• 제목/요약/키워드: Consensus development

검색결과 559건 처리시간 0.023초

Development of a Single Chain Antibody Using a Phage Display Cloning Method for the Detection of 2,4-Dinitrotoluene

  • Na, Jung-Hyun;Joo, Man-Seok;Lee, Won-Kyu;Shim, Hyunbo;Lim, Si-Hyung;Jung, Sang Taek;Yu, Yeon Gyu
    • Bulletin of the Korean Chemical Society
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    • 제34권2호
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    • pp.460-464
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    • 2013
  • Single-chain variable fragments of antibodies (scFv) specific to 2,4-dinitrotoluene (DNT) were isolated from a phage library displaying synthetic human scFv fragments with 6 diversified complementary determining regions (CDRs). A DNT derivative that contained an extended amine group was synthesized and conjugated to the NHS-group that was linked to magnetic beads. Phages specific to the immobilized DNT derivatives were isolated from the library after 4 rounds of sequential binding and elution processes. The displayed scFv fragments from the isolated phages showed consensus CDR sequences. One DNT-specific scFv was expressed in E. coli and purified using Ni-affinity chromatography. The purified DNT-specific scFv binds specifically to the immobilized DNT-derivative with $K_D$ value of $6.0{\times}10^{-7}$ M. The scFv and DNT interaction was not disrupted by the addition of 4-nitrotoluene or benzoic acid. These data demonstrate that the screened scFv from the phage displayed library could be used for selective and sensitive detection of explosives such as TNT.

폭력남편에 대한 한국에서의 개입모델 개발을 위한 시론적 연구 (A Study on the Development of the Intervention Model for Korean Men Who Batter)

  • 이은주
    • 한국사회복지학
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    • 제40권
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    • pp.157-190
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    • 2000
  • As the Law on the Prevention of Domestic Violence was enacted in Korea, it has become necessary to work on how to intervene effectively in Korean men who batter. The purpose of this study is to establish the framework of the intervention model which is relevant to Korean wife-batterers. In the States, the psychoanalytic model, cognitive-behavioral model, and feminist model are most widely used with men who batter. As yet, the consensus on which model is most effective has not been reached. In this study, each model is reviewed briefly. And then it is suggested that in the light of Korean culture the educational model is more relevant than therapeutic model. Several points are also suggested, which need to be considered when feminist model is used in Korean culture. It is also insisted that the integrated model based on ecological theory is necessary to intervene effectively in such a multi-dimensional problem as domestic violence. For the group intervention, it is suggested to use educational model primarily and to use therapeutic model complementarily. Based on the framework suggested in this study, to develop the specific structure of the program, to implement it, and to test its effectiveness will be the tasks of the future researches.

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Application of numerical models to determine wind uplift ratings of roofs

  • Baskaran, A.;Borujerdi, J.
    • Wind and Structures
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    • 제4권3호
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    • pp.213-226
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    • 2001
  • Wind uplift rating of roofing systems is based on standardised test methods. Roof specimens are placed in an apparatus with specified table size (length and width) then subjected to the required wind load cycle. Currently, there is no consensus on the table size to be used by these testing protocols in spite of the fact that a table size plays a significant role in evaluating the performance. This paper presents a study with the objective to investigate the impact of table size on the performance of roofing systems. To achieve this purpose, extensive numerical experiments using the finite element method have been conducted to investigate the performance of roofing systems subjected to wind uplift pressures. Numerical results were compared with results obtained from experimental work to benchmark the numerical modeling. Required table size and curves for the determinations of appropriate correction factors are suggested. This has been completed for various test configurations with thermoplastic waterproofing membranes. Development of correction factors for assemblies with thermoset and modified bituminous membranes are in progress. Generalization of the correction factors and its usage for wind uplift rating of roofs will be the focus of a future paper.

