• Korean Journal of Medicinal Crop Science
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• v.22 no.3
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• pp.223-230
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• 2014

This study was performed to enhance contents of low molecular ginsenoside using steaming and fermentation process in low quality fresh ginseng. For increase in contents of Rg2, Rg3, Rh2 and CK in low quality fresh ginseng, a steaming process was applied at $90^{\circ}C$ for 12 hr which was followed by fermentation process at Lactobacillus rhamnosus HK-9 incubated at $36^{\circ}C$ for 72 h. The contents of ginsenoside Rg1, Rb1, Rc, Re and Rd were decreased with the steaming associated with fermentation process but ginsenoside Rg2, Rg3, Rh2 and CK increased after process. It was found that under the steaming associated with fermentation process, low molecule ginsenosides such as Rg2, Rg3, Rh2 and CK were increased as 3.231 mg/g, 2.585 mg/g and 1.955 m/g and 2.478 mg/g, respectively. In addition, concentration of benzo[${\alpha}$]pyrene in extracts of the low quality fresh ginseng treated by the complex process was 0.11 ppm but it was 0.22 ppm when it was treated with the steaming process. This result could be caused by that the most efficiently breakdown of 1,2-glucoside and 1,4-glucoside linkage to backbone of ginsenosides by steaming associated with fermentation process. This results indicate that steaming process and fermenration process can increase in contents of Rg2, Rg3, Rh2 and CK in low quality fresh ginseng.

• Genomics & Informatics
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• v.10 no.2
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• pp.117-122
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• 2012

A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger sample sizes to achieve an adequate statistical power. We estimated the statistical power with increasing numbers of markers analyzed and compared the sample sizes that were required in case-control studies and case-parent studies. We computed the effective sample size and statistical power using Genetic Power Calculator. An analysis using a larger number of markers requires a larger sample size. Testing a single-nucleotide polymorphism (SNP) marker requires 248 cases, while testing 500,000 SNPs and 1 million markers requires 1,206 cases and 1,255 cases, respectively, under the assumption of an odds ratio of 2, 5% disease prevalence, 5% minor allele frequency, complete linkage disequilibrium (LD), 1:1 case/control ratio, and a 5% error rate in an allelic test. Under a dominant model, a smaller sample size is required to achieve 80% power than other genetic models. We found that a much lower sample size was required with a strong effect size, common SNP, and increased LD. In addition, studying a common disease in a case-control study of a 1:4 case-control ratio is one way to achieve higher statistical power. We also found that case-parent studies require more samples than case-control studies. Although we have not covered all plausible cases in study design, the estimates of sample size and statistical power computed under various assumptions in this study may be useful to determine the sample size in designing a population-based genetic association study.

• Fire Science and Engineering
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• v.29 no.4
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• pp.39-48
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• 2015

This research was done to develop a duct-dedicated intelligent fire detection system to prevent fires and minimize fire damage of the industrial duct having a high fire risk. To understand the fire hazards of the ducts, the analysis was centered on the Daegu Textile Industrial Complex, where industrial ducts are used frequently. With this in the background, dedicated fire detectors and fire alarm control panel, which can prevent fires and to minimize fire damages to the ducts, were designed and produced, after which the performance was confirmed. As a result of performance experiments, it was shown that a duct-dedicated intelligent fire detection system had excellent adaptability and temperature accuracy. Through real-time temperature monitoring of the inside of the ducts, it was confirmed that duct fires could be efficiently extinguished by stepwise control of linkage facilities according to the setting temperature.

• Journal of Korean Institute of Industrial Engineers
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• v.26 no.1
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• pp.73-80
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• 2000

To determine the exact direction and location of the human joint in motion is crucial in developing a more accurate human model and producing a more fitting artificial joint. There have been several reports on the biomechanical analysis of the joint to determine the anatomy and movement of joints. However, all the previous researches were made in vitro study, that is, they investigated the passive movement of the joint from cadavers and the suggested location of the joint axis was difficult to make practical applications due to the lack of the direction of joint axis. Also, in many biomechanical models, each joint axis is assumed to lie horizontally or vertically to the adjacent links. Such an assumption causes inherent inaccuracy. In this study, the direction and location of the transverse elbow axis was obtained with respect to the global coordinate system whose origin is on the lateral epicondyle of the humerus. The suggested result based on the global coordinate system lying on the external landmark will be helpful to understand the information of the axis and to make an application. From the experiments conducted for five subjects, the direction and location of the elbow transverse joint was determined for each subject by the helical axis method. A statistical validation was also performed to confirm the result. Finally, the result was applied to develop a simple elbow model which is a part of the kinematic arm model. The simple elbow movement model was developed to validate the significance of the result and the kinematic arm model was able to describe the geometry of any complex linkage system. As a result, the errors incurred from the proposed model were significantly reduced when compared to the ones from the previous approach.

