• 대한수학회논문집
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• 제12권4호
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• pp.869-880
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• 1997

In this paper, we give sufficient conditions of certain elliptic systems involving competing iteractions with nonlinear diffusion rates. The existence of positive solution depends on the sign of the first eigenvalue of operators of Schr$\ddot{o}$dinger type. More precisely, if the sign of such operators are either both positive or both negative, then system has a positive solution. The main tool employed is the fixed point index of compact operator on positive cones.

• 충청수학회지
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• 제13권1호
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• pp.119-130
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• 2000

We give alternative proof of the existence theorem for certain elliptic systems describing competing interactions with nonlinear di usion. The existence of positive solution depends on the sign of the principal eigenvalue of suitable operators of Schr$\ddot{o}$dinger type. If the sign of such operators are both positive, then system has a positive solution. The main tool employed is the fixed point index of compact operator on positive cones.

• 대한수학회보
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• 제32권1호
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• pp.123-132
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• 1995

Our interest is to study the existence of positive solutions to the following elliptic system involving competing interaction $$ (1) { -\partial(x,u,\upsilon)\Delta u = uf(x,u,v) { - \psi(x,u,\upsilon)\Delta \upsilon = \upsilon g(x,u,\upsilon) { \frac{\partial n}{\partial u} + ku = 0 on \partial\Omega { \frac{\partial n}{\partial\upsilon} + \sigma\upsilon = 0 $$ in a bounded region $\Omega$ in $R^n$ with a smooth boundary, where the diffusion terms $\varphi, \psi$ are strictly positive nondecreasing function, and k, $\sigma$ are positive constants. Also we assume that the growth rates f, g are $C^1$ monotone functions. The variables u, $\upsilon$ may represent the population densities of the interacting species in problems from ecology, microbiology, immunology, etc.

• Animal cells and systems
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• 제14권1호
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• pp.1-10
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• 2010

Previously we showed that CHIP, a co-chaperone of Hsp70 and E3 ubiquitin ligase, can promote the degradation of mutant SOD1 linked to familial amyotrophic lateral sclerosis (fALS) via a mechanism not involving SOD1 ubiquitylation. Here we present evidence that CHIP functions in the interaction of mutant SOD1 with 26S proteasomes. Bag-1, a coupling factor between molecular chaperones and the proteasomes, formed a complex with SOD1 in an hsp70-dependent manner but had no direct effect on the degradation of mutant SOD1. Instead, Bag-1 stimulated interaction between CHIP and the proteasome-associated protein VCP (p97), which do not associate normally. Over-expressed CHIP interfered with the association between mutant SOD1 and VCP. Conversely, the binding of CHIP to mutant SOD1 was inhibited by VCP, implying that the chaperone complex and proteolytic machinery are competing for the common substrates. Finally we observed that mutant SOD1 strongly associated with the 19S complex of proteasomes and CHIP over-expression specifically reduced the interaction between S6/S6' ATPase subunits and mutant SOD1. These results suggest that CHIP, together with ubiquitin-binding proteins such as Bag-1 and VCP, promotes the degradation of mutant SOD1 by facilitating its translocation from ATPase subunits of 19S complex to the 20S core particle.

• BMB Reports
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• 제43권12호
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• pp.807-812
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• 2010

$NF{\kappa}B$ and ZAS3 are transcription factors that control important cellular processes including immunity, cell survival and apoptosis. Although both proteins bind the ${\kappa}B$-motif, they produce opposite physiological consequences; $NF{\kappa}B$ activates transcription, promotes cell growth and is often found to be constitutively expressed in cancer cells, while ZAS3 generally represses transcription, inhibits cell proliferation and is downregulated in some cancers. Here, we show that ZAS3 inhibits $NF{\kappa}B$-dependent transcription by competing with $NF{\kappa}B$ for the ${\kappa}B$-motif. Transient transfection studies show that N-terminal 645 amino acids is sufficient to repress transcription activated by $NF{\kappa}B$, and that the identical region also possesses intrinsic repression activity to inhibit basal transcription from a promoter. Finally, in vitro DNA-protein interaction analysis shows that ZAS3 is able to displace $NF{\kappa}B$ by competing with $NF{\kappa}B$ for the ${\kappa}B$-motif. It is conceivable that ZAS3 has therapeutic potential for controlling aberrant activation of $NF{\kappa}B$ in various diseases.

