• Journal of Pharmaceutical Investigation
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• v.31 no.1
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• pp.7-12
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• 2001

Amphotericin B (AmB) is a drug of choice for the treatment of systemic fungal diseases, but its use is considerably limited due to a high incidence of toxicity, particularly nephrotoxicity. It has been demonstrated that the toxicity of AmB is caused by self-aggregated species of the drug and that unaggregated (monomeric) drug is nontoxic but still expresses antifungal activity. Poly (ethylene oxide) (PEO) is a water-soluble polymer, which may impact the aggregation state of AmB. We have studied the aggregation state of AmB as a function of PEO molecular weight and concentration. At 3,000 and 8,000 g/mole, there was minimal or no change of critical aggregation concentration (CAC) of AmB regardless of the concentration of polymer. By contrast at 20,000 g/mole, the CAC of AmB strikingly increased to 24.3 and $37.5\;{\mu}M$ at 5.0% and 10 % w/v of polymer, respectively. The critical overlap concentration (COC) of PEO 20,000 g/mole was 5.5%. It appears that an interaction between monomeric AmB and polymer coil increases above the COC, competing with self-aggregation of the drug. Accordingly, the degree of aggregation of AmB stayed low and the toxicity became less. There was no such effect at 3,000 and 8,000 g/mole of PEO, owing perhaps to small dimensions in comparison to AmB. Based upon these findings, less toxic AmB formulation may be developed by a pharmaceutical technique such as solid dispersion system containing both AmB and PEO 20,000 g/mole.

• ALGAE
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• v.32 no.2
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• pp.101-130
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• 2017

The ichthyotoxic Cochlodinium polykrikoides red tides have caused great economic losses in the aquaculture industry in the waters of Korea and other countries. Predicting outbreak of C. polykrikoides red tides 1-2 weeks in advance is a critical step in minimizing losses. In the South Sea of Korea, large C. polykrikoides red tide patches have often been recorded offshore and transported to nearshore waters. To explore the processes of offshore C. polykrikoides red tides, temporal variations in 3-dimensional (3-D) distributions of red tide organisms and environmental parameters were investigated by analyzing 4,432 water samples collected from 2-5 depths of 60 stations in the South Sea, Korea 16 times from May to Nov, 2014. In the study area, the vegetative cells of C. polykrikoides were found as early as May 7, but C. polykrikoides red tide patches were observed from Aug 21 until Oct 9. Cochlodinium red tides occurred in both inner and outer stations. Prior to the occurrence of large C. polykrikoides red tides, the phototrophic dinoflagellates Prorocentrum donghaiense (Jun 12 to Jul 11), Ceratium furca (Jul 11 to Aug 21), and Alexandrium fraterculus (Aug 21) formed red tides in sequence, and diatom red tides formed 2-3 times without a certain distinct pattern. The temperature for the optimal growth of these four red tide dinoflagellates is known to be similar. Thus, the sequence of the maximum growth rates of P. donghaiense > C. furca > A. fraterculus > C. polykrikoides may be partially responsible for this sequence of red tides in the inner stations following high nutrients input in the surface waters because of heavy rains. Furthermore, Cochlodinium red tides formed and persisted at the outer stations when $NO_3$ concentrations of the surface waters were < $2{\mu}M$ and thermocline depths were >20 m with the retreat of deep cold waters, and the abundance of the competing red-tide species was relatively low. The sequence of the maximum swimming speeds and thus potential reachable depths of C. polykrikoides > A. fraterculus > C. furca > P. donghaiense may be responsible for the large C. polykrikoides red tides after the small blooms of the other dinoflagellates. Thus, C. polykrikoides is likely to outgrow over the competitors at the outer stations by descending to depths >20 m and taking nutrients up from deep cold waters. Thus, to predict the process of Cochlodinium red tides in the study area, temporal variations in 3-D distributions of red tide organisms and environmental parameters showing major nutrient sources, formation and depth of thermoclines, intrusion and retreat of deep cold waters, and the abundance of competing red tide species should be well understood.

