• 대한한의학방제학회지
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• 제19권1호
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• pp.23-34
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• 2011

Objectives : Yiemyo-San(二妙散) is a basic oriental medicinal prescription used in basically musculoskeletal pain. Way down to posterity, Yiemyo-San has been combined with various prescriptions to treat a variety of diseases. the purpose of In this study is to investigate indications and etiology of indication using Yiemyo-San. Methodes : For prescriptions combining Yiemyo-San in Dongyeubogam(東醫寶鑑), the name of prescriptions, configuration herbs and indication were investigated and prescriptions were classified according to etiology of indication. Results : the numbers of prescriptions combining Yiemyo-San in Dongyeubogam were 45. Yiemyo-San was used frequently in musculoskeletal disease such as beriberi, amyotrophy, gout and arthritis(36%). In addition, it was applied to an internal diseases, ENT diseases and headache. it was used frequently in pathological condition due to supyeol(濕熱)(45%). Yiemyo-San was combined with various prescriptions as a primary prescription at 51% and as a secondary prescription at 49%. Conclusions : When Yiemyo-San is combined with other prescription, it may be used in various disease as well as musculoskeletal disease due to supyeol. combined with various prescriptions as a primary prescription at 51% and as a secondary prescription at 49%. Conclusions : When Yiemyo-San is combined with other prescription, it may be used in various disease as well as musculoskeletal disease due to supyeol.

• 운동영양학회지
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• 제13권3호
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• pp.193-201
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• 2009

The purpose of this study was to examine the effects of combined exercise and creatine consumption to muscular function and pain in 24 middle-aged men in back pain patients. The patients were categorized into three groups; 8 patients underwent combined exercise alone, 8 patients underwent creatine consumption as well as combined exercise and the control group was 8 patients without these options. The follow-up period was 10 weeks doing aerobic exercise, resistance exercise or creatine consumption. The group that underwent creatine intake as well as combined exercise simultaneously showed significant increase on the 0°, 12°, 24°, 36°, 48°, 60° and 72° of back muscular power in the muscular function changes compared to control group, furthermore, it showed statistically significant improvement on the 24°, 36°, 48° and 60° in the combined exercise group compared to control group. However, between the group that underwent creatine consumption as well as combined exercise and the group that underwent combined exercise, the back muscular power was high in the all angles, but it was not statistically significant. The group that performed both creatine consumption and combined exercise showed pain relief relatively, comparing with either combined exercise or control group and the pain was also alleviated in the combined exercise group.

• 사상체질의학회지
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• 제19권2호
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• pp.1-10
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• 2007

1. Objectives This paper was written in order to understand prescription's combination of Taeumin. 2. Methods We analysis prescription's combination of Taeumin through pathology and new prescription in Sinchukbon(辛丑本) of ${\ulcorner}$Dongyisusebowon${\lrcorner}$. 3. Results and Conclusions New prescription of Taeumin is combined with a few specific prescription. We analysis new prescription of the exterior disease and get the basic prescription that is Chobonkwon Taeummahwang-tang(太陰麻黃湯), Chobonkwon Saengmac-san(生脈散) and Gunyul ${\cdot}$ Euiin ${\cdot}$ Nabokja(乾栗 ${\cdot}$ 薏苡仁). And we analysis new prescription of the interior disease and get the basic prescription that is Jojung-tang(調中湯), Galgunhagi-tang(葛根解肌湯) and Isunggugo-hwan(二聖救苦丸) of old prescription. However, pharmacology of Eumhyulmogal is different from the other symptom and disease. That contain the pharmacology of Chungsimyunja-tang(淸心蓮子湯). We can't find Chungsimyunja-tang from the discussion of symptom and disease. So we can estimate that Chungsimyunja-tang belongs to the prescription of Eumhyulmogal.

