• 한국환경보건학회지
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• 제49권2호
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• pp.78-88
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• 2023

Background: Exposure to volatile organic compounds (VOCs) can have acute and chronic health effects on human beings in general and in working environments. In particular, VOCs are often emitted in large quantities in industrial settings. In such circumstances, there is a need to improve the indoor air quality at workplaces. Objectives: The purposes of this study were to verify the effectiveness of air cleaning devices in workplaces and provide alternative solutions for improving working environments. Methods: Personal exposure and area level of VOCs for workers were evaluated in a car-part adhesive process before and after installing an air cleaning device with a TiO₂-coated filter. Passive samplers and direct reading instruments were used to collect and analyze the VOCs, and the removal efficiency and improvement of air quality were evaluated. We also calculated the exposure index (EI) to assess the risk level in the workplace. Results: The removal efficiency for VOCs through the installation of the air cleaning device was approximately 26.9~69.0% as determined by the concentration levels before and after installation. The measured substances did not exceed the exposure limits for the work environment and the EI was less than 1. However, carcinogenic substances such as benzene, formaldehyde, carbon tetrachloride, and trichloroethylene were detected. Conclusions: The application of an air cleaning device can be a solution for controlling the indoor air quality in a workplace, particularly in cases where ventilation systems cannot be installed due to process limitations.

• 대한치과의사협회지
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• 제55권2호
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• pp.180-188
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• 2017

Introduction : Inadequate oral health control is a major risk of oral diseases. Regular home-based care is essential to maintain good oral hygiene. In particular, mouthrinses can support conventional tooth brushing in reducing accumulation of oral plaque. Effect : Antimicrobial mouthrinses are used as part of daily oral care to reduce plaque and gingivitis. Mouthrinses contains fluoride could help remineralization of enamel and dentin. The most common molecules contained in mouthrinses are chlorhexidine, essential oils, cetyl pyridinium chloride, triclosan, hyaluronic acid. Currently, chlorhexidine is the most efficacious compound, with both antiplaque and antibacterial activities. Similar results are reported for essential oils and cetyl pyridinium chloride, although with a somewhat reduced efficacy. Considering the adverse effects of chlorhexidine and its time-related characteristics, this molecule may best be indicated for acute/short term use, while essential oils and cetyl pyridinium chloride may be appropriate for long-term, maintenance treatment. Conclusion and suggestion : Antimicrobial mouthrinses are safe and effective, and when used in conjunction with brushing and flossing, they are an important method of reducing plaque and gingivitis. To improve compliance, dental health care professionals should adapt oral health care recommendations to fit patients' specific needs.

• Advances in environmental research
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• 제3권1호
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• pp.29-43
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• 2014

Pharmaceutical wastewater effluents are well known for their difficult elimination by traditional biotreatment methods and their important contribution to environmental pollution due to its fluctuating and recalcitrant nature. OTC is one of the nonbiodegradable antibiotics that makes antibiotic-resistant, so it can make be high risk for environment. NZVI can be a good choice for removal of OTC in aqueous solution. Response surface methodology (RSM) was used to optimize the amounts of NZVI and OTC to be used at pH 3 and under 200 W, UV-A irradiation. The responses were removal percent of absorption at 290 and 348 nm, TOC and COD of OTC. In the optimum condition, Linear model was performed 155 ppm of OTC were removed by 1000 ppm NZVI after 6.5 hours and the removal efficiency of absorption at 290 and 348 nm, TOC and COD were 87, 95, 85 and 89 percent, respectively. In the similar process, there is no organic compound after 14 hours. The parameters ORP, DO and pH were investigated for 6:30 hours to study the type of NZVI reaction in process. In the beginning of reaction, oxidation was the dominant reaction after 3 hours, photocatalytic reaction was remarkable. The mechanism of OTC degradation is proposed by HPLC/ESI-MS and four by products were found. Also the rate constants (first order kinetic chain reaction model) were 0.0099, 0.0021, 0.0010, 0.0049 and $0.0074min^{-1}$, respectively.

• Journal of Microbiology and Biotechnology
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• 제13권1호
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• pp.43-49
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• 2003

Metabolism of a new fungicide ethaboxam by soil fungi was studied. Among the fungi tested, Cunninghamelia elegans produced metabolites from ethaboxam, which were not found in the control experiments. M5, a major metabolite from ethaboxam was firmly identified as N-deethylated ethaboxam by LC/MS/MS and NMR. N-Deethylated ethaboxam has been found as a single metabolite in in vitro metabolism with rat liver microsomes. Ml was proved to be 4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide (ETC) by comparing with the authentic compound. In addition, M2, M3, and M4, and M6 were tentatively Identified by LC/MS/MS as hydroxylated and methoxylated ethaboxams, respectively. Production of the major metabolite, N-deethylated ethaboxam, by the fungus suggested that C. elegans would be an efficient eukaryotic microbial candidate for evaluating xenobiotic-driven mammalian risk assessment.

• 한국수산과학회지
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• 제40권1호
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• pp.16-23
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• 2007

Nonylphenol (NP) is an estrogen-mimicking compound or xenoestrogen. This study investigated the effects of nonylphenol on the reproductive status of the equilateral venus Gomphina veneriformis. The experiment lasted 24 weeks, Experimental groups consisted of a control and three nonylphenol exposures ($1.0,\;2.5,\;and\;5.0\;{\mu}g\;NP/L$). Mortality did not differ significantly between the control and the exposure groups. The sex ratio (F:M) was 1:1 in nature and 1:1.03 in the control group. However, it changed to 1:3.5 with $5.0\;{\mu}g\;NP/L$ exposure. Gonad maturity in females was higher in the nonylphenol exposure groups than in the control group. By contrast, in males, it was lower in the nonylphenol exposure groups. Intersex individuals constituted 0% in nature, 3.08% in the control group, and 23.6% in the group exposed to nonylphenol, with female characteristics more prevalent than male. As the concentration of nonylphenol increased, the accumulation of lipofuscin increased in the mid-gut gland.