• 상하수도학회지
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• 제27권1호
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• pp.121-128
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• 2013

The concern for dissolved phosphate in water/wastewater has been increasing because of the risk for eutrophication. A variety of conventional and advanced technologies were applied to meet the enforced new regulation of phosphate around the world. However, there still remained a lot of challenge because most introduced/developed method, for example, biological and physic-chemical treatment is not easy to satisfy the new regulation of phosphate in water. In order to meet the new regulation, the application of ion exchanger has been tried which showed that the removal efficiency for phosphate was strongly determined by in the presence of the competing ion, especially sulfate. As results, a new class of ion exchanger governed by ligand exchange was developed and investigated to increase the selectivity for phosphate. The current study using organic/inorganic anion exchanger developed with Lewis acid-base interaction confirms the selectivity for phosphate over sulfate. According to isotherm test and column test, the value of the maximum phosphate uptake (Q) showed 64 mg/g as $po{_4}^{3-}$ and the breakthrough for phosphate occurs after 1000 min and completely finishes at 2500 min, respectively.

• 한국의류학회지
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• 제37권1호
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• pp.76-89
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• 2013

The exploration of the interaction effect among the components of attractiveness is impossible; therefore, this study uses an indirect estimates approach with multiple scale items that can measure the interaction effect among the components of attractiveness to solve the problem of direct estimates. Previous studies focused on intra-store type competition as their subjects; subsequently, this study dealt with intra-store type competition as well as inter-store type competition in the competing and selecting activities among fashion retailing stores with different business models (such as department stores, road brand stores, discount stores, outlets and internet shopping malls). This study suggests a generalized model for shopping attractiveness of stores and proposes a fashion retailing store type attractiveness (FaRSTA) model instead of a simple relative importance between store selection standards.

• 한국융합학회논문지
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• 제9권6호
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• pp.251-259
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• 2018

본 연구는 경영학의 경쟁가치모형을 보육직무에 적용하여 교사의 감정노동과 이직의도의 영향관계에서 소진의 조절효과를 융합적으로 연구하였다. 이를 위하여 어린이집에 종사하는 보육교사 296명을 대상으로 설문하였으며, 자료 분석은 SPSS V22.0 프로그램을 사용하여 평균중심화 기법을 적용한 조절회귀분석을 실시하였다. 연구 결과를 요약하면 첫째, 표면감정노동은 이직의도에 유의한 영향을 미쳤고 내면감정노동은 이직의도에 영향을 미치지 않았다. 둘째, 이직의도에 가장 크게 영향을 미치는 요인은 소진으로 확인되었다. 셋째, 소진과 내면감정노동의 상호작용효과는 이직의도에 유의한 조절효과를 갖는 것으로 나타났다. 이 결과를 바탕으로 보육교사의 이직의도를 관리하기 위하여 보육교사의 소진을 완화시키는 정책적 방안을 제시하였고, 보육현장에서 교사소진과 내면감정노동의 상호작용효과를 활용하여 이직의도를 관리하는 제도적 실천적 방안을 제시하였다.

• 지식경영연구
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• 제3권2호
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• pp.71-84
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• 2002

Global firms have to acquire various kinds of knowledge from worldwide markets and use it strategically in local markets. Especially, the ability to learn competitive advantage of an industry leader or competing firm is a critical factor in a firm's competitiveness. The concept of knowledge transfer has been used to explain these phenomena. However, with the broadening concept of knowledge and increasing importance of interaction between firms, the perspective of knowledge transfer has reached its limits. In this study we will conceptualize the new concept of 'knowledge translation', and analyze the globalization case of Hyundai Motor Co. to improve the validity and usefulness of this perspective. The results show that knowledge translation is a critical factor of success in a firm's globalization and efficient management of the knowledge translation process enhances a firm's global competitiveness.

• 고려인삼학회:학술대회논문집
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• 고려인삼학회 2004년도 추계 학술대회 및 정기총회
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• pp.7-11
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• 2004

We previously reported that ginseng inhibited NMDA receptors in cultured hippocampal neurons. Here, we further examined the detailed mechanism of ginseng-mediated inhibition using its main active ingredient, ginsenoside Rg$_3$. Co-application of ginsenoside Rg$_3$ with increasing concentrations of NMDA did not change the EC$_{50}$ of NMDA to the receptor, suggesting ginsenoside Rg$_3$ inhibits NMDA receptors without competing with the NMDA-binding site. Ginsenoside Rg$_3$-mediated inhibition also occurred in a distinctive manner from the well-characterized NMDA receptor open channel blocker, MK-801, However, ginsenoside Rg$_3$ produced its effect in a glycine concentration-dependent manner and shifted the glycine concentration-response curve to the right without changing the maximal response, suggesting the role of ginsenoside Rg$_3$ as a competitive NMDA receptor antagonist. We also demonstrated that ginsenoside Rg$_3$ significantly protected neurons against NMDA insults. Therefore, these results suggest that ginsenoside Rg$_3$ protects NMDA-induced neuronal death via a competitive interaction with the glycine-binding site of NMDA receptors in cultured hippocampal neurons.