• YAKHAK HOEJI
• /
• v.55 no.2
• /
• pp.91-97
• /
• 2011

To search a new anti-depressant agents against para-chloroamphetamine-induced excitation, three dimensional quantitative-structure relationships (3D-QSAR) models between structure of 3a,4-dihydro-3H-[1]-benzopyronao[4,3]isoxazoles (1-30) and thieir inhibitory activity against para-chloroamphetamine-induced excitation were performed and discussed quantitatively using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) methods. From these basis on the findings, the optimized CoMSIA-2F model ($q^2$=0.793 and $r^2$=0.952) showed the best statistical results. And also, it is found that the para-chloroamphetamine inhibitory activity from the optimized CoMSIA-2F model was dependent on steric field (35.2%) and electrostatic field (64.8%) of tricyclic isoxazoles. Particularly, it is predicted that the inhibitory activity against para-chloroamphetamine-induced excitation will be able to increase by the designed compounds from the CoMSIA-2F model.

• Molecular & Cellular Toxicology
• /
• v.1 no.3
• /
• pp.157-163
• /
• 2005

Because of their widespread occurrence and substantial biological activity, halogenated aromatic hydrocarbons are one of the important classes of contaminants in the environment. We have performed comparative molecular field analysis (CoMFA) on structurally diverse ligands of Ah (dioxin) receptor to explore the physico-chemical requirements for binding. All CoMFA models have given $q^{2}$ value of more than 0.5 and $r^{2}$ value of more than 0.83. The predictive ability of the models was validated by an external test set, which gave satisfactory predictive $r^{2}$ values. Best predictions were obtained with CoMFA model of combined modified training set ($q^{2}=0.631,\;r^{2}=0.900$), giving predictive residual value = 0.002 log unit for the test compound. We have suggested a model comprises of four structurally different compounds, which offers a good predictability for various ligands. Our QSAR model is consistent with all previously established QSAR models with less structurally diverse ligands. The implications of the CoMFA/QSAR model presented herein are explored with respect to quantitative hazard identification of potential toxicants.

• International Journal of Internet, Broadcasting and Communication
• /
• v.15 no.3
• /
• pp.32-42
• /
• 2023

There are serious problems worldwide, such as a pandemic due to an unprecedented infection caused by COVID-19. On previous approaches, they invented medical vaccines and preemptive testing tools for medical engineering. However, it is difficult to access poor medical systems and medical institutions due to disparities between countries and regions. In advanced nations, the damage was even greater due to high medical and examination costs because they did not go to the hospital. Therefore, from a software engineering-based perspective, we propose a learning model for determining coronavirus infection through symptom data-based software prediction models and tools. After a comparative analysis of various models (decision tree, Naive Bayes, KNN, multi-perceptron neural network), we decide to choose an appropriate decision tree model. Due to a lack of data, additional survey data and overseas symptom data are applied and built into the judgment model. To protect from thiswe also adapt human normalization approach with traditional Korean medicin approach. We expect to be possible to determine coronavirus, flu, allergy, and cold without medical examination and diagnosis tools through data collection and analysis by applying decision trees.

• Language and Information
• /
• v.14 no.1
• /
• pp.1-24
• /
• 2010

The complexity of comparative constructions in each language has given challenges to both theoretical and computational analyses. This paper first identifies types of comparative constructions in Korean and discusses their main grammatical properties. It then builds a syntactic parser couched upon the typed feature structure grammar, HPSG and proposes a context-dependent interpretation for the comparison. To check the feasibility of the proposed analysis, we have implemented the grammar into the existing Korean Resource Grammar. The results show us that the grammar we have developed here is feasible enough to parse Korean comparative sentences and yield proper semantic representations though further development is needed for a finer model for contextual information.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
• /
• v.9 no.6
• /
• pp.566-572
• /
• 2016

Software Reliability implemented in software development is one of the most important issues. In finite failure NHPP software reliability models for software failure analysis, the hazard function that means a failure rate may have constant independently for failure time, non-increasing or non-decreasing pattern. In this study, software development cost analysis considering the variable shape parameter of Erlang distribution as the failure life distribution in the software product testing process was studied. The software failure model was applied finite failure Non-Homogeneous Poisson Procedure and the parameters approximation using maximum likelihood estimation was accompanied. Thus, this paper was presented comparative analysis by applying a software failure time data to the software, considering the shape parameter of Erlang distribution for development cost model analysis. When compared to the cost curve in accordance with the shape parameter, the model of smaller shape can be seen that the optimal software release time delay and more cost. Through this study, it is thought that it can serve as a preliminary information which can basically help the software developers to search for development cost according to software shape parameters.

