• 한국노년학
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• 제39권2호
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• pp.241-259
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• 2019

본 연구는 노인 자원봉사활동의 성과를 성공적 노화나 생산적 노화가 아닌 노인의 자기효능감과 자기확장성의 관점에서 연구하고자 하였다. 이를 통해 노년기에 일어날 수 있는 내적성장과 자가의 확장을 검증 할 수 있으며, 노년기 삶을 재조명하는 계기를 마련하는데 연구의 목적이 있다. 이러한 연구목적을 검증하기 위하여 부산광역시의 시청 및 구청에서 진행하는 자원봉사활동에 참여한 노인 300명을 연구대상으로 하여, 2018년 9월부터 11월까지 약 3개월에 걸쳐 설문지를 배부하여 불성실하게 응답되었다고 판단된 34부의 설문지를 제외한 후 266부의 자료를 본 연구에 사용하였다. 연구결과는 다음과 같다. 첫째, 노인의 자원봉사활동참여 동기(가치기능, 사회기능, 이해기능)는 자기효능감에 긍정적인 영향을 미치는 것으로 나타났다. 둘째, 자원봉사활동참여 동기(가치기능, 사회기능, 이해기능)는 자기확장성에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 노인의 자기효능감(자기조절 효능감, 자신감)은 자기확장성에 긍정적인 영향을 미치는 것으로 나타났다. 넷째, 자기효능감((자기조절 효능감, 자신감)은 노인의 자원봉사활동 참여동기와 자기확장성의 관계에서 매개효과가 발생하는 것으로 나타났다. 본 연구는 노인의 자원봉사활동 참여동기가 자기효능감과 자기확장성에 영향을 미친다는 관련성을 규명 하였다. 특히, 노인에게 심리사회적 개념인 자기효능감의 매개변수를 활용하여, 노인복지의연구의 새로운 관점을 제공함으로써 향후 노인의 자원봉사활동 활성화를 위한 실천적, 정책적 방안을 제시하였다는데 연구의 의의가 있다.

• Journal of Pharmaceutical Investigation
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• 제39권2호
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• pp.133-139
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• 2009

The purpose of the present study was to evaluate the bioequivalence of two pioglitazone HCl tablets, $Actos^{TM}$, tablets (Lilly Korea. Ltd., Korea) as a reference drug and $Piros^{TM}$, tablets (Reyon Pharm. Co., Ltd., Korea) as test drug, according to the guideline of Korea Food and Drug Administration (KFDA). Twenty-four healthy male Korean volunteers received one tablet containing pioglitazone HCl 15 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of pioglitazone were monitored for over a period of 36 hr after administration by using a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The area under the plasma concentration-time curve from time zero to 36 hr ($AUC_{0-36hr}$), maximum plasma drug concentration ($C_{max}$) and time to reach $C_{max}$ ($T_{max}$) were complied from the plasma concentration-time data. Analysis of variance (ANOVA) test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_{0-36hr}$ and $C_{max}$. The 90% confidence intervals of the $AUC_{0-36hr}$ ratio and the $C_{max}$ ratio for $Piros^{TM}$/$Actos^{TM}$. were log 0.8753-log 1.1286 and log 0.8669-log 1.1734, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25, recommended by KFDA. In all of these results, we concluded that the $Piros^{TM}$. tablet was bioequivalent to the $Actos^{TM}$. tablet, based on the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• 제41권3호
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• pp.191-196
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• 2011

