• 대한기계학회논문집A
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• 제33권11호
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• pp.1202-1208
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• 2009

An inverse finite element (FE) model parameter estimation algorithm can be used to characterize mechanical properties of biological tissues. Using this algorithm, we can consider the influence of material nonlinearity, contact mechanics, complex boundary conditions, and geometrical constraints in the modeling. In this study, biomechanical experiments on macro and micro samples are conducted and characterized with the developed algorithm. Macro scale experiments were performed to measure the force response of porcine livers against mechanical loadings using one-dimensional indentation device. The force response of the human liver cancer cells was also measured by the atomic force microscope (AFM). The mechanical behavior of porcine livers (macro) and human liver cancer cells (micro) were characterized with the algorithm via hyperelastic and linear viscoelastic models. The developed models are suitable for computing accurate reaction force on tools and deformation of biomechanical tissues.

• 한국소음진동공학회논문집
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• 제23권3호
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• pp.234-239
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• 2013

There are many types of speed reducer for industrial uses. However the cycloid speed reducer is widely used in manipulators based on excellent performance of low backlash, high reduction ratio and compact size. It is essential to use precision speed reducer for accuracy of position controls on robot systems and electric vehicles. The cycloid speed reducer has a eccentric rotating motion and offset to avoid some problem of assembly, so it has a disadvantage for vibration. In this paper, a multi-body dynamic model is developed for a cycloid speed reducer and the dynamic behaviors of the reducer are investigated. The cycloid speed reducer consists of cycloidal plate gears, housing gear, input shaft, output pin and shaft, and eccentric bearings. Using a CAD program, each component of cycloid reducer is modeled based on the offset and eccentric. Multi-body simulations using Recurdyn and test using a rig tester are performed. As a result, the pin reaction force and the amplitude of housing displacement are increased by the larger offset and smaller eccentric value of cycloid reducer.

• 한국가시화정보학회지
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• 제12권2호
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• pp.13-17
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• 2014

In the present study, the optofluidic droplet manipulation in a microfluidic platform was demonstrated via theoretical and experimental approaches. Optical scattering force and gradient force were used to separate and trap droplets. Two types of droplets were generated by a T-junction method in the microfluidic channel. While they approach a test region where the optical beam illuminates the droplets, they were pushed by the optical scattering beam. The displacement by the laser beam is dependent on the refractive index of the droplets. By using the optical gradient force, the droplets can be trapped and coalesced. In order to bring the droplets in a direct contact, the optical gradient force was used to trap the droplets. A theoretical modeling of the coalescence was derived by combining the optical force and drag force on the droplet.

• BMB Reports
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• 제42권5호
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• pp.260-264
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• 2009

Tumor necrosis factor-$\alpha$ (TNF-$\alpha$) exhibits cytotoxicity towards various tumor cells in vitro and induces apoptotic necrosis in transplanted tumors in vivo. It also shows severe toxicity when used systemically for the treatment of cancer patients, hampering the development of TNF-$\alpha$ as a potential anticancer drug. In order to understand the structure-function relation of TNF-$\alpha$ with respect to receptor binding, we selected four regions on the bottom of the TNF-$\alpha$ trimer that are in close contact with the receptor and carried out mutagenesis studies and computational modeling. From the study, various TNF-$\alpha$ muteins with a high therapeutic index were identified. These results will provide a structural basis for the design of highly potent TNF-$\alpha$ for therapeutic purposes. By conjugating TNF-$\alpha$ muteins with a high therapeutic index to a fusion partner, which targets a marker of angiogenesis, it could be possible to develop TNF-$\alpha$ based anticancer drugs.

• Steel and Composite Structures
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• 제26권1호
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• pp.55-66
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• 2018

In this paper, the response of an underground fibreglass reinforced plastic (FRP) composite pipe system subjected to realistic loading scenarios that may be experienced by an actual buried pipeline is investigated. The model replicates an arbitrary site with a length of buried pipeline, passing through a $90^{\circ}$ bend and into a valve pit. Various loading conditions, which include effects of pipe pressurization, differences in response between stainless steel and fibreglass composite pipes and severe loss of bed-soil support are studied. In addition to pipe response, the resulting soil stresses and ground settlement are also analysed. Furthermore, the locations of potential leakage and burst have also been identified by evaluating the contact pressures at the joints and by comparing stresses to the pipe hoop and axial failure strengths.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.237-242
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• 2001

