• Korean Journal of Construction Engineering and Management
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• v.17 no.3
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• pp.71-80
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• 2016

PERT(Project Evaluation and Review Technique) is typical method in order to probabilistically establish the schedule plan for large scale complex project or mega project. PERT technique is impossible to estimate relationship of each activity probabilistically when there are overlapping relationships because it is limited to Finish-to-Start(FS) relationship. In order to overcome this kind of limitation of PERT technique, PLET(Probabilistic Linkage Evaluation Technique) has been suggested to probabilistically estimate project duration for various overlapping relationships for each activity. However, estimating project duration by PLET technique only considers uncertainty of relationship between activities and not activity time, thus it is not the perfect duration estimating method. The main objective of this research is to propose the integration model of PERT and PLET and verify its probabilistic validity. By verifying application of time calculation method of integration model in practical case, this research will suggest probabilistic project duration estimating method in schedule plan of high-risk construction industry.

• Korean Institute of Interior Design Journal
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• v.26 no.3
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• pp.45-54
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• 2017

A social phenomenon that occurs in a physical space is said to be a complex system. However, space syntax, which is commonly employed by researchers to identify such social phenomena, has various limitations in interpreting their complexity. On the other hand, agent-based modeling considers a variety of factors including the personality of the agent, objective-oriented work flows, estimation according to time flows and better prediction of space use through diverse parameters depending the situation, as well as the characteristics of the space. The agent-based method thus has the potentials to be developed as an alternative to space syntax techniques. In particular, discrete event driven simulation(DEVS), which is part of the agent-based modeling method, embraces the concept of networks just like space syntax, which allows a possible theoretical linkage in the future. This study suggests a procedural model of agent-based DEVS reflecting two different connection methods, i.e. connections between adjacent areas and those of the entire space, and attempts to identify the relationship between the local and regional indices of space syntax. A number of spaces were selected as examples-one for a preliminary experiment and eight modified for the main experiment-and space syntax and DEVS were applied to each of them. The comparative analysis of the results led to the conclusions as follows: 1) Adjacent connections were closely related to local indices, while the whole-space approach to regional indices. Local integration shows both characteristics. 2) Observation of the time flow model indicated a faster convergence with the range of 1 to 3-fold of the total time of one lap, with the error of less than 10%. 3) The heat map analysis showed more obvious characteristics of using the space for the entire space rather than adjacent connections. 4) Space syntax shows higher eligibility than ABM.

• BMB Reports
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• v.31 no.1
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• pp.64-69
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• 1998

Recent studies have suggested that integrin (CR3) participates in the signal transduction pathways of certain GPI-anchored phagocytic receptors including $Fc{\gamma}RIIIB$. One consequence of this functional linkage is an inducible association between CR3 and cortical microfilaments that is triggered by $Fc{\gamma}RIIIB$ binding to immobilized immune complexes (IC). That this signaling event requires the co-expression of $Fc{\gamma}RIIIB$ with CR3 was documented by the use of NIH 3T3 transfectants expressing both CR3 and $Fc{\gamma}RIIIB$ (clone 3-23), CR3 alone (clone 3-19), and $Fc{\gamma}RIIIB$ alone (clone 3-15). Pretreatment of 3-23 cells with protein kinase inhibitors such as staurosporine and methyl 2,5-dihydroxycinnamate (MDHC) blocked IC-stimulated CR3 microfilament proximity without affecting the extent to which $Fc{\gamma}RIIIB$ constrains the lateral membrane mobility of a subset of CR3 on the cell surface (as measured in fluorescence recovery after photobleaching experiments). These data support that CR3 and $Fc{\gamma}RIIIB$ molecules are physically and functionally associated and that ligation of FcgRIIIB triggers CR3-dependent signal transduction.

• Korean Institute of Interior Design Journal
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• v.21 no.5
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• pp.3-11
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• 2012

The first visual contact in architecture happens in surface, and it could be significant object as well as the starting point to recognize the essence and perceive the buildings. Architecture surface could not get out of the restriction of structures and materials that support buildings for a long time in the past. Architecture surface in the past should fulfill the structural role to form are appearance of buildings and support buildings at the same time, so it was difficult to get out of logic for material and thickness of walls, arrangements and sizes of windows. However, since the modern age, architecture surface came to be freer according to the development of building technology, and development of technology changes shows tendencies to express role of new design factor as an architectural element emphasized expression and autonomy,s which was escaped from the subordinate relationship that the surface of building must do the structural function. In this study, it would be examined the expressive characteristics of various epidermis that are expressed in architecture of Herzog & de Meuron since the end of 20thcentury focused on comprehended and analyzed results of changes and characteristics of contemporary society. Through this, it would be comprehended the epidermis of architecture that has particular character expressed in modern buildings of Herzog & de Meuron, and it would be composed a certain linkage between this and characteristics of contemporary society and it would be investigated that the establishing process of inner spaces. Identification through case analysis for this would perform a role of catalyst for the new possibility and development of contemporary architecture's surface expression in the future.

