• Journal of Sasang Constitutional Medicine
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• v.35 no.4
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• pp.10-22
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• 2023

Objectives The aim of this study is to explore the mechanism of action and target diseases of Sasang constitutional prescriptions using a multiscale interactome approach. Methods The compound and target information of Sasang constitutional prescriptions were retrieved from various databases such as the TM-MC, STITCH, and TTD. Key targets for Sasang constitutional prescriptions were identified by selecting the top 100 targets based on the number of simple paths within the constructed network. Diffusion profiles for Sasang constitutional prescriptions and diseases were calculated based on a biased random walk algorithm. Potential diseases and key mechanisms of Sasang constitutional prescriptions were identified by analyzing diffusion profiles. Results We identified 144 Sasang constitutional prescriptions and their targets, finding 80 herbs with effective biological targets. A cluster analysis based on selecting up to 100 key targets for each prescription revealed a more cohesive grouping of prescriptions according to Sasang constitution. We then predicted potential diseases for 62 Sasang constitutional prescriptions using diffusion profiles calculated on a multiscale interactome. Finally, our analysis of diffusion profiles revealed key targets and biological functions of prescriptions in obesity and diabetes. Conclusions This study demonstrates the effectiveness of a multiscale interactome approach in elucidating the complex mechanisms and potential therapeutic applications of prescriptions in Sasang constitutional medicine.

• Journal of Sasang Constitutional Medicine
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• v.22 no.3
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• pp.110-121
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• 2010

1. Objectives: This investigation compares the eating behaviors across normal-weight male groups of different Sasang constitutional types. 2. Methods: We recruited 31 male participants aged 20-35 with BMI 18.5-23. The eating behavior was assessed using Gastrointestinal Symptom Rating Scale (GSRS), Bulimia Test Revised (BULIT-R), Korean Version of Eating Attitude Test-26 (KEAT-26), and Dutch Eating Behavior Questionnaire (DEBQ). 3. Results: 1) Assessments made by GSRS, KEAT-26, and BULIT-R were not significantly different across different Sasang constitutional types. (p<0.05) 2) The Soeum group showed significantly lower BMI and body weight compared to the Soyang and Taeeum groups. 3) The Emotional eating subscale of DEBQ differed significantly across different Sasang constitutional types. (p<0.05) 4) The Soeum group showed a significantly lower Emotional eating subscale score of DEBQ compared to the Soyang and Taeeum groups. 4. Conclusions: The results of this study suggest that emotional factors could influence eating behaviors differently across different Sasang constitutional types, in which the Soeum type is less affected than the Soyang type by emotional states.

• Journal of Sasang Constitutional Medicine
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• v.24 no.3
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• pp.93-103
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• 2012

Objectives Rate of gastroesophageal reflux disease accompanied by irritable bowel syndrome is on the increase. This case study reports significant improvement of patients with gastroesophageal reflux disease and irritable bowel syndrome who had suffered from chest pain, globus pharyngis and diarrhea after taking Sasang constitutional treatment. Methods This patient was diagnosed as Large Yin type Esophagus Cold pattern(Taeeumin Wiwanhanjeung). Herb medicine(Jowiseungcheong-tang) was taken by the patient, three or two times per day during treatment periods. We assessed the changes of the main symptoms such as chest pain, globus pharyngis, defecation discomfort, insomnia et al. using visual analogue scale(VAS). Results The symptoms of chest pain, globus pharyngis, defecation discomfort, insomnia decreased from VAS 7~8 to VAS 0~1 for about three months. Conclusions This case shows that Sasang constitutional medicine treatment can be effective treatment method for gastroesophageal reflux disease accompanied by irritable bowel syndrome.

• Journal of Sasang Constitutional Medicine
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• v.17 no.1
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• pp.170-173
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• 2005

1. Objectives Chronic pyelonephritis is one of the obstinate disease in current medicine. chronic pyelonephritis can be healed through cooperative treatment of western medicine and Sasang constitutional medicine. 2. Methods This patient who was not treated by western medicine alone was healed when Sasang constitutional medicine was prescripted with modern western medicine 3. Results We can get significal changes in lab results when western medicine and clinical Sasang constitutional medicine was practiced together. 4. Conclusions We suggest that cooperation with western and Sasang constitutional medicine is much effective in treating chronic pyelonephritis and other obstinate diseases.

• Journal of Sasang Constitutional Medicine
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• v.13 no.2
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• pp.138-143
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• 2001

1. Background Among the clinical application of Sasang Constitutional diagnostic methods, a morphologic study of face is recognized by the Ministry of Health and Welfare as a legitimate Hanbang diagnostic method. But there are some indirect different view about this method. We should criticize this method for the better. 2. Method We criticize the current morphologic study of face by its literature basis, its measurement and its result, compared with ${\ulcorner}$Dongyisoosebowon${\lrcorner}$ and other related literatures. 3. Conclusions We suggest thar the current morphologic study of face is not proper for the clinical application of Sasang Constitutional diagnostic method in the point of the lack of literature basis and the intervention of the examiner's subjectivities.

