• Clinical and Experimental Reproductive Medicine
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• v.38 no.4
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• pp.238-241
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• 2011

A 35-year-old man with infertility was referred for chromosomal analysis. In routine cytogenetic analysis, the patient was seen to have additional material of unknown origin on the terminal region of the short arm of chromosome 4. To determine the origin of the unknown material, we carried out high-resolution banding, comparative genomic hybridization (CGH), and FISH. CGH showed a gain of signal on the region of $4q32{\rightarrow}q35$. FISH using whole chromosome painting and subtelomeric region probes for chromosome 4 confirmed the aberrant chromosome as an intrachromosomal insertion duplication of $4q32{\rightarrow}q35$. Duplication often leads to some phenotypic abnormalities; however, our patient showed an almost normal phenotype except for congenital dysfunction in spermatogenesis.

• Journal of Genetic Medicine
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• v.2 no.2
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• pp.71-77
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• 1998

Comparative genomic hybridization (CGH) can now be applied to detect the origin of extra or missing chromosomal material in cases with common unbalanced aberrations and in prenatal investigations. This method has been used in 13 cases of fetal samples for this study; 3 for amniocytes, 2 for cord blood and 8 for abortus tissues. These samples were previously subjected to GTG-banding. Our study showed aneuploidy in 8 cases, and partial monosomy, partial trisomy or marker chromosome in the remaining 5. The CGH disclosed further small genetic imbalances in 4 of all 13 cases: a prenatal sample showing del(20)(q13) by GTG confirmed a loss of the segment 20p13-pter by CGH; a marker chromosome manifested normal CGH profile; chromosome der(?)(?;15) found in an abortus sample by GTG turned out to be a loss of 15pter-q14 (partial monosomy) and a gain of 10pter-q22 (partial trisomy); the der(15) shown by GTG represented partial trisomy of 3q24-qter. These findings show that CGH is very useful and efficient for cytogenetic investigations of clinical cases.

• Korean Journal of Pharmacognosy
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• v.43 no.3
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• pp.231-238
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• 2012

Menthae herba (MH) extracts exhibit anti-inflammatory effects. The purpose of this study was to determine whether the anti-inflammatory effects of MH extracts vary according to the cultivation regions. We performed a comparative analysis of MH extracts by evaluating the production of inflammatory mediators in RAW 264.7 murine macrophage cells and HaCaT human keratinocyte cells. MH extracts obtained from different cultivation regions in Korea and China significantly reduced the production of nitric oxide (NO), prostaglandin $E_2$ ($PGE_2$), and tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in RAW 264.7 cells stimulated with lipopolysaccharide (LPS). No differences in these inhibitory activities were observed between MH extracts. In HaCaT cells stimulated with TNF-${\alpha}$ and interferon-${\gamma}$ (IFN-${\gamma}$), MH extracts did not inhibit the production of macrophage-derived chemokine (MDC/CCL22), but most extracts reduced the production of the regulated on activation normal T-cell expression and secreted (RANTES/CCL5). We used clustering tree analysis of the MH extracts according to the chromatographic pattern and anti-inflammatory potency of MH extracts. We observed differences in the chromatographic pattern of MH extracts but no difference in anti-inflammatory potency. Our findings suggest that MH extracts from different regions do not show any differences in their pharmacological potency in that MH extracts are used as therapeutic agents to treat inflammatory disorders.

• Korean Journal of Oriental Medicine
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• v.15 no.3
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• pp.63-74
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• 2009