In this study simple and sensitive high performance liquid chromatographic method using a commercially available column, was developed and validated for the determination of zolpidem tartrate in human plasma. The developed method with suitable validation was applied to a bioequivalence study of two different kinds of zolpidem tartrate. Two different formulations containing 10 mg of zolpidem tartate (CAS : 99294-93-6) were compared in 24 healthy male volunteers in order to compare the bioavailability and prove the bioequivalence. The study was performed in an open, single dose randomized, 2-sequence, cross-over design in 24 healthy male volunteers with a one-week washout period. Blood samples for pharmacokinetic profiling were drawn at selected times during 12 h. The mean $AUC_{0-12h}$, $C_{max}$, $T_{max}$ and $T_{1/2}$ were $676.6{\pm}223.4$ $ng{\cdot}h{\cdot}mL^{-1}$, $177.4{\pm}34.2$ $ng{\cdot}mL^{-1}$, and $0.8{\pm}0.4$ and $3.5{\pm}2.1$, respectively, for the test formulations, and $640.7{\pm}186.6$ $ng{\cdot}h{\cdot}mL^{-1}$, $193.0{\pm}64.5$ $ng{\cdot}mL^{-1}$, and $0.9{\pm}0.4$ and $2.7{\pm}0.9$, respectively, for the reference formulation. Both primary target parameters $AUC_{0-12h}$ and $C_{max}$ were log-transformed and tested parametrically by analysis of variance (ANOVA). 90% confidence intervals of $AUC_{0-12h}$ and $C_{max}$ were in the range of acceptable limits of bioequivalence (80-125%). Based on these results, the two formulations of zolpidem tartate are considered to be bioequivalent.

• Journal of Pharmaceutical Investigation
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• 제38권6호
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• pp.421-427
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• 2008

The purpose of the present study was to evaluate the bioequivalence of two etodolac capsules, Kuhnillodin capsule (Kuhnil. Co., Ltd., Seoul, Korea) as reference drug and Etodin capsule (Myungmun Pharm. Co., Ltd., Seoul, Korea) as test drug, according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-three healthy male Korean volunteers received one capsule at the dose of 200 mg etodolac in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of etodolac were monitored by a high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) for over a period of 24 hr after the administration. $AUC_{0-24\;hr}$ was calculated by the linear trapezoidal rule method. $C_{max}$ and $T_{max}$ were compiled from the plasma concentration-time data. Analysis of variance (ANOVA) was carried out using logarithmically transformed $AUC_{0-24\;hr}$ and $C_{max}$. The 90% confidence intervals of the $AUC_{0-24\;hr}$ ratio and the $C_{max}$ ratio for Etodin/Kuhnillodin were $\log\;0.97{\sim}\log\;1.08$ and $\log\;0.89{\sim}\log\;1.19$, respectively. These values were within the acceptable bioequivalence intervals of $\log\;0.80{\sim}\log\;1.25$. Thus, our study demonstrated that Etodin was bioeqiovalent to Kuhnillodin preparation when the rate and extent of absorption between two preparations were compared.

• Korean Journal of Radiology
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• 제21권4호
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• pp.402-412
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• 2020

Objective: To evaluate the performance of predicting early recurrence using preoperative factors only in comparison with using both pre-/postoperative factors. Materials and Methods: We retrospectively reviewed 549 patients who had undergone curative resection for single hepatcellular carcinoma (HCC) within Milan criteria. Multivariable analysis was performed to identify pre-/postoperative high-risk factors of early recurrence after hepatic resection for HCC. Two prediction models for early HCC recurrence determined by stepwise variable selection methods based on Akaike information criterion were built, either based on preoperative factors alone or both pre-/postoperative factors. Area under the curve (AUC) for each receiver operating characteristic curve of the two models was calculated, and the two curves were compared for non-inferiority testing. The predictive models of early HCC recurrence were internally validated by bootstrap resampling method. Results: Multivariable analysis on preoperative factors alone identified aspartate aminotransferase/platelet ratio index (OR, 1.632; 95% CI, 1.056-2.522; p = 0.027), tumor size (OR, 1.025; 95% CI, 0.002-1.049; p = 0.031), arterial rim enhancement of the tumor (OR, 2.350; 95% CI, 1.297-4.260; p = 0.005), and presence of nonhypervascular hepatobiliary hypointense nodules (OR, 1.983; 95% CI, 1.049-3.750; p = 0.035) on gadoxetic acid-enhanced magnetic resonance imaging as significant factors. After adding postoperative histopathologic factors, presence of microvascular invasion (OR, 1.868; 95% CI, 1.155-3.022; p = 0.011) became an additional significant factor, while tumor size became insignificant (p = 0.119). Comparison of the AUCs of the two models showed that the prediction model built on preoperative factors alone was not inferior to that including both pre-/postoperative factors {AUC for preoperative factors only, 0.673 (95% confidence interval [CI], 0.623-0.723) vs. AUC after adding postoperative factors, 0.691 (95% CI, 0.639-0.744); p = 0.0013}. Bootstrap resampling method showed that both the models were valid. Conclusion: Risk stratification solely based on preoperative imaging and laboratory factors was not inferior to that based on postoperative histopathologic risk factors in predicting early recurrence after curative resection in within Milan criteria single HCC patients.