• Journal of Sasang Constitutional Medicine
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• v.20 no.3
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• pp.176-183
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• 2008

1. Objectives The purpose of this case study is to evaluate the effects of Yangkyuksanhwa-tang which is based on Sasang Constitutional Medicine for strabismus of abducence nerve paralysis. 2. Methods This patient was created by Soyangin's Constitutional Medications according to the result of Sasang Constitutional diagnosis. We evaluated the abduction deficit that described how to use Scott and kraft. 3. Results & Conclusions This case study shows an efficient result of using Yangkyuksanhwa-tang in treatment of Strabismus of abducence nerve paralysis.

• Journal of Sasang Constitutional Medicine
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• v.31 no.1
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• pp.1-12
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• 2019

Objective The purpose of this study is to reveal the universal truthfulness of Sasang Constitutional Medicine from the perspective of the perennial philosophy and the integral psychology. Methods Aldous Huxley's The perennial philosophy and Ken Wilber's Literature of integral psychology such as A Brief History of Everything was compared with "Gyukchigo(格致藁)" and "Donguisusebowon(東醫壽世保元)". Also investigated the literature of various countries related to constitution(temperament). Results and Conclusions 1. Historically, there are various constitutional theories, but the constitution that best corresponds to the constitution in the perennial philosophy of Aldous Huxley is Sasang Constitutional Medicine. 2. The Sasang theory(四象說) and Four element structure(四元構造) of Sasang Constitutional Medicine was confirmed to be the same as AQAL(all quadrants & all levels) of Ken Wilber. 3. The Sasang theory(Four element structure) of Sasang Constitutional Medicine was presented ahead of Ken Wilber's AQAL(all quadrants & all levels), therefore, Sasang Constitutional Medicine has universal truthfulness.

• Journal of Sasang Constitutional Medicine
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• v.33 no.4
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• pp.65-77
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• 2021

Objective We report a case about a Soyangin patient with diabetic neuropathy. His symptoms were alleviated with Sasang Constitutional medicine. Methods A Soyangin patient with diabetic neuropathy was treated by herbal medicine, acupuncture, pharmacopuncture according to Sasang Constitutional Medicine. The progress was evaluated with numerical rating scale(NRS) and blood sugar test(BST). Results Sasang Constitutional Medicine seems to be effective for the symtoms of the patient with diabetic neuropathy in this case. Conclusions This case study shows that Sasang Constitutional Medicine may be an effective treatment for Soyangin's diabetic neuropathy.

• Journal of Sasang Constitutional Medicine
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• v.17 no.3
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• pp.22-30
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• 2005

1. Objectives The purpose of this study is to verify whether one's constitutional medicine can be used for others or not. The results of this study will help us to understand sasang constitutional medicine. 2. Methods In Dong-Mu's writings - ${\ulcorner}$DongMuYooGo${\lrcorner}$, ${\ulcorner}$Dongyi Suse Bowon Sasang ChobonGuen${\lrcorner}$, ${\ulcorner}$Dongyi sasang shinpyun${\lrcorner}$-, I found out that one's constitutional medicine has been used for others. 3. Results and Conclusions 1) There are 13 medicines that have been used and mixed with other constitutional medicines in ${\ulcorner}$DongMuYooGo${\lrcorner}$. 2) There are 3 medicines that have been used and mixed with other constitutional medicines in ${\ulcorner}$Dongyi Suse Bowon Sasang ChobonGuen${\lrcorner}$. 3) There are 18 prescriptions that have combined with other constitutional medicines in ${\ulcorner}$Dongyi sasang shinpyun${\lrcorner}$.

• Journal of Sasang Constitutional Medicine
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• v.19 no.3
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• pp.176-187
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• 2007

1. Objectives The purpose of this research is to find out the Sasang Constitutional difference in Heart Rate Variability. 2. Methods We enrolled 8498 workers who tested for Heart Rate Variability(HRV) from September 1, 2005 to November 28, 2005 except works whose body constitusions were undetermined according to QSCCII. 3. Results & Conclusions The result of HRV of autonomic activity and stress resistance were arranged in the order of Soeumin, Soyangin and Taeumin. On the other hand Stress Index and Fatigue Index were arranged in the order of Taeumin, Soyangin and Soeumin. But autonomic balance was no significance relationship between Sasang Constitutions. This research has shown that there is a statistical significance between the HRV and Sasang Constitutions. The findings indicated that HRV could be useful mean to make a diagnosis of Sasang Constitution or apprehended Constitutional differences.