• Title/Summary/Keyword: Compound Ⅲ

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Studies on the Pharmacological Actions and Biological Active Components of Korean Traditional Medicine (V) -Isolation of an Antimicrobial Phenolic Compound from Duchesnea indica- (한국전통생약의 약리작용과 활성물질에 관한 연구(V) -사매(蛇?)의 항균성분획의 페놀성물질-)

  • Lee, Ihn-Rhan;Lee, Yun-Sil;Han, Yong-Nam
    • YAKHAK HOEJI
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    • v.32 no.5
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    • pp.308-312
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    • 1988
  • A phenolic compound isolated from the ethylacetate extract of Duchesnea indica (Andr.) Focke (Rosaceae) showed antimicrobial activities against Staphylococcus aureus, Shigella dysentriae and Pseudomonas aeruginosa. This compound was identified as ellagic acid by spectral analysis.

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Isolation of a Cytotoxic Agent from Asiasari Radix

  • Park, Jong-Dae;Baek, Nam-In;Lee, You-Hui;Kim, Shin-Il
    • Archives of Pharmacal Research
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    • v.19 no.6
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    • pp.559-561
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    • 1996
  • A minor cytotoxic compound was isolated by bioassay-guided fractionation from Asiasari Radix and identified as aristolactam III(1) on the basis of spectral data and chemical evidence. This is the first report on the isolation of compound 1 from Asiasarum genus. Compound 1 exhibited a significant cytotoxic activity against the three kinds of human cancer cell lines (A 549, SK-MEL-2 and SK-OV-3).

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The Program of progress control and quality control for the high-rise compound building (초고층 주상복합건물의 수장공사 공정관리 및 품질관리 방안)

  • Jung, Eul-Kyu;Lim, Chil-Soon
    • Journal of the Korea Institute of Building Construction
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    • v.3 no.4
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    • pp.111-117
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    • 2003
  • Recently SAMWOO EMC received order and built interior walls which was used the day process in several high-rise compound buildings. On the way to build, this process was brought about several matter according to the progress and qualify control. So, this study is the improving way of the dry process from experiences on those constructions

Aqeous Neutralizer as Reactive Solvents for Odorous Ammonia Removal

  • Park, Young-G.
    • Environmental Engineering Research
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    • v.13 no.3
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    • pp.119-124
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    • 2008
  • Ammonia is an inorganic compound that may cause severe odor problem. In this study the effectiveness of applying natural neutralizer to destroy and remove the odor-causing compound from gas streams was studied. Experimental result evaluated with a bench-scale apparatus via the neutralization of gas phase. This indicates that the natural neutralization depends on the gas concentration, gas residence time, temperature and pH. Removal efficiency of ammonia from gas stream was achieved by 95% using theconvection in the packed bed. This study proved the chemical neutralization technology was effective for controlling inorganic odor-causing compound.

Selective Esterification of N-Benzyl-L-aspartic Acid. (I). Some Modified Methods for the Preparation of N-Benzylaspartic Anhydride Hydrobromide

  • Lee Chal-Ho;Chai, Kyu-Yun;Lee, Man-Koo;Chung, Bong-Young
    • Bulletin of the Korean Chemical Society
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    • v.8 no.6
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    • pp.457-459
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    • 1987
  • Racemic N-benzylaspartic acid (4) was prepared from maleic anhydride and used to modify and develop some efficient methods for the preparation of N-benzylaspartic anhydride hydrobromide (5). Thus, successive treatment of the compound 4 with 30% HBr in acetic acid and acetic anhydride afforded the title compound 5 in 75% yield. From this compound 5, ${\alpha}$-benzyl and ${\alpha}$-methyl N-benzylaspartates were also prepared.

Photooxidation of a Polyacetylene Compound from Panax Ginseng C.A. Meyer

  • Koh, Hun-Yeong;Chang, Suk-Ku;Shim, Sang-Chul;Moon, Soon-Ku;Min, Tae-Jin
    • Bulletin of the Korean Chemical Society
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    • v.7 no.3
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    • pp.179-182
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    • 1986
  • A major polyacetylene compound from Panax ginseng roots, heptadeca-1-en-4,6-diyn-3,9,10-triol, was irradiated with 300 nm UV light to obtain a photooxidized acetylenic compound having the conjugated en-on-diyne chromophore, heptadeca-1-en-4,6-diyn-9,10-diol-3-one. The same oxidation product was obtained exclusively by 4-(dimethylamino) pyridinium chlorochromate at room temperature.

