• 대한한방부인과학회지
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• 제36권2호
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• pp.55-68
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• 2023

Objectives: The purpose of this study is to analyze the effectiveness of Guibi-tang that are used for postpartum depression. Methods: We searched on five databases [Korean studies Information Service (KISS), Oriental medicine advanced searching integrated system (OASIS), The Cochrane Library, PubMed, and China national knowledge infrastructure (CNKI)] with keywords for Postpartum depression (English, Korean, and Chinese) and evaluated the risk of bias. Meta-analysis was performed on the selected studies. Results: 8 potentially relevant articles were retrieved for further evaluation. There was evidence that Guibi-tang compared with Western medicine was significantly higher rate in total effect rate (RR 1.20, 95% CI 1.04, 1.39, p=0.01). Also, the combined therapeutic effects of Guibi-tang and Psychological intervention compared with Psychological intervention were statistically significant in total effect rate (RR 1.14, 95% CI 1.05, 1.24, p=0.002). And they showed improvement on scores of HAMD (Hamilton depression scale, HAMD) and SF-36 (36-Item short form health survey, SF-36). Conclusion: Guibi-tang appears to be more effective compared to Western medicine in the treatment of postpartum depression. The combination Guibi-tang and Psychological intervention was more effective than psychological intervention alone treated for postpartum depression. However, since unclear risk of bias, the result of this study should be considered carefully. Further clinical trials should be carried out in order to academical clinical progress regarding treatment of Postpartum Depression.

• Korean Journal of Acupuncture
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• 제30권4호
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• pp.298-304
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• 2013

목적 : Carrageenan(CA)으로 유발시킨 슬관절염 동물 모델에서 족삼리와 대릉을 배오한 전침의 효과를 알아보기 위해 실험을 수행하였다. 두 개 이상의 경혈에 동시에 자침함으로써 상승작용을 일으키는 연구는 많이 보고되었으나, 본 연구에서는 배합한 경혈(족삼리와 대릉)에 의한 전침 진통 작용의 감쇄 효과가 발생할 수 있는지에 대해 알아보고자 하였다. 방법 : CA을 흰쥐의 슬관절강 내에 주입하여 염증성 통증을 유발시켰다. 실험동물을 임의로 4군으로 배정하였다; PC7 군: 양쪽 상지 대릉 전침 군, ST36 군: 양쪽 하지 족삼리 전침 군, ST36+PC7 군: 양쪽 상지 대릉과 양쪽 하지 족삼리 전침 군, CON: 무처치군. 통증 정도를 측정하기 위해서 weight bearing force의 변화를 측정하였고, 척수의 후각에 유도된 COX-2 발현을 측정하기 위해 면역조직화학법과 western blot 분석을 실시하였다. 결과 : ST36+PC7군은 ST36군과 비교하여, 행동실험에서는 weight bearing force가 유의하게 감소하였고, 면역조직화학법과 western blot 분석에서는 COX-2 발현이 상대적으로 유의하게 증가하였다. 결론 : 이상의 실험결과를 통하여 족삼리와 대릉을 배오한 전침 자극은 슬관절염 모델에서 족삼리 전침의 진통 효과를 감소시킴을 알 수 있었다.

• 대한한방내과학회지
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• 제27권4호
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• pp.969-974
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• 2006

This is clinical report of one patient with pneumonia in stroke who improved with the administration of an herb drug. During treatment for stroke, he broke out with pneumonia, a complication of stroke, which was confirmed by chest radiography. He was administrated Hwangkibyulgap-tang with antibiotics because of old age middle stage pneumonia. After administration, the symptoms improved and chest x-ray film showed no pneumonic finding. This result suggests that oriental medicine is an effective treatment for pneumonia but more clinical case reports are needed.

• 대한예방한의학회지
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• 제27권3호
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• pp.47-67
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• 2023

Objectives : The objective of this study is to examine the findings of a survey assessing the treatment and management status of individuals with diabetes and pre-diabetes, along with their inclination to participate in the Korean Medicine Chronic Disease Management Program. Methods : The survey focused on individuals with diabetes and pre-diabetes, gathering information on respondents' demographic details, diabetes diagnosis, duration of diabetes, attitudes and experiences regarding Korean medicine diabetes treatment, and their willingness to participate in the 'Korean Medicine Chronic Disease Management Program'. Results : 33.1% of participants reported prior experience with Korean medicine treatment for diabetes. The intention to actively utilize Korean medicine treatment was positively observed, with a response rate of 61.1% expressing a favorable inclination and 8.9% indicating a negative stance. Furthermore, 75.3% of patients expressed their intention to participate in the 'Korean Medicine Chronic Disease Management Program' in the future. Among those expressing this intention, 81.4% stated a preference for the 'Korean-Western medicine combined management' in the chronic disease management Program. Conclusions : Patients' willingness to participate in 'Korean Medicine Diabetes Management Program' is high, but lack of information about Korean medicine is a factor that deprives people of the opportunity to experience Korean medicine treatment, and non-medical factors such as difficulty in visiting and administrative complexity are factors that impede participation in the 'Korean Medicine Chronic Disease Management Program'. It should be considered for improvement when formulating policies.

