• Journal of Chest Surgery
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• v.7 no.2
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• pp.201-208
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• 1974

The purpose of this paper is to present author's experience with 6 cases of ruptured aneurysm of sinus of Valsalva which were treated surgically during last 10 years. Among the 6 cases, 5 were male and one was female. All of them originated from the right coronary sinus and 5 cases were ruptured into the RV while remained one into RA. The diagnosis was obtained in 4 cases by cineangiocardiogram. Clinically, we had difficulties in differential diagnosis with combined cases of VSD with A.I. and had special experience in its differentiation during cardiac catheterization. By simultaneous trans-venous and trans-arterial catheterization, identified two catheter tips in the RV, and pull back tracing obtained aortic pressure directly from RV, and RA from RV pressure which were benefit in confirm ruptured aneurysm of the aortic sinus. Surgical correction was performed by means of direct suture closure or combined Teflon pledget Of patch enforcement graft after aneurysm resection by trans-RA or trans-RV approach. All patients had no history of bacterial endocarditis, syphilis, or tuberculosis and operative findings revealed intact coronary sinus except involved one moreover 3 cases combined with high VSD which uggested congenital in origin although pathologic reports revealed only fibrosis. Post-operative course were uneventful in all cases but one who had bleeding and 2 months to 9 years follow up results were good and spend their usual life in all cases.

• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.381-386
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• 2011

Multi-drug resistance (MDR) has been known as a major hurdle in cancer chemotherapy. One of the most clinically significant causes of MDR was the efflux of anticancer agents mediated by p-glycoprotein (p-gp) over-expressed in MDR cancer cells. To overcome MDR, there have been several strategies such as co-administration with p-gp inhibitors and encapsulation of anticancer drugs into drug delivery systems. In the present study, curcumin was evaluated for its potential as p-gp inhibitor and MDR reversal activity when combined with paclitaxel incorporated into lipid nanoparticles (PTX/LN). Western blot assay showed curcumin did not modulate the level of p-gp expression in MCF-7/ADR which is a MDR variant of human breast cancer cell line, MCF-7, and over-expresses p-gp. However, curcumin inhibited p-gp-mediated efflux of calcein in a dose-dependent manner even though it showed lower activity compared to verapamil, a well-known p-gp inhibitor. Incorporation of paclitaxel into lipid nanoparticles partially recovered the anticancer activity of paclitaxel in MCF-7/ADR. The combined use of curcumin and PTX/LN exhibited further full reversal of MDR, suggesting susceptibility of PTX/LN to the efflux system. In conclusion, combined approach of using p-gp inhibitors and incorporation of the anticancer agents into nano-delivery systems would be an efficient strategy to overcome MDR.

• Journal of Microbiology and Biotechnology
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• v.25 no.9
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• pp.1502-1509
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• 2015

The objectives of this study were to evaluate the effect of combined treatments (slightly acidic electrolyzed water (SAEW), ultrasound (US), or mild heat (60℃)) on the growth of Listeria monocytogenes and Salmonella enterica serovar Typhimurium in fresh-cut bell pepper, and the shelf-life and sensory quality (color and texture) were followed during storage at 4℃ and 25℃. An additional 0.65, 1.72, and 2.70 log CFU/g reduction was achieved by heat treatments at 60℃ for 1 min for DW, SAEW, and SAEW+US, respectively. Regardless of the type of pathogen, the combined treatment (SAEW+US+60℃) achieved a significantly (p < 0.05) longer lag time in all treatment groups. This combined treatment also prolonged the shelf-life of bell pepper up to 8 days and 30 h for the storage at 4℃ and 25℃, respectively. There was also no significant difference in the color and hardness of treated (SAEW+US+60℃) bell pepper from that of control during the storage. This new hurdle approach is thus expected to improve the microbial safety of bell peppers during storage and distribution.

• Archives of Plastic Surgery
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• v.41 no.5
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• pp.480-485
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• 2014

Background The objective of this article is to evaluate clinical outcomes of combined orbital floor and medial wall fracture repair using a three-dimensional pre-bent titanium implant in an East Asian population. Methods Clinical and radiologic data were analyzed for 11 patients with concomitant orbital floor and medial wall fractures. A combined transcaruncular and inferior fornix approach with lateral canthotomy was used for the exposure of fractures. An appropriate three-dimensional preformed titanium implant was selected and inserted according to the characteristics of a given defect. Results Follow-up time ranged from 2 to 6 months (median, 4.07 months). All patients had a successful treatment outcome without any complications. Clinically significant enophthalmos was not observed after treatment. Conclusions Three-dimensional pre-bent titanium implants are appropriate for use in the East Asian population, with a high success rate of anatomic restoration of the orbital volume and prevention of enophthalmos in combined orbital floor and medial wall fracture cases.

• Steel and Composite Structures
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• v.19 no.3
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• pp.615-633
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• 2015

Composite steel-concrete beams are used frequently in situations where axial forces are introduced. Some examples include the use in cable-stayed bridges or inclined members in stadia and bridge approach spans. In these situations, the beam may be subjected to any combination of flexure and axial load. However, modern steel and composite construction codes currently do not address the effects of these combined actions. This study presents an analysis of composite beams subjected to combined loadings. An analytical model is developed based on a cross-sectional analysis method using a strategy of successive iterations. Results derived from the model show an excellent agreement with existing experimental results. A parametric study is conducted to investigate the effect of axial load on the flexural strength of composite beams. The parametric study is then extended to a number of section sizes and employs various degrees of shear connection. Design models are proposed for estimating the flexural strength of an axially loaded member with full and partial shear connection.

