• Journal of Animal Science and Technology
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• 제58권4호
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• pp.14.1-14.9
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• 2016

Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candidate genes in a mixed sample panel composed of several cattle breeds with different meat quality, validate single nucleotide polymorphisms (SNPs) in a local crossbred population (Angus - Hereford - Limousin) and evaluate their effects on meat quality traits (backfat thickness, intramuscular fat content and fatty acid composition), supporting the association tests with bioinformatic predictive studies. Results: Globally, nine SNPs were detected in the PPARG and CEBPA genes within our mixed panel, including a novel SNP in the latter. Three of these nine, along with seven other SNPs selected from the Single Nucleotide Polymorphism database (SNPdb), including SNPs in the RXRA gene, were validated in the crossbred population (N = 260). After validation, five of these SNPs were evaluated for genotype effects on fatty acid content and composition. Significant effects were observed on backfat thickness and different fatty acid contents (P < 0.05). Some of these SNPs caused slight differences in mRNA structure stability and/or putative binding sites for proteins. Conclusions: PPARG and CEBPA showed low to moderate variability in our sample panel. Variations in these genes, along with RXRA, may explain part of the genetic variation in fat content and composition. Our results may contribute to knowledge about genetic variation in meat quality traits in cattle and should be evaluated in larger independent populations.

• 농촌계획
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• 제19권4호
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• pp.17-32
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• 2013

Reckless development policy, which has continued during the past several decades, caused landscape damage. In order to solve this problem, it is very urgent to conserve the habitat and to establish systematic database. Recently, various researches related to landscape damage have been conducted actively and the necessity of landscape ecological planning based on the biotop mapping has been issued as one of the solutions. Therefore, the purpose of this study is to select the study area, which is located in Guji-meon, Dalseong-gun, Daegu and will be formed into Daegu Science Park, and then to develop and apply the landscape ecological planning model based on biotop mapping in district unit. The results are as follows. Fist of all, according to the results of biotop classification with field survey and literature review, total 13 biotop and total 63 biotop types were classified. According to the first evaluation with B-VAT, total 19 biotop types were classified I grade including natural river with abundant plants(BA) and so on. While V grade, which has lowest value, was classified 16 biotop types including vegetable garden adjacent to river(BC). Also the second evaluation, we analyzed total 30 areas such as 1a, 1b grades, which had special meaning for the conservation of species and biotop. Next, 2a, 2b, 2c grades were analyzed total 82 areas. Secondly, in the compliance with Ecological landscape planning, we divided landscape planning model into two parts such as setting of improvement goal and detailed implement plan. For instance, setting of improvement goal, we classified 9 parts such as conservation region and parts of detailed implement plan, we classified total 28 planning indicators with 4 view such as the region which should be special protected from nature and landscape. Lastly, with the developed landscape model we applied to research areas, made maps, and differentiate proposals in each region. Specially, the final master plan was made to help understand the contents of detailed landscape planning. This study will be a useful data, which can solve the landscape damage problem systematically and control it landscape-friendly with biotop classification, evaluation, landscape ecological planning model, and application method which we developed.

• 동의생리병리학회지
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• 제24권3호
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• pp.361-366
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• 2010

This study was practiced to investigate the existing study trends for Injinho that is numerously used for hepatobiliary diseases in oriental medicine. The studies selected from the domestic academic database included the following keywords in the title or abstract; 'Artemisia capillaris', 'Artemisia iwayomogi', 'Artemisia scoparia'. The studies considered were those published from January 1990 to May 2009. 198 studies were found to include the keywords related to the study subjects either in their title of contents or abstracts, and 104 studies among them were finally selected as subjects for this study. 81 studies among 104 studies(78%) were published between 2000 and 2009, while 23 studies(22%) were published between 1990 and 1999. Classification was proceeded according to study subjects as followed; 23 studies confirming hepatoprotective effect after artificial liver damage in a number of cells or the organ itself, 18 studies on anti-tumor effect, 12 studies on hyperlipidemia and fatty liver disease, and 4 studies on liver cirrhosis and hepatocyte regeneration. Furthermore, classification was conducted according to study methods as followed; 56 studies practicing in vitro, 33 studies practicing in vivo, 11 studies practicing both in vitro and in vivo. 2 studies on specific cases and 1 study on documentary records. The majority of studies report the affirmative effects of Injinho. However most study methods were restricted to in vitro and in vivo. Hereafter, case reports on various fields and multicenter clinical trials on Injinho is necessary.

