• 약학회지
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• 제44권5호
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• pp.470-477
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• 2000

WooHwangChungSimWon is a traditional medicine for treatment of hypertension, arteriosclerosis, coma, and stroke in China, Korea, and Japan. In the new prescription of WooHwangChungSimWon, the civet is substituted for the musk, the major component of WooHwangChungSimwon, because of the prohibition law about the musk. We have made a comparative study of the effects on the central nervous system between the musk containing and civet containing WooHwangChungSimWon. In order to investigate the effects on the central nervous system, we have examined spontaneous motor activities, anti-convulsion activities induced by chemicals or electric shock, sleep induced by hexobarbital, and antistress effects. In the examination of anti-convulsion effects against the electric shock and injection of pentetrazol, only the civet containing WooHwangChungSimWon showed the anti-convulsion effects, i.e. the duration of convulsion by electric shock was decreased (control: 104.0 seconds, low dose of civet containing WooHwangChungSimWon: 60.7 seconds) and the duration of suppression against pentetrazol induced convulsion was increased (control: 392.3 seconds, low dose of civet containing WooHwangChungSimWon: 574.0 seconds, high dose of civet containing WooHwangChungSimWon: 561.4 seconds). In the other examinations, all kinds of WooHwangChungSimWon showed sedation, anti-convulsion activities, and induction of sleeping. These results suggest that there are no significant differences between the musk containing and civet containing WooHwangChungSimWon except the anti-convulsion effects against the convulsions induced by electric shock and pentetrazol.

• 대한영양사협회학술지
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• 제27권3호
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• pp.179-190
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• 2021

The high caffeine intake by adolescents has been a concern. The purpose of this study was to examine the awareness and consumption of caffeine-containing foods among 443 high school students using a questionnaire. An analysis of the spending patterns of the students' weekly allowance showed that the amounts spent on purchasing caffeine-containing foods were higher for female students than male students (P <0.001). The scoring of the perception of caffeine was 3.1 out of 5, interest in the caffeine content of food was 2.6, consumption of caffeine-containing foods was 2.6, and usefulness of caffeine-containing foods was 2.7. The awareness of caffeine content in food was significantly higher in females (7.3 out of 11) than male students (6.7) (P<0.01). Approximately 59% of students perceived that the relationship between caffeine-containing foods and health, was harmful, and the experience of side effects after taking caffeine was significantly higher in female students than males. These side effects include heartburn (P<0.001), headache or dizziness (P<0.001), irregular heartbeat (P<0.05), and hands and feet shake (P<0.01). Caffeine-containing foods were purchased at convenience stores (62.1%). The factor considered when purchasing caffeine-containing foods was taste (72.2%), and the use of nutrition labeling for caffeine-containing foods scored 2.0 out of 5 points. When assessing the intake of caffeine-containing foods, the foods consumed more than once a week were in the order of coke, chocolate, chocolate milk, chocolate pie, and chocolate bars. These results suggest that it is necessary to prepare a caffeine-related nutrition guide improvement by sales management, and strengthen food labeling standards for the desirable recognition of caffeine and its safe intake by adolescents.

• 한국환경보건학회지
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• 제47권6호
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• pp.513-520
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• 2021

Background: Benzalkonium chloride (BKC) has been extensively used as a preservative in industrial products and in hygiene, medical, and cosmetic applications. Humidifier disinfectant (HD) products containing BKC have been used in South Korea. Objectives: This study was aimed to review types of products containing BKC, to summarize the regulations in the US, EU, Japan, and South Korea, and to review the health effects associated with the use of HD. Methods: We reviewed and summarized documents which were searched through PubMed and Google Scholar with the key words: BKC and asthma/contact dermatitis, humidifier disinfectant-associated lung injury (HDLI), and more. Results: Regulations in most countries including South Korea do not allow its use as disinfectants in spray-type of products for medicine, cosmetics, and household products. Two types of HD containing BKC (800~1,270 ppm) were marketed in South Korea from 1996~2003. Health effects reported from people who used products containing BKC were allergic contact dermatitis, erythema, and respiratory disease, including asthma. Two people who responded as HD users containing BKC only were confirmed to have developed asthma. HD-associated lung injury (HDLI) was reported by consumers who used both HD containing polyhexamethylene guanidine (PHMG) and HD containing BKC. Conclusions: In conclusion, the use of BKC as a biocide has to be controlled considering the route and pattern of exposure. Products containing BKC as preservatives were reviewed with exposure routes and sites in the human body such as skin, eyes, and the respiratory tract. HD containing BKC was clinically evaluated to be associated with asthma.