• 지능정보연구
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• 제21권2호
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• pp.131-150
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• 2015

영어와 달리 한국어나 일본어 문장의 경우 용언의 필수격을 채우는 명사구가 생략되는 무형대용어 현상이 빈번하다. 특히 백과사전이나 위키피디아의 문서에서 표제어로 채울 수 있는 격의 경우 그 격이 문장에서 더 쉽게 생략된다. 정보검색, 질의응답 시스템 등 주요 지능형 응용시스템들은 백과사전류의 문서에서 주요한 정보를 추출하여 수집하여야 한다. 그러나 이러한 명사구 생략 현상으로 인해 양질의 정보추출이 어렵다. 본 논문에서는 백과사전 종류 문서에서 생략된 명사구 즉 무형대용어를 복원하는 시스템의 개발을 다루었다. 우리 시스템이 다루는 문제는 자연어처리의 무형대용어 해결 문제와 거의 유사하나, 우리 문제의 경우 문서의 일부가 아닌 표제어도 복원에 이용할 수 있다는 점이 다르다. 무형대용어 복원을 위해서는 먼저 무형대용어의 탐지 즉 문서 내에서 명사구 생략이 일어난 곳을 찾는 작업을 수행한다. 그 다음 무형대용어의 선행어 탐색 즉 무형대용어의 복원에 사용될 명사구를 문서 내에서 찾는 작업을 수행한다. 문서 내에서 선행어를 발견하지 못하면 표제어를 이용한 복원을 시도해 본다. 우리 방법의 특징은 복원에 사용된 문장성분을 찾기 위해 Structural SVM을 사용하는 것이다. 문서 내에서 생략이 일어난 위치보다 앞에 나온 명사구들에 대해 Structural SVM에 의한 시퀀스 레이블링(sequence labeling) 작업을 시행하여 복원에 이용 가능한 명사구인 선행어를 찾아내어 이를 이용하여 복원 작업을 수행한다. 우리 시스템의 성능은 F1 = 68.58로 측정되었으며 이는 의미정보의 이용 없이 달성한 점을 감안하면 높은 수준으로 평가된다.

• Journal of Pharmaceutical Investigation
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• 제37권4호
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• pp.255-261
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• 2007

A bioequivalence study of $Nimegen^{TM}$ soft capsule (Medica Korea Pharma. Co., Ltd.) to $RoAccutane^{(R)}$ soft capsule (Roche Korea Ind. Co., Ltd.) was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). Thirty healthy male Korean volunteers received each medicine at the isotretinoin dose of 60 mg in a $2{\times}2$ crossover study. There was one week wash-out period between the doses. Plasma concentrations of isotretinoin were monitored by a high performance liquid chromatography (HPLC) for over a period of 48 hours after drug administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 48 hr) was calculated by the linear trapezoidal rule method. $C_{MAX}$ (maximum plasma drug concentration) and $T_{MAX}$ (time to reach $C_{MAX}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t\;and\;C_{MAX}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{MAX}$ ratio for $Nimegen^{TM}/RoAccutane^{(R)}$ were $log0.860{\sim}log0.98\;and\;log0.85{\sim}log1.00$, respectively. These values were within the acceptable bioequivalence intervals of $log0.80{\sim}log1.25$. Thus, our study demonstrated the bioequivalence of $Nimegen^{TM}\;and\;RoAccutane^{(R)}$ with respect to the rate and extent of absorption.

