• 약학회지
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• 제27권1호
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• pp.11-19
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• 1983

Rifampicin-arginine complex was prepared to increase the solubility and dissolution rate of rifampicin. Solvation method was applied to make the complex and its formation was identified by the solubility method, powder x-ray diffractometry, differential thermal analysis and spectroscopic determination. The complex was formed in the molar ratio of 1 : 1 which was proved by the slope ratio method and continuous variation method. The complex was a non-crystalline form determined by the x-ray powder diffractometric analysis. The solubility of complex in water was significantly higher than that of rifampicin itself. The stability constant and thermodynamical properties of the complex were determined to investigate the solubilization phenomena. The thermodynamic data showed that the complexation between rifampicin and arginine was an exothermic and spontaneous reaction. Simulated absorption studies carried out through the artificial lipid barrier in artificial gastric and intestinal juices. The results showed that the complex had an enhanced absorption rate of rifampicin nearly twice compared with that of rifampicin itself.

• Journal of Pharmaceutical Investigation
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• 제20권3호
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• pp.153-159
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• 1990

To increase the solubility of fentiazac which is used widely as a non-steroidal antiinflammatory drug, its inclusion complex and suppositories were prepared and studied. Inclusion complexes of fentiazac with ${\beta}-cyclodertin$ $({\beta}-CyD)$ were prepared by four diffrent methods; coprecipitation method, kneading method, solvent evaporation method, freeze drying method. Suppositories of $fentiazac/{\beta}-CyD$ with PEG 1500 and Witepsol H-15 were prepared by solvent evaporation method and freeze drying method. Inclusion complex formation of fentiazac with ${\beta}-CyD$ was ascertained by powder X-ray diffractometry, differential scanning calorimetry and IR spectroscopy. The dissolution rate of fentiazac from the inclusion complex increased in distilled water and KP 2nd disintegration test fluids (pH 6.8) but extemly decreased in KP 1st disintegration test fluid (pH 1.2). Inclusion complexes prepared by freeze drying method and solvent evaporation method were similar. Freeze drying method seemed to be suitable for preparation of complex with most higher dissolution rate but coprecipitation method seemed not to be suitable. The dissolution rate of fentiazac increased markedly by ${\beta}-CyD$ complexation. The release rates of suppositories increased in the following order. Complex prepared by freeze dying method in PEG 1500 > complex prepared by solvent evaporation method in PEG 1500 > fentiazac in PEG 1500 > complex prepared by freeze dying method in Witepsol H-15 > complex prepared by solvent evaporation method in Witepsol H-15 > fentiazac in Witepsol H-15.

• Smart Structures and Systems
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• 제15권1호
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• pp.81-97
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• 2015

Recently, a new output-only modal identification method based on time-frequency independent component analysis (ICA) has been developed by the authors and shown to be useful for even highly-damped structures. In many cases, it is of interest to identify the complex modes of structures with non-proportional damping. This study extends the time-frequency ICA based method to a complex ICA formulation for output-only modal identification of non-proportionally-damped structures. The connection is established between complex ICA model and the complex-valued modal expansion with sparse time-frequency representation, thereby blindly separating the measured structural responses into the complex mode matrix and complex-valued modal responses. Numerical simulation on a non-proportionally-damped system, laboratory experiment on a highly-damped three-story frame, and a real-world highly-damped base-isolated structure identification example demonstrate the capability of the time-frequency complex ICA method for identification of structures with complex modes in a straightforward and efficient manner.

• Educational Technology International
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• 제6권2호
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• pp.69-85
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• 2005

The purpose of the article is to address a new instructional approach to a complex engineering course. We design a novel instructional method that combines mobile technology, simulation program, collaborative teamwork, problem-solving process, and a variety of evaluation techniques. We suggested five instructional principles that might be required to change the fundamental educational process by which learning is done. The proposed instructional method is expected to aspire for new perspectives on complex learning environment. Nevertheless we solely began by the research on the development of students' complex problem-solving performance in a complex engineering course, the new instructional method in the article can promote the adoption of new instructional methods and strategies across different knowledge domains. In addition, the instructional method can provide a valuable bridge to acquisition and transfer of problem solving, motivation, and meaning learning.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.418-423
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• 2008

Among various sensitivity evaluation techniques, semi-analytical method is quite popular since this method is more advantageous than analytical method and global finite difference method. However, SAM reveals severe inaccuracy problem when relatively large rigid body motions are identified for individual elements. Such errors result from the numerical differentiation of the pseudo load vector calculated by the finite difference scheme. In the present study, the adjoint variable method combined with complex variable is proposed to obtain the shape and size sensitivity for structural optimization. The complex variable can present accurate results regardless of the perturbation size as well as easy to be implemented. Through a few numerical examples of the static problem for the structural sensitivity, the efficiency and reliability of the adjoint variable method combined with complex variable is demonstrated.

