• Journal of Power System Engineering
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• v.11 no.3
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• pp.29-34
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• 2007

Existent researches about indoor thermal environment have been focused on to seek human's comfort in daytime. Also researches about thermal comfort during the sleeping time that is important for resting and recharging to modern people have been seldom existed. At present, as global warming phenomenon is being continued, most people are going through inconvenience by sultriness during the sleeping hours in sweltering summer night. Therefore we need another control method of an air conditioner to keep human's thermal comfort. Ambient temperature is a common factor of the environment, but analysis of its effect on human body physiology is still unknown. The effect of ambient temperature on human sleep has been increasingly studied in the last decade. This research investigated about optimal indoor temperature to maintain proper skin temperature and comfortable sleep when indoor air is cooled by an air conditioner in sweltering summer night.

• Korean Journal of Plant Resources
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• v.27 no.6
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• pp.593-600
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• 2014

Osteoporosis is a progressive bone disease characterized by low bone mass which is caused by disturbance in the balance between the activities of osteoblasts and osteoclasts. Postmenopausal osteoporosis is one of the most common disorders in women after menopause, which is linked to an estrogen deficiency and characterized by an excessive loss of trabecular bone. Rubus coreanus has been used for their various pharmacological properties in Asia as a traditional medicine. To investigate the effect of unripe fruits of R. coreanus 30% ethanol extract (RCE) on osteoblast-like cells (MG63) differentiation, we examined the effects of RCE on in vitro osteoblastic differentiation markers, alkaline phosphatase (ALP) activity and receptor activator of nuclear factor ${\kappa}$-B ligand (RANKL) and osteoprotegerin (OPG) expression. The high concentration (50 and $100{\mu}g/mL$) of RCE markedly increased ALP activity, whereas decreased the RANKL/OPG. We also investigated the effect of RCE on M-CSF plus RANKL-induced differentiation of pre-osteoclast cells (RAW 264.7). RCE treatment remarkably inhibited M-CSF/RANKL-induced formation of osteoclast-like multinuclear cells from RAW 264.7 cells. Moreover, the inhibitory effect of RCE was reduced by selective estrogen receptor-${\alpha}$ antagonist. Our research suggests that suggested that unripe fruits of R. coreanus may act beneficial effects on bone mass by regulating both osteoblast and osteoclast.

• Journal of Environmental Health Sciences
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• v.48 no.4
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• pp.236-243
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• 2022

Background: In the case of multiple exposures to different types of heavy metals, such as the conditions faced by residents living near a smelter, it would be preferable to group hazardous substances with similar characteristics rather than individually related substances and evaluate the effects of each group on the human body. Objectives: The purpose of this study is to evaluate the utility of factor analysis in the assessment of health effects caused by exposure to two or more hazardous substances with similar characteristics, such as in the case of residents living near a smelter. Methods: Heavy metal concentration data for 572 people living in the vicinity of the Janghang smelter area were grouped based on several subfactors according to their characteristics using factor analysis. Using these factor scores as an independent variable, multiple regression analysis was performed on health effect markers. Results: Through factor analysis, three subfactors were extracted. Factor 1 contained copper and zinc in serum and revealed a common characteristic of the enzyme co-factor in the human body. Factor 2 involved urinary cadmium and arsenic, which are harmful metals related to kidney damage. Factor 3 encompassed blood mercury and lead, which are classified as related to cardiovascular disease. As a result of multiple linear regression analysis, it was found that using the factor index derived through factor analysis as an independent variable is more advantageous in assessing the relevance to health effects than when analyzing the two heavy metals by including them in a single regression model. Conclusions: The results of this study suggest that regression analysis linked with factor analysis is a good alternative in that it can simultaneously identify the effects of heavy metals with similar properties while overcoming multicollinearity that may occur in environmental epidemiologic studies on exposure to various types of heavy metals.

