• Molecules and Cells
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• v.45 no.8
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• pp.513-521
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• 2022

Cytotoxic T lymphocyte antigen-4 (CTLA-4) is an immune checkpoint molecule that is mainly expressed on activated T cells and regulatory T (Treg) cells that inhibits T-cell activation and regulates immune homeostasis. Due to the crucial functions of CTLA-4 in T-cell biology, CTLA-4-targeted immunotherapies have been developed for autoimmune disease as well as cancers. CTLA-4 is known to compete with CD28 to interact with B7, but some studies have revealed that its downstream signaling is independent of its ligand interaction. As a signaling domain of CTLA-4, the tyrosine motif plays a role in inhibiting T-cell activation. Recently, the lysine motif has been shown to be required for the function of Treg cells, emphasizing the importance of CTLA-4 signaling. In this review, we summarize the current understanding of CTLA-4 biology and molecular signaling events and discuss strategies to target CTLA-4 signaling for immune modulation and disease therapy.

• International Journal of Internet, Broadcasting and Communication
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• v.15 no.3
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• pp.160-165
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• 2023

Physical education bodybuilders compete by means of external appearance, and more and more people are starting bodybuilding with an interest in improving their individual constitution and diet. However, some of the bodybuilders in sports for life started using banned substances to show off their appearance or to expect good results in bodybuilding competitions. Prohibited drugs only have a short-term positive effect on the subject, and the seriousness of side effects was greater when taking the drug for a long time. An education program that can provide professional education and information on drugs to bodybuilding athletes for life sports should be preceded, and a system that can check regular health should be introduced if necessary. A periodic doping education program for bodybuilders for sport for life is needed to focus on the positive changes in bodybuilding through banned substances and to educate and understand the side effects and damage to life that occur later. Therefore, in order to prevent doping, it is essential to educate various aspects of doping, and it is required to expand the scope not only to elite athletes but also to participants as sports for all

• International conference on construction engineering and project management
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• 2005.10a
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• pp.1100-1105
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• 2005

To compete with large construction companies whose dominance in market share is deepening recently, the needs for improving field production system of mid-size construction companies have increased rapidly. The development of an adequate model that focuses on the organizational size and work process of the mid-size construction companies are needed to increase productivity through the informatization in the construction industry[0]. The authors of this study used case studies on the problems of the mid-size construction companies in procuring work and presented a method to solve such problems so that the managers in head office of those mid-size construction companies can effecitively deal with multiple sites[0].

• Asia Marketing Journal
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• v.19 no.4
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• pp.37-59
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• 2018

This study investigates the effects of the distribution channel structure on quality decisions under duopoly competition. I considers a set-up in which two retailers compete on product quality and retail price. In the set-up, the integrated retailer has the power to determine the quality of its exclusive product, while the decentralized retailer does not. For the decentralized retailer, the supplier determines product quality. I find that asymmetric pairs of a decentralized channel by one retailer and an integrated channel by the other retailer can be a Nash equilibrium in a simultaneous-channel-choice model. The two retailers select different levels of quality, and this quality competition benefits retailers by softening price competition. In a sequential-channel-choice model, I find that the leader can obtain a first-mover advantage. From the perspective of the supplier, which can decide the distribution channel structure and level of quality, both suppliers choose the decentralized channel in equilibrium.

• Asia Marketing Journal
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• v.21 no.3
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• pp.47-64
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• 2019

We analyze and study competition in differentiated product market using public data source. Understanding competitive market structure is critical for firms to assess how their products compete against other firms in a given market. In this paper, we estimate consumer demand, extend clout and vulnerability framework, and study competition among multi-product manufacturers in differentiated product market. For our empirical analysis, we adopt choice-based aggregate demand model and estimate consumer demand while accounting for unobserved product characteristics. Once we estimate consumer demand, we compute full price elasticity matrix and investigate intra- and inter- manufacturer substitutions among consumers. This research offers a framework for marketers to analyze and understand market structures, leading them to informed decisions.