• Journal of the Korean Institute of Landscape Architecture
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• v.30 no.6
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• pp.128-140
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• 2003

The purpose of this research was to present characteristics for the classification of biotopes and classification method of biotopes as basic data for ecological landscape planning in Metropolitan Daegu. The results of this study were as follows. 1) The study identified fifteen characteristics for classification of biotopes. Ecological landscape characteristics were divided into structural and functional factors. There are six structural factors such an inclination, and nine functional factors such as temperature. 2) The study area was separated into sixty eight biotope types. For example, an industrial district was divided into two biotope types: a biotope type of an industrial district with abundant green space, and a biotope type of an industrial district with scarce green space. 3) In the result of cluster analysis using the average linkage method between groups, biotope groups were divided into fifteen clusters and biotope groups were divided into seven clusters. Each cluster was named according to the features of a descriptive statistics analysis. For example, cluster 8 was identified as a biotope type with an impermeable pavement rate of more than 90 percent and an afforestation rate under 10 percent. 4) Fifteen biotope groups were converted to land use patterns for remote application and utilization of urban biotope in city planning. Biotope groups of a building area beyond an intermediate floor with an afforestation rate under 20-30 percent was converted to a land use pattern such as a tall apartment complex or commercial district. When examining the characteristics that were established in this research, there was a limit to achieve the objective of grade-classification because of a lack of related basic data. The research of landscape ecological characteristics for the classification of biotopes could not be completed due to a lack of time and resources, thus the study of ecological landscape characteristics will be accomplished over time.

• Journal of the Ergonomics Society of Korea
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• v.33 no.3
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• pp.203-214
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• 2014

Objective: This study aims to examine the psychological effects of pilots caused by the environmental differences between actual and simulated flights by measuring biochemical stress level and subjective stress level. Background: Currently, the flight system of the air force suffers from several problems including a limited training area, increase of complex and tangled missions and rise in oil prices. In order to overcome these problems an L-V-C (Live, Virtual, Constructive) training system has been proposed as a solution. However, to establish the effective L-V-C training system, it is required to figure out the characteristics of each system first. Also we have to solve the problems which could occur when these systems are connected together. Method: In order to measure the biochemical stress level of pilots, we investigated the differences in cortisol responses after actual and simulated flight training separately. Meanwhile, we conducted the questionnaire survey of about 40 pilots to identify the subjective stress level of pilots. Results: There was significant difference in cortisol level between actual and simulated flight tasks. However, we found that there was no significant difference in pilots' feelings about two flight tasks. Conclusion: The results from this study can be used as basis for the further research on not only how to decrease linkage errors of the L system and the V system but also how to make the L-V training system more practical. Application: The results of the analysis might help to develop the Live-Virtual-Constructive (LVC) pilot training system.

• Bulletin of the Korean Chemical Society
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• v.32 no.8
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• pp.2565-2570
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• 2011

The reaction of bromoacetonitrile with 3,14-dimethyl-2,6,13,17-tetraazatetracyclo[$16.4.1^{2.6}.0^{1.18}.0^{7.12}$]tricosane ($L^{10}$) containing a N-$CH_2$-N linkage produces 17-cyanomethyl-3,14-dimethyl-2,6,13,17-tetraazatetracyclo-[$16.4.1^{2.6}.0^{1.18}.0^{7.12}$]tricosane ($L^{11}$). The mono-N-functionalized macrocyclic complexes $[ML^2]^{2+}$ (M = Ni(II) or Cu(II); $L^2$ = 2-cyanomethyl-5,16-dimethyl-2,6,13,17-tetraazatricyclo[$16.4.0.0^{7.12}$]docosane) can be prepared by the reaction of $L^{11}$ with nickel(II) or copper(II) ion in acetonitrile. The N-$CH_2CN$ group attached to $[ML^2]^{2+}$ readily reacts with water or methanol to yield the corresponding complexes of $HL^3$ bearing one N-$CH_2CONH_2$ pendant arm or $L^4$ bearing one $N-CH_2C(=NH)OCH_3$ group. The $N-CH_2CONH_2$ or $N-CH_2C(=NH)OCH_3$ group of each complex is coordinated to the central metal ion. Both $[NiL^4(H_2O)]^{2+}$ and $[CuL^4]^{2+}$ are quite stable in acidic aqueous solutions, but undergo hydrolysis to yield $[Ni(HL^3)(H_2O)]^{2+}$ or $[Cu(HL^3)]^{2+}$ in basic aqueous solutions. In contrast to $[Cu(HL^3)]^{2+}$, $[Ni(HL^3) (H_2O)]^{2+}$ is readily deprotonated to form $[NiL^3 (H_2O)]^+$ ($L^3$ = a deprotonated form of $HL^3$) in basic aqueous solutions.

