• 국제학술발표논문집
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• The 4th International Conference on Construction Engineering and Project Management Organized by the University of New South Wales
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• pp.299-303
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• 2011

Congestion is a growing concern of many global cities and the demands on Infrastructure services within a locale coupled by the rising expectations from the growing population places stress on these cities. This entails the ability to build a sustainable community that requires an understanding and recognition of Population growth, changing demographics and the ever changing urban development on both a macro and micro level. Infrastructure is an integral part of Australian economy, particularly the 'Infrastructure Assets Management' which highlights the importance towards the development of sustainable communities for Melbourne's future. Melbourne 2030 is a comprehensive representation of government's response to a wide-ranging population growth within Melbourne metropolitan and surrounding areas. Urban plan and specific Infrastructure Assets Planning needs not only to provide sufficient Infrastructure to a community, but it must also be efficient and innovative so that it produces an optimised management system. A system that incorporates engineering techniques that will be sustainable for decades to come by maintaining an acceptable level of services to its intended community in an effective manner, which also strengthens service delivery. The fundamental challenges for optimization of Infrastructure with the Melbourne urban plan is, the ability to manage and sustain maintenance of Infrastructure to provide the acceptable level of service required by the community in a most effective manner which also strengthens service delivery to contribute towards Melbourne 2030. This paper particularly investigates some of the fundamental issues within the Melbourne urban plan such as Infrastructure Asset Management, AusLink and the Australian Road Management Act 2004, which the Governments at all levels must deal with to provide an economically viable solution to the changing Infrastructure so it may suits the needs and services the strategies of a metropolis.

• 대한한방부인과학회지
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• 제37권1호
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• pp.23-39
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• 2024

Objectives: Primary dysmenorrhea (PD) is defined as abdominal pain during menstruation period in the absence of an identifiable pathological lesion. Corydalis tuber (CT) is an herbal medicine that has an excellent effect in relieving pain and convulsions. The purpose of this study is to observe the effect of Corydalis tuber aqueous extracts (CTe) on primary dysmenorrhea. Methods: The rats were injected with estradiol benzoate subcutaneously for 10 days (2.5 mg/kg on the first and 10th days, and 1 mg/kg from the 2~9th day). Oxytocin 1 U/kg was treated by peritoneal injection 1 hour after the last 10th injection of estradiol benzoate. CTe 400, 200 and 100 mg/kg were administered orally, once a day for 10 days at 30 minutes after each estradiol benzoate treatment. The results of CTe were compared to those of IND 5 mg/kg orally treated rats. Results: As results of estradiol benzoate and oxytocin administration, noticeable decreases of body weights and gains, uterus weights were observed with congestion and enlargement of the uterus at gross inspections, and increases of abdominal writhing responses, uterus MDA levels, GSH contents, SOD and CAT activities. However, these oxidative stress mediated PD signs were dose-dependently decreased by 10 consecutive days of oral administration of three different doses of CTe 400, 200 and 100 mg/kg as comparable to those of IND 5 mg/kg in CTe 200 mg/kg. Conclusions: CTe had a significant improvement effect on primary dysmenorrhea in the PD rat model induced by estrogen benzoate and oxytocin.

• 대한간호학회지
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• 제26권4호
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• pp.963-975
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• 1996

The purpose of this study was to call attention to the mental, physical and occupational hazards of the anticancer-drug-handling nurses by examining the possible urinary mutagenicity and measuring physical symptoms and stress level of the nurses exposed to anticancer drugs. The experimental group of the urinary mutagenicity assay was 14 nurses handling anticancer drugs at the medical wards of a hospital located in J city ; the control group was 12 psychiatric nurses of the same hospital. The test material was the nurses' 24hrs urine, which was concentrated by XAD-2 column chromatography. Tester strains were TA98(±S9 mix), TA100(±S9 mix), TA1535(±S9 mix) and TA1537(±S9 mix) ; Salmonella mammalian-microsomal test(Ames test) was employed for the urinary mutagenicity assay. The physical symptoms of which the nurses experienced were investigated through self-reports on open-questionnaires. The stress levels of the experimental group were measured by a stress measuring instrument developed by this author. Reliability of this instrument was found to be adequate (Cronbach's Alpha=0.9079). To ascertain the urinary mutagenicity of the experimental group, the mean and the standard deviation of the colonies of Tester strains appearing on the minimal plates were taken and compared differences between two groups. T-test was employed for the significance test of two groups. The physical symptoms were compared between the two groups through the analysis of the nurse' self-reports. The mean and standard deviation of the stress levels of the experimental group were also calculated and were examined through t-test. The results were summarized as follows : 1. The experimental group revealed significantly higher urinary mutagenicity both in the activation method test and the non-activation method test of the tester strains TA98, TA100 and TA1535. In the case of TA1537, two groups showed no difference in the non-activation method test, but the activation method revealed difference. 2. The physical symptoms were also much more frequently reported in the experimental group. 79.3% of the experimental group reported more than 1 kind of physical symptoms. On the other hand, 33.2% of the control group complained of 1 kind of physical symptom. The items with high symptom frequency were 'headache', 'itching sensation', 'corneal congestion', 'skin allergy' 3. The mean score of stress in the experimental group was 2.41(range 1-4). The experimental group showed the stress level above 2.0 in the 14 of 15 items in all. The highest stress level were recorded in the following items in the order quoted, 'I fear that anticancer drug may touch any part of body while handling it.', 'I feel concerned there is no protective countermeasure against anticancer drug handling.', 'I am afraid the anticancer drug handling may produce a fetal loss in the future'.