• Computers and Concrete
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• 제29권1호
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• pp.47-57
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• 2022

The increase in waste tires has brought serious environmental problems. Using waste tires rubber particles as aggregate in concrete can reduce pollution and decrease the usage of natural aggregate. The paper describes an investigation on flexural bearing capacity of self-compacting concrete (SCC) pavement slabs containing crumb rubber. Cyclic loading tests with different stress ratios and loading frequencies are carried out on SCC pavement slabs containing crumb rubber. Based on Paris Law and test data, the fatigue life of SCC pavement slab containing crumb rubber is discussed, and a revised mathematical model is established to predict the fatigue life of SCC pavement slab containing crumb rubber. The model applies to different stress ratios and loading frequencies. The fatigue life of SCC pavement slab containing crumb rubber is affected by the stress ratio and loading frequency. The fatigue life increases with the increase of stress ratio and loading frequency. Real-time acoustic emission (AE) signals in the SCC pavement slab containing crumb rubber under cyclic loading are measured, and the characteristics of crack propagation in the SCC pavement slab containing crumb rubber under different stress ratios and loading frequencies are compared. The AE signals provide abundant information of fracture process zone and crack propagation. The variation of AE ringing count, energy and b-value show that the fracture process of SCC pavement slab containing crumb rubber is divided into three stages.

• Elastomers and Composites
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• 제30권2호
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• pp.112-121
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• 1995

The physical properties of rubber compounds containing silica and siliane coupling agent in order to replace the carbon black and prepare for environmental regulation showed improved dynamic properties(rebound, heat build-up, $60^{\circ}C\;tan\;{\delta}$), but the abrasion resistance did not improve compared with the compounds containing carbon black. Also, curing retardation because of coherent structure of silica improved by the addition of DEG, but the mixing step change of activators did not so much improve the static and dynamic properties of the compounds containing high synthetic rubber, the status of mixing and dispersion showed that the compounds containing carbon black was much better than the compounds containing silica by TEM investigation.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2006년도 추계 학술발표회 논문집
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• pp.745-748
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• 2006

This study investigates the fundamental properties and examines spalling appearances and residual compressive strength of high strength concrete containing hybrid organic fibers subjected to fire. Test showed that overall, an increase of fiber content decreased the fluidity of concrete, but specimens containing polyvinyl alcoho(PVA)+polypropylene(PP) fiber and nylon(NY)+PP fiber had improved flow. In addition, the air content of all specimens was properly ranged in target value, regardless of fiber content. As for the spalling properties when completed the fire test, control concrete exhibited spalling occurrence due to sudden elevated temperature. However, specimens containing more than 0.1 vol% of PP fiber prevented the spalling, while specimens containing PP+CL and PVA+PP fiber can protected from fire in more than 0.15vol% of the fiber content. Importantly, a specimen containing only 0.05vol% of NY+PP showed the favorable spalling resistance performance.

• Journal of Pharmaceutical Investigation
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• 제21권2호
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• pp.97-101
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• 1991

Six different O/W cream bases containing 4% ascorbic acid dipalmitate and two different O/W cream bases containing 1% ascorbic acid were prepared. Percutanceous absorption of ascorbic acid as well as safety were determined using rabbits. The stability of the creams was also tested at room temperature. Ascorbic acid concentrations in urines varied depending on the characteristics of cream bases used. The absorption of ascorbic acid was increased and sustained with the cream bases containing branched chain esters of fatty acid instead of natural oils used currently. The excretion level of ascorbic acid in urine was high with the cream base including nonionic surfactants and a small quantity of natural oils. The creams containing nonionic surfactants showed excellent stability, while those containing anionic surfactants were not stable in terms of pH, odor and coloring test at room temperature during six months. But, the two creams containing ascorbic acid were unstable. All the cream bases tested showed good safety.