Residual stress is a dominant obstacle to efficient production and safe usage of products by reducing the mechanical strength and failure properties. Especially, it causes interfacial failure and substrate deflection in the case of thin film. So, the exact evaluation and optimum control of thin film residual stress is indispensable. However, hole drilling or X-ray diffraction techniques have some limits in application to thin film. And, curvature technique for thin film materials cannot give the information about local stress variation. Therefore, we applied the nanoindentation technique in evaluating the thin film residual stress. In this study, we modeled the change of indentation loading curve for residually stressed and stress-free thin films during stress relaxation. The value of residual stress was directly related to the indentation depth change by relaxation. The residual stress from nanoindentation analysis was consistent with the result from curvature technique.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.357.1-357.1
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• 2014

Superhydrophobic WOx nanowire (NW) arrays were fabricated using a thermal evaporation and surface chemistry modification methods by self-assembled monolayer (SAM). As-prepared non-wetting WOx NWs surface shows water contact angle of $163.2^{\circ}$ and has reliable stability in underwater conditions. Hence the superhydrophobic WOx NWs surface exhibits silvery surface by total reflection of water layer and air interlayer. The stability analysus of underwater superhydrophobicity of WOx NWs arrays was conducted by changing hydrostatic pressure and surface energy of WOx NWs arrays. The stability of superhydrophobicity in underwater conditions decreased exponentially as hydrostatic pressure applied to the substrates increased3. In addition, as surface energy decreased, the underwater stability of superhydrophobic surface increased sharply. Specifically, sueprhydrophobic stability increased exponentially as surface energy of WOx NWs arrays was decreased. Based on these results, the models for explaining tendencies of superhydrophobic stability underwater resulting from hydrostatic pressure and surface energy were designed. The combination of fugacity and Laplace pressure explained this exponential decay of stability according to hydrostatic pressure and surface energy. This study on fabrication and modeling of underwater stability of superhydrophobic W18O49 NW arrays will help in designing highly stable superhydrophobic surfaces and broadening fields of superhydrophobic applications even submerged underwater.

• Environmental Engineering Research
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• 제25권4호
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• pp.605-613
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• 2020

This study is to investigate the possibility of using activated carbon prepared from Iraqi date-pits (ADP) which are produced from palm trees (Phoenix dactylifera L.) as low-cost reactive material in the permeable reactive barrier (PRB) for treating lead (Pb⁺²) from the contaminated groundwater, and then compare the results experimentally with other common reactive materials such as commercial activated carbon (CAC), zeolite pellets (ZP). Factors influencing sorption such as contact time, initial pH of the solution, sorbent dosage, agitation speed, and initial lead concentration has been studied. Two isotherm models were used for the description of sorption data (Langmuir and Freundlich). The maximum lead sorption capacities were measured for ADP, CAC, and ZP and were found to be 24.5, 12.125, and 4.45 mg/g, respectively. The kinetic data were analyzed using various kinetic models particularly pseudo-first-order, pseudo-second-order, and intraparticle diffusion. COMSOL Multiphysics 3.5a depend on finite element procedure was applied to formulate transmit of lead (Pb⁺²) in the two-dimensional numerical (2D) model under an equilibrium condition. The numerical solution shows that the contaminant plume is hindered by PRB.

• 한국자동차공학회논문집
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• 제12권4호
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• pp.173-180
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• 2004

The tread pattern of a tire has an important effect on tire performances such as handling, wear, noise, hydroplaning and so on. However, a finite element analysis of a patterned tire with detailed tread blocks has been limited owing to the complexity of making meshes for tread blocks and the huge computation time. The computation time has been shortened due to the advance in the computer technology. The modeling of tread blocks usually requires creating a solid model using a CAD software. Therefore it is a very complicated and time-consuming job to generate meshes of a patterned tire using a CAD model. A new efficient and convenient method for generating meshes of a patterned tire has been developed. In this method, 3-D meshes of tread pattern are created by mapping 2-D meshes of tread geometry onto 3-D tread surfaces and extruding them through tread depth. Then, the tread pattern meshes are assembled with the tire body meshes by the tie contact constraint. Residual aligning torque and frictional energy are calculated by using a patterned tire model and compared to the experimental results. It is shown that the calculated results of a patterned tire model are in a good agreement with the experimental ones.

• 한국정밀공학회지
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• 제32권2호
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• pp.117-125
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• 2015

This paper presents a dynamic modeling method for the indeterminate spindle-bearing system supported by multiple bearings of different types. A spindle-bearing system supported by ball and cylindrical roller bearings is considered. The de Mul's bearing model is extended for calculating ball and cylindrical roller bearing stiffness matrices with inclusion of centrifugal force and gyroscopic moment. The dependence between spindle shaft reaction forces and bearing stiffness is effectively resolved using an iterative approach. The spindle rotor dynamics is established with the Timoshenko beam theory based finite elements. The spindle reaction forces, bearings stiffness and spindle natural frequencies are obtained with taking into account spindle radial load, ball bearing axial preload and rotational speed effects. The developed method is verified by comparing the simulation results with those from a commercial program.