• 한국동물위생학회지
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• 제36권4호
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• pp.233-242
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• 2013

The genus Taraxacum, known by the common name Dandelion, is a medicinal herb in the family Asteraceae. It has been traditionally used as a folk medicine for the treatment or prevention of various diseases due to its anti-inflammatory and anti-oxidative properties. In this study, we attempted to evaluate protective effects of Dandelion related with anti-oxidative activity to Thioacetamide (TAA)-induced liver damage. 36 rats were randomly assigned to six experimental groups : Control, Dandelion water extract (DWE), TAA, TAA&DWE 300, TAA&DWE 600, TAA&DWE 1,200 groups. Rats in DWE and TAA&DWE groups were pretreated with DWE (300, 600 or 1,200 mg/kg BW) by gavage for 7 days. All rats were treated intraperitoneally with TAA (200 mg/kg BW) or normal saline at 12 hours after last oral administration and sacrificed at 12 hours after last treatment. Levels of WBC and Neutrophil count were significantly decresed in TAA&DWE 1,200 group compared with that in TAA group (P<0.05). In TAA&DWE 600 and TAA&DWE 1,200 groups, serum AST, ALT, GGT levels were lower than TAA group (P<0.05). The serum TG level was significantly elevated in TAA&DWE groups compared with those in TAA group. Liver tissues from TAA group showed extensive histopathological changes, characterized by moderate or severe hepatocytes degeneration, inflammatory cell infiltration, and congestion. In the TAA&DWE group, The severity of histopathological lesions were decreased compared to those in the TAA group. The MDA concentration was significantly decreased and GSH content was significantly increased in the TAA&DWE 1,200 group compared to those in the TAA group. GR, CAT and GST activities in the TAA&DWE 1,200 group were significantly increased compared to those in the TAA group.

• 대한본초학회지
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• 제26권4호
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• pp.39-47
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• 2011

Objective: The roots, leaves, flowers, stems and seeds of Cirsium japonicum var. ussuriense are often used in treatment of human diseases such as hemorrhage, blood congestion and inflammation. Focusing our attention on natural and bioavailable sources of antioxidants and anti-inflammation, we undertook to investigate the antioxidant and anti-inflammatory properties of Cirsium japonicum var. ussuriense used as a folk medicine in Korea. Methods: The extracts of the leaves, stems, flowers, seeds and roots from C. japonicum var. ussuriense were prepared by extracting with water or 80% ethanol. Total flavonoids and polyphenols were measured by a colorimetric assay. The free radical scavenging activity of the extract was analyzed by the DPPH (1,1-diphenyl-2-picryl hydrazyl), ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and Griess reagent assay. An oxidative product of nitric oxide (NO), was measured in the culture medium by the Griess reaction. The level of prostaglandin $E_2$ ($PGE_2$) was measured by enzyme-linked immunosorbent assay. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were measured by Western blot analysis. Results: Total flavonoid and polyphenol amounts of the leaves (CLE) and flowers (CFE) showed higher than those of the seed extract (CSE), stem extract (CSTE) and roots (CRE). CLE and CFE also showed the high antioxidant activities such as DPPH, NO-like and ABTS radical scavenging activity. An antioxidant activities of these water extracts showed higher than those of 80% ethanol extracts. We investigated the anti-inflammatory effects of CLE on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. CLE significantly suppressed the levels of the inflammatory mediators such as NO and prostaglandin $E_2$ ($PGE_2$) in dose dependant. Furthermore, the levels of iNOS and COX-2 protein expressions were markedly suppressed by the treatment with CLE extract in a dose dependent manner. Conclusions: These results suggest that CLE water extract has a higher anoxidant and anti-inflammatory activity, these properties may contribute to the oxidative and inflammatory related disease care.