• Journal of the Korean Institute of Landscape Architecture
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• v.47 no.3
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• pp.81-92
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• 2019

This study was conducted to establish vegetation structure characteristics and vegetation management plan of the cultural landscape forests located around Unmun Temple in Cheongdo-gun and to provide the basic data needed to manage the cultural landscape forests. The landscape characteristics are analyzed in two perspectives including the landscape as viewed from inside and outside of Unmun Temple and eight landscape views are selected. Main views are Pinus densiflora forest and Abies holophylla forest around Unmun Temple. As a result of the survey of existing vegetation around Cheongdo-gun Unmun Temple, P. densiflora forests and P. densiflora-A. holophylla forests are widely distributed, occupying 79.2% of the forest. The plant community structure was classified into seven types according to the three topographic characteristics, flat forests, slope forests, and lower forests, Which were divided into a total of 30 survey plots and the average relative importance percentage was determined. The P. densiflora community on the flat are dominated by Carpinus tschonoskii in Under-canopy. The P. densiflora-A. holophylla community on the flat had a relatively high rate of domination in the shrubs. There were no competing species for the A. holophylla community on the plat. The large standard P. densiflora and the small standard P. densiflora were expected to be confined by P. serrulata var. pubescens and the Quercus variabilis on the slopes. The managed P. densiflora community had a relatively high rate of P. densiflora domination in the shrubs. The P. densiflora community on the lowland was dominated by Styrax japonicus and P. serrulata var. pubescens. The Shannon species diversity index was 0.2360 to 1.4088. The results of the correlation analysis with P. densiflora, A. holophylla and other species were P. densiflora had negative correlation with Acer mono, Corylus heterophylla var. heterophylla, Zelkova serrata and A. holophylla, and A. holophylla have negative correlation with S. japonicus and P. densiflora. Landscape characteristics and plant community structures are analyzed to propose management methods of maintaining and restoring The P. densiflora and A. holophylla cultural forest landscapes around Unmun Temple.

• Korean Journal of Environment and Ecology
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• v.34 no.1
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• pp.27-41
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• 2020

The purpose of this study was to survey vegetation characteristics of Jeopdo (island) for the construction of a database. We installed and analyzed 52 plots with 100㎡ quadrat to investigate the vegetation characteristics. The community classification based on TWINSPAN found seven categories of vegetation communities in the surveyed region: Pinus thunbergii-Pinus densiflora community, Pinus densiflora-Quercus serrata community, Carpinus turczaninowii-Quercus variabilis community, Carpinus turczaninowii-Quercus acutissima community, Quercus variabilis-Carpinus turczaninowii community, Castanopsis sieboldii community, and Actinodaphne lancifolia-Camellia japonica community. The vegetation in Jeopdo is largely composed of evergreen conifer trees community (communities I and II), Carpinus turczaninowii-deciduous broad-leaved trees such as Quercus spp. community (communities III, IV, and V), and evergreen broad-leaved trees community (communities VI and VII). The evergreen conifer tree (Quercus serrata) community is currently competing with Pinus densiflora and Pinus thunbergii. The current state is expected to continue due to the lack of forces, such as Castanopsis sieboldii and Actinodaphne lancifolia, in the succession middle stage and climax stage. The current state of Carpinus turczaninowii-deciduous broad-leaved trees such as Quercus spp. community is expected to last for a long time due to slow vegetation development because of soil conditions. The evergreen broad-leaved trees community is transforming from the initial stage of Pinus densiflora and Pinus thunbergii through the stage in Quercus serrata to Castanopsis sieboldii and Actinodaphne lancifolia. The overall ages of the specimens were similar, and the oldest tree was the 59-year old Castanopsis sieboldii. The correlation analysis of major species showed a high positive correlation between Pinus thunbergii and Eurya japonica, Pinus densiflora and Fraxinus sieboldiana, and Actinodaphne lancifolia and Camellia japonica and a high negative correlation between Pinus densiflora and Carpinus turczaninowii and Carpinus turczaninowii and Eurya japonica.