기록관리 시스템 기능요건 표준의 정부산하공공기관 적용에 관한 사례 연구 (A Case Study on the Application of Requirements Standard of Systems for Government-Affiliated Organizations)

  • 김형주;김수현
    • 한국비블리아학회지
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    • 제28권2호
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    • pp.35-56
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    • 2017
  • 정부산하공공기관은 경영 자주성, 업무 전문성을 고려하여 기록물을 자체적으로 보존 관리할 것을 원칙으로 하고 있다. 정부산하공공기관을 위한 범용 기록관리시스템이 없는 상황에서 "정부산하공공기관 등 기록관리시스템 기능요건(NAK/S 24:2014(v1.0))" 표준의 제정은 각 기관이 자체적으로 기록관리시스템을 구축할때 공통적으로 고려해야 될 기능요건과 시스템 방향성을 일치시킨다는 점에서 의의가 있다. 본 연구에서는 표준에서 제안하는 기능요건을 분석하고, 기록관리시스템 구축 사례를 중심으로 표준의 기능요건을 적용하기 위한 절차와 방안을 제시하였다.

Identifying Wastes in Construction Process and Implementing the Last Planner System in India

  • Bhatla, Ankit;Pradhan, Bulu;Choi, Jin Ouk
    • Journal of Construction Engineering and Project Management
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    • 제6권1호
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    • pp.11-19
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    • 2016
  • Most of the Indian contractors are not well equipped to handle the growing demand of infrastructure development; hence construction projects frequently run in to time and cost overruns, disputes and quality issues. This study aims to improve the construction industry in India by implementing lean principles to eliminate non-value adding activities (wastes). The purpose of this study is to 1) identify the wastes and their sources affecting the construction process, and 2) to identify problems and document lessons by applying a Last Planner System (LPS) to a sample project. First, the researchers identified that Delays, Rework, and Interruptions were the most critical wastes affecting the construction process and Poor management control, Poor Planning and Shortage of Resources were the major sources of the above mentioned wastes. Second, the researchers report the Percent of Planned Complete (PPC) analysis results and experienced problems after implementation of LPS at the sample project. It was observed that much more improvement could have been achieved if there was consensus between the owners and the contractor on the implementation of the LPS in its entirety. Some of the problems experienced in the implementation of the LPS like lack of scheduling, resource and material shortage were found to be similar to those in developed countries.

오픈소스 ILS 실현에 관한 연구 (A Study on the Integrated Library System Based on Open Source Software)

  • 조재인
    • 정보관리학회지
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    • 제28권1호
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    • pp.69-88
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    • 2011
  • 연구 이용 수정 재배포를 허용하는 오프소스 소프트웨어(OSS)는 경쟁이 아닌 협력과 공유를 통해 발전해 나가는 도서관 정신과 유사하다. OSS는 사서들의 창의적 아이디어와 표준 업무프로세스를 기반으로 저비용 기술혁신을 실현할 수 있는 대안으로 평가되고 있으나, 지속적 발전을 위해서는 경험과 지식을 공유하는 성숙한 커뮤니티 정신이 요구된다. 본 연구에서는 커뮤니티 중심의 OSS ILS 사례인 KOHA와 Next_L을 심층 분석하고 이를 기반으로 국내 OSS ILS의 실현 방안을 제안하였다. 우리나라의 경우 관종별 도서관 컨소시엄을 중심으로 중소규모 도서관을 위한 OSS ILS 개발을 추진해 나가는 것이 바람직해 보인다. 그러나 아직 생소한 OSS ILS 필요성에 대한 현장의 공감대 형성, 커뮤니티 활성화를 위한 기운의 성숙이 전제되어야 할 것이다.

지역정체성을 기반으로 한 공공환경 디자인의 방향 연구 (A Study on the Direction of the Public Environment Design based on the Regions' Sense of Identity)

  • 송영민
    • 한국실내디자인학회논문집
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    • 제21권5호
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    • pp.98-105
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    • 2012
  • The purpose of this study is to present the direction for effective public environment design by becoming aware of the social, cultural and historical values that are inherent to the specific regions once again. Concept of regions' sense of identity, regions' resources and regionality were identified as a means based on the basic cityscape plan and guideline for public design. Sample city was analyzed by extracting the regionality elements, and the results are as follows. First, appropriateness of the direction for the public environment design based on the regional identity was confirmed. The need to establish regional identity in the cityscape plan is specified when it comes to the basic goal, strategy and direction. Second, public environment design should be planned within the context of the cityscape. It is necessary to improve with integrated plan by setting up the consistent goal, direction and detailed guideline based on the basic concept of cityscape plan. Third, 'design city' requires the development of the unique design and planned techniques based on the harmony with the existing resources. It is necessary to uncover the powerful design elements that are exclusive to specific regions, and to search for differentiation and visualization to form consensus. Public environment based on regional identity will improve if the above mentioned research results are used as the basic data when it comes to the implementation of public environment design.

