• 제목/요약/키워드: Computer Aided Application

검색결과 273건 처리시간 0.038초

Computer-Aided Drug Discovery in Plant Pathology

  • Shanmugam, Gnanendra;Jeon, Junhyun
    • The Plant Pathology Journal
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    • 제33권6호
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    • pp.529-542
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    • 2017
  • Control of plant diseases is largely dependent on use of agrochemicals. However, there are widening gaps between our knowledge on plant diseases gained from genetic/mechanistic studies and rapid translation of the knowledge into target-oriented development of effective agrochemicals. Here we propose that the time is ripe for computer-aided drug discovery/design (CADD) in molecular plant pathology. CADD has played a pivotal role in development of medically important molecules over the last three decades. Now, explosive increase in information on genome sequences and three dimensional structures of biological molecules, in combination with advances in computational and informational technologies, opens up exciting possibilities for application of CADD in discovery and development of agrochemicals. In this review, we outline two categories of the drug discovery strategies: structure- and ligand-based CADD, and relevant computational approaches that are being employed in modern drug discovery. In order to help readers to dive into CADD, we explain concepts of homology modelling, molecular docking, virtual screening, and de novo ligand design in structure-based CADD, and pharmacophore modelling, ligand-based virtual screening, quantitative structure activity relationship modelling and de novo ligand design for ligand-based CADD. We also provide the important resources available to carry out CADD. Finally, we present a case study showing how CADD approach can be implemented in reality for identification of potent chemical compounds against the important plant pathogens, Pseudomonas syringae and Colletotrichum gloeosporioides.

THE MANAGEMENT OF A COMPLEX IMPLANT CASE USING CAD-CAM TECHNOLOGY: A CLINICAL REPORT

  • Park, Eun-Jin
    • 대한치과보철학회지
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    • 제46권6호
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    • pp.634-638
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    • 2008
  • PURPOSE: The application of computer-aided technology to implant dentistry has created new opportunities for treatment planning, surgery and prosthodontic treatment, but the correct selection and combination of available methods may be challenging in times. Hence, the purpose of this case report is to present a combination of several computer-aided tools as approaches to manage complicated implant case. MATERIAL AND METHODS: A 47 year-old female patient with severe dental anxiety, high expectations, financial restrictions and poor compliance presented for a fixed rehabilitation. A CT scan with a radiographic template obtained with software (SimPlant, Materialize, Leuven, Belgium) was used for treatment planning. The surgical plan was created and converted into a stereolithographic model of the maxilla with bone-supported surgical templates (SurgiGuide, Materialise, Leuven, Belgium), that allowed for the precise placement of 7 implants in a severely resorbed edentulous maxilla. After successful osseointegration, an accurate scan model served as the basis for the fabrication of a one-piece milled titanium framework using the Procera (Nobel Biocare, Gothenburg, Sweden) technology. The final rehabilitation of the edentulous maxilla was rendered in the form of a screw-retained maxillary metal-reinforced resin-based complete prosthesis. RESULTS: Despite challenging circumstances, 7 implants could be placed without bone augmentation in a severely resorbed maxilla using the SimPlant software for pre-implant analysis and the SurgiGuide-system as the surgical template. The patient was successfully restored with a fixed full arch restoration, utilizing the Procera system for the fabrication of a milled titanium framework.

임상가를 위한 특집 2 - CAD/CAM 시스템을 이용한 Custom abutment의 제작 (Fabrication of custom abutment using dental CAD/CAM system)

  • 김형섭
    • 대한치과의사협회지
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    • 제50권3호
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    • pp.118-125
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    • 2012
  • CAD/CAM systems (computer-aided design / computer-aided manufacturing) used for decades in restorative dentistry have its application to implant dentistry. This study aimed to overview CAD/CAM systems used implant dentistry, especially emphasizing custom implant abutments manufacturing. CAD/CAM custom abutments present the advantages of being specific to each patient and providing a better fit than the stock and cast custom abutments. This cutting edge technology of virtual-designed and computer-milled implant abutments will likely replace traditional implant restorative protocols and become the standard for implant dentistry in the foreseeable future.

표면조도가 윤활효과에 미치는 영향에 관한 연구 (A Study on the Lubrication effects of surface roughness)

  • 윤재복;윤문철
    • Tribology and Lubricants
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    • 제3권1호
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    • pp.18-25
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    • 1987
  • The influence of one sided striated surface roughness on load carrying capacity of a slider bearing is analyzed for very low clearance films. A Reynolds equation appropriate for slider bearing is derived and analyzed by the method of finite difference method. For a slider bearing with several simple roughness form, the pressure, load capacity and other parameters can be revealed and also this results can be stored in sequential data file. After all, their distribution can be displayed easily by using the CADG(Computer Aided Design and Graphics) program. Also exact solutions with this nemerical method are compared with those of the theory attributed to Tonder and White. The results reported here should find application in the computer peripherals where computer aided design and graphic package is needed.

Limit state assessment of nodal zone capacity in strut-and-tie models

  • Tjhin, Tjen N.;Kuchma, Daniel A.
    • Computers and Concrete
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    • 제4권4호
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    • pp.259-272
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    • 2007
  • A method based on the lower-bound theorem of limit analysis is presented for the capacity assessment of nodal zones in strut-and-tie models. The idealized geometry of the nodal zones is formed by the intersection of effective widths of the framing struts and ties. The stress distribution is estimated by dividing the nodal zones into constant stress triangles separated by lines of stress discontinuity. The strength adequacy is verified by comparing the biaxial stress field in each triangle with the corresponding failure criteria. The approach has been implemented in a computer-based strut-and-tie tool called CAST (Computer-Aided Strut-and-Tie). An application example is also presented to illustrate the approach.