• Journal of The Korean Association For Science Education
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• v.38 no.2
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• pp.249-257
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• 2018

The purpose of this study was to analyze the knowledge and ability levels of middle school students in four areas: conceptual understanding, argument construction, justification schemes, and use of scientific knowledge in a causal explanation for a genetic phenomenon. A group of 162 middle school students who have taken a class titled Genetics and Evolution participated in the study. Each student answered-and justified the answer to-one question pertaining to genetics. Ability levels were rated from level 0 to level 4, with 4 being the top rating. Students were required to choose one of two competing arguments to explain whether green seed pimps and red seed pimps of the same size and shape were the same species or not. Analyzing conceptual understanding: 47% of the respondents provided the correct answer. Analyzing their abilities for constructing an argument: 75% of the students with the correct answer and 42% of the students with the incorrect answer were evaluated to be at ability level 3 or 4 for argument construction. Analyzing the students' justification schemes: "Scientific idea" and "Analogy" were the most frequently used schemes. Analyzing their use of scientific knowledge: of the students who selected the scientific idea justification scheme, 36% used the correct scientific knowledge, but the remainder used inaccurate or nonspecific scientific knowledge. These findings provide implication for encouraging argumentative writing explaining scientific phenomena regarding epistemic practice.

• Journal of Korean Society of Forest Science
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• v.90 no.3
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• pp.363-372
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• 2001

The objective of this study was to investigate the site and growth characteristics of dominating Cornus controversa in the hardwood stands at Mt. Gariwang and Mt. Joongwang area located in Pyungchang-gun, Kangwon-do. The C. controversa was mainly distributed at the rather steep slope and aspect facing from northeast to northwest, and altitudes ranging from 800 to 1,100m. The C. controversa grew at relatively deep A soil layer with high moisture and nutrients. Major competing species in upper stories were Quercus mongolica, Acer mandshuricum, Salix hulteni, Acer pictum, and herb plants such as Polystichum tripteron, Dryopteris crassirhizoma, Meehania urticifolia, Pseudostellaria pahbiniana, Ligularia fischeri, Impatiens noli-tangere, Corydalis speciosa in the floor. The average annual diameter growth of C. controversa according to the altitude was $4.06({\pm}0.90)mm$ below 900m, $2.51({\pm}0.65)mm$ from 900 to 1,000m, $3.28({\pm}0.12)mm$ from 1,000m to 1,100m and $2.81({\pm}0.35)mm$ above 1,100m. Good annual growth was shown at northwest site, but no difference due to micro-topography.

• Applied Chemistry for Engineering
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• v.4 no.2
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• pp.365-372
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• 1993

$CO_2$ methanation was performed over Ni supported on cation-exchanged Y zeolites under atmospheric pressure at $250{\sim}550^{\circ}C$ and $H_2/CO_2$ mole ratio of 4. Adsorption strength between carbon dioxide and nickel was found to be Influenced by the cation exchanged in the zeolite. TPD(Temperature-programmed desorption) results show that the adsorption strength decreases in the order of Ni/NaY>Ni/MaY>Ni/HY. TPSR(Temperature-programmed surface reaction) results indicate that enhanced methanation activity is obtained when the adsorption strength between carbon dioxide and nickel is stroing. As the reduction temperature increases, the methantion activity of the catalyst increase. From this result the larger size nickel particle seems advantageous for $CO_2$ methanation reaction. The maximum activity is obtained when nickel loading is 3.3wt%. Carbon monoxide is produced as a by-product throughout the reaction temperature range, and as the contact time increases, the selectivity to methane increases and the selectivity to carbon monoxide decreases steadily. Thus methane seems to be produced from $CO_2$ via CO as an intermediate species. In the temperature range of $410{\sim}450^{\circ}C$, the methane production rate is found to be dependent on the orders of 3.3~-0.5 and 1.4~3.6 with respect to $CO_2$ and $H_2$ partial pressures, respectively. This clearly shows that $CO_2$ and $H_2$ are competing for adsorption sites and as the reaction temperature increases, it becomes increasingly difficult for $H_2$ to be adsorbed on the catalyst surface.