Synthesis, crystal structure, and analytical characterizations of amphiphilic palladium(II) compound containing bis(benzylthio)methylenepropanedioate

  • Tae Hwan Noh
    • Analytical Science and Technology
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    • v.36 no.4
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    • pp.198-203
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    • 2023
  • The reaction of cis-protected (Me4en)Pd(II) species with potentially multidentate bis(benzylthio)methylenepropanedioate (L) was carried out to obtain a monometallic compound, [(Me4en)Pd(L)], in O,O'-coordination mode. The bis(benzylthio)methylene group was bent strikingly from the palladium square plane at the dihedral angle of 70.40°. The physicochemical properties of the present palladium(II) compound were fully characterized by means of infrared and nuclear magnetic resonance spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction measurement.

Isolation, Physico-chemical Properties and Biological Activity of Aurodox Group Antibiotics

  • Kim, Si-Kwan;Yeo, Woon-Hyung;Kim, Sang-Seock
    • Journal of Microbiology and Biotechnology
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    • v.6 no.4
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    • pp.265-269
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    • 1996
  • An isolate of Streptomyces rochei synonym was found to produce antibiotics with narrow anti-microbial spectrum against Streptococcus and Xanthomonas sp. Among the antibiotic complex produced by the strain, the main active compound was isolated, and its physico-chemical properties and biological activities were investigated. Molecular weight of the compound was determined to be ${[M+H]}^+$ 797 (FAB-MS). UV, $^1H \;and\;^{13}C$ NMR, and IR spectra suggested that the compound is a kirromycin-like aurodox group antibiotic. However, the anti-microbial spectrum of the main compound was slightly different from that of kirromycin. In addition, it was newly found that kirromycin showed a selective anti-microbial activity against Streptococcus pyogenes and phytopathogenic Xanthomonas sp.

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Design and Synthesis of an Anticancer Diarylurea Derivative with Multiple-Kinase Inhibitory Effect

  • El-Gamal, Mohammed I.;Oh, Chang-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.33 no.5
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    • pp.1571-1576
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    • 2012
  • A diarylurea compound 1 possessing pyrrolo[3,2-$c$]pyridine nucleus was designed and synthesized with structure similarity to Sorafenib. Compound 1 was tested over 60-cancer cell line panel at a single dose concentration of 10 ${\mu}M$ and showed high activity. It was further tested in a five-dose mode to determine its $IC_{50}$, TGI, and $LC_{50}$ values over the 60 cell lines. Compound 1 showed high potency and good efficacy, and was accordingly tested at a single dose concentration of 10 ${\mu}M$ over a panel of 40 kinases. At this concentration, it completely inhibited the enzymatic activities of a number of oncogenic kinases, including ABL, ALK, c-RAF, FLT3, KDR, and TrkB. The target compound was subsequently tested over these 6 kinases in 10-dose testing mode in order to determine its $IC_{50}$ values.

Fatigue properties of nitrided titanium using fluidized bed furnace (유동상로를 이용한 질화처리티타늄의 피로강도 특성)

  • Kim, Min-Gun;Ji, Jueng-Keun
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.22 no.1
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    • pp.142-147
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    • 1998
  • Rotary bending fatigue tests were carried out on the nitrided titanium in order to investigate the effect of nitriding layer on fatigue limit. Main results obtained are as follows. (1) The fatigue limit of nitrided pure titanium is remarkably reduced because of enlargement of grain size at high heat treating temperature and high stress field created from the elastic interaction in the compound layer. (2) Further test using specimen which was removed nitrified layer gradually, were also conducted and it was found that by removing the compound layer the fatigue limit recovered as the level of basic material and rather increased by coming of a diffusion layer. Therefore it is concluded that the surface compound layer generated by nitriding treatment reduced the fatigue limit but diffusion layer increased it.