• 한국식품조리과학회지
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• 제13권3호
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• pp.348-355
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• 1997

As a trial to expand the use of oligosaccharide, tomato jams were made with various kinds and addition rate levels of oligosaccharide and their quality characteristics were evaluated by instrumental analyses and sensory evaluation. As the addition rate of oligosaccharides increased, 1. the sweetness of tomato jams decreased compared to those of control containing sugar, 2. the lightness and yellowness were increased, however, the redness was decreased, 3. the hardness and adhesiveness of tomato jams containing liquid type oligosacchairdes were lower and those of powder type were higher than control. The springiness of the samples containing oligosaccharide was lower than that of control, however, there was no significant difference in cohesiveness. In sensory evaluation, tomato jams containing oligosaccharides were generally similar or better than control. Color, viscosity, flavor and overall acceptability of the samples containing powder type oligosaccharide were higher than those of liquid type. Tomato jams containing 15% powder type oligosaccharide and 35% sugar showed the highest overall acceptability.

• Geomechanics and Engineering
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• 제8권4호
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• pp.541-557
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• 2015

This research aims to analyze the fracture coalescence characteristics of brittle sandstone specimen ($80{\times}160{\times}30mm$ in size) containing various flaws (a single fissure, double squares and combined flaws). Using a rock mechanics servo-controlled testing system, the strength and deformation behaviours of sandstone specimen containing various flaws are experimentally investigated. The results show that the crack initiation stress, uniaxial compressive strength and peak axial strain of specimen containing a single fissure are all higher than those containing double squares, while which are higher than those containing combined flaws. For sandstone specimen containing combined flaws, the uniaxial compressive strength of sandstone increase as fissure angle (${\alpha}$) increases from $30^{\circ}$ to $90^{\circ}$, which indicates that the specimens with steeper fissure angles can support higher axial capacity for ${\alpha}$ greater than $30^{\circ}$. In the entire deformation process of flawed sandstone specimen, crack evolution process is discussed detailed using photographic monitoring technique. For the specimen containing a single fissure, tensile wing cracks are first initiated at the upper and under tips of fissure, and anti-tensile cracks and far-field cracks are also observed in the deformation process; moreover anti-tensile cracks usually accompanies with tensile wing cracks. For the specimen containing double squares, tensile cracks are usually initiated from the top and bottom edge of two squares along the direction of axial stress, and in the process of final unstable failure, more vertical splitting failures are observed in the ligament region. When a single fissure and double squares are formed together into combined flaws, the crack coalescence between the fissure tips and double squares plays a significant role for ultimate failure of the specimen containing combined flaws.

• Journal of Oral Medicine and Pain
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• 제25권1호
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• pp.1-7
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• 2000

The purpose of this study is to investigate effects of several zinc solutions including Artemisia asiatica-containing zinc solution on concentration of oral volatile sulfur compounds(VSCs). We determined the VSCs concentration of breath of human subjects before and after use of zinc solutions(O.25% $ZnF_2$ Artemisia asiatica-containing 0.25% $ZnCl_2$ and Artemisia asiatica-containing 0.25% $ZnCl_2$ solutions) The results were as follows : 1. 0.25% $ZnCl_2$ solution was more effective than 0.25% $ZnF_2$ solution in reducing the concentration of oral VSCs and the maintenance duration of effectiveness. 2. Artemisia asiatica-containing 0.25% $ZnCl_2$ solution was more effective than Artemisia asiatica-containing 0.25% $ZnF_2$ solution in reducing the concentration of oral VSCs and the maintenance duration of effectiveness. 3. Artemisia asiatica-containing 0.25% $ZnF_2$ solution and 0.25% $ZnF_2$ solution showed no significant difference in reducing the concentration of oral VSCs and the maintenance duration of effectiveness but, Artemisia asiatica-containing 0.25% $ZnF_2$ solution was slightly more effective. 4. Artemisia asiatica-containing 0.25% $ZnCl_2$ solution and 0.25% $ZnCl_2$ solution showed no significant difference in reducing the concentration of oral VSCs and the maintenance duration of effectiveness but, Artemisia asiatica-containing 0.25% $ZnF_2$ solution was slightly more effective.