• Journal of the East Asian Society of Dietary Life
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• v.23 no.3
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• pp.265-272
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• 2013

In order to globalize Korean foods successfully, it is necessary to understand foreigners' attitudes about ethnic foods and how foreigners perceive Korean foods. It would be valuable to survey the degree of interest from foreigners when purchasing Korean foods. Thus, a survey was performed on the most common tourists in Korea, the Japanese, Chinese and Americans. 313 respondents completed the survey on ethnic foods (16 questions), purchasing intention of Korean foods (3 questions), and socio-demographic conditions (9 questions). Factor analysis and reliability analysis were conducted to identify the indicators of attitudes toward ethnic foods. Correlation analysis was conducted to confirm the relation between attitudes toward ethnic foods and Korean food purchasing intention. From the results of factor analysis, 5 factors emerged from the 13 out of 16 questions; and were labeled new food seekers, ethnic food seekers, familiarity seekers, new taste seekers and challenge seekers. Items were analyzed to determine the differences according to nationality by using the ANOVA, and it showed that Americans have the highest Korean food purchasing intentions. The regression analysis indicated that attitude factors on ethnic foods, new foods and new taste seekers are strongly related to Korean food purchase intentions.

• Natural Product Sciences
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• v.28 no.2
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• pp.80-88
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• 2022

Colorectal cancer is one of the most common cancers globally, ranking second for the number of cancer-related deaths. Metastasis has been reported as the main cause of death in patients with colorectal cancer. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a transcription factor that functions as a tumor suppressor by inhibiting cellular proliferation, migration, and invasion. In our previous efforts to generate natural product-motivated PPAR-γ ligands, the compounds 1 and 2 were obtained. These compounds activated PPAR-γ and inhibited the migration and invasion of HCT116 colorectal cancer cells, and they were also found to inhibit the epithelial-to-mesenchymal transition, which is a key process in cancer metastasis. Compounds 1 and 2 upregulated expression of the epithelial marker (E-cadherin), and downregulated expression of the mesenchymal marker (N-cadherin) and transcriptional factor (Snail). Therefore, the PPAR-γ agonists 1 and 2 could serve as a valuable model for the study on anti-metastatic leads for the treatment of colorectal cancer.

• The Magazine of the Society of Air-Conditioning and Refrigerating Engineers of Korea
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• v.10 no.1
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• pp.1-11
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• 1981

In this paper, a new performance equation of bath tubs has been derived, which is very characteristically illuminating and in good agreement with experiments : $$T=T_{\infty}+(T_0-T_{\infty})e-\frac{k(A'_f+A_0)}{Mc_{P{\Delta}x}t$$, where $T_{\infty}$ is the temperature of the bathroom, $T_0$ that of the bathwater at t=0, k the overall heat conductivity of the tub- wall, $A'_f$ the equivalent surface area to the wall, $A_0$ the submerged area of the tub-wall, M mass of the bath-water, $C_p$ the specific heat of the bathwater and ${\Delta}x$ the thickness of the tub-wall. Here the equivalent-free surface area is written as $$A'_f=mA_f,\;m=const.(1-{\phi})^{0.88}$$ : where m is a numerical factor which is determined by a simple experiment and some calculation, {\phi}$ the relative humidity and $A_f$ the real free-surface area. From this study, it has been clarified that cooling of bath-water is mainly due to mass-transfer through evaporation from the free surface and conductive heat loss through the tub-wall is minor, which rather gaily mock at common sense. The effect of keeping bathwater warn by increase of the tub-wall thickness is also analyzed by a new idea of the thickness gain factor.

• Steel and Composite Structures
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• v.49 no.2
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• pp.181-196
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• 2023

Marine structures including offshore wind turbines (OWTs) always work under cyclic loads, which arouses much attention on the fatigue design. The tripod substructure is one of the typical foundation forms for fixed OWTs. The three-planar tubular Y-joint (3Y joint) is one of the important components in fatigue design as it is most likely to have cracks. With the existence of the multiplanar interaction effect, calculating the hot spot stress (HSS) of 3Y joints is complicated. To assist with fatigue design, the distributions of stress concentration factor (SCF) and multiplanar interaction factor (MIF) along weld toe curves induced by the out-of-plane bending moment are explored in this study. An FE analysis method was first developed and verified against experimental results. This method was applied to build a numerical database including 1920 FE models covering common ranges of geometric parameters. A parametric study has been carried out to reveal the distribution patterns of SCF and MIF. After multidimensional nonlinear fittings, SCF and MIF distribution formulas have been proposed. Accuracy and reliability checking prove that the proposed formulas are suitable for calculating the HSS of 3Y joints.

