Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Selective Esterification of N-Benzyl-L-aspartic Acid. (I). Some Modified Methods for the Preparation of N-Benzylaspartic Anhydride Hydrobromide

  • Published : 1987.12.20
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Abstract

Racemic N-benzylaspartic acid (4) was prepared from maleic anhydride and used to modify and develop some efficient methods for the preparation of N-benzylaspartic anhydride hydrobromide (5). Thus, successive treatment of the compound 4 with 30% HBr in acetic acid and acetic anhydride afforded the title compound 5 in 75% yield. From this compound 5, ${\alpha}$-benzyl and ${\alpha}$-methyl N-benzylaspartates were also prepared.

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