• Structural Engineering and Mechanics
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• v.31 no.5
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• pp.545-566
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• 2009

Bridge columns are subjected to combined actions of axial force, shear force and bending moment during earthquakes, caused by spatially-complex earthquake motions, features of structural configurations and the interaction between input and response characteristics. Combined actions can have significant effects on the force and deformation capacity of RC columns, resulting in unexpected large deformations and extensive damage that in turn influences the performance of bridges as vital components of transportation systems. This paper evaluates the seismic response of three prototype reinforced concrete bridges using comprehensive numerical models that are capable of simulating the complex soil-structural interaction effects and nonlinear behavior of columns. An analytical approach that can capture the shear-flexural interacting behavior is developed to model the realistic nonlinear behavior of RC columns, including the pinching behavior, strength deterioration and stiffness softening due to combined actions of shear force, axial force and bending moment. Seismic response analyses were conducted on the prototype bridges under suites of ground motions. Response quantities of bridges (e.g., drift, acceleration, section force and section moment etc.) are compared and evaluated to identify the effects of vertical motion, structural characteristics and the shear-flexural interaction on seismic demand of bridges.

• YAKHAK HOEJI
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• v.55 no.1
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• pp.49-55
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• 2011

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is one of the promising anti-cancer agent because of its ability to selectively induce apoptosis in tumor cell lines but not in normal cells. However, TRAIL resistance has been reported in some cancer cells including hepatocarcinoma cells. Therefore, studies of agents that sensitize TRAIL-resistant cancer cells could be a effective therapeutic approach in cancer management. In our study, we examined the effect of combination of TRAIL with apigenin in human hepatocellular carcinoma cells. As a result, the combined use of TRAIL and apigenin significantly enhanced the cytotoxicity in PLC-PRF5 cells. Flow cytometry analysis after annexin V-FITC/PI dual staining showed that this increase of cell cytotoxicity was related to enhanced apoptosis in combined treatment of TRAIL with apigenin. Furthermore, synergistic induction of apoptosis was also confirmed by observation of morphological changes and annexin V-FITC/PI fluorescence. Our findings suggests that apigenin has the potential to improve the efficiency of TRAIL-based therapies in human hepatocellular carcinoma cells. Further study is needed to reveal the molecular mechanisms of this combined therapy.

• Geomechanics and Engineering
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• v.31 no.2
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• pp.223-235
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• 2022

Bearing capacity of shallow foundations is often determined for either dry or saturated soils. In some occasions, foundations may be subjected to external loading which is inclined and/or eccentric. In this study, the ultimate bearing capacity of shallow foundations resting on partially saturated coarse-grained cohesionless and fine-grained cohesive soils subjected to a wide range of combined vertical (V) - horizontal (H) - moment (M) loadings is rigorously evaluated using the well-established limit equilibrium method. The unified effective stress approach as well as the suction stress concept is effectively adopted so as to simulate the behaviour of the underlying unsaturated soil medium. In order to obtain the bearing capacity, four equilibrium equations are solved by adopting Coulomb failure mechanism and Bishop effective stress concept and also considering a linear variation of the induced matric suction beneath the foundation. The general failure loci of the shallow foundations resting on unsaturated soils at different hydraulic conditions are presented in V - H - M spaces. The results indicate that the matric suction has a marked influence on the bearing capacity of shallow foundations. In addition, the effect of induced suction on the ultimate bearing capacity of obliquely-loaded foundations is more pronounced than that of the eccentrically-loaded footings.

• Smart Structures and Systems
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• v.15 no.2
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• pp.425-445
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• 2015

Parametric identification of structures is one of the important aspects of structural health monitoring. Most of the techniques available in the literature have been proved to be effective for structures with small degree of freedoms. However, the problem becomes challenging when the structure system is large, such as bridge structures. Therefore, it is highly desirable to develop parametric identification methods that are applicable to complex structures. In this paper, the LSE based techniques will be combined with the substructure approach for identifying the parameters of a cable-stayed bridge with large degree of freedoms. Numerical analysis has been carried out for substructures extracted from the 2-dimentional (2D) finite element model of a cable-stayed bridge. Only vertical white noise excitations are applied to the structure, and two different cases are considered where the structural damping is not included or included. Simulation results demonstrate that the proposed approach is capable of identifying the structural parameters with high accuracy without measurement noises.

• Journal of Mechanical Science and Technology
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• v.17 no.10
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• pp.1411-1422
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• 2003

The detection of free spaces between obstacles in a scene is a prerequisite for navigation of a mobile robot. Especially for stereo vision-based navigation, the problem of correspondence between two images is well known to be of crucial importance. This paper describes multi-range approach of area-based stereo matching for grid mapping and visual navigation in uncertain environment. Camera calibration parameters are optimized by evolutionary algorithm for successful stereo matching. To obtain reliable disparity information from both images, stereo images are to be decomposed into three pairs of images with different resolution based on measurement of disparities. The advantage of multi-range approach is that we can get more reliable disparity in each defined range because disparities from high resolution image are used for farther object a while disparities from low resolution images are used for close objects. The reliable disparity map is combined through post-processing for rejecting incorrect disparity information from each disparity map. The real distance from a disparity image is converted into an occupancy grid representation of a mobile robot. We have investigated the possibility of multi-range approach for the detection of obstacles and visual mapping through various experiments.