• 한국측량학회지
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• 제33권4호
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• pp.287-296
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• 2015

최근 내비게이션에서는 실시간 교통정보와 과거의 교통정보를 가공하여 미래의 교통정보를 예측하는 패턴 교통정보를 같이 활용하여 빠른 길을 안내해주고 있다. 그러나 현재 사용되는 패턴 교통정보는 과거의 정보를 가공하여 교통정보를 예측하기 때문에 특별한 상황(유고, 날씨 등)에서는 예측이 정확하지 않는 문제점을 가지고 있다. 그래서 본 연구에서는 빠른 길을 찾기 위해 실시간으로 운전자들이 요청하는 경로탐색 데이터를 분석하여 가까운 미래 운전자들이 위치할 도로의 교통 혼잡도를 미리 파악하여 패턴 교통정보 보다 정확한 예측 교통정보를 제시하였다. 연구결과 첫째, 연구지역의 정체경로인 양재에서 마포간 차량속도 비교에서는 기존 상습정체 도로의 속도가중치 정확도가 3km/h에서 18km/h의 오차율이 발생하였지만, 본 연구의 Real 예측 교통 정보를 적용한 결과는 1km/h에서 5km/h의 오차율이 발생하였다. 둘째, 경로 품질에서 기존의 경로보다 최대 약 9분, 평균 약 3분 일찍 목적지에 도착하여 예측 교통정보 결과의 신뢰성을 입증할 수 있었다. 셋째, 기존의 경로탐색 결과 보다 혼잡도를 미리 예측하여 혼잡이 발생할 도로에 대해 회피되는 경로탐색 결과를 도출할 수 있었다. 따라서 본 연구결과의 경로탐색 비교를 통해 교통량에 대한 예측정보를 획득할 수 있었으며 이를 활용하여 실시간 빠른 길 탐색이 가능하고, 향후 교통 흐름을 분산 시키는데도 도움이 될 것으로 판단된다.

• 대한원격탐사학회지
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• 제11권3호
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• pp.101-116
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• 1995

최근 안전성과 경제성을 고려한 교통자료획득 방법으로 인공위성 영상자료를 사용하는 기술이 논의되어졌다. 본 논문은 인공위성영상을 이용한 고속도로 교통량 측정 자동화에 관한 연 구로서, 현재 사용되고 있는 교통량 측정방법의 단점 및 문제점을 평가, 분석하였으며, 본 보고서 에서 제안된 인공위성영상을 이용한 방안의 적용 및 가능성을 연구, 분석 하였다. 기존 인공위성 영상자료의 해상도가 교통자료획득에 적합하지 않으므로, 사진영상에 제안된 방 안을 도입하여, 실효성에 바탕을 둔 적용 여부를 검증하였다. 차량종류 및 교통량 측정에 필요한 인공위성영상의 해상도를 구하기 위하여 세 단계 (1m, 2m, 3,)의 사진영상해상도가 검토되었으며, 본 연구에서 제안된 일련의 영상처리 결과를 분석하였다. 전색성(panchromatic) 영상에서 도로와 차량의 반사율이 유사함으로, 도로상에서 차량을 탐지하 기 위하여 차량의 반사율을 이용하지않고 차량그림자의 반사율을 이용하였으며, 두가지 처리방법 이 제시되었다. 또한 차량종류를 구분하기위하여 여러가지 형태계수를 개발, 적용하였으며, 처리 과정을 상세히 설명하였다.

• 한국조경학회지
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• 제42권5호
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• pp.52-63
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• 2014

본 연구는 여가제약에 따른 한강시민공원의 여가공간개발 영향에 대한 이용자의 인식차이에 관한 연구로 한강시민공원 이용에 표출되는 여가제약을 파악하고, 한강시민공원의 이용행태 특성 및 여가공간개발에 따른 긍정적 부정적 영향에 대한 인식을 파악하고자 하였다. 여가제약에 따른 한강시민공원 이용자의 여가공간개발에 대한 인식차이를 비교분석 하기 위해 한강시민공원에서의 여가활동에 미치는 정보와 자원, 경제적 여유, 시간적 여유를 영향정도가 높은 집단과 낮은 집단으로 분류하여 심층분석하였다. 그 결과는 다음과 같다. 첫째, 한강시민공원은 산책 및 휴식을 비롯한 조깅 및 마라톤, 자전거 등 여가제약요인에 영향이 적은 근린이용의 성격을 지닌 간단한 운동을 위해 방문하는 공간이었다. 둘째, 한강시민공원의 여가공간개발에 따른 영향에 있어서 저렴한 여가활동 비용, 접근의 용이를 가장 높게 평가하고 있었으며, 이용자 증가로 인한 혼잡 및 운영 관리상 예산과 관리인원의 증가를 가장 많이 우려하고 있었다. 셋째, 한강시민공원에서의 여가제약은 시간적 여유, 경제적 여유, 정보와 자원의 순으로 영향을 미치고 있었으며 여가제약의 영향정도에 따라 다양한 여가기회 및 여가수준의 향상, 한강에 대한 자부심 및 애착심 고취, 저렴한 여가활동 비용을 비롯하여 운영 관리상 예산과 관리인원의 증가, 이용자의 증가로 인한 혼잡에 있어 인식차이를 나타내고 있었다. 따라서 본 연구는 한강시민공원 이용자들에게 영향을 미치는 여가제약과 이에 따른 여가공간개발에 대한 인식을 확인할 수 있었으며, 여가제약의 영향정도가 한강시민공원의 여가공간개발에의 이용행태 및 긍정적 부정적 개발영향의 지각에 차이가 있음을 밝혀냈다는 점에서 연구의 의의가 있다고 할 수 있겠다. 또한 여가제약에 따른 여가불만을 해소하기 위해서 한강시민공원의 여가공간에 대한 홍보 및 정보전달과 함께 여가공간 운영 및 관리체제 수반, 다채로운 맞춤형 프로그램 개발, 사익보단 공익이 우선적인 여가공간 및 시설의 도입 등의 필요성이 고찰되었다.

