• Journal of Korean Ophthalmic Optics Society
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• v.15 no.3
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• pp.227-234
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• 2010

Purpose: The cleaning effect of protein deposit and the change of contact lens parameters by ultrasonic cleaner for eye glasses on the soft contact lenses were investigated. Methods: Etafilcon A contact lenses contaminated with protein, was ultrasonicated by ultrasonic cleaner for eye glasses and for the control group, spoiled contact lenses were cleaned by multi-purpose solution. The remaining protein deposits on the contact lenses were determined after extraction and the changes of overall diameter, base curve, center thickness power, and water contents on contact lenses were measured and surfaces of contact lenses were observed by scanning electron microscope. Results: The cleaning efficacies of multi-purpose solution on protein deposited etafilcon A contact lenses were 6.08%, and 23.73~33.92% in the group of ultrasonic cleaner for eye glasses with multi-purpose solution and 0~12.99% in the group of ultrasonic clear for contact lens with multipurpose solution depending on the treatment time. The changes of parameters and surface on contact lenses by ultrasonication were not observed. Conclusions: Ultrasonic cleaner for eye glasses can be used to eliminate protein deposits for the diagnostic soft contact lens in the office since it was effective to eliminate protein deposits and not caused change of parameters on soft contact lenses.

• Journal of Korean Ophthalmic Optics Society
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• v.16 no.1
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• pp.31-40
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• 2011

Purpose: This study was performed to investigate the actual state about ultrasonic cleaning of soft contact lenses in local optical shops and evaluate the removal effect of protein deposit on soft contact lenses with different lens containers by ultrasonic cleaner for eyeglasses. Methods: The actual state about ultrasonic cleaning of soft contact lenses was surveyed in total 75 local optical shops in Seoul, Korea. The cleaning efficacy of different lens containers was compared by measuring the protein remained on ocufilcon D contact lenses after washing by an ultrasonic cleaner for eyeglasses. The changes on surfaces and wetting angles of ocufilcon D contact lenses by repeat ultrasonication were further investigated. Results: The main purpose to use ultrasonic cleaners in local optical shops was rapid cleaning. The ultrasonic cleaning efficacy of ocufilcon D contact lenses with glass containers was little higher than it with plastic containers, but was not significantly different. The changes on surfaces and wetting angles of ocufilcon D contact lenses in a plastic lens container by repeat ultrasonication such as 30 and/or 60 times were shown. Conclusions: There was not significant difference in cleaning efficacy between glass and plastic lens containers. However, repeat cleaning with ultrasonic cleaner for eyeglasses would be carefully considered since some significant changes in the parameters of lens surface and wetting angles were detected by repeat ultrasonification even when lens containers were used for ocufilcon D contact lens during ultrasonictions.

• Journal of Korean Ophthalmic Optics Society
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• v.15 no.4
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• pp.347-353
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• 2010

Purpose: An in vitro study was conducted to compare the lipid cleaning efficacy of care solutions on balafilcon A silicone hydrogel (SiHy) lens. Methods: Lipid spoilation was performed by incubating balafilcon A SiHy lenses in phosphate buffered saline (PBS) containing oleic acid, oleic acid methyl ester and cholesterol. Spoiled contact lenses rinsed with PBS were cleaned with surfactant cleaner, alcohol containing cleaner and multipurpose solution (MPS) respectively and repetitive spoilation and cleaning was conducted up to 14 times. To observe the cleaning effect of ultrasonic wave on the lipid deposit, each spoiled lens was ultrasonicated and then compared with non-sonicated lens. Lipids deposit on the contact lenses was extracted by methanol:chloroform (1:1, v/v) solution. High performance liquid chromatography was used to analyze and quantify lipid deposit extracts. Results: The effectiveness of alcohol containing surfactant cleaner on the lipid deposits was better than that of surfactant cleaner and MPS, and the cleaning efficacy was significantly higher in the ultrasonic wave treated group. Lipid deposits were not removed completely by contact lens care solutions so that lipid deposits increased continuously and cumulatively. Conclusions: The cleaning efficacy of contact lens care solutions was not satisfactory to remove lipid deposits on the SiHy lens that new cleaning products specially designed for SiHy lenses are needed to develop.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.4
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• pp.37-41
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• 2007

