• The Journal of the Korean dental association
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• v.48 no.3
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• pp.205-217
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• 2010

Purpose The aim of this study is to evaluate the survival rates and analyze the stability of lateral approach and trans-crestal approach for maxillary sinus floor elevation of simultaneous implant placement. Materials and method 407 patients who have been treated in LivingWell dental hospital between 2003 to 2009 were selected. Lateral window technique, osteotome technique and sinus drill technique were used for sinus floor elevation procedure. A total of 714 implants-MP-1 HA coated implant(Tapered Screw $Vent^{TM}$, $Spline^{TM}$, Zimmer, USA), FBR surfaced implant(Pitt-$Easy^{TM}$, Oraltronics, Germany)-were placed in grafted maxillary sinus simultaneously. The autogenous bone or a combination with the allograft or alloplast was grafted into sinus. Sinus floor elevation was combined with vertical/horizontal onlay bone grafts to reconstruct the defect of alveolar ridge. Results The average preoperative height of the maxillary alveolar bone was 5.78mm(range: 0.4mm~12.5mm). 14 implants failed during the healing period(lateral approach: 4, trans-crestal approach: 10) and 3 implant failed after prosthetic loading(lateral approach: 2, trans-crestal approach: 1). The cumulative survival rate of implants after 6 years was 97.6%. Trans-crestal approach(97.4%) and lateral approach(97.9%) had similar survival rates. Conclusion The results indicate that the trans-crestal approach and lateral approach for maxillary sinus elevation is a acceptable method at atrophic maxillary posterior area.

• Journal of Veterinary Science
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• v.25 no.1
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• pp.12.1-12.10
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• 2024

Background: Staphylococcus aureus and S. pseudintermedius are the major etiological agents of staphylococcal infections in humans, livestock, and companion animals. The misuse of antimicrobial drugs has led to the emergence of antimicrobial-resistant Staphylococcus spp., including methicillin-resistant S. aureus (MRSA) and methicillin-resistant S. pseudintermedius (MRSP). One novel therapeutic approach against MRSA and MRSP is a peptide nucleic acid (PNA) that can bind to the target nucleotide strands and block expression. Previously, two PNAs conjugated with cell-penetrating peptides (P-PNAs), antisense PNA (ASP)-cmk and ASP-deoD, targeting two essential genes in S. aureus, were constructed, and their antibacterial activities were analyzed. Objectives: This study analyzed the combined antibacterial effects of P-PNAs on S. aureus and S. pseudintermedius clinical isolates. Methods: S. aureus ATCC 29740 cells were treated simultaneously with serially diluted ASP-cmk and ASP-deoD, and the minimal inhibitory concentrations (MICs) were measured. The combined P-PNA mixture was then treated with S. aureus and S. pseudintermedius veterinary isolates at the determined MIC, and the antibacterial effect was examined. Results: The combined treatment of two P-PNAs showed higher antibacterial activity than the individual treatments. The MICs of two individual P-PNAs were 20 and 25 µM, whereas that of the combined treatment was 10 µM. The application of a combined treatment to clinical Staphylococcus spp. revealed S. aureus isolates to be resistant to P-PNAs and S. pseudintermedius isolates to be susceptible. Conclusions: These observations highlight the complexity of designing ASPs with high efficacy for potential applications in treating staphylococcal infections in humans and animals.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10647-10652
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• 2015

Background: The aim of our study was to establish COLD-PCR combined with an unlabeled-probe HRM approach for detecting KRAS codon 12 and 13 mutations in plasma-circulating DNA of pancreatic adenocarcinoma (PA) cases as a novel and effective diagnostic technique. Materials and Methods: We tested the sensitivity and specificity of this approach with dilutions of known mutated cell lines. We screened 36 plasma-circulating DNA samples, 24 from the disease control group and 25 of a healthy group, to be subsequently sequenced to confirm mutations. Simultaneously, we tested the specimens using conventional PCR followed by HRM and then used target-DNA cloning and sequencing for verification. The ROC and respective AUC were calculated for KRAS mutations and/or serum CA 19-9. Results: It was found that the sensitivity of Sanger reached 0.5% with COLD-PCR, whereas that obtained after conventional PCR did 20%; that of COLD-PCR based on unlabeled-probe HRM, 0.1%. KRAS mutations were identified in 26 of 36 PA cases (72.2%), while none were detected in the disease control and/or healthy group. KRAS mutations were identified both in 26 PA tissues and plasma samples. The AUC of COLD-PCR based unlabeled probe HRM turned out to be 0.861, which when combined with CA 19-9 increased to 0.934. Conclusions: It was concluded that COLD-PCR with unlabeled-probe HRM can be a sensitive and accurate screening technique to detect KRAS codon 12 and 13 mutations in plasma-circulating DNA for diagnosing and treating PA.