• The Journal of the Convergence on Culture Technology
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• v.10 no.1
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• pp.465-470
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• 2024

Kitchen cabinets are widely used for their spacious storage and efficient use of space, but their high installed location makes it difficult for the elderly and disabled to access. Therefore, in this paper, we propose a new height-adjustable kitchen cabinet that can be used more easily and safely. The lift-down range of cabinet was set considering the installation location of cabinet for efficient use of kitchen space and the maximum height accessible to the elderly and disabled, and the link geometry and driving method of the complex link mechanism were determined through the mechanism design procedure to ensure that the selected floor come down safely along the optimal descend path. In addition, the appropriate motor and control algorithm were added to allow the user to descend to the desired height with a simple button operation. It was confirmed through actual production that the proposed linkage mechanism performs the desired lift-down motion.

• Animal cells and systems
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• v.5 no.4
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• pp.341-346
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• 2001

Hypertension is a complex disease with strong genetic influences. Essential hypertension has been shown to be associated with insulin resistance. To clarify the genetic basis of insulin resistance in Hypertension, case-control association studies were performed to examine candidate genes for insulin resistance in hypertension. Polymorphisms investigated were the BstO I polymorphism of the $\beta$3-adrenergic receptor (ADRB3) gene, the Xba I Polymorphism of the glycogen synthase (GSY) gene, the Dde I polymorphism of the protein phosphatase 1 G subuit (PP1G) gene, the BstE II polymorphism of the glucagon receptor (GCG-R) gene, the Pst 1 polymorphism of the insulin (INS) gene and the Acc I polymorphism of the glucokinase (GCK) gene. No significant differences were observed in the distribution of alleles and genotypes of the ADRB3, GSY PP1G, GCG-R, INS, and GCK genes between hypertensive and normotensive groups. Although the frequencies in each of these polymorphisms were not significantly different between essential hypertensive and normotensive individuals, our results may provide additional information for linkage analysis and associative studies of disorders in carbohydrate metabolism or in cardiovascular disease.

• Journal of The Korean Digital Architecture Interior Association
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• v.13 no.3
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• pp.5-14
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• 2013

In recent years, the change of urban function and the decrease in birth rate have given rise to merge, abolition and relocation of the existing schools. This study explores the possibilities for various land utilizations of disused school sites, aims to propose the effective asset management and the proper development methodology. Firstly it examines the status of small class school in urban area and the linkage complex development method. Among various methods, it compares the validity between the closed school management and public asset management method. In addition, it analyses the national finance method and public-private partnership investment as a proper development methodology to ensure both the common-benefit and profitable business. As a result of study, it prposes the BTO(build-transfer-operate) method to use effectively the disused school sites in urban area.

• Journal of Korea Multimedia Society
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• v.23 no.5
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• pp.673-682
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• 2020

Buildings are becoming more and more high-rise and large-scale in recent years, so in the event of a disaster such as a fire, enormous human and economic damage is expected. Therefore, management, security, and fire control are essential for large buildings in the city. Because these large buildings are very complex outside and inside, they need a three-dimensional control based on 3D modeling rather than a simple flat-oriented control. To do this, this paper designed and implemented a building control system based on 3D modeling. Specifically, we designed a 3D building / facility editing module for 3D modeling of buildings, a 3D based control module for building control, and a linkage module that connects information such as firefighting equipment, electrical equipment and IoT equipment. Based on this design, a building control system based on 3D modeling was implemented.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.22
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• pp.9707-9711
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• 2014

Background: Acute lymphoblastic leukemia (ALL) is a complex disease caused by interactions between hazardous exogenous or/and endogenous agents and many mild effect inherited susceptibility mutations. Some of them are known, but their functional roles still requireinvestigation. Age is a recognized risk factor; children with disease onset after the age of ten have worse prognosis, presumably also triggered by inherited factors. Materials and Methods: The MDR1 gene polymorphisms rs1045642, rs2032582 and MTHFR gene polymorphisms rs1801131 and rs1801133 were genotyped in 68 ALL patients in remission and 102 age and gender matched controls; parental DNA samples were also available for 42 probands. Results: No case control association was found between analyzed polymorphisms and a risk of childhood ALL development. Linkage disequilibrium was not observed in a family-based association study either. Only marginal association was observed between genetic marker rs2032582A and later disease onset (p=0.04). Conclusions: Our data suggest that late age of ALL onset could be triggered by mild effect common alleles.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.16
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• pp.117-154
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• 2001

The objective of the study is to propose to the strategy to make korean main ports to international logistics center in Northeast Asia. so this study's construction is constructed four steps. First, analysis the environment of economy, business and logistics industry in Northeast Asia. Second, analysis the constructions and characters of Free Zone Act. Third, analysis of Korean Government's policy about Free Zone. Forth, propose the growing strategy of Free Zone. In 1999 Northeast Asia was adopted in Korea, which will facilitate the process and strengthen the international logistics capability as a international logistics hub in Northeast Asia. But only adoption in the point of law is not enough to growing korean main seaport and airport to a international logistics hub. so various strategies are needed. In this study, we propose the growing strategies that are to establish and manage the free zone of ports and its hinterland are: the establishment of a long-term vision of international logistics complexes, the improvement of the proximity to markets/customers by way of linkage of global networks, the activation of the industrial complex in hinterland, the development of the skilled labor and the labor climate, the cooperation between governmental bodies and government/provincial bodies, continuous development of logistics infrastructure and so on.