• 대한한방부인과학회지
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• 제35권4호
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• pp.77-90
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• 2022

Objectives: This study was aimed to figure out korean medicine doctors' opinion and treatment of Korean medicine clinical practice guidelines (CPG) for premenstrual syndrome (PMS). Methods: We conducted a questionnaire survey targeting korean medicine doctors belonging to the Korean Association of Oriental Medicine by e-mail and text and analyzed the answers. Results: 1. The average monthly number of patients visiting the respondents' clinics for PMS was 2.7, the main age group was 20-30s (80.8%) and the treatments the patients given before were mostly western treatments such as painkiller and combined oral contraceptives. 2. The treatment period for PMS was mostly less than 3 months (69%), and the frequency of acupuncture treatment was the most twice per week (41.1%). 3. The most effective herbal medicine for affective symptoms was Soyo-san, and for physical symptoms was Gyejibokryung-hwan. The most commonly used acupuncture point was 三陰交 (SP6). 4. Other opinions of the clinicians about Korean medicine clinical practice guideline of PMS were the need for promotion of PMS, convenience of taking herbal medicines and price competitiveness. Conclusions: We figured out korean medicine doctors' opinion of PMS CPG, clinical diagnosis and treatment.

• 대한한방내과학회지
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• 제21권5호
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• pp.723-728
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• 2000

Objective : Pneumonia is a frequent complication in stroke and is very important as a prognostic factor. So We had a clinical study about pneumonic patients combined with stroke in which we administered both antibiotics and oriental herbal medicine to them. Methods : The 14 cases were patients that admitted visited 31CU at neurologic department in Kyunghee medical center from the 1st of October to the 31st of November, 1998. because of stroke. We selected cases complicated pneumonia. We diagnosed stroke as brain CT or MRI and pneumonia as chest simple X-ray, fever, sputurn culture et al. We divided the group into several categories(衛分證, 氣分證, 營分證, 血分證, 正虛邪退證) and medicined them both Paerum-bang(肺炎方) and antibotics. We evaluated the results as increased signs and some tests including chest simple X-ray, GOT, GPT, BUN and Creatinine. Results : Among total 14 cases, cases of perfect cure including improvement were 10, aggravation were 2 and discontinued cases were 2. We observed 17.4 days on the average. Their functions of liver and kidney weren't aggravated as medicining both antibiotics and oriental herbal treatment. Conclusion : We suggest that eastern treatment need to improve resistance of pneumonic patients and may reduce the side effect of western antibiotics therapy.

• 대한한의학방제학회지
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• 제30권4호
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• pp.351-361
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• 2022

Objectives : The purpose of this study is to report the clinical effect of herbal medicine decoction on COVID-19 symptoms remaining after administering Western medicine and worsening eczema during the COVID-19 prevalence period in patients with chronic eczema. Methods : The two chronic eczema patients suffering from COVID-19 symptoms and worsening eczema received a series of herbal medicine decoction for treatment. The effectiveness of treatment was evaluated by VAS, NRS, EASI, PASI, DLQI, photography and subjective evaluation of the patient's improvement of symptoms. Results : After treatment, all symptoms of COVID-19 disappered and aggravated eczema lesions were remarkably improved in both cases. Compared to its peak, the first case shows that PASI improved by 88% and DLQI by 44%. According to photo and symptom changes, the size of the affected area of facial acne and lip eczema was decreased. The second case shows that EASI improved by 43% and DLQI by 65%. According to photo and symptom changes, redness, rash were stopped and pruritus was decreased. Conclusion : This study suggests that herbal medicine could induce effectiveness on both COVID-19 symptoms as well as chronic eczema.