• 한국산업보건학회지
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• 제27권4호
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• pp.398-422
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• 2017

Objectives: The major aim of this study is to construct the database of retrospective exposure assessment for crystalline silica through reviews of literatures in South Korea. Methods: Airborne concentrations of crystalline silica were collected using an academic information search engine, Research Information Service System(RISS), operated by the Korea Education & Research Information Service(KERIS). The key words used for the literature search were 'silica', 'crystalline silica', 'cristobalite', 'quartz' and 'tridymite'. A total number of 18 published documents with the information of crystalline silica level in air or bulk samples were selected and used to estimate retrospective exposures to crystalline silica. Weighted arithmetic mean(WAM) calculated across studies was summarized by industry type. Industries were classified according to Korea Standard Industrial Classification(KSIC) using information provided in the literature. Results: A total of 2,131 individual air sampling data measured from 1987 to 2012 were compiled. Compiled individual measurement data consisted of 827 respirable crystalline silica (RCS), 31 total crystalline silica(TCS), 24 crystalline silica(CS), 778 respirable dust(RD) and 471 total dust(TD). Most of RCS measurements(68.9%) were collected from 'cast of metals(KSIC 243)'. Comparing industry types, 'mining coal and lignite(KISC 051)' showed the highest WAM concentration of RCS, $0.14mg/m^3$, followed by $0.11mg/m^3$ of 'manufacture of other non-metallic mineral products(KSIC 239)', $0.108mg/m^3$ of 'manufacture of ceramic ware(KSIC 232)', $0.098mg/m^3$ of 'heavy construction(KSIC 412)' and $0.062mg/m^3$ of 'cast of metals(KSIC 243)'. In terms of crystalline silica contents in airborne dust, 'manufacture of other non-metallic mineral products(KSIC 239)' showed the highest value of 7.3%(wt/wt), followed by 6.8% of 'manufacture of ceramic ware(KSIC 232)', 5.8% of 'mining of iron ores(KSIC 061)', 4.9% of 'cast of metals(KSIC 243)' and 4.5% of 'heavy construction(KSIC 412)'. WAM concentrations of RCS had no consistent trends over time from 1994 ($0.26mg/m^3$) to 2012 ($0.12mg/m^3$). Conclusion: The data set related RCS exposure level by industries can be used to determine not only the possibility of retrospective exposure to RCS, but also to evaluate the level of quantitative retrospective exposure to RCS.

• 인터넷정보학회논문지
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• 제19권1호
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• pp.97-103
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• 2018

대부분의 동양화 작품에는 작가의 정보를 압축시켜 하나의 그림으로 표현한 낙관이 존재하고 이러한 낙관은 작품의 제목이나 작가의 이름 등 다양한 정보를 포함하고 있다. 따라서 동양화를 수집하거나 즐기는 사람들에게 낙관은 동양화에 대한 중요한 정보를 제공하는 단서 역할을 한다. 하지만 낙관에 있는 글자들은 대부분 어려운 한자나 간자 혹은 다양한 모양으로 변형되어 있어 일반인들이 쉽게 해석하기 어려운 문제점이 있다. 본 논문에서는 낙관의 정보를 손쉽게 확인할 수 있도록 안드로이드 기반의 낙관 검색 애플리케이션을 개발하였다. 해당 애플리케이션은 촬영한 낙관 이미지를 분석하여 서버에 전송해 서버 내의 데이터베이스에서 촬영한 낙관 사진과 가장 유사한 낙관 후보에 대한 정보를 검색하는 알고리즘을 적용하였다. 또한 제안하는 알고리즘의 성능 분석을 위해서 촬영된 낙관 사진과 170개의 낙관 데이터 후보 중에서 정확하게 낙관을 찾아내는지에 대한 여부와 제공되는 낙관의 순위를 바탕으로 알고리즘의 정확도를 비교 및 분석하였다. 정확도 분석 실험 결과 본 애플리케이션의 검색 알고리즘의 정확도는 약 90%로 확인되었으며 추후 알고리즘의 최적화와 멀티쓰레딩 알고리즘의 보완을 통해 빅 데이터 환경에서 자동으로 이미지를 분석 및 검색하는 플랫폼으로의 발전이 가능할 것으로 기대한다.