• Korean Institute of Interior Design Journal
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• v.24 no.2
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• pp.189-196
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• 2015

In case of Senior Hospitals, meticulous care is required in both amount and quality of natural lighting because of the semi-long term residence of patients. Natural lighting has a huge impact on the physical and psychological part for the seniors. Likewise, natural lighting is an important factor considered for hospital design because it can also effect hospitalization period of patients. Research subject was K Senior Hospital which was determined as the courtyard-type building made to provide healing environment through natural lighting. Analysis was performed by dividing the space of K Senior Hospital into Central Treatment Department directly used by patients, Outpatient Department(OPD), Ward Department, Common Use Department. Research was carried out in two ways of integration value analysis using SPACE SYNTAX and illumination intensity analysis using ECOTECT. K Senior Hospital intended to actively let in natural light through courtyard and to make patients exposed to natural light when they walk along the circuit corridor built around the courtyard. This environmental consideration affected the utilization rate of Common Use Department and residence time of patients raising the average of Common Use Department on every floor. As a resuit of this study presenting type C and type D, part of four types of illumination intensity, takes higher percentage of almost every spaces compare to the others therefore K Senior Hospital was designed on the assumption of healing environment composition through natural light. The result of this research would be used meaningfully in the space programming phase of Senior Hospitals in the future. Utilization rate can be adjusted using illumination intensity value in the space that integration rate should be planed to be high. The use(purpose) of space and integration rate can be used as a guideline to set illumination intensity of natural.

• Journal of Korea Trade
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• v.24 no.8
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• pp.189-206
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• 2020

Purpose - This paper attempted to verify the process by which a multinational corporation (MNC)'s subsidiary practices entrepreneurship to create effective knowledge (KC) in the local market. We have looked at whether subsidiary entrepreneurship (SENT) has a moderation effect in creating knowledge for the local market when a subsidiary has been given autonomy (AUT) from the headquarters (HQ). We also argue that when a subsidiary creates meaningful knowledge, the effect of the increased status by the HQ within the MNC network position (NP) has an indirect effect on whether knowledge is transferred to other overseas subsidiaries (KTO). Design/methodology - This paper used a structural equation model (SEM) of 282 effective foreign companies invested in Korea. To test the hypothesis about the process of SENT on KTO, descriptive statistics, confirmatory factor analysis, reliability, convergent and discriminant validities, and common method bias were analyzed using STATA. In addition, the moderation effect was verified along with SEM. The moderation effect of AUT on SENT and KC was presented graphically by confirming \mathrm{\pm1} standard deviation of AUT for the main effect. Findings - Our findings are as follows. First, while the hypothesis about the direct effect of SENT and KC on KTO was not supported, all other hypotheses were supported. Second, both the AUT and moderating effect and the indirect effect of NP were significant. In the conclusion, these findings are discussed in relation to its various theoretical and practical implications. Originality/value - This study attempted to contribute to the knowledge creation theory of MNC by contemplating how subsidiaries can move away from HQ and grow in the local market. Although there is still a shortage of foreign investment in the Korean market, our practical implications offer guidance for how current subsidiaries can develop more than other overseas subsidiaries.

• International journal of advanced smart convergence
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• v.6 no.4
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• pp.1-8
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• 2017

In this work, the effects of fairly influential factors on performance of vacuum system, such as constant pressure and outgassing effect were simulated to propose the optimum design factors. Outgassing effects of selected vacuum materials on the vacuum characteristics were simulated by the $VacSim^{Multi}$ simulation tool. This investigation examined the feasibility of reliably simulating the outgassing characteristics of common vacuum chamber materials (aluminum, copper, stainless steel, nickel plated steel, Viton A). The optimum design factors for vacuum systems were suggested based on the simulation results. And, the effects of throttle valve applications on vacuum characteristics were also simulated to obtain the optimum design model of variable conductance on high vacuum system. Simulated vacuum characteristics of the proposed modelling were agreed with the observed experimental behaviour of real systems. Pressure limit valve and normally on-off control valve were schematized as the modelling of throttle valve for the constant process-pressure. Simulation results were plotted as pump-down curve of chamber and variable conductance of throttle valve. Simulated behaviors showed the applications of throttle valve sustained the process-pressure constantly, stably, and reliably.