• Journal of Convergence Society for SMB
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• v.6 no.4
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• pp.79-84
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• 2016

A novel diagnosis scheme PCADP(personalized computer aided diagnosis probability) is proposed to overcome the problems mentioned above. PCADP scheme is a personalized diagnosis method based on ontology and it makes the bio-data analysis just a 'process' in the Smart healthcare service system. In addition, we offer a semantics modeling of the smart healthcare ontology framework in order to describe smart healthcare data and service specifications as meaningful representations based on this PCADP. The PCADP scheme is a kind of statistical diagnosis method which has real-time processing, characteristics of flexible structure, easy monitoring of decision process, and continuous improvement.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.1
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• pp.89-99
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• 2020

Although microscopic analysis of tissue slides has been the basis for disease diagnosis for decades, intra- and inter-observer variabilities remain issues to be resolved. The recent introduction of digital scanners has allowed for using deep learning in the analysis of tissue images because many whole slide images (WSIs) are accessible to researchers. In the present study, we investigated the possibility of a deep learning-based, fully automated, computer-aided diagnosis system with WSIs from a stomach adenocarcinoma dataset. Three different convolutional neural network architectures were tested to determine the better architecture for tissue classifier. Each network was trained to classify small tissue patches into normal or tumor. Based on the patch-level classification, tumor probability heatmaps can be overlaid on tissue images. We observed three different tissue patterns, including clear normal, clear tumor and ambiguous cases. We suggest that longer inspection time can be assigned to ambiguous cases compared to clear normal cases, increasing the accuracy and efficiency of histopathologic diagnosis by pre-evaluating the status of the WSIs. When the classifier was tested with completely different WSI dataset, the performance was not optimal because of the different tissue preparation quality. By including a small amount of data from the new dataset for training, the performance for the new dataset was much enhanced. These results indicated that WSI dataset should include tissues prepared from many different preparation conditions to construct a generalized tissue classifier. Thus, multi-national/multi-center dataset should be built for the application of deep learning in the real world medical practice.

• The Journal of the Korea Contents Association
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• v.15 no.3
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• pp.184-191
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• 2015

Prostate ultrasound is used to diagnose prostate cancer, BPH, prostatitis and biopsy of prostate cancer to determine the size of prostate. BPH is one of the common disease in elderly men. Prostate is divided into 4 blocks, peripheral zone, central zone, transition zone, anterior fibromuscular stroma. BPH is histologically transition zone urethra accompanying excessive nodular hyperplasia causes a lower urinary tract symptoms(LUTS) caused by urethral closure as causing the hyperplastic nodule characterized finding progressive ambient. Therefore, in this study normal transition zone image for hyperplasia prostate and normal transition zone image is analyzed quantitatively using a computer algorithm. We applied texture features of GLCM to set normal tissue 60 cases and BPH tissue 60cases setting analysis area $50{\times}50pixels$ which was analyzed by comparing the six parameters for each partial image. Consequently, Disease recognition detection efficiency of Autocorrelation, Cluster prominence, entropy, Sum average, parameter were high as 92~98%.This could be confirmed by quantitative image analysis to nodular hyperplasia change transition zone of the prostate. This is expected secondary means to diagnose BPH and the data base will be considered in various prostate examination.

• Journal of Korea Multimedia Society
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• v.9 no.12
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• pp.1588-1595
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• 2006

In this paper, we proposed a liver extracting procedure for computer aided liver diagnosis system. Extraction of liver region in an abdominal CT image is difficult due to interferences of other organs. For this reason, liver region is extracted in a region of interest(ROI). ROI is selected by the window which can measure the distribution of Hounsfield Unit(HU) value of liver region in an abdominal CT image. The distribution is measured by an existential probability of HU value of lever region in the window. If the probability of any window is over 50%, the center point of the window would be assigned to ROI. Actually, liver region is not clearly discerned from the adjacent organs like muscle, spleen, and pancreas in an abdominal CT image. Liver region is extracted by the watershed segmentation algorithm which is effective in this situation. Because it is very sensitive to the slight valiance of contrast, it generally produces over segmentation regions. Therefore these regions are required to merge into the significant regions for optimal segmentation. Finally, a liver region can be selected and extracted by prier information based on anatomic information.

• The Journal of the Korea Contents Association
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• v.10 no.10
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• pp.54-67
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• 2010

Applying the conventional machine-learning method which has been frequently used in health-care area has several fundamental problems for modern U-health service analysis. First of all, we are still lack of application examples of the traditional method for our modern U-health environment because of its short term history of U-health study. Second, it is difficult to apply the machine-learning method to our U-health service environment which requires real-time management of disease because the method spends a lot of time in the process of learning. Third, we cannot implement a personalized U-health diagnosis system using the conventional method because there is no way to assign weights on the disease-related variables although various kinds of machine-learning schemes have been proposed. In this paper, a novel diagnosis scheme PCADP is proposed to overcome the problems mentioned above. PCADP scheme is a personalized diagnosis method and it makes the bio-data analysis just a 'process' in the U-health service system. In addition, we offer a semantics modeling of the U-health ontology framework in order to describe U-health data and service specifications as meaningful representations based on this PCADP. The PCADP scheme is a kind of statistical diagnosis method which has characteristics of flexible structure, real-time processing, continuous improvement, and easy monitoring of decision process. Upto the best of authors' knowledge, the PCADP scheme and ontology framework proposed in this paper reveals one of the best characteristics of flexible structure, real-time processing, continuous improvement, and easy monitoring among recently developed U-health schemes.