• 인터넷정보학회논문지
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• 제16권1호
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• pp.75-82
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• 2015

주요 기업들과 포털들은 사용자들에게 웹 기반 환경에서 보다 효율적인 콘텐츠 이용을 지원하기 위해 이른바 콘텐츠관리시스템(CMS, Contents Management Systems)과 콘텐츠의 데이터베이스 내 물리적 주소를 연결하여 관리하는 링크 서버를 적극적으로 도입하고 있다. 이를 통해 웹브라우저 화면에서 보여지는 콘텐츠의 URL과 실제 데이터베이스 안의 콘텐츠의 물리적 주소를 자동으로 연결해 주고, URL이나 데이터베이스의 물리적 주소의 변경시 두 주소를 재 연결하는 역할을 수행한다. 최근 빅데이터 환경의 도래에 따라 디지털 콘텐츠와 사용자 접속수가 폭발적으로 증가하고 있는 상황에서 CMS와 링크 서버에서 수행해야 하는 유효 링크 검사 횟수도 따라서 증가하고 있다. Peta-Byte 또는 Eta-Byte 환경 하에서 수행되는 유효 링크 검사를 기존 URL 기반의 순차적 방식으로 수행할 경우 속도저하에 따른 데이터 링크 식별률(identification rate)의 저하와 빈번한 링크 검사에 따른 데이터베이스에 부하를 주는 요인으로 작용될 수 있다. 따라서, 본 연구는 상기와 같은 종래의 문제점을 해결하기 위해 대량의 URL에 대해 B-Tree 기반의 정보식별자의 구간별 개수 분석을 기반으로 URL 삭제 링크 및 추가 링크를 인식하고 효과적으로 관리하는 것이 가능하도록 해주는 링크 서버를 제공하는 데 있다. 본 연구를 통해 기존 방식보다 빠르고 낮은 부하를 주는 데드 링크 체크 처리가 가능해 질 것이다.

• 한국산업정보학회논문지
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• 제23권5호
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• pp.61-76
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• 2018

현대인이 살고 있는 네트워크 세상으로 모든 사물들이 들어오고 있다. 사물에 센서를 부착하는 사물인터넷의 영향으로 인해 네트워크로 실시간 데이터를 주고받는 것이 가능해졌다. 현대인들의 필수품인 모바일 디바이스는 일상생활의 모든 자취를 실시간으로 남기는 역할을 하고 있다. 바로 소셜 네트워크 서비스를 통하여 정보획득 활동과 커뮤니케이션 활동을 실시간으로 거대한 네트워크에 남기고 있는 것이다. 비즈니스 관점에서 고객의 니즈 분석은 바로 SNS 자료에서부터 시작된다는 등가가 성립된다. 본 연구는 웹 환경의 SNS 콘텐츠를 파이썬을 이용하여 실시간으로 자동 수집시스템을 구축하고자 한다. 세계적으로 많은 이용자수를 확보하고 있는 인스타그램, 트위터, 유튜브의 비정형적 데이터 수집 시스템을 통하여 고객의 니즈 분석에 도움이 되고자 한다. 파이썬의 웹드라이버 환경에서 가상 웹브라우저를 이용하여 마이닝 처리와 NLP 과정을 거쳐 DB에 저장된다. 본 연구의 결과 웹페이지를 통하여 서비스를 진행하고자하며 검색 기능만으로 원하는 데이터가 자동 수집되며 데이터의 시계열 분석을 통하여 네티즌의 이슈 반응을 실시간으로 확인할 수 있었다. 또한 검색부터 실행결과가 나오기까지 5초 이내 이루어지므로 제시된 알고리즘의 우수성을 확인하였다.