• 생물정신의학
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• 제28권2호
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• pp.50-57
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• 2021

Objectives Clozapine is the most effective atypical antipsychotic agent for the treatment-resistant schizophrenia (TRS), however, only 40%-70% of TRS patients respond to clozapine. Moreover, TRS encompasses various symptom dimensions. Therefore, augmentation with other medications for clozapine is frequently applied. However, the prescription pattern of clozapine and combined medications in Korea is yet to be examined. This study aims to investigate the maintenance treatment pattern of clozapine and augmentation agents in one Korean tertiary hospital. Methods The patients with schizophrenia spectrum disorders under clozapine maintenance, defined as one-year clozapine continuation, were subjected for analysis. Medication data at one-year time-point after clozapine initiation was extracted and analyzed. Results Among total 2897 patients having clozapine prescription experience from January 2000 to December 2018, 1011 patients were on clozapine maintenance. The mean age of clozapine initiation was 30.2 ± 11.3 years, and the maintenance dose of clozapine was 217.8 ± 124.3 mg/day. Combination rate of antipsychotics, mood stabilizers, and antidepressants were 43.5%, 25.3%, 38.6%, respectively. Most frequently prescribed drugs in each category were aripiprazole, valproate, and sertraline. Olanzapine equivalent dose of combined antipsychotics was 10.4 ± 7.7 mg/day. Male patients were prescribed higher dose of combined antipsychotics and higher rate of antidepressants. Female patients had later onset of clozapine prescription. Patients with two or more combined antipsychotics were prescribed higher dose of clozapine and higher rate of antidepressants compared to patients with one combined antipsychotic. Conclusions Taken together, among the patients taking clozapine, a substantial rate of patients were under polypharmacy. The present findings based on the real-world prescription pattern could provide the valuable clinical information on the treatment of TRS-related conditions.

• International journal of advanced smart convergence
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• 제10권4호
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• pp.206-214
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• 2021

The purpose of this study is to identify the level of polypharmacy use, drug knowledge, and drug misuse behavior in the elderly, and to understand the correlation between them and their effect on drug misuse behavior. The study design was a descriptive survey study, and the participants of the study were 215 elderly people from the local community center. The research tool used drug knowledge, drug misuse behavior, and the data collection period was from February 8 to 19, 2021. The data analysis were descriptive statistics, t-test, one-way ANOVA, Pearson's correlation coefficient, and regression analysis. As a result of the study, a significant correlation variable for the drug knowledge of the elderly showed a significant correlation with prescription and non-prescription, r=.145 (p<0.05), and r=.-. 136, which showed a negative significant correlation (p<0.05). As for the significant correlation variable in the drug misuse behavior of the elderly, when prescription and non-prescription were combined, there was a significant correlation with r=.256 (p<0.01), and when not using drugs, r=.-.225 was negative. showed a significant correlation (p<0.01). In terms of the effect on drug misuse behavior, chronic disease =.145, prescription and non-prescription use = .233, which had a positive effect, and non-prescription = -.328, indicating a negative and significant effect. The provision of education on the safe use of drugs by the elderly should first be provided in the community. In addition, we need systematic education and social support for the transmission of correct knowledge on multi-drug use by the elderly and for health management.

• 대한한의학방제학회지
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• 제20권2호
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• pp.103-116
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• 2012

Objectives : Bangyakhappyeon was classified into three tongs of prescription. When juxtaposed with existing publications on oriental medicine, this composition was considerably original. Due to its ease of searching for diseases and prescription, it has been read by not only doctors and researchers but also among general citizens alike. Based on the fundamentals of Bangyakhappyeon composition, this thesis focused on the thorough research on the prescription of Bupleuri Radix mixture. Methods : 42 prescriptions of Bupleuri Radix mixtures have been divided in to three tongs based on the composition of Bangyakhappyeon. Then, these prescriptions, dosage, and composition were researched and organized. Results : After analyzing the prescription of Bupleuri Radix mixture in the Uibanghwaltu chapter of the Bangyakhappyeon text, the following results were attained. 1. Of the 42 prescriptions of Bupleuri Radix mixtures, jungtong constitutes the most prescription at 30, 8 at hatong, and 4 at sangtong. 2. 42 prescriptions are documented into 18 medical divisions and 44 disease symptoms. 3. After analyzing the prescription dosage of Bupleuri Radix mixture, the dosage of Bupleuri Radix was 3 puns to 4 jeons used in 14 sections. Most use was 1 jeon 14 prescriptions, 33.3% were recorded. 4. Invigorating vital function, catharsis, malaria, mediation method, and clearing away method of Bupleuri Radix have a close relationship with the dosage. 5. The 42 prescriptions formation of using Bupleuri Radix consisted of decoction at 39 prescriptions (92.9%) and the others at 3 prescriptions (7.1%). 6. As a result of researching the component of the prescription of Bupleuri Radix mixture, Sosihotang, Soyosan and Bojungikgitang were used as the basic prescription. Conclusions : prescription of Bupleuri Radix mixture in Uibanghwaltu of Bangyakhappyeon as based on Sosihotang, Soyosan and Bojungikgitang, combined with various oriental medicine was found to treat many kinds of diseases.