• International Journal of Internet, Broadcasting and Communication
• /
• v.13 no.2
• /
• pp.14-19
• /
• 2021

Aim of this research was to investigate the effects of Digital Elevation Model (DEM) for sensitivity analysis with two types of DEMs: 1 to 24,000 and 1 to 250,000 DEM. Another emphasis was given to the development of methodology for processing DEMs to create ArcGIS Pro and GRASS layers. This was done while developing water quality system modeling using DEMs which were used to model hydrological processes and SWAT model. Sensitivity analysis with DEMs resulted in different runoff volumes in the model simulation. Runoff volume was higher for the 1:24,000 DEM than 1:250,000 DEM, probably due to the finer resolution and slope which increased the estimated runoff from the watershed. Certainly the DEMs were factors in precision of the simulations and it was obvious during sensitivity analysis that DEMs had significant effect on runoff volumes. We suggest, however, that additional comparative research could be conducted involving more parameters such as soil and hydrologic parameters to provide insight into the overall physical system which the SWAT model represents.

• Journal of the Korean housing association
• /
• v.16 no.6
• /
• pp.65-72
• /
• 2005

The purpose of this study is to get preeminent data from comparative analysis of multi-family housing unit plans between Korea and China nowadays. Even though Korea and China belong to common cultured band in Asia, there are many different Housing aspects and unit plans. Through this study we want to grasp the characteristics of both nation's apartment unit plans and to contribute for advance into the China apartment market. Analysis target is constructing and lotting out apartment at South Korea and China in 2004, and the space syntax model is used as an analysis tool. First, analyze kind, number and special quality of each room by use area, and second, analyze area and scale of the rooms. Through the integration analysis we know the grade of rank and centrality of each rooms, and search difference of South Korean and Chinese apartment.

• Clinical and Experimental Pediatrics
• /
• v.64 no.12
• /
• pp.642-651
• /
• 2021

Background: Infantile colic (IC) is excessive crying in otherwise healthy children. Despite vast research efforts, its etiology remains unknown. Purpose: Most treatments for IC carry various side effects. The collection of evidence may inform researchers of new strategies for the management and treatment of IC as well as new clues for understanding its pathogenesis. This review and meta-analysis aimed to evaluate the efficacy and possible mechanisms of probiotics for mananaging IC. Methods: Ten papers met the study inclusion and exclusion criteria, and the meta-analysis was conducted using Review Manager (RevMan) software and a random-effects model. Results: This meta-analysis revealed that probiotics are effective for treating infantile colic, while the review showed that this efficacy may be due to their anti-inflammatory effects. Conclusion: Probiotics may be an important treatment option for managing infantile colic due to their anti-inflammatory properties.

• Korean Parent-Child Health Journal
• /
• v.17 no.1
• /
• pp.37-45
• /
• 2014

Purpose: This study aimed to review measurements of environmental health behavior and assess the construct validity of Environmental Health Engagement Profile (EHEP) through confirmatory factor analysis. Methods: The literature review was performed for selection of measurements. Confirmatory factor analysis with AMOS 19.0 was used for validation of EHEP. Results: The model fitness was not appropriate in the one-factor model; $x^2=91.11$ (df=5, p<.001), Comparative Fit Index (CFI)=8.19, Non Normed Fit Index (NNFI)=6.39, and Root Mean Square Error of Approximation (RMSEA)=0.20. The model fitness was appropriate in the two-factor model; $x^2=3.19$ (df=1, p=.074), CFI=9.95, NNFI= 9.71, RMSEA=0.07. A modification of scale was found to be the most suitable for use in the investigation of environmental health behavior. Conclusion: This study confirms that a two-factor model underlies the concept of environmental health behavior. The review of measurements can help nurses and researchers to assess the environmental health behaviors.

• Fire Science and Engineering
• /
• v.28 no.2
• /
• pp.14-19
• /
• 2014

A current standard exist only on the surface tension in the current domestic wetting agent technology standards, so it is difficult to the performance evaluation of the wetting agent through the standard. So this study presents the optimized performance evaluation methods by scale model experimental equipment in order to present techniques for performance evaluation of wetting agents. The purpose of this study is to investigate validity of experimental results of the self-designed scale model experiment equipment by a comparative analysis of experimental results of the NFPA 18 experiment and the experiment using the self-designed scale model experiment equipment. As a result of a comparative analysis of experimental results of the NFPA 18 experiment that evaluate only the permeation performance on the contton and the experiment using the self-designed scale model experiment equipment that evaluate the permeation performance and fire extinguishing performance on wood flour, the discrimination of the permeation performance was confirmed in both the NFPA 18 experiment and the self-designed scale model experiment equipment. And a result of self-designed experiment equipment have clear discriminatory more than NFPA 18 by internal temperature measurement using the thermocouples.