• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.680-687
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• 2016

Small and middle sized architectural design firms still have trouble using BIM (Building Information Modeling) for their tasks, which means that it is necessary to develop BIM Libraries and Technical contents. These BIM libraries should be based on common technical standards that reflect the technical contents to provide optimum BIM design support. This is essential to reduce the technological burden on the design office, because BIM does not just involve the 3D modeling of the design, but provides very important information for calculating the quantity of materials required for the construction and providing materials for the design work. Therefore, this research was aimed at improving the efficiency of the BIM design process by developing a system module based on the BIM technical contents data for the purpose of linking the BIM data and technical contents. The developed system module will be expanded to other uses of BIM in the long term.

• Journal of KIISE:Software and Applications
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• v.33 no.6
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• pp.539-549
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• 2006

Component-Based Development (CBD) has emerged as a new effective technology that reduces development cost and time-to-market by assembling reusable components in developing software. The degree of conformance to standards and common features in a domain largely determines the reusability of components. In addition, variability within commonality should also be modeled and customization mechanism for the variability should be designed into components. Enterprise JavaBeans (EJB) is considered a most suitable environment for implementing components. However. the reusability of EJB is limited because EJB does not have built-in variability design mechanisms. In this paper, we present efficient variability design techniques for implementing components in EJB. We propose a method to customize the variability of EJB-based components by applying three variability design mechanisms; selection, plug-in, and external profile. And we elaborate the suitable situations where each variability design mechanism can be applied, and conduct a technical comparison to other approaches available.

• Journal of Power Electronics
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• v.18 no.6
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• pp.1729-1750
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• 2018

Voltage source inverters (VSIs) are widely used to drive induction motors in industry applications. The quality of output waveforms depends on the switching sequences used in pulse width modulation (PWM). In this work, all existing optimal space vector pulse width modulation (SVPWM) switching strategies are studied. The performance of existing SVPWM switching strategies is optimized to realize a tradeoff between quality of output waveforms and switching losses. This study generalizes the existing optimal switching sequences for total harmonic distortions (THDs) and switching losses for different modulation indexes and reference angles with a parameter called quality factor. This factor provides a common platform in which the THDs and switching losses of different SVPWM techniques can be compared. The optimal spatial distribution of each sequence is derived on the basis of the quality factor to minimize harmonic current distortions and switching losses in a sector; the result is the minimum ripple loss SVPWM (MRSLPWM). By employing the sequences from optimized switching maps, the proposed method can simultaneously reduce THDs and switching losses. Two hybrid SVPWM techniques are proposed to reduce line current distortions and switching losses in motor drives. The proposed hybrid SVPWM strategies are MRSLPWM 30 and MRSLPWM 90. With a low-cost PIC microcontroller (PIC18F452), the proposed hybrid SVPWM techniques and the quality of output waveforms are experimentally validated on a 2 kVA VSI based on a three-phase two-level insulated gate bipolar transistor.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.6
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• pp.3007-3013
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• 2016

Background: Gastrointestinal cancers are common malignancies associated with high mortality rates. Healthcare systems are always faced with high costs of treatment of gastrointestinal cancers including stomach cancer. Identification and prioritization of these costs can help determine economic burden and then improve of health planning by policy-makers. This study was performed in 2015 in Kerman City aimed at estimating the direct hospital costs for patients with gastric cancer. Materials and Methods: In this cross-sectional study, the medical records of 160 patients with stomach cancer admitted from 2011 to 2014 to Shafa Hospital were examined, the current stage of the disease and the patients' health status were identified, and the direct costs related to the type of treatment in the public and private sectors were calculated. SPSS-19 was used for statistical analysis of the data. Results: Of the patients studied, 103 (65%) were men and 57 (35%) were women. The mean age of patients was 65 years. Distribution into four stages of the disease was 5%, 20%, 30%, and 45%, respectively. Direct costs in four stages of the disease were calculated as 2191.07, 2642.93, 2877, and 2674.07 USD (63,045,879, 76,047,934, 82,783,019, and 76,943,800 IRR), respectively. The highest percentage of costs was related to surgery in Stage I and to medication in Stages II, III, and IV. According to the results of direct costs of treatment for stomach cancer in Kerman, the mean total cost of treating a patient in the public sector was estimated at 74,705,158 IRR, of which averages of 60,141,384 IRR and 14,563,774 IRR were the shares of insurance and patients, respectively. Conclusions: The high prevalence and diagnosis of disease in old age and at advanced stages of disease impose great costs on the patients and the health system. Early diagnosis through screening and selecting an appropriate treatment method might largely ameliorate the economic burden of the disease.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.2
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• pp.267-276
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• 2009