• Korean Journal of Environment and Ecology
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• v.20 no.2
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• pp.200-207
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• 2006

The objective of this study was to investigate the site and growth characteristics of Acer pictum var. mono growing in the deciduous stands at Mt. Joongwang area located in Pyungchanggun, Kangwon-do. A. pictum var. mono was mainly distributed at the rather steep slope and aspect facing from northeast to northwest, and altitudes ranging from 1,000 to 1,200m. It grew at relatively deep a soil layer with high moisture and nutrients. Major competing species in the upper stories were Betula costata, Acer mandshuricum, Quercus mongolica, Cornus controversa, and herb plants such as Meehania urtidfolia, Isodon excisus, Astilbe chinensis var. davidii, Dryopteris crassirhizoma and Ainsliaea acerifolia in the floor. The height growth was 0.25m in early time, decreased gradually and sustained growth of lower than 10cm. The diameter growth of A. pictum was under 1mm in early time, but increased to 0.3mm/yr and showed continuous growth of 2mm/yr recently. Annual volume growth showed rapid increased about age 120 and then showed stable growth, so the rotation period of A. pictum is expected more than 200 years without decay of heartwood.

• Journal of Wetlands Research
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• v.20 no.3
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• pp.243-248
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• 2018

This study was carried out to clarify changes in community structure of Quercus acutissima dominant stand on the south slope of Mt. Danseok-san with fixed twenty quadrates. Five field surveys were conducted from Aug. 1999 to May 2018. During the period, the density lessened to 0.20 in 2012 comparing with 0.33 in 1999. However recent field study in 2018 showed moderate rising to 0.24. In 1999, the DBH class distribution of all trees formed reverse J curve. However, the reverse J curve was torn down, forming bell curve. In 2018, the curve showed similar shape of reverse J shape on the group of young trees, forming bell shape on the group of mature trees. It reveals that DBH 13cm is on the threshold of trees competition trend where the downtrend in the trees are on uptrend. The most dominant Q. acutissima formed bell curve. The peak of the curve shows the shift to the right of the graph as it gets lower by year.In case of Q. mongolica, shows a change in the shape of a low bell as the distribution curve increases. The oak stand in this study is in the process of changing from the initial stage of the secondary forest succession to the intermediate stage. The most dominant tree is Q. acutissima, and the sub-dominant tree is Q. mongolica in present. Considering the age distribution of the two competing tree species, the succession of this stand is expected to transfer to the Q. mongolica-dominant community.

• Ecology and Resilient Infrastructure
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• v.9 no.2
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• pp.83-92
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• 2022

The 2020 summer extreme flood severely disturbed the riparian ecosystem of the Seomjin River. Some trees were killed by the flood impact, whereas others have recovered through epicormic regeneration after the disturbance. At the same time, several tree individuals newly germinated. This research aimed to explain the recovery of the riparian ecosystem by spatial proximity between each tree individual of different characteristics, such as "dead", "recovered", and "newly germinated". A spatial point pattern analysis based on K and g-functions revealed that the newly germinated trees and the existing trees were distributed in the spatially clumping patterns. However, further detailed analysis revealed that the new trees were statistically less attracted to the recovered trees than the dead trees, implying competitive interactions hidden in the facilitative interactions. Habitat amelioration by the existing trees positively affected the growth of the new trees, while "living" existing trees were competing with the new trees for resources. This research is expected to provide new knowledge in this era of rapid climate change, which likely induces stronger and more frequent natural disturbance than before. Environmental factors have been widely used for ecosystem modeling, but species interactions, represented by the relative spatial distribution of plant individuals, are also valuable factors explaining ecosystem dynamics.