• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7343-7350
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• 2015

Genetic changes associated with acute lymphoblastic leukemia (ALL) provide very important diagnostic and prognostic information with a direct impact on patient management. Detection of chromosome abnormalities by conventional cytogenetics combined with fluorescence in situ hybridization (FISH) play a very significant role in assessing risk stratification. Identification of specific chromosome abnormalities has led to the recognition of genetic subgroups based on reciprocal translocations, deletions and modal number in B or T-cell ALL. In the last twelve years 102 newly diagnosed childhood/adult ALL bone marrow samples were analysed for chromosomal abnormalities with conventional G-banding, and FISH (selected cases) using specific probes in our hospital. G-banded karyotype analysis found clonal numerical and/or structural chromosomal aberrations in 74.2% of cases. Patients with pseudodiploidy represented the most frequent group (38.7%) followed by high hyperdiploidy group (12.9%), low hyperdiploidy group (9.7%), hypodiploidy (<46) group (9.7%) and high hypertriploidy group (3.2%). The highest observed numerical chromosomal alteration was high hyperdiploidy (12.9%) with abnormal karyotypes while abnormal 12p (7.5%) was the highest observed structural abnormality followed by t(12;21)(p13.3;q22) resulting in ETV6/RUNX1 fusion (5.4%) and t(9;22)(q34.1;q11.2) resulting in BCR/ABL1 fusion (4.3%). Interestingly, we identified 16 cases with rare and complex structural aberrations. Application of the FISH technique produced major improvements in the sensitivity and accuracy of cytogenetic analysis with ALL patients. In conclusion it confirmed heterogeneity of ALL by identifying various recurrent chromosomal aberrations along with non-specific rearrangements and their association with specific immunophenotypes. This study pool is representative of paediatric/adult ALL patients in Oman.

• Smart Structures and Systems
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• v.18 no.6
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• pp.1189-1202
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• 2016

This paper describes an application of wavelet analysis for damage detection of a steel frame structure with bolted connections. The wavelet coefficients of the acceleration response for the healthy and loosened connection structure were calculated at each measurement point. The difference of the wavelet coefficients of the response of the healthy and loosened connection structure is selected as an indicator of the damage. At each node of structure the norm of the difference of the wavelet coefficients matrix is then calculated. The point for which the norm has the higher value is a candidate for location of the damage. The above procedure was experimentally verified on a laboratory-scale 2-meter-long steel frame. The structure consists of 11 steel beams forming a four-bay frame, which is subjected to impact loads using a modal hammer. The accelerations are measured at 20 different locations on the frame, including joints and beam elements. Two states of the structure are considered: healthy and damaged one. The damage is introduced by means of loosening two out of three bolts at one of the frame connections. Calculating the norm of the difference of the wavelet coefficients matrix at each node the higher value was found to be at the same location where the bolts were loosened. The presented experiment showed the effectiveness of the wavelet approach to damage detection of frame structures assembled using bolted connections.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.15 no.3 s.96
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• pp.251-258
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• 2005

The free vibration of a spinning flexible disk-spindle system supported by hydro dynamic bearings (HDB) in an HDD is analyzed by FEM. The spinning flexible disk is described using Kirchhoff plate theory and von Karman non-linear strain, and its rigid body motion is also considered. It is discretized by annular sector element. The rotating spindle which includes the clamp, hub, permanent magnet and yoke, is modeled by Timoshenko beam including the gyroscopic effect. The flexible supporting structure with a complex shape which includes stator core, housing, base plate, sleeve and thrust pad is modeled by using a 4-node tetrahedron element with rotational degrees of freedom to satisfy the geometric compatibility. The dynamic coefficients of HDB are calculated from the HDB analysis program, which solves the perturbed Reynolds equation using FEM. Introducing the virtual nodes and the rigid link constraints defined in the center of HDB, beam elements of the shaft are connected to the solid elements of the sleeve and thrust pad through the spring and damper element. The global matrix equation obtained by assembling the finite element equations of each substructure is transformed to the state-space matrix-vector equation, and the associated eigen value problem is solved by using the restarted Arnoldi iteration method. The validity of this research is verified by comparing the numerical results of the natural frequencies with the experimental ones. Also the effect of supporting structures to the natural modes of the total HDD system is rigorously analyzed.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2003.11a
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• pp.572-578
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• 2003

The free vibration of a spinning flexible disk-spindle system supported by hydro dynamic bearings in a HDD is analyzed by FEM. The spinning flexible disk is described using Kirchhoff plate theory and von Karman non-linear strain, and its rigid body motion is also considered. It is discretized by annular sector element. The rotating spindle which includes the clamp, hub, permanent magnet and yoke, is modeled by Timoshenko beam including the gyroscopic effect. The flexible supporting structure with a complex shape which includes stator core, housing, base plate, sleeve and thrust pad is modeled by using a 4-node tetrahedron element with rotational degrees of freedom to satisfy the geometric compatibility. The dynamic coefficients of HDB are calculated from the HDB analysis program, which solves the perturbed Raynolds equation using FEM. Introducing the virtual nodes and the rigid link constraints defined in the center of HDB, beam elements of the shaft are connected to the solid elements of the sleeve and thrust pad through the spring and damper element. The global matrix equation obtained by assembling the finite element equations of each substructure is transformed to the state-space matrix-vector equation, and the associated eigenvalue problem is solved by using the restarted Arnoldi iteration method. The validity of this research is verified by comparing the numerical results of the natural frequencies with the experimental ones. Also the effect of supporting structures to the natural modes of the total HDD system is rigorously analyzed.