• Imaging Science in Dentistry
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• 제50권3호
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• pp.237-243
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• 2020

Purpose: The aim of this study was to evaluate the clinical efficacy of a Tanner-Whitehouse 3 (TW3)-based fully automated bone age assessment system on hand-wrist radiographs of Korean children and adolescents. Materials and Methods: Hand-wrist radiographs of 80 subjects (40 boys and 40 girls, 7-15 years of age) were collected. The clinical efficacy was evaluated by comparing the bone ages that were determined using the system with those from the reference standard produced by 2 oral and maxillofacial radiologists. Comparisons were conducted using the paired t-test and simple regression analysis. Results: The bone ages estimated with this bone age assessment system were not significantly different from those obtained with the reference standard (P>0.05) and satisfied the equivalence criterion of 0.6 years within the 95% confidence interval (-0.07 to 0.22), demonstrating excellent performance of the system. Similarly, in the comparisons of gender subgroups, no significant difference in bone age between the values produced by the system and the reference standard was observed (P>0.05 for both boys and girls). The determination coefficients obtained via regression analysis were 0.962, 0.945, and 0.952 for boys, girls, and overall, respectively (P=0.000); hence, the radiologist-determined bone ages and the system-determined bone ages were strongly correlated. Conclusion: This TW3-based system can be effectively used for bone age assessment based on hand-wrist radiographs of Korean children and adolescents.

• 대한의용생체공학회:의공학회지
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• 제32권3호
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• pp.237-244
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• 2011

In this paper, a feature-based registration technique is proposed for pre-contrast and post-contrast lung CT images. It utilizes three dimensional(3-D) features with their descriptors and estimates feature correspondences by nearest neighborhood matching in the feature space. We design a transformation model between the input image pairs using a free form deformation(FFD) which is based on B-splines. Registration is achieved by minimizing an energy function incorporating the smoothness of FFD and the correspondence information through a non-linear gradient conjugate method. To deal with outliers in feature matching, our energy model integrates a robust estimator which discards outliers effectively by iteratively reducing a radius of confidence in the minimization process. Performance evaluation was carried out in terms of accuracy and efficiency using seven pairs of lung CT images of clinical practice. For a quantitative assessment, a radiologist specialized in thorax manually placed landmarks on each CT image pair. In comparative evaluation to a conventional feature-based registration method, our algorithm showed improved performances in both accuracy and efficiency.

• 한국식품영양과학회지
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• 제45권3호
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• pp.342-351
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• 2016

본 연구는 한국에서 식용색소로 지정되지 않은 keto-carotenoid계의 canthaxanthin에 대한 최적 분석방법을 확보하기 위해 수행되었다. HPLC-UVD를 이용한 외국의 canthaxanthin 공인분석법을 검토하여 직선성, 분리능, 민감도, 검출한계(LOD), 정랑한계(LOQ)를 도출하고, 각 실험 데이터를 비교하여 최적의 canthaxanthin 분석방법을 확보하였다. 또한 확보된 최적 분석방법에 대한 정밀도, 정확도, 회수율, 실험실 간 교차검증, 측정불확도를 산출하여 canthaxanthin 최적 분석법에 대한 타당성을 검증하였다. AOAC법, 일본 및 영국의 공인분석법을 이용하여 canthaxanthin 표준용액을 5, 10, 20, 50, 100, $300{\mu}g/mL$의 6 point로 희석한 후 얻은 검량선의 상관계수는 모두 $R^2=0.999$ 이상으로 나타나 우수한 직선성을 보였으나 분리능, 민감도, LOD, LOQ는 일본의 공인분석법이 가장 우수하였다. 일본 공인분석법의 LOD와 LOQ는 각각 0.084 mg/kg, 0.254 mg/kg으로 나타났으며, 1보다 낮은 정밀도, 100%에 가까운 정확도, $100{\pm}10%$ 사이의 회수율, 교차검증 시 세 기관의 변동계수가 5이하로 나타나 canthaxanthin 분석을 위해 가장 최적화된 방법으로 확인되었다. 또한 측정하는 중에 나타나는 불확실성을 알아보기 위하여 canthaxanthin이 함유된 가공식품을 분석하여 측정불확도를 산출한 결과 $39.5{\pm}5.29mg/kg$(95% 신뢰구간, k=2.78)으로 나타났다. 확장불확도는 측정 농도의 13.4%로 나타나 유럽연합의 기준(16% 이하)에 적합한 결과를 보였다.