• 동의생리병리학회지
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• 제23권6호
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• pp.1282-1291
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• 2009

A combined prescription of GGB and CHS (G&C prescription group) was used to investigate its effects on immune related factors and histological changes in atopic dermatitis(AD) induced mice. Significant decrease of atopic dermatitis clinical index in G&C prescription group. In DLN, G&C prescription group significantly modulated the immune cells. G&C prescription group also showed significant effect on the immune cells of the dorsal skin as well as DLN. The group indicated significant decrease of the biosynthesis of IL-4, IL-5, IL-13, GM-CSF, cytokines in serum. On the other hand, the biosynthesis of TNF-$\alpha$ was decreased. G&C prescription group significantly decreased the immunoglobulin IgE levels in serum. The results suggest that G&C prescription significantly improves atopic dermatitis through regulation of immune cells and cytokines. Comparative studies with Protopic ointment also showed that G&C prescription showed significant effect in AD patients, and active application of the prescription in clinicals is anticipated. However, the reason for the results that oppose to those of previous studies should be investigated. Also, therapeutic effects of both internal and external applications should be studied individually as well as for any synergistic effects. Safety, toxicity, as well as stability studies should follow to develop G&C prescription into long-term external clinical product.

• Journal of Acupuncture Research
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• 제22권3호
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• pp.113-122
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• 2005

한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 유발된 생쥐의 당뇨병에 미치는 영향에 확인한 결과 다음과 같은 결론을 얻었다. 1. 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술이 STZ에 의한 혈청 중 insulin 함량에는 변화를 나타내지 않았으나 혈청 중 glucose 함량은 감소시켰다. 2. 한약복합여방(韓藥複合濾方)의 경구 투여 및 약침 병용 시술이 STZ에 의해 상승된 혈청 중 triglyceride 함량을 유의하게 감소시켰으나 혈청 중 total cholesterol 함량에는 영향을 나타내지 못했다. 3. STZ 투여로 인해 혈청 내 지질과산화물의 함량이 증가되었으나 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술은 이에 영향을 미치지 못 하였다. 4. STZ에 의해 증가된 catalase활성이 한약복합처방(韓藥複合處方)의 경구 투여 및 약침 병용 시술에 의해 감소되었으나, GSH의 활성에는 유의한 변화가 나타나지 않았다.

• 대한예방한의학회지
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• 제24권2호
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• pp.57-62
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• 2020

Objectives : This study is retrospective chart review research on the combined-prescription of Western and Korean medicine in Public Health Center in rural area. Methods : Researchers reviewed medical records of patients who was prescribed Korean medicine and Western medicine from 1st, Jan, 2019 to 31st, Dec, 2019 in Public Health Center. 50 patients' medical records were included. Results : Total number of treatment is 3,808 cases and 1.3% of them is prescribed Korean medicine and Western medicine simultaneously. Prescription of Korean medicine is 153 cases and Western medicine is 160. Jowiseunggi-tang and Diroba tablet were the most frequently prescribed Korean medicine and Western medicine. Furthermore, Korean Medicine Doctors of Public Health Center use muscular skeletal disease system code(M code among KCD code) for prescription and Western Medicine Doctors use diseases of the circulatory system(I code among KCD code) frequently. Conclusions : We analyze 50 patients who were prescribed both Korean medicine and Western medicine. Mostly, patients were prescribed medicine for different diseases in each clinic. In western medicine clinic, drugs about circulatory or endocrine disease were prescribed frequently and in Korean Medicine clinic, drugs about muscular skeletal disease were