A study on the computer aided testing and adjustment system utilizing artificial neural network

  • Koo, Young-Mo;Woo, Kwang-Bang
    • 제어로봇시스템학회:학술대회논문집
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    • 제어로봇시스템학회 1992년도 한국자동제어학술회의논문집(국제학술편); KOEX, Seoul; 19-21 Oct. 1992
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    • pp.65-69
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    • 1992
  • In this paper, an implementation of neuro-controller with an application of artificial neural network for an adjustment and tuning process for the completed electronics devices is presented. Multi-layer neural network model is employed with the learning method of error back-propagation. For the intelligent control of adjustment and tuning process, the neural network emulator (NNE) and the neural network controller(NNC) are developed. Computer simulation reveals that the intelligent controllers designed can function very effectively as tools for computer aided adjustment system. The applications of the controllers to the real systems are also demonstrated.

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하이브리드 무선 네트워크에서 위치 정보를 사용한 효율적인 라우팅 프로토콜 (An Efficient Location Aided Routing Protocol for Hybrid Wireless Networks)

  • 김선일;이준용
    • 한국컴퓨터정보학회논문지
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    • 제14권1호
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    • pp.117-125
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    • 2009
  • 하이브리드 무선 네트워크에서는 MANET의 모바일 노드가 다른 모바일 노드와의 통신 및 인터넷에 있는 노드와 연결되어 통신을 한다. 이런 네트워크는 기존의 한정된 응용 영역을 가지고 있던 MANET을 다양하고 일반적인 응용 영역으로 확장시켜 줄 수 있다. 이전의 하이브리드 무선 네트워크에서의 라우팅 프로토콜들은 노드의 위치 정보사용을 고려하지 않았다. 위치 정보를 이용하는 라우팅 프로토콜은 기본적으로 제어 메시지에 의한 오버헤드를 줄여 줄 수 있고 하이브리드 무선 환경에서 네트워크가 효율적으로 동작 할 수 있게 도와 줄 수 있다. 본 논문에서는 하이브리드 무선 네트워크에서 위치 정보를 이용하여 제어 메시지의 오버 헤드를 줄여주기 위한 방법으로 Location-aided AODV+ (LAp) 프로토콜을 제시하고 성능을 AODV+ 프로토콜과 비교 평가하였다. LAp 프로토콜은 AODV+ 프로토콜을 효율적으로 노드의 위치 정보를 사용할 수 있도록 확장한 방법으로 경로 설정을 위한 충분한 수의 노드가 보장 될 때 AODV+ 더 좋은 성능을 보여준다.

선행재하 공법 설계를 위한 전문가 시스템 (Expert System for the Design of the Preloading Method)

  • 김병일;김명모
    • 한국지반공학회지:지반
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    • 제10권1호
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    • pp.83-102
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    • 1994
  • 주로 매립 지역에 적용되는 선행재하 공법은 가장 널리 사용되고 있는 지반개량 공법 중의 하나로서, 복잡다단한 설계과정을 포함하고 있는데, 특히 모래말뚝 공법파 같은 배수 공법이 병용될 때는 더욱 더 복잡해진다. 그러나 이와같이 복잡한 설계 과정도 일단 전문가 시스템화해 놓으면 사용자가 쉽게 설계할 수 있다. 전문가 시스템은 상업적 실용화에 성공한 대화식 컴퓨터 프로그램으로 최근 몇년사이에 지반 공학적 문제들에도 응용되기 시작한 새로운 CAE(computer aided engineering)분야 중의 하나이다. 이 논문에서는 배수 공법을 포함하는 선행재하 공법에 관한 지식베이스를 구축하여 공학자와 관련 기술자들에게 실질적인 도움을 주는 시스템을 개발하였다. 이 연구에서 전문가 시스템은 ClIPS를 사용하여 구축하였으며, Workstation환경에서 개발되었다.

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CAD-CAM Konus type 부착장치를 이용한 하악 임플란트 피개의치 보철수복 증례 (Mandibular implant-supported overdenture using CAD-CAM Konus type attachment: A case report)

  • 박종희;김인주;김경아;송광엽;서재민
    • 대한치과보철학회지
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    • 제54권3호
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    • pp.259-266
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    • 2016
  • 하악 완전 무치악 환자의 보철수복에 있어 임플란트 식립 후 피개의치 제작은 첫 번째 치료 옵션으로 고려된다. 코너스 타입 부착장치를 이용한 피개의치는 견고한 지지를 제공하고 cross arch stabilization을 이루도록 하여 교합압을 균일하게 분산시키며, 의치에 의한 이차 고정으로 장기간의 안정성을 제공한다. 최근 소개된 팔라듐-은(Pd-Ag) 합금(Innovium)은 팔라듐, 은, 금 등의 귀금속 함량이 72% 이상인 CAD-CAM 시스템 전용 귀금속 합금으로 코너스 타입 부착장치를 제작하는데 적합한 물성을 가지고 있다. 본 증례에서는 완전 무치악 환자에서 상악에는 통상적인 총의치, 하악에는 임플란트를 4개 식립한 후에 코너스 타입 부착장치 피개의치 수복을 하였다. CAD-CAM 시스템을 이용하여 팔라듐-은 합금(Innovium)으로 제작된 코너스 타입 부착장치를 장착하였으며 이를 통해 의치의 유지와 안정을 향상시켰으며 만족할 만한 결과를 얻었기에 보고하고자 한다.