• Transactions of the Korean Society of Automotive Engineers
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• v.18 no.2
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• pp.83-90
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• 2010

The windshield wiper consists of 4 parts: a blade, an arm, a linkage and a motor. The wiper blade makes contact with the windshield and is designed to be operated normally at an angle of 30~50 degrees to the front glass. If the contact pressure between the wiper blade and windshield surface is too high, noise and wear of the rubber will result. On the other hand, if the contact pressure is too low, the performance will do badly, since foreign substances such as dust and stains will not be removed well. The pressure and friction of the wiper blade has a great influence on its effectiveness in cleaning the front window. This is due to the contact of the rubber with the window. This paper presents the dynamic analysis method to estimate the performance of the flat type blade of the wiper system. The blade has a nonlinear characteristic since the rubber is an incompressible hyper-elastic and visco-elastic material. Thus, Structural dynamic analysis using a complex contact model for the blade is performed to find the characteristics of the blade. The flexible multi-body dynamic model is verified by the comparison between test and analysis result. Also, the optimization using the central composite design table is performed.

• Journal of Engineering Education Research
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• v.18 no.1
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• pp.47-53
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• 2015

The aim of this paper is to explore the formation of the Seoul-focused network city for technological commercialization compared with Seoul as a mega city. The growth of Seoul and subsequently, the Seoul metropolitan region as a mega city and mega region has led the uneven regional development in Korea since the 1960s. To reduce a huge gap between the Seoul metropolitan and the non-metropolitan region, the concept of network city can be suggested in terms of the functional and spatial division of labor. More specifically, such division of labour throughout the formation of the Seoul-focused network city concentrates on technological commercialization which is deeply concerned with R&BD (research and business development). For this network city, there are 4 axes such as the axis of South-North Korean cooperation (the axis of R&BD for complex technologies), that of the expansion of a mega city (that of R&BD for green growth technology), that of the linkage of small and medium-sized cites (that of R&BD for life science and technology) and that of megalopolis (that of R&BD for basic technology) with regards to the axis of urban development and technological specialization. It shall be argued that the formation of Seoul-focused network city can be an alternative to the contemporary uneven regional development between the Seoul metropolitan and non-metropolitan region in Korea.

• Health Policy and Management
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• v.11 no.1
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• pp.131-152
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• 2001

Public health system and public health practice have changed over the past decades as the result of social and epidemiologic changes. New public health concept emphasizes leadership, strategical thinking, systematic planning and effective performance to identify and solve complex health problem In Korea, the role of Health Center has been expanded rapidly. However there is strong suspicion that Health Center can achieve their mission. This paper aims at understanding what is the needed functions of Health Center and which of its aspects needs improvement. The main results of this study are summarizes as follows. District Health Law does not address the core functions of Health Center. The staffs of Health Center have difficulties in prioritizing their services. The recent attempt to restructure Health Center and change delivery pattern of public health services ended with only limited success. To effectively confront threats to the public's health, the three major function of Health Center must be ${\circled}1$ modifying individual behavior and lifestyle, ${\circled}2$ improving social and economic conditions, and ${\circled}3$ reforming health policies. Better results do not come from setting new functions only; they come from understanding and improving the processes that will then leads to better outcome. We recommend that policy-makers focus economic evaluation of public health programs, building and spreading of the scientific evidence of programs, linkage of public health research and public health program. The criteria of delegation of public health service to private sector is urgently needed. Making community health information data available on a routine basis to providers, managers and researchers of public health services helps promote the efficiency of the overall operation of public health system.