• Journal of applied mathematics & informatics
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• v.41 no.1
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• pp.215-228
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• 2023

The ready-made garments (RMG) have been making a crucial contribution about of 81% of total export and 12.36 % of total GDP of the country which is now the single biggest export earner for Bangladesh. The cheap production cost is the key important factor to explore this RMG sector. But these RMG sector is running on the basis of intuition based decisions. Though they are making profit it is not optimal. In this study, a deterministic model is developed to help the RMG to minimize the production cost and to maximize their profit along with optimal utilization of available resources. 10 different types of products are taken from one of the garments factories of Gazipur, Dhaka to prepare this research work. This model suggests the manufacturer on which products along with how much should be produced to meet the future demand by maintaining the lowest production cost that ultimately maximize the profit of the organization, and also helps Bangladesh to compete in the international market with 'Made in Bangladesh'. LINDO programming is used here to solve this LP model.

• Electronics and Telecommunications Trends
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• v.38 no.1
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• pp.1-8
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• 2023

In this research, policies, and technology trends associated with quantum computers were examined, and through this, implications for domestic methods were derived. It is not a guarantee that developing quantum computing technology suited for domestic use would be successful to emulate the success stories of technology-leading nations. Technology leaders like the United States, China, and Europe are putting together strategic technology blocks to compete for technological hegemony. Adapting to and exploiting this trend will help us develop future technologies and secure market competitiveness. The dominant technology in the area of quantum computing has not yet been established. In the future, there will be fair competition in every specific technology area. At this point, it may be claimed that making audacious decisions will still lead to technological superiority.

• Communications for Statistical Applications and Methods
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• v.30 no.2
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• pp.179-189
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• 2023

Hybrid sufficient dimension reduction (SDR) methods to a weighted mean of kernel matrices of two different SDR methods by Ye and Weiss (2003) require heavy computation and time consumption due to bootstrapping. To avoid this, Park et al. (2022) recently develop the so-called cross-distance selection (CDS) algorithm. In this paper, two variations of the original CDS algorithm are proposed depending on how well and equally the covk-SAVE is treated in the selection procedure. In one variation, which is called the larger CDS algorithm, the covk-SAVE is equally and fairly utilized with the other two candiates of SIR-SAVE and covk-DR. But, for the final selection, a random selection should be necessary. On the other hand, SIR-SAVE and covk-DR are utilized with completely ruling covk-SAVE out, which is called the smaller CDS algorithm. Numerical studies confirm that the original CDS algorithm is better than or compete quite well to the two proposed variations. A real data example is presented to compare and interpret the decisions by the three CDS algorithms in practice.

• The Journal of Economics, Marketing and Management
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• v.2 no.3
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• pp.20-25
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• 2014

Comfortable sleeping itself is thought to be very much important to have great influence upon remaining lives. Bed-clothes can be an essential factor of comfortable bedding. Korea that has four seasons requires different blanket each season. The Koreans make change of use of the quilt at least 2 to 3 times a year. The quilt may vary depending upon use of either Ondol or bed. Brand bedding governs quilt market. Brand bedding shops have good cognition of customers to be located at the place easy to find out and to have various kinds of products and excellent designs and to take the lead in all of the areas. Non-brand bedding products are difficult to compete with brand products at the bedding market. This study investigated cases of not only management of non brand bedding but also competition between brand bedding and non brand bedding. First, How does non brand bedding elevate competitiveness to win at competition with brand bedding? Second, How dose non brand quilt's approach to consumers and sales strategies?

• Advances in nano research
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• v.15 no.1
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• pp.67-74
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• 2023

The combination of physical activities and individual skills in sports creates an entertaining and competitive environment governed by a set of rules. In today's world, sports attract significant attention and are approached differently by various groups. Inevitably, injuries occur in sports, significantly impacting an athlete's performance and ability to participate in exercises and competitions. Addressing this issue, one of the crucial measures involves restoring the athlete's ability to engage in sports and compete. Sports rehabilitation serves as a treatment to mitigate the effects of injuries, and when combined with surgery, it can expedite the recovery process. Therefore, the primary objective of this study is to utilize a biocompatible technology for synthesizing zinc oxide (ZnO) nanoparticles in sports rehabilitation, ensuring minimal harm to the environment.