Background and Purpose : Oncheongeum(溫淸飮) composed of Samultang(四物湯) and Hwangryunhaedoktang(黃連解毒湯) was mainly used for healing metrorrhagia in the Qing dynasty of China. At present, Oncheongeum is used for treating a broad spectrum of diseases such as skin disease, stomatitis, behcets disease, diabetes mellitus and, especially in Japan, atopic dermatitis. To our knowledge, however, neither the precise constituents and their effects of Oncheongeum nor the criteria for the prescription of Oncheongeum were defined. To address this issue, we searched and performed analysis of Korean, Chinese and Japanese articles reporting the clinical and experimental studies of Oncheongeum. Methods : We searched articles in the national assembly library of Korea by using keyword 'Oncheongeum' korean. Similarly, we did chinese articles in the CNKI and japanese ones in the CiNii, respectively. Results : We found 13 korean articles about Oncheongeum in the national assembly library, 34 chinese articles in the CNKI, and 23 japanese in the CiNii. The papers were divided into clinical and experimental articles. The clinical articles were mainly published from China and Japan, and their subjects were predominantly on skin diseases. Conclusions : There were a lot of case reports about Oncheongeum used in the clinical studies. In order to better understand the effects of Oncheongeum, systematic review of the studies seems essential. The efficacy of Oncheongeum reported in the clinical studies should be supported by experimental data. Not much were clinical reports in Korea, although we are expecting more to come. It is possible to not only analyse but compare Oncheongeum with other prescriptions used for atopic dermatitis. More comprehensive and comparative analysis of three countries' prescriptions might provide a way of how to standardize prescriptions, which leads oriental medicine to an evidence based medicine.

• The Journal of Korean Medicine
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• v.34 no.1
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• pp.35-51
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• 2013

Objectives: The purpose on this study was to analyze medical health insurance to provide useful data to reestablish oriental medical insurance fees for long-term care hospitals. Methods: First, comparative analysis on medical health insurance was performed, calculating insurance fees of patients admitted to Mungyung Long-term Care Hospital. The oriental medical insurance fee of the patients was calculated as if the patients have been admitted to oriental long-term care hospitals, and the ratio of oriental medical insurance fee to western was calculated. Results: 1. The ratios of total medical expenses were 90% within 3 months and 82% over 3 months. 2. The ratios of co-pays were 86% within 3 months and 82% over 3 months. Conclusions: Oriental medical insurance fees need to be reevaluated.

• The Journal of Internal Korean Medicine
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• v.12 no.2
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• pp.52-58
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• 1991

Review of literature on the symptoms of sweat. According to comparative studies of oriental and occidental medical literature on the symptoms of sweat, following results were obtained. 1. oriental medicine 1) time: ja han (自汗), do han (盜汗) 2) body : du han (頭汗), su jog han (手足汗), sim han (心汗), eum ban (陰汗) pyun hang (偏汗) 3) kan (肝) : hwang han (黃汗), sim(心) : sin han (心汗), hyul han(血汗), bee (脾) : sig hu han (腎虛汗) sin(腎) : eum han (陰汗) By the study of the oriental medical literature, sweat were concerned with physiological function and pathological transformation of the body, 2. occidental medicine 1) NO sweat of the whole body 2) NO sweat of the part 3) much sweat of the whole body, 4) much sweat of the part. By the study of the western medical literature, sweats were tiny reaction of the· nerve and the mind.

• Journal of Korean Medicine for Obesity Research
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• v.16 no.1
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• pp.50-63
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• 2016

Objectives: The aim of this study is to analyze methods and outcomes about fasting for obesity in korea medicine research. Methods: We searched the studies with key words of 'obesity' and 'fasting or starvation' in Korean database (Korean traditional knowledge portal, OASIS, KISS, KMBASE, DBPIA, RISS). Studies were analyzed for contents, evaluation methods and adverse effects. Results: Twenty-one studies were reviewed. Studies were published in 1983~2015. 1. Studies can be classified into three types: comparative study on before and after, comparative study between groups, case study on other disease occurred during the fasting therapy period. 2. The most common step of fasting were 3 steps: reducing food intakes period (3~5 days), fasting period (7~10 days) and refeeding period (3~5 days) and additional period-diet period (28 days). 3. The most common evaluation methods were body weight (BW), body fat mass (BFM), muscle weight (MW), fat free mass, body mass index, body fat percentage, etc. 4. BW, BFM, MW were reduced largely in fasting period. 5. The most common adverse effects were fatigue, nausea, headache, vomiting, insomnia, etc. Conclusions: As a result of the review papers, fasting therapy have positive effects for obesity. To verify the effectiveness of the fasting, more studies are needed such as randomized controlled trial.