• 대한중풍순환신경학회지
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• 제22권1호
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• pp.45-56
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• 2021

■ Background Heart Failure with Preserved Ejection Fraction(HFpEF) is a heart failure that appears to have normal contraction function. In the case of HFpEF, no pharmacological therapy has been found to improve clinical prognosis, so it should be approached as an symptomatic treatment, therefore alternatives are needed due to concerns over adverse effects such as electrolyte imbalance caused by medication. ■ Case report A 81 year old female patient with Heart Failure with Preserved Ejection Fraction(HFpEF) patient complained dyspnea. Herbal prescription Mokbanggi-tang and Oryeongsan was administered on 6th day and 8th day respectively since the symptoms started. The NYHA Classification and Chest X-ray had been evaluated during the treatment period. Until the 7th day, the patient was classified as Class II, and when discharged from the hospital on the 28th day, it gradually improved and was classified as Class II. Chest X-Ray took on 2nd day showed pleural effusion and it was aggravated until 13th day. Follow up Chest X-Ray showed improving state of pleural effusion from 20th day and gradually got better. Mokbanggi-tang treatment continued for 52 days and stopped on 58th day. After Mokbanggi-tang treatment ended, only Oryeongsan treatment was maintained. ■ Conclusion The present case report suggests that Korean-Western medicine approach with Mokbangki-tang and Oryeongsan might be effective to pleural effusion and heart failure symptoms such as poor physical activity shown in a NYHA Classification. This shows that Mokbanggi-tang and Oryeongsan can be a therapeutic option as a treatment for patient with Heart Failure with Preserved Ejection Fraction(HFpEF).

• 대한약침학회지
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• 제15권4호
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• pp.7-14
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• 2012

Objectives: The purpose of this study is to compare the effects of bee venom pharmacopuncture (BVP) therapy according to the methods used to treat knee osteoarthritis (OA): intra-acupoint combined with intra-articular injection, intra-acupoint injection, and intra-articular injection. Methods: A total of 69 patients were recruited by the Department of Acupuncture & Moxibustion at Dong-Eui Oriental University Hospital from February 1 to July 23, 2012. The patients were assigned to 3 groups: the first group with intra-acupoint combined with intra-articular BVP Injection (the experimental group), the 2nd group with intra-acupoint BVP injection (control group II), and the 3rd group with intra-articular BVP injection (control group II). The participants were assigned in the order in which they were recruited. Treatments were done twice a week, for a total of 9 times. The effectiveness was assessed by using the visual analouge scale (VAS) and the Korea Western Ontario and McMaster Universities Osteoarthritis Index (KWOMAC). Results: All three groups exhibited significant VAS and KWOMAC effects. Moreover, the 4 week follow-up after the final treatment showed a persistence of BVP effects. However, when the groups were compared, no statistically significant differences in VAS and KWOMAC were noted, but when improvement was considered, the results showed that intra-articular injection was more effective than intra-acupoint injection. Especially, intra-acupoint combined with intra-articular injection was the most effective among the three treatments. Conclusions: Combining intra-acupoint with intra-articular injection, depending on the patient's symptoms, may produce better results when conservatively treating knee OA.

• Tuberculosis and Respiratory Diseases
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• 제76권3호
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• pp.114-119
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• 2014

Background: Epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, has anti-cancer activity in human and animal models. We investigated the schedule-dependent effect of EGCG and paclitaxel on growth of NCI-H460 non-small cell lung cancer cells. Methods: To investigate the combined effect of EGCG (E) and paclitaxel (P), combination indices (CIs) were calculated, and cell cycle analysis was performed. For the effect on cell apoptosis, western blot analysis was also performed. Results: CI analysis demonstrated that both concurrent and sequential E ${\rightarrow}$ P treatments had antagonistic effects (CIs >1.0), but sequential P ${\rightarrow}$ E had synergistic effects (CIs <1.0), on the growth inhibition of NCI-H460 cells. In the cell cycle analysis, although paclitaxel induced $G_2/M$ cell cycle arrest and increased the sub-G1 fraction, concurrent EGCG and paclitaxel treatments did not have any additive or synergistic effects compared with the paclitaxel treatment alone. However, western blot analysis demonstrated that sequential P ${\rightarrow}$ E treatment decreased the expression of Bcl-2 and procaspase-3 and increased poly(ADP-ribose) polymerase (PARP) cleavage; while minimal effects were seen with concurrent or sequential E ${\rightarrow}$ P treatments. Conclusion: Concurrent or sequential E ${\rightarrow}$ P treatment had opposite effects to P ${\rightarrow}$ E treatment, where P ${\rightarrow}$ E treatment showed a synergistic effect on growth inhibition of NCI-H460 cells by inducing apoptosis. Thus, the efficacy of EGCG and paclitaxel combination treatment seems to be schedule-dependent.