• Journal of the Korea institute for structural maintenance and inspection
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• v.18 no.3
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• pp.101-107
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• 2014

Damage location and extent of structure could be detected by the inverse analysis on dynamic response properties such as frequencies and mode shapes. The dynamic response of building structures has many noise and affected by nonstructural members and, above all, the behavior of building structure is more complex than civil structure and this makes the damage detection difficult. In recent researches the damage is detected by the indirect index such as sensitivity or assumed values. However, for the more reasonable damage detection, it needs to use the damage index directly induced from dynamic equation. The purpose of this study is to provide the damage detection method on shear building structures by the damage index directly induced from dynamic equation. The provided damage index could be estimated from measured mode shape of undamaged structure and frequency difference between undamaged and damaged structure. The damage detection method is applied to numerical analysis model such as MATLAB and MIDAS GENw for the verification. The damage index at damaged story represents (-) sign and 15 times than other undamaged sories.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.34 no.2
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• pp.71-75
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• 2021

Despite the development of computational resources, the need to analyze models is increasing. The size of model has been increased to analyze the entire structure more accurately and precisely. As the analysis model becomes larger and more complex, the computation time increases exponentially. Various industries use many structures that have repeated patterns. We focus on these structures with repeated patterns and propose a dynamic analysis method to efficiently calculate these repeated structures. To devise an efficient method for repeated structures, the substructuring scheme and the degree of freedom-based reduction method are used in this study. We modify the existing reduction method in consideration of the characteristics of the repeating structure. In the proposed method, the entire structure was expressed as a combination of substructures, where each substructure was represented as an unit cell of repeated structures. The substructures were condensed and assembled using the substructuring scheme and the modified condensation method. Finally, numerical examples were demonstrated to verify the efficiency and accuracy of proposed method.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.12
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• pp.94-101
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• 2019

In this study, the FEM technique was applied to design the shape of the horn that transmits ultrasonic vibration energy to the base material, and the shape of the welding horn with a one-wavelength bar shape used in the 20kHz region was designed. The shape design of the horn was performed by applying the rod longitudinal vibration theory to Ansys APDL (Ansys Parametric Design Language). Twenty-five models were designed using the ratio of the area of the input and output surfaces of the vibration and the length of the horn to derive the appropriate horn shape. The horn was designed with a total length of 130mm, a step length of 65mm, and an output area of 28.79mm. The horn was fabricated using the optimized dimensions, and the vibration and displacement characteristics of the horn were evaluated using the measurement system. Finally, a uniform longitudinal step horn was designed, and more than 97.4% of the uniformity of the tip was secured. The amplitude ratio of the optimized horn was improved by 51%.

• International Journal of Aeronautical and Space Sciences
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• v.15 no.1
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• pp.32-43
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• 2014

Automatic fiber placement (AFP) has become a popular processing technique for composites in the aerospace industry, due to its ability to place prepregs or tapes precisely in the exact position when complex parts are being manufactured. This paper presents the design, analysis, and manufacture of an AFP mandrel for composite aircraft fuselage skin fabrication. According to the design requirements, an AFP mandrel was developed and a numerical study was performed through the finite element method. Linear static load analyses were performed considering the mandrel structure self-weight and a 2940 N load from the AFP machine head. Modal analysis was also performed to determine the mandrel's natural frequencies. These analyses confirmed that the proposed mandrel meets the design requirements. A prototype mandrel was then manufactured and used to fabricate a composite fuselage skin. Material load tests were conducted on the AFP fuselage skin curved laminates, equivalent flat AFP, and hand layup laminates. The flat AFP and hand layup laminates showed almost identical strength results in tension and compression. Compared to hand layup, the flat AFP laminate modulus was 5.2% higher in tension and 12.6% lower in compression. The AFP curved laminates had an ultimate compressive strength of 1.6% to 8.7% higher than flat laminates. The FEM simulation predicted strengths were 4% higher in tension and 11% higher in compression than the flat laminate test results.

• Journal of the Earthquake Engineering Society of Korea
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• v.5 no.6
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• pp.55-64
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• 2001

Industrial machines are sometimes exposed to the danger of earthquake. In the design of a mechanical system, this factor should be accounted for from the viewpoint of reliability to analyze a complex nonlinear structure system under random excitation is proposed. First, the actual random excitation, such as earthquake, is approximated to the corresponding Gaussian process for the statistical analysis. The modal equations of overall system are expanded sequentially. Then, the perturbed equations are synthesized into the overall system and solved in probabilistic way. Several statistical properties of a random process that are of interest in random vibration are evaluated in each substructure. Comparing with the results of the numerical simulation proved the efficiency of the proposed method.

• Database Research
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• v.34 no.3
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• pp.148-158
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• 2018

The optical character recognition (OCR) is a technique to extract and recognize texts from images. It is an important preprocessing step in data analysis since most actual text information is embedded in images. Many OCR engines have high recognition accuracy for images where texts are clearly separable from background, such as white background and black lettering. However, they have low recognition accuracy for images where texts are not easily separable from complex background. To improve this low accuracy problem with complex images, it is necessary to transform the input image to make texts more noticeable. In this paper, we propose a method to segment an input image into text lines to enable OCR engines to recognize each line more efficiently, and to determine the final output by comparing the recognition rates of CLAHE module and Two-step module which distinguish texts from background regions based on image processing techniques. Through thorough experiments comparing with well-known OCR engines, Tesseract and Abbyy, we show that our proposed method have the best recognition accuracy with complex background images.