• 대한인간공학회:학술대회논문집
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• 대한인간공학회 1996년도 춘계학술대회논문집
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• pp.313-319
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• 1996

Human posture prediction and motion simulaiton methods try to solve inverse kinematic problems based on the optimization concept. It is of great concern to develop an optimization method which soloves complicated optimization models in an efficient way in order for the models to be biomechanically sound. In this study, a new optimization method for posture prediction, which is named the Complex Method, is presented. The Complex Method demonstrates more flexibility in a way that it can deal with various forms of objective functions with constraints. This is because the method is a function-value-based approach. A two-eimensional whole-body lifting task was selected as an example of posture prediction, and a comparison study with te incrementation method was conducted in order to evaluate the accuracy of the Complex Method.

• 한국소음진동공학회논문집
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• 제20권11호
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• pp.1089-1096
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• 2010

The relation between the vibration induced from machinery and the radiated sound is complicated. Acoustic intensity method is widely used to obtain the accuracy of noise measurement and noise identification. In this study, as groundwork, the complex acoustic intensity method is performed to identify noise source and transmission path on different free space point source fields. As an industrial application, the complex acoustic intensity method is applied to HVAC to identify sound radiation characteristics in the near field. Experimental complex acoustic intensity method was applied to HVAC, it is possible to identify noise sources in complicated sound field characteristics which noise sources are related with each other, and certificate the validity of complex acoustic intensity. Especially, it can be seen that complex acoustic intensity method using both of active and reactive intensity is vital in devising a strategy for identification of noise. Also, the vector flow of acoustic intensity was investigated to identify sound intensity distributions and energy flow in the near field of HVAC.

• 한국자동차공학회논문집
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• 제5권3호
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• pp.171-171
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• 1997

Sound intensity distributions and energy flow in the near field of dipole source system and flat plate were investigated. First, the effectiveness of complex acoustic intensity was proved by using mathmatical and experimental methods in order to indentify noise sources and transmission paths of dipole field which is effected by the presence of neighbouring coherent sources. Next, analytical complex acoustic intensity method was discussed and the characteristics and energy flow of sound induced from the plate are clarified. The velocity of plate obtained from Finite Element Method was used for calculation of complex acoustic intensity in the near field. Finally experimental complex acoustic intensity method was applied to a passenger car. It can be seen that complex acoustic intensity method using both of active and reactive intensity is vital in devising a strategy for the identification and the reduction of vibration and noise.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 1993년도 봄 학술발표회논문집
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• pp.37-44
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• 1993

There are a lot of linear dynamic analysis methods for complex structures. Each method has advantages and shortcomings. Method of dynamic analysis for complex structure is selected considering characteristics of dynamic loading, computer facility available number of degree of freedem and accuracy of results. It is a main point of view to get economical results rather then accurate ones for analysis of general complex structures, Mode superposition method and direct integration method are generally used. However, the characteristics of load is not considered in mode superpositon method, the personal computer cannot be used in direct integration methods. To over-come these shortcomings, the component mode method incorporating Ritz algorithm updated is proposed to solve economically dynamic behavior of the structures. The purpose of study is a formulation of algorithm, and computer programing suitable for dynamic analysis of the complex structure in personal computer environment.

• 한국세라믹학회지
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• 제35권8호
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• pp.801-806
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• 1998

$Eu^{3+}$ -doped $Y_2$$O_3$ phosphors has been prepared by a polymerized complex method and investigated their powder and luminescence properties. They were compared with phosphors prepared by a solid state reac-thion method. The phosphors synthesized have been characterized by X-ray diffraction low-voltage lu-minescent emission spectroscopy etc. Under low-voltage electron excitation $Eu^{3+}$-doped $Y_2$$O_3$ exhibited a strong narrow-band red emission peaking at 612nm. On the other hand the critical value for concentration quenching of sample prepared by the polymerized complex method fired at $1400^{\circ}C$ is x=0.05 for $(Y_{1-x}Eu_x__2O_3$ The emission intensity of phosphors prepared by the polymerized complex method was higher than that of phosphors prepared by the solid state reaction method.