• 한국안전학회지
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• 제25권1호
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• pp.32-37
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• 2010

When back-out & firing Process applies heat, hume is piled up in exhaust duct by organic compound and it have high dangerousness. There by, the process is happening a lot of damage that is exhaust duct fire. However we do not have certain fire dangerousness estimation and digestion countermeasure. So we need preventive measure. Back-out & firing is a process which has fine structure, electrical and mechanical characteristics, such as firing kiln and back-out kiln which has pipe line and box type. The box oven is made of heating coil, fan motor and control panel. Back-out & firing process has air circulation institution of quick ventilation type. When we operate this process for long time, fire can break out easily. Duct is made by zinc shredder. If fire breaks out in duct inside, fire by deposit fume can be dispersed easily. Accordinglym, This project estimate danger for back-out & firing process exhaust duct through real fire test. And there is purpose of study to establish preventive measure.

• 디지털콘텐츠학회 논문지
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• 제18권1호
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• pp.225-229
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• 2017

본 논문에서는 다양한 재난안전 위협요소를 단위 산업체 시설물뿐만 아니라 지역 및 국가 단위에서 실시간으로 감지 예측하고 예방 대응하는 시스템에 대하여 알아본다. 예방 대비 대응 복구로 이뤄지는 재난관리의 전 단계를 체계적 효율적으로 관리할 수 있는 정보통신기술을 기반으로한 융복합 구현에 대하여 분석하였다. 또한 조기예측을 통한 선제적 예방과 대비 즉각적인 재난 정보 전달로 피해규모의 축소와 첨단 기술을 통해 재난현장에서의 인간한계 극복에 대하여 분석하였으며 스마트 재난안전관리의 전략으로 선제적 위험관리 및 예방 신속하고 효율적 현장 대응 및 복구와 민관 상호협력 및 효율적 연계협력의 사회안전 스마트 재난안전관리 시스템을 제시하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1637-1641
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• 2016

Oxaliplatin, a third generation novel platinum compound is the most effective first line chemotherapeutic agent for colorectal cancer (CRC) in combination with 5FU and leucovorin. It is indicated for pancreatic, gastric and testicular cancers combined with bevacuzimab, capecitabine, irinotecan and other cytotoxic agents. However, moderate to severe hypersensitivity reactions (HSR) during or after oxaliplatin infusion usually require cessation of chemotherapy or substitution of the key therapeutic drug which largely interferes with improved patient prognosis. This mini- review showcases recent and accepted opinions/approaches in oxaliplatin induced HSR management. Physicians and oncologists have varying attitudes regarding the decision to rechallenge the patient after an HSR experience, efficacy of desensitization protocols, effectiveness and selection of drugs for premedication and possibilities of cross sensitivity to other platinum agents (e.g. carboplatin). A brief insight into underlying molecular mechanisms and clinical manifestations of oxaliplatin induced HSR is offered. We have also discussed the management of oxaliplatin induced HSR and risk stratification for a successful and complete chemotherapeutic plan.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.37-40
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• 2016

Mucopolysaccharidosis type III (MPS III) is a rare genetic disorder caused by lysosomal storage of heparan sulfate. MPS IIIB results from a deficiency in the enzyme alpha-N-acetyl-D-glucosaminidase (NAGLU). Affected patients begin showing behavioral changes, progressive profound mental retardation, and severe disability from the age of 2 to 6 years. We report a patient with MPS IIIB with a long-term follow-up duration. He showed normal development until 3 years. Subsequently, he presented behavioral changes, sleep disturbance, and progressive motor dysfunction. He had been hospitalized owing to recurrent pneumonia and epilepsy with severe cognitive dysfunction. The patient had compound heterozygous c.1444C>T (p.R482W) and c.1675G>T (p.D559Y) variants of NAGLU. Considering that individuals with MPS IIIB have less prominent facial features and skeletal changes, evaluation of long-term clinical course is important for diagnosis. Although no effective therapies for MPS IIIB have been developed yet, early and accurate diagnosis can provide important information for family planning in families at risk of the disorder.

• 한국산림과학회지
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• 제10권1호
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• pp.1-3
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• 1970

조림지(造林地)의 수익성분석(收益性分析)은 여러 가지 복잡한 요인(要因)이 개재(介在)하므로 믿을만한 것을 얻기는 대단히 어려운 일이나 기업경영(企業經營)의 건전성(健全性)을 타진해 보기 위해서는 일단 수익성(收益性)을 계산(計算)해 보는 것도 좋은 일이다. 이곳 낙엽송조림지(落葉松造林地)의 조림(造林)에 몇가지 전제조건(前提條件)을 네세우고 그 수익율(收益率)을 계산(計算)하여 본 바 이율(利率)이 8%이하(以下)로 되어야만 실패율(失敗率)이 감소된다. 6% 정도이면 대단히 유리(有利)하게 조림성과(造林成果)가 전개(展開)된다. 그러나 이곳 수익성(收益性)에만 꼭 매달릴 수 없는 임업경영(林業經營)의 사정(事情)이 있음을 우리는 알고 있어야 한다.