• Structural Engineering and Mechanics
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• v.83 no.3
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• pp.293-304
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• 2022

In this work, a novel reliability approach for combined high and low cycle fatigue (CCF) estimation is developed by combining active learning strategy with least squares support vector machines (LS-SVM) (named as ALS-SVM) surrogate model to address the multi-resources uncertainties, including working loads, material properties and model itself. Initially, a new active learner function combining LS-SVM approach with Monte Carlo simulation (MCS) is presented to improve computational efficiency with fewer calls to the performance function. To consider the uncertainty of surrogate model at candidate sample points, the learning function employs k-fold cross validation method and introduces the predicted variance to sequentially select sampling. Following that, low cycle fatigue (LCF) loads and high cycle fatigue (HCF) loads are firstly estimated based on the training samples extracted from finite element (FE) simulations, and their simulated responses together with the sample points of model parameters in Coffin-Manson formula are selected as the MC samples to establish ALS-SVM model. In this analysis, the MC samples are substituted to predict the CCF reliability of turbine blades by using the built ALS-SVM model. Through the comparison of the two approaches, it is indicated that the reliability model by linear cumulative damage rule provides a non-conservative result compared with that by the proposed one. In addition, the results demonstrate that ALS-SVM is an effective analysis method holding high computational efficiency with small training samples to gain accurate fatigue reliability.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.26 no.5B
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• pp.481-488
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• 2006

This paper suggests a novel approach of integrating the quasi-distributed watershed model SWAT with the fully-distributed groundwater model MODFLOW. Since the SWAT model has semi distributed features, its groundwater components hardly considers distributed parameters such as hydraulic conductivity and storage coefficient. Generating a detailed representation of groundwater recharge, head distribution and pumping rate is equally difficult. To solve these problems, the method of exchanging the characteristics of the hydrologic response units (HRUs) in SWAT with cells in MODFLOW by fully combined manner is proposed. The linkage is completed by considering the interaction between the stream network and the aquifer to reflect boundary flow. This approach is provisionally applied to Gyungancheon basin in Korea. The application demonstrates a combined model which enables an interaction between saturated zones and channel reaches. This interaction plays an essential role in the runoff generation in the Gyungancheon basin. The comprehensive results show a wide applicability of the model which represents the temporal-spatial groundwater head distribution and recharge.

• MALSORI
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• no.62
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• pp.97-112
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• 2007

The speech recognizer in general operates in noisy acoustical environments. Many research works have been done to cope with the acoustical variations. Among them, the multiple-HMM model approach seems to be quite effective compared with the conventional methods. In this paper, we consider a multiple-model approach combined with the model compensation method and investigate the necessary number of the HMM model sets through noisy speech recognition experiments. By using the data-driven Jacobian adaptation for the model compensation, the multiple-model approach with only a few model sets for each noise type could achieve comparable results with the re-training method.

• International Journal of Aeronautical and Space Sciences
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• v.14 no.1
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• pp.67-74
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• 2013

Nonlinear guidance law combined with a pseudo pursuit guidance is proposed, to perform stationary target observation mission. Multiple UAVs are considered, with waypoint constraint. The whole guidance is divided into two steps: firstly, waypoint approach, with specified incidence angle; and secondly, loitering around the stationary target. Geometric approach is used to consider the constraint on the waypoint, and a specified phase angle between the loitering UAV and the approaching UAV. In the waypoint approach step, UAVs fly to the waypoint using the pseudo pursuit guidance law. After passing the waypoint, UAVs turn around the target, using a distance error dynamics-based guidance law. Numerical simulations are performed, to verify the performance of the proposed guidance law.

• Proceedings of the Korea Association of Information Systems Conference
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• 2002.11a
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• pp.289-312
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• 2002

This study suggests the Link weight analysis approach to choose input variables and an integrated model to make more accurate bankruptcy prediction model. the Link weight analysis approach is a method to choose input variables to analyze each input node's link weight which is the absolute value of link weight between an input nodes and a hidden layer. There are the weak-linked neurons elimination method, the strong-linked neurons selection method in the link weight analysis approach. The Integrated Model is a combined type adapting Bagging method that uses the average value of the four models, the optimal weak-linked-neurons elimination method, optimal strong-linked neurons selection method, decision-making tree model, and MDA. As a result, the methods suggested in this study - the optimal strong-linked neurons selection method, the optimal weak-linked neurons elimination method, and the integrated model - show much higher accuracy than MDA and decision making tree model. Especially the integrated model shows much higher accuracy than MDA and decision making tree model and shows slightly higher accuracy than the optimal weak-linked neurons elimination method and the optimal strong-linked neurons selection method.

• Proceedings of the KIEE Conference
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• 2006.04b
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• pp.316-318
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• 2006

It can be considered that the safety of software is combined with that of hardware, and also directly connected to system safety. Because the software in the railway system takes the form of Embedded that let it behave at the system level, instead of independent operation, the safety of the railway S/W is also important. The approach, for ensuring the quality and safety of those software, can be considered with two points of view. Those are views seeing from products, and from processes. The two points of approach are all necessary in the railway system. For the first of all, the process approach is to validate maturity of the organizations in accordance to the judging processes of organizations, which are specified by CMMI(Capability Maturity Model Integration) or SPICE(Software Process Improvement and Capability dEtermination: ISO/IECl5504). In this paper, as the first step of them, we are trying to find approaches to estimate the maturity of manufacturer and assessment organization in the railway system.

• Korean Journal of Head & Neck Oncology
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• v.22 no.2
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• pp.155-158
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• 2006

Intrathoracic goiters can be classified anterior and posterior mediastinal goiter with its locations. Most intrathoracic goiters are retrosternally situated in the anterior mediastinal compartment. Posterior mediastinal goiters are rare, but might present a difficult diagnostic and surgical problem. Although thyroid goiters are nearly always amenable to a cervical approach, posterior mediastinal goiters may require a combined cervicothoracic approach with sternotomy or thoracothomy. We herein describe a case of posterior mediastinal goiter which was excised only by cervical approach. The relevant literature is briefly reviewed.