• 제목/요약/키워드: Component Joint

검색결과 362건 처리시간 0.022초

Can herbal drug(s) meet the challenges of genomewide screen results on rheumatoid arthritis

  • Paul, Bholanath
    • Advances in Traditional Medicine
    • /
    • 제5권4호
    • /
    • pp.251-261
    • /
    • 2005
  • Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis $factor-{\alpha}\;TNF-{\alpha}\;and\;interleukin-1{\beta}\;(IL-1{\beta})$ and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like $TNF-{\alpha},\;IL-1{\beta}$ and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB $(NF-{\kappa}B)$ and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.

Local minimization behavior of weighted kinematically decoupled joint space decomposition for redundant manipulators

  • Park, Jonghoon;Chung, Wan-Kyun;Youm, Youngil
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 제어로봇시스템학회 1996년도 Proceedings of the Korea Automatic Control Conference, 11th (KACC); Pohang, Korea; 24-26 Oct. 1996
    • /
    • pp.123-128
    • /
    • 1996
  • Kinematically redundant manipulators have been studied because of its usefulness of kinematic redundancy. It is natural that the kinematic redundancy induces a kind of control redundancy. By using the weighted kinematically decoupled joint space decomposition, we unify the control redundancy and the kinematic redundancy parameterized by the joint space weighting matrix. Concentrating to the particular component of each decomposition, we can describe the local minimization behavior of the control weighted quadratic by each weighted decomposition. The result extends the conventional results on general setting, and should be of interest in understanding the motion behavior of kinematically redundant manipulators.

  • PDF

최소 공정온도하에서 Mg-Ni의 열확산 접합에 관한 연구 (A Study on the Diffusion Bonding of Mg-Ni under Low Eutectic Temperature)

  • 진영준
    • 한국안전학회지
    • /
    • 제32권1호
    • /
    • pp.9-14
    • /
    • 2017
  • Diffusion bonding is a technique that has the ability to join materials with minimum change in joint micro-structure and deformation of the component. The quality of the joints produced was examined by metallurgical characterization and the joint micro-structure developed across the diffusion bonding was related to changes in mechanical properties as a function of the bonding time. An increase in bonding time also resulted in an increase in the micro-hardness of the joint interface from 55 VHN to 180 VHN, The increase in hardness was attributed to the formation of intermetallic compounds which increased in concentration as bonding time increased.

구호로봇용 연성 매니퓰레이터를 위한 조인트 제어 및 충돌감지 알고리즘 (Development of Joint Controller and Collision Detection Methods for Series Elastic Manipulator of Relief Robot)

  • 정병진;김태근;원건;김동섭;황정훈
    • 로봇학회논문지
    • /
    • 제13권3호
    • /
    • pp.157-163
    • /
    • 2018
  • This paper deals with the development and application of control algorithms for series elastic relief robots for rescue operations in harsh environment like disasters or battlefield. The joint controller applied in this paper has a cascade structure combining inner loop for torque control and outer loop for position control. The torque loop contains feedforward and feedback controller and disturbance observer for independent, decentralized joint control. The effect of the elastic component and motor dynamics are treated as the nonlinear disturbance and compensated with the disturbance observer of torque controller. For the collision detection, Band Designed Disturbance Observer is configured to recognize/respond to external disturbance robustly in the continuously changing environment. The controller is applied to a 7-dof series elastic manipulator to evaluate the torque tracking and collision detection/response performance.

Calibration of model parameters for the cyclic response of end-plate beam-to-column steel-concrete composite joints

  • Nogueiro, Pedro;da Silva, Luis Simoes;Bento, Rita;Simoes, Rui
    • Steel and Composite Structures
    • /
    • 제9권1호
    • /
    • pp.39-58
    • /
    • 2009
  • Composite joints, considering the composite action of steel and concrete, exhibit, in general, high strength and high ductility. As a consequence, the use of this type of joint has been increasing in many countries, especially in those that are located in earthquake-prone regions. In this paper, a hysteretic model with pinching is presented that is able to reproduce the cyclic response of steel and composite joints. Secondly, the computer implementation and adaptation of the model in a spring element within the computer code Seismosoft is described. The model is subsequently calibrated using a series of experimental test results for composite joints subjected to cyclic loading. Finally, typical parameters for the various joint configurations are proposed.