The aim of this study is to establish RGP lens care system using RGP lens multi-purpose solution(MPS) and cleaner. Each RGP lens was incubated in Pseudomonas aeruginosa standard strain, and the numbers of P. aeruginosa colony remaining after treatment by using MPS and/or cleaner including surface activating components were estimated. Soaking only in MPS for 30 min reduced the number of P. aeruginosa up to 50%. 95% of P. aeruginosa was eliminated at RGP lenses soaked in MPS for 4 hr, but P. aeruginosa was not detected at RGP lenses soaked for 6 hr. When only cleaner was used for RGP lens care, 70% of P. aeruginosa was eliminated. This result showed that using cleaner had more effective at removing P. aeruginosa than soaking in MPS for 30 min. When soaking in MPS for 30 min after using cleaner reduced the number of P. aeruginosa up to 36% of that which soaking only in MPS for 30 min. This result suggested that using cleaner could be helpful to improve the disinfection efficacy of short time soaking in MPS.

• Journal of Korean Ophthalmic Optics Society
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• v.10 no.2
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• pp.91-97
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• 2005

We investigated the question whether protein removing activities of enzyme cleaner - protein remover for soft contact lens - are associated with the material of soft contact lens as well as action time, temperature and pH of enzyme solution. We used a subtilisin cleaner as protein remover and estimated the protein amount remained on soft contact lens after using the subtilisin cleaner under the different conditions. The remained protein in soft contact lens was greatly decreased until treatment for 60min, but no significant differences were found from 60min to 24hr. The cleaning effect of the enzymatic treatment in the range of $15{\sim}30^{\circ}C$ was constant. however, there was a significant decline of the protein removing effect at $10^{\circ}C$ and less. The pH of the solution was also important for the efficacy of the enzymatic treatment. The activity of the enzyme cleaner was highest in pH 8.0 and significantly decreased a pH below 7. The pH dependence was found to be related to the conformational change of subtilisin. Furthermore, significant differences in the protein deposit removing efficacy of the subtilisin cleaner were found among the soft contact lens materials.

• Journal of Korean Ophthalmic Optics Society
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• v.18 no.2
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• pp.107-115
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• 2013

Purpose: This study was conducted to investigate the change of soft contact lens parameters after eyeliner deposition and compare the cleaning efficiency and the recovery rate of lens parameters by different cleaning methods. Methods: The eyeliner was deposited on three types of soft contact lenses made of different materials for 1 hour, 4 hours and 6 hours and those lenses were washed by the eyeglasses ultrasonic cleaning and by hands. The changes in visible light transmittance, diameter and surface of those lenses were compared before and after cleaning of the lens. Results: The visible light transmittance of soft contact lenses decreased along with the deposition time of eyeliner. The patterns of the eyeliner deposition on soft contact lens appeared differently depending on the physical properties of the lens material. Thus, the largest eyeliner deposition was found on narafilcon A lens. The diameters of hilafilcon B and etafilcon A lenses were decreased, however, the diameter of narafilcon A lens was increased. The cleaning efficiency of the eyeliner deposition was greater with the multipurpose solution by hands than with the eyeglasses ultrasonic cleaner. However, the recovery of lens parameters such as the lens diameter, visible light transmittance and lens surface due to the eyeliner deposition to its original state was limited. Conclusions: From these results, it is suggested to minimize eye makeup when wearing soft contact lens. Furthermore, the reduced wearing time and shorter cycle of lens replacement may be needed by considering a change of lens parameter when the repeat eye makeup is applied.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.274-274
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• 1996

1차적인 제형의 조제를 위해서 비이온성 계면활성제인 poloxamer 류, Tween 류, octylphenylether와 양심 계면활성제인betaine 류와 방부제인 croquat 류에 대한 시험을 실시하여 자극을 나타내지 않은 성분을 선별하였다. 이를 근거로 isotonic sodium borate 용액을 완충액으로 사용하여, 최종제형을 조제하여 시험한 결과 자극반응을 나타내지 알았으며, 본 제형을 실온과 4$0^{\circ}C$에서 2, 4, 6개월간 안정성 시험을 거친 후 시험시에도 전혀 자극반응을 나타내지 않았다.