• Asian-Australasian Journal of Animal Sciences
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• 제30권7호
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• pp.957-966
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• 2017

Objective: To understand the dynamic structure, function, and influence on nutrient metabolism in hosts, it was crucial to assess the genetic potential of gut microbial community in yaks of different ages. Methods: The denaturing gradient gel electrophoresis (DGGE) profiles and Illumina-based metagenomic sequencing on colon contents of 15 semi-domestic yaks were investigated. Unweighted pairwise grouping method with mathematical averages (UPGMA) clustering and principal component analysis (PCA) were used to analyze the DGGE fingerprint. The Illumina sequences were assembled, predicted to genes and functionally annotated, and then classified by querying protein sequences of the genes against the Kyoto encyclopedia of genes and genomes (KEGG) database. Results: Metagenomic sequencing showed that more than 85% of ribosomal RNA (rRNA) gene sequences belonged to the phylum Firmicutes and Bacteroidetes, indicating that the family Ruminococcaceae (46.5%), Rikenellaceae (11.3%), Lachnospiraceae (10.0%), and Bacteroidaceae (6.3%) were dominant gut microbes. Over 50% of non-rRNA gene sequences represented the metabolic pathways of amino acids (14.4%), proteins (12.3%), sugars (11.9%), nucleotides (6.8%), lipids (1.7%), xenobiotics (1.4%), coenzymes, and vitamins (3.6%). Gene functional classification showed that most of enzyme-coding genes were related to cellulose digestion and amino acids metabolic pathways. Conclusion: Yaks' age had a substantial effect on gut microbial composition. Comparative metagenomics of gut microbiota in 0.5-, 1.5-, and 2.5-year-old yaks revealed that the abundance of the class Clostridia, Bacteroidia, and Lentisphaeria, as well as the phylum Firmicutes, Bacteroidetes, Lentisphaerae, Tenericutes, and Cyanobacteria, varied more greatly during yaks' growth, especially in young animals (0.5 and 1.5 years old). Gut microbes, including Bacteroides, Clostridium, and Lentisphaeria, make a contribution to the energy metabolism and synthesis of amino acid, which are essential to the normal growth of yaks.

• Spatial Information Research
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• 제22권5호
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• pp.27-41
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• 2014

최근 건축정보 분야에서는 터널, 교량 등 도시의 인프라에도 건축정보모델링(BIM: Building Information Modeling)이 적용되면서 대형화된 도시 건축물의 유지 및 관리를 위해 BIM 뿐만 아니라 건물의 외부환경에 대한 정보가 필요하게 되었다. 또한, 건축물정보모델 및 도시/지리정보 모델 간 정보의 상호운용성을 바탕으로 다양한 시뮬레이션 및 도시계획, 국토보안 등 기타 응용프로그램에서의 상당한 이익과 발전을 가져올 수 있다는 관점에서 공간정보와 빅 데이터의 융합은 강한 잠재력을 지니고 있다. 이에 본 연구에서는 건축정보 분야의 개방형 BIM(open BIM) 표준모델인 IFC(Industry Foundation Classes)와 GIS분야의 표준모델인 CityGML의 정보를 효율적으로 연계하기 위해 IFC와 CityGML, LandXML의 정보체계 및 형상표현의 차이점을 비교분석하였으며 공간정보 분석을 위한 객체기반의 건축 도시통합모델의 개발방향을 제시하고 BIM과 GIS 간의 기초 융합전략 및 활용방안을 마련하고자 하였다.

• 임상간호연구
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• 제23권1호
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• pp.83-90
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• 2017

Purpose: This study was to develop evidence-based clinical practice guideline in order to prevent contrastinduced nephropathy (CIN) for patients undergoing percutaneous coronary intervention (PCI). Methods: The guideline was developed based on the "Scottish Intercollegiate Guidelines Network (SIGN)". The first draft of guideline was developed through 5 stages and evaluated by 10 experts.(1) Clinical questions were ensured in PICO format.(2) Two researchers conducted a systematic search through electronic database, identifying 170 studies. We selected 27 full text articles including 16 randomized clinical trials, 7 systematic reviews, and 4 guidelines. Quality of each studies were evaluated by the Cochran's Risk of Bias, AMSTAR, K-AGREEII. Among the studies, 11 studies were excluded.(3) The strength of recommendations were classified and quality of recommendations were ranked.(4) Guideline draft was finalized.(5) Content-validation was conducted by an expert group. All contents were ranked above 0.8 in CVI. Results: Evidence-based clinical practice guideline to prevent CIN was dveloped.(1) The guideline for preventing CIN recommends using 0.9% saline.(2) Standardized rate of fluid therapy is 1 to 1.5ml/kg/hr.(3) Execute hydration for 6~12hrs before PCI and after PCI. Conclusion: This study suggests evidence-based clinical practice guideline for preventing CIN which can be more efficiently used in clinical practice.