유니버설 조인트 베어링용 Seal의 성능평가를 위한 유한요소해석 (FEM Analysis for Performance Evaluation of Seal in Universal Joint Bearing)

  • 김태완;문석만;구영필;조용주
    • 한국정밀공학회:학술대회논문집
    • /
    • 한국정밀공학회 2000년도 추계학술대회 논문집
    • /
    • pp.571-574
    • /
    • 2000
  • Seals in universal joint bearing are a important component reinforcing lubrication performance by holding a lubricant and preventing infiltration of dust, moisture, etc. There is a great difference in seal performance according to seal shape and bonding position. Therefore, in this study, as for the lib type seal and O-ring type seal, FEM analysis are conducted using Mooney-Rivlin Model. The results are indicate that O-ring having higher contact stress and larger contact area than lib type is more profitable.

  • PDF

Overlapped Subband-Based Independent Vector Analysis

  • Jang, Gil-Jin;Lee, Te-Won
    • The Journal of the Acoustical Society of Korea
    • /
    • 제27권1E호
    • /
    • pp.30-34
    • /
    • 2008
  • An improvement to the existing blind signal separation (BSS) method has been made in this paper. The proposed method models the inherent signal dependency observed in acoustic object to separate the real-world convolutive sound mixtures. The frequency domain approach requires solving the well known permutation problem, and the problem had been successfully solved by a vector representation of the sources whose multidimensional joint densities have a certain amount of dependency expressed by non-spherical distributions. Especially for speech signals, we observe strong dependencies across neighboring frequency bins and the decrease of those dependencies as the bins become far apart. The non-spherical joint density model proposed in this paper reflects this property of real-world speech signals. Experimental results show the improved performances over the spherical joint density representations.

주관절 운동의 상완·전완좌표계 타당도 및 굴곡/신전과 회내/회외의 상호작용 (The Validity Test of Upper·Forearm Coordinate System and the Exploratory Analysis of the Interactive Effect between Flexion/Extension and Pronation/Supination during Elbow Joint Motion)

  • 김진욱
    • 한국운동역학회지
    • /
    • 제20권2호
    • /
    • pp.117-127
    • /
    • 2010
  • The axes of upper forearm coordinate system have been considered as principal axis of each segment which was component of elbow joint. The purpose of this study was to verify whether the mean direction(principal axis) of instantaneous axes of rotation for pure flexion/extension motion coincided with the flexion/extension axis of upper forearm coordinate system. The same procedure was done for pronation/supination motion. Furthermore, it was tested indirectly that there was an interaction effect between the two rotational motions. The results showed that most segment coordinate axes statistically were not consistent with the mean directions of flexion/extension and pronation/supination axes of rotation. From the results, it would be concluded that the ISB coordinate systems was proved to be a little valid for human movement analysis. There also was an effect of pronation/supination angles on flexion/extension motion.

상관신호의 판별력 개선을 위한 광 BPEFTC 시스템 (Optical Binary Phase Extraction Joint Transform Correlator System for Improving the Correlation Discrimination)

  • 이상이;김은수
    • 전자공학회논문지A
    • /
    • 제31A권6호
    • /
    • pp.78-87
    • /
    • 1994
  • In this paper, a binary phase extraction joiont transform correlator (BPEJTC)system is proposed as a new phase-type optical correlator in which the correlation errors and DC component are dramtically reduced and optical efficiency and correlation performance are also improved by reconstructing the joint transform power spectrum (JTPS) of the conventional joint transform correlator (JTC)system form which the autocorrelation and crosscorrelation siganls generated in each self-plane are removed, and the binary phase function is extracted from the phase value of the reconstructed JTPS. Through some computer simulation and optical experimental results, the possibility of the implementation of the real-time multi-target tracking and recognition system is also suggested.

  • PDF

Structural Design on Joint Component of Composite Wing of WIG Craft

  • Lee, Younggyu;Park, Hyunbum
    • International Journal of Aerospace System Engineering
    • /
    • 제8권2호
    • /
    • pp.1-3
    • /
    • 2021
  • This study proposed a specific preliminary structural design procedure of the main wing for a small scale WIG vehicle to meet the target weight of the system requirement. The high stiffness and strength Carbon-Epoxy material was used for lightness, and the foam sandwich type structure at the upper skin and the spar webs was adopted for improvement of structural stability. After structural design, wing joint part was designed. Through investigation on structural design result, design modification was performed. After design modification, even thought the designed wing weight was a little bit heavier than the target wing weight, the structural safety and stability of the final design feature was confirmed.