• The Journal of Pediatrics of Korean Medicine
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• v.27 no.2
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• pp.31-47
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• 2013

Objectives This study was done to confirm reliability, validity and the internal structure of the Korean Medicine Satisfaction Questionnaire(KMSQ). Methods 154 parents who visited in Department of Pediatrics of Korean Medicine, University Hospital participated in this study. They were statistically analyzed by using PASW Statistics 20.0K for Windows. Results Factor analyses were largely divided into six categories such as Hospital, Waiting & Consultation Time, Doctor, Medicine, Therapy, and Cost. The validity and reliability of KMSQ were favorable. The highest average score of satisfaction was Doctor category as $4.20{\pm}0.51$ and the lowest one was Cost as $3.33{\pm}0.71$. The six factors showed highly positive relationship from correlation analysis. The result of comparative study on parent's demographic characteristics showed only one significant difference in satisfaction of Doctor within occupation. The result of comparative study on child's demographic characteristics showed significantly different in satisfaction of Therapy within gender, and of Medicine within age. Every average score of satisfaction showed somewhat difference within each section, and only 5.6% of them showed significantly difference in T-test. Conclusions Uses and research with the KMSQ as subjective tool in various department or medical institution are suggested.

• The Journal of Korean Medicine
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• v.36 no.3
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• pp.98-110
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• 2015

Objectives: The purpose of this study was to analyze the medical cost of facial paralysis in payer perspective and to estimate the practice pattern of patient using 2011 Health Insurance Review & Assessment Service-National Patients Sample(HIRA-NPS). Methods: Basic statistical system was used for descriptive analysis of NPS dataset. A table for general information (table20) was extracted by disease code, and social demographic characteristics, distribution of the use among inpatients and outpatients, utilization of each kind of medical care institutions, medical cost were analyzed. Subgroup analysis was conducted for assuming the practice pattern of korean medicine and western medicine. Results: A total of 8,219 people and 64,345 claims data were identified as having facial paralysis. Proportion of outpatient was 95.23%, inpatient 0.84% and patient using both services 3.93%. Mean patient charges was 44,229 won per outpatient, 178,886 won per inpatient and 523,542 won per patient using both services. Utilization of korean medical care institutions was 68.81%(claims), 40.46%(patients), utilization of western medical care institutions was 31.19%(claims), 59.54%(patients). The amount charged by korean medical care institutions was 52.61% and western medical care institutions was 47.39%. Cost per claim was higher than those of the korean treatment and cost per patient of western treatment was lower than those of the korean treatment. Conclusions: The research assessed the medical cost and practice pattern associated with facial paralysis. These findings could be used in health care policy and subsequent studies.

• Journal of Gastric Cancer
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• v.15 no.1
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• pp.29-38
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• 2015

Purpose: Before expanding our indications for laparoscopic gastrectomy to advanced gastric cancer and adopting reduced port laparoscopic gastrectomy, we analyzed and audited the outcomes of laparoscopy-assisted distal gastrectomy (LADG) for adenocarcinoma; this was done during the adoptive period at our institution through the comparative analysis of short-term surgical outcomes and learning curves (LCs) of two surgeons with different careers. Materials and Methods: A detailed comparative analysis of the LCs and surgical outcomes was done for the respective first 95 and 111 LADGs performed by two surgeons between July, 2006 and June, 2011. The LCs were fitted by using the non-linear ordinary least squares estimation method. Results: The postoperative morbidity and mortality rates were 14.6% and 0.0%, respectively, and there was no significant difference in the morbidity rates (12.6% vs. 16.2%, P=0.467). More than 25 lymph nodes were retrieved by each surgeon during LADG procedures. The LCs of both surgeons were distinct. In this study, a stable plateau of the LC was not achieved by both surgeons even after performing 90 LADGs. Conclusions: Regardless of the experience with gastrectomy or laparoscopic surgery for other organs, or the age of surgeon, the outcome was quite acceptable; the learning process differ according to the surgeon's experience and individual characteristics.