• 대한본초학회지
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• 제24권3호
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• pp.1-12
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• 2009

Objectives : The objective of this study was to compare, the potency of toxicity of Cantharidin containing dried Mylabis phalerata (MP) extract and it's modifier. Methods ： They were monitored at dosage level 2,000, 1,000, 500, 250 and 125 mg/kg, respectively. Changes of body weight, clinical signs, mortality, LD50, macroscopic changes of gastrointestinal tract and liver were observed after single oral dose of test articles with changes of serum Gastrin and Somatostatin levels. Results ： Dosage-dependent decrease of body weight and/or gains were demonstrated in dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, the body weights were significantly increased compared to that of equal dosage group of dried MP extract-dosing group. Dosage-dependently detected clinical signs in dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, these clinical signs dramatically were decreased compared to that of equal dosage group of dried MP extract-dosing group. Dosage-dependent increase of mortality rates were observed in dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, the mortalities were significantly decreased compared to that of equal dosage group of dried MP extract-dosing group. The LD50 of dried MP extract in male mice was dramaticlly increased in their modify, 265.86 vs 426.99 mg/kg. Dosage-dependently increase of number of hemorrhagic and/or erythematous spots detected in the gastrointestinal tracts of dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, these abnormal spots were dramatically decreased compared to that of equal dosage group of dried MP extract-dosing group. Dosage-dependently increase of degrees of enlargement and congestion detected in the liver of dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, these abnormal signs were dramatically decreased compared to that of equal dosage group of dried MP extract-dosing group. Dosage-dependently increase of serum gastrin levels of dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, these abnormal increase were dramatically decreased compared to that of equal dosage group of dried MP extract-dosing group. Dosage-dependently increase of serum somatostatin levels of dried MP extract-dosing groups, were also detected in modified and dried MP extract-dosing groups at 2,000 and 1,000 mg/kg-dosing group. However, below 500 mg/kg-dosing group, these abnormal increase were dramatically decreased compared to that of equal dosage group of dried MP extract-dosing group. Conclusions ： The toxicity of dried MP extract was reduced by their modify.

• Toxicological Research
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• 제21권2호
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• pp.151-160
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• 2005

In order to monitor the histological and general profiles of lung after direct expose of p,p-DDE, 1, 5 and 10 mg/ml of p,p-DDE were sprayed to male ICR mouse, and seven days after exposure, changes of body weight, lung weight, clinical signs, histological profiles of lung and total WBC in blood were investigated with changes of total cell number and their differential count in bronchoalveolar lavage fluid (BALF). In the present study, a significant and dosage-dependent decrease of body weight was detected in p,p-DDE exposed groups and body weight gains during observational periods (7 days) were also significantly and dosage-dependently decreased in p,p-DDE exposed groups compared to that of vehicle control group. In addition general depression signs were detected in all p,p-DDE exposed groups with dosage-dependent manners, and lung weights were also increased in p,p-DDE exposed groups. Congestion, hemorrhage and severe exudate were observed in the lung of p,p-DDE exposed groups with sarcomatous changes and these signs were also showed by dosage-dependent manners. In addition, foreign body pneumonia signs were observed in the lung of p,p-DDE exposed groups in histological levels. The percentage of ALSA (Area of luminal surface of alveoli) was also significantly and dosage-dependently decreased in p,p-DDE exposed groups and total blood WBC and BALF cell numbers were significantly and dosage-dependently increased in p,p­DDE exposed groups compared to that of vehicle control group and increase percentage of neutrophil, eosinophil, and lymphocyte in BALF were monitored in p,p-DDE exposed groups compared to that of vehicle control group. In conclusion, severe allergic response and/or foreign body pneumonitic changes were induced by direct exposure of p,p-DDE containing beverage. So it is considered that strong and powerful regulation was need to control production of residence of environmental pollutant especially to p,p-DDE.