Nowadays, numerous of valuable internet services are available not only for personal computer but also for mobile appliances in wireless network environment. Therefore, as the amount of contents is increased for those services, the storage limitation on mobile devices has became a significant issue. In this paper, we present a new block-level storage network protocol, iATA (Internet Advanced Technology Attachment) as a solution to the above problem. iATA is designed to transport ATA block-level data and command over the ubiquitous TCP/IP network. With iATA, a mobile appliance is able to access and control the ATA storage devices natively through network from anywhere and at anytime as if the storage devices is attached locally. We describe the concepts, design and diverse consideration of iATA protocol. Based on the benchmark experiments and application exploitation, we strongly believe that iATA as a light-weight protocol is efficient and cost-effective to be used as a storage network protocol on a resource limited device that utilizes common-off-the-shelf storage hardware and existing IP infrastructure.

• Annals of Laboratory Medicine
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• v.39 no.1
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• pp.50-57
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• 2019

Background: The Automated Fluorescent Immunoassay System (AFIAS) rotavirus assay (Boditech Med Inc., Chuncheon, Korea) is a new rapid antigen test for rotavirus detection. We evaluated the performance of this assay for detecting rotaviruses and their specific genotypes in clinical stool samples. Methods: AFIAS rotavirus assay was performed in 103 rotavirus-positive and 103 rotavirus-negative stool samples (confirmed by both PCR and ELISA), and its results were compared with those of PCR, ELISA, and immunochromatographic assay (ICA). We evaluated diagnostic sensitivity/specificity, the detectability of rotavirus subtypes, lower limit of detection (LLOD), reproducibility, cross-reactivity, and interference of AFIAS rotavirus assay. Results: Based on PCR and ELISA results, diagnostic sensitivity and specificity of the AFIAS rotavirus assay were both 99.0%. LLOD results showed that the AFIAS assay had sensitivity similar to or greater than ICA and ELISA. High reproducibility was confirmed, and no cross-reactivity or interference was detected. This assay could detect genotypes G1P[8], G2P[4], G3P[8], G4P[6], G4P[8], G8P[4], G8P[8], G9P[4], and G9P[8]. Conclusions: The AFIAS rotavirus assay showed high reproducibility, sensitivity, and specificity as well as excellent agreement with ELISA, PCR, and ICA. It detected the most common as well as unusual genotypes of rotavirus prevalent in Korea. It could be a useful onsite assay for rapid, convenient, and cost-effective detection of rotavirus infection.

• Journal of Korean Medical Science
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• v.33 no.49
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• pp.310.1-310.11
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• 2018

