of the Earthquake Engineering Society of Korea
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• v.20 no.7_spc
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• pp.537-543
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• 2016

In low to moderate seismic regions, there are limited earthquake ground motion data recorded from past earthquakes. In this regard, the Gyeongju earthquake (M=5.8)occurred on September 12, 2016 produces valuable information on ground motions. Ground motions were recorded at various recording stations located widely in Korean peninsula. Without actual recoded ground motions, it is impossible to make a ground motion prediction model. In this study, a point source model is constructed to accurately simulate ground motions recorded at different stations located on different soil conditions during the Gyeongju earthquake. Using the model, ground motions are generated at all grid locations of Korean peninsula. Each grid size has $0.1^{\circ}(latitude){\times}0.1^{\circ}(longitude)$. Then a contour hazard map is constructed using the peak ground acceleration of the simulated ground motions.

• Journal of Institute of Control, Robotics and Systems
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• v.4 no.2
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• pp.273-279
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• 1998

철강석 또는 석탄의 적치장에서는 이들 원석을 퍼내어 용광로로 보내주는 불출기(reclaimer)가 사용되고 있다. 불출기를 자동화하려면 야적파일에 불출용 회전 버킷(bucket)을 자동착지시키는 방법이 요구된다. 본 논문에서는 야적 파일 표면위의 버킷 착지점을 추출하는 방법을 제시한다. 이 방법은 파일의 3차원 형상 검출, 파일의 등고선 추출, 불출기의 역기구학해의 도출 및 착지점 추출 알고리즘으로 이루어진다. 파일의 3차원 형상과 거리를 측정하기 위한 3차원 형상 검출기가 2차원 레이저 검출기에 수평주사(scanning)용 모터를 부착하여 개발하였고, 다 단계의 영상처리를 통해 버킷이 작업할 수 있도록 파일의 작업 등고선을 추출하였다. 불출기가 회전 버킷에 의해 기구학적으로 여유자유도로 이루어 졌음을 보였으며, 역기구학 해를 구하는 방법을 아울러 제시하였다. 그리고 버킷의 착지점을 과부하 방지와 단위 시간당 생산성을 최대화하는 성능기준에 근거하여 구하였다. 또한 개발된 시스템을 제철소 원석 야적장의 불출기에 설치 시험하여 타당성을 입증하였다.

• Journal of the Korean Chemical Society
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• v.57 no.5
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• pp.554-559
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• 2013

In this study, we have investigated potential energy of ${\beta}$-D-glucopyranose in vacuum and implicit water condition. By Comparing two conditions we find that how solvation energy influence ${\beta}$-D-glucopyranose structure. We use AMBER package program and GLYCAM_06 force field. Solvation model was used for the generalized Born model with Hawkins, Cramer, Truhlar has been proposed. We conclude that difference of contour map of two conditions is caused by solvation effect by reducing hydrogen bonding interaction.

• Korean Journal of Materials Research
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• v.12 no.1
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• pp.44-47
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• 2002

DV(Discrete Variation)-X${\alpha}$ cluster calculation was employed to calculate the electronic states of ${\gamma}'- Fe_4N$ which was one of iron nitride phases synthesized from plasma ion nitriding to improve surface hardness and wear resistance. The result of calculated electron density of states for Fe was similar to the result of band calculation. The cluster used for calculation of electronic states of ${\gamma}'-Fe_4N$ was based on $Fe_{14}N$ cluster which comprises 15 atoms. Finally the electronic states of ${\gamma}'- Fe_4N$ such as net-charge, band order, energy level, electron wave-function, and contour map for electron density were derived by the calculation.

• Journal of the Korean Institute of Landscape Architecture
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• v.23 no.1
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• pp.141-156
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• 1995

This research is executed to find out the boundary of use by the conscious of local residents and to get the basic materials for the distribution of outdoor leisure-facilities. The map of use distribution of the outdoor leisure-facilities in a neighbourhood unit is made by applying a concept of the probabilistic contour line based on the choice model of outdoer leisure-facilities in the city of Seoul, Taegu an\ulcorner Kwangju. The results are listed as follows. 1) The use of outdoor leisure-facilities is influenced on the accessibility by the physical obstacles of streets and hills, etc. 2) The limitation of uses applying the model of choice probability are different according to the accessibility, the percentage of utilities and the arriving range based on the questionnaires which are surveyed the choice of outdoor leisure facilities of the residents of Seoul, Taegu and Kwangju. 3) The distribution of outdoor leisure facilities is decided by the limitation of use with the conscious of local residents.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2008.08a
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• pp.79-82
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• 2008

For expression of isogram in mobile GIS environments, the client needs to receive the value data with the topographical map from a server. At this point, a client can't get the entire raw data because of the mobile characteristics. The approach to get representative points and to make isogram by interpolation methods, has some problems. The approach requires huge computing overhead at the client and doesn't guarantee the correctness of the isogram. In this paper, a data structure and algorithm for efficient transmission of contour information to a client which is constructed from a elevation information at a server, arc proposed. A proposed methods are focused at minimizing the transmission data volume and time.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.20 no.3
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• pp.303-311
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• 2002

Recently, the research that analyze topography parameters that need in hydrology analysis using GIS techniques is achieved. DEM that is used in topography analysis can be constructed effectively using contour data of digital map. Therefore, DEM's applicability is increasing gradually in several fields. In this study, DEM of 20∼l00m grid size was applied PYONGCHANG river and JUBANG river basin to analyze what effect DEM grid size causes about slope and drainage watershed at topography parameter extraction. This study drew a regression equation about slope change by DEM grid size. As a result, according as DEM grid size increases, slope decreases, and basin area could know that is not change almost.

• Journal of the Korean Society of Food Science and Nutrition
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• v.26 no.6
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• pp.1039-1043
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• 1997

Correlation among color intensity, electron donating ability to $\alpha$, $\alpha$-diphenyl-$\beta$-dicrylhydrazy(DPPH) and cultivation conditions by Bacillus subtilis DC-2 were tested with response surface methodology. Both of pigment generation ability and DPPH were more affected by temperature than any other factor. The highest correlation was appeared between color intensity and DPPH as 0.8364 which is significant at 1% level. After fixing cultivation time which is not significant at 10% level to 84hrs as optical cultivation time, response surface methodology was conducted in regarding temperature and color intensity. As a result of overlapped contour map of color intensity and DPPH, when cultivation temperature was in the range of 38.9~41.1$^{\circ}C$ and pH was in the range of 8.34~9.12, optical density of color intensity was predicted higher than 0.374 at 390nm and DPPH was infered higher than 1.310 at 528nm. In the range of optical culture condition, cultivation temperature, pH and cultivation time was fixed to 4$0^{\circ}C$, 8.5 and 85hrs, respectively. In resulting, observation value of color intensity and DPPH was in the range of anticipation value as 0.386 at 390nm and 1.332 at 528nm respectively.

• Journal of the Korean Solar Energy Society
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• v.35 no.3
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• pp.1-8
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• 2015

The MERRA reanalysis data provided online by NASA was applied to predict the monthly energy productions of Donghai Bridge Offshore wind farms in China. WindPRO and WindSim that are commercial software for wind farm design and energy prediction were used. For topography and roughness map, the contour line data from SRTM combined with roughness information were made and used. Predictions were made for 11 months from July, 2010 to May, 2011, and the results were compared with the actual electricity energy production presented in the CDM(Clean Development Mechanism)monitoring report of the wind farm. The results from the prediction programs were close to the actual electricity energy productions and the errors were within 4%.