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다기능형(多技能形) 여행용(旅行用) 재킷의 디자인 개발(開發) (A Development of Designs for the Multifunctional Traveler's Jacket)

  • 서윤정;이주현
    • 패션비즈니스
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    • 제6권4호
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    • pp.46-61
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    • 2002
  • The purpose of this study was to analyze critical needs and demands for the multifunctional traveler's jacket and to develop design prototypes based on the findings from the analysis. A self-report questionnaire with the stimuli was applied. Total 163 travelers were purposively sampled for the survey and the data were analyzed quantitatively as well as qualitatively. The results were as follows: 1. The respondents were divided into three groups - "digital-functionality-needs group", "non-digitalfunctionality-needs group", "no-need group", according to their preference and needs for the multifunctional traveler's jacket. 2. The three groups were analyzed (1) to have meaningful differences in experiencing inconvenience in their traveling, (2) to have statistically significant differences in their needs for the multifunctional traveler's jacket, (3) while some imperative consensus in their needs were found in part. 3. Based on the findings of the analysis mentioned above, three design prototypes were developed and visualized with conclusion.

CARE(CAse REport) 지침에 따른 대한한방부인과학회지의 증례보고에 대한 질 평가 (Evaluation of the Quality of the Case Reports from the Journal of Obstetrics and Gynecology of Korean Medicine Based on the CARE Guidelines)

  • 남은영;박주연
    • 대한한방부인과학회지
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    • 제32권2호
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    • pp.71-86
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    • 2019
  • Objectives: The purpose of this study is to assess the quality of case reports from the Journal of Obstetrics and Gynecology of Korean Medicine. Methods: Case reports were selected from the Obstetrics and Gynecology of Korean Medicine from January 2015 to March 2019, by utilizing Oriental Medicine Advanced Searching Integrated System (OASIS). The quality of the reports were reviewed based on the Consensus-based Clinical Case Reporting Guideline Development (CARE) guideline. Results: Total of 41 case reports were finally selected for the assessment. 69.23% of the case reports included necessary information based on the CARE guideline but the rest of the reports did not. More than 50% of the reports were missing data regarding 'Diagnostic challenges', 'Intervention adherence and tolerability', 'Adverse and unanticipated events', or 'Patient perspective or experience', and 'Informed consent'. Also, the reports did not include 'Key word', 'timeline'. Conclusions: Case reports from the Journal of Obstetrics and Gynecology of Korean Medicine have important role in women. Efforts are needed to improve the quality of the case reports as well as to develop reporting guidelines for the Journal of Obstetrics and Gynecology of Korean Medicine.

지역문화자원을 활용한 문화도시 조성 방안 (A Study on Creating a Cultural City Using Local Cultural Resources)

  • 김용남;권기창
    • 한국멀티미디어학회논문지
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    • 제22권1호
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    • pp.88-98
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    • 2019
  • This study was conducted to explore ways to create a cultural city using local cultural resources. To that end, the qualitative case study was applied. As the original city center had been declining due to the expansion and changes of city space caused by the changes of city function and social change, the old downtown of Andong city was selected as an example. For the result, research shows that the region's historical resources and culture have to blend and develop together with abundant cultural resources, such as contents development, city's symbolic space settings, differentiated cultural and artistic establishment, comfort in living, utilization of cultural infrastructure, and supporting facilities which are suitable for cultural diversity. In particular, we found that the importance of establishing a new city image that leads local residents willing to participate and of forming a consensus among tourists. Therefore, for the implementation of a cultural city, policies, undertaking, and administrative support that meet to the city's conditions and environment are required, and a further study on that issue is needed.