Background: Acute pyelonephritis (APN) is one of the most common community-acquired bacterial infections. Recent increases of antimicrobial resistance in urinary pathogens might have changed the other epidemiologic characteristics of APN. The objective of this study was to describe the current epidemiology of APN in Korea, using the entire population. Methods: From the claims database of the Health Insurance Review and Assessment Service in Korea, the patients with International Classification of Diseases, 10th Revision codes N10 (acute tubulo-interstitial nephritis) or N12 (tubulo-interstitial nephritis, neither acute nor chronic) as the primary discharge diagnosis during 2010-2014 were analyzed, with two or more claims during a 14-day period considered as a single episode. Results: The annual incidence rate of APN per 10,000 persons was 39.1 and was on the increase year to year (35.6 in 2010; 36.7 in 2011; 38.9 in 2012; 40.1 in 2013; 43.8 in 2014, P = 0.004). The increasing trend was observed in both inpatients (P = 0.014) and outpatients (P = 0.004); in both men (P = 0.042) and women (P = 0.003); and those aged under 55 years (P = 0.014) and 55 years or higher (P = 0.003). Eleven times more women were diagnosed and treated with APN than men (men vs. women, 6.5 vs. 71.3), and one of every 4.1 patients was hospitalized (inpatients vs. outpatients, 9.6 vs. 29.4). The recurrence rate was 15.8%, and the median duration from a sporadic episode (i.e., no episode in the preceding 12 months) to the first recurrence was 44 days. The recurrence probability increased with the number of previous recurrences. The average medical cost per inpatient episode was USD 1,144, which was 12.9 times higher than that per outpatient episode (USD 89). Conclusion: The epidemiology of APN in Korea has been changing with an increasing incidence rate.

• Journal of the Korea Society of Computer and Information
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• v.26 no.11
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• pp.101-110
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• 2021

The Weapon Control Software performs the function of supporting weapon operation within the Naval Combat System in connection with the Weapon System. As Weapon Control Software depends on an Weapon System, it has the characteristic that software modification is unavoidable with the change in Interface information. Modification of software causes an increase in development costs since it must take verification step such as software reliability test. In this paper, We design the standard architecture of weapon control software to minimize the modification elements of existing weapon control software. For Interface information management, Feature Model were applied to make a division between common factor and variable factor. In addition, Strategy Pattern were applied to improve the software design. Software evaluation test results show that new architecture provides better modifiability and reuse than existing software as well as the cost of development decrease.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.21 no.5
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• pp.89-94
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• 2021

Recently, manufacturing companies are introducing many intelligent production processes that apply IIoT/ICT to improve competitiveness, and a system that maintains availability, improves productivity, and optimizes management costs is needed as a preventive measure using environmental data generated from air ejectors. Therefore, in this study, a dedicated control board was developed and LoRa communication module was applied to remotely control it to collect and manage information about compressors from cloud servers and to ensure that all operators and administrators utilize common data in real time. This dramatically reduced M/S steps, increased system operational availability, and reduced local server operational burden. It dramatically reduced maintenance latency by sharing system failure conditions and dramatically improved cost and space problems by providing real-time status detection through wired and mobile utilization by maintenance personnel.

• Journal of Microbiology and Biotechnology
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• v.29 no.2
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• pp.304-310
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• 2019

Interleukin-21 is a common ${\gamma}$-chain cytokine that controls the immune responses of B cells, T cells, and natural killer cells. Targeting IL-21 to strengthen the immune system is promising for the development of vaccines as well as anti-infection and anti-tumor therapies. However, the practical application of IL-21 is limited by the high production cost. In this study, we improved IL-21 production by codon optimization and selection of appropriate signal peptide in CHO-K1 cells. Codon-optimized or non-optimized human IL-21 was stably transfected into CHO-K1 cells. IL-21 expression was 10-fold higher for codon-optimized than non-optimized IL-21. We fused five different signal peptides to codon-optimized mature IL-21 and evaluated their effect on IL-21 production. The best result (a 3-fold increase) was obtained using a signal peptide derived from human azurocidin. Furthermore, codon-optimized IL-21 containing the azurocidin signal peptide promoted $IFN-{\gamma}$ secretion and STAT3 phosphorylation in NK-92 cells similar to codon-optimized IL-21 containing original signal peptide. Collectively, these results indicate that codon optimization and azurocidin signal peptides provide an efficient approach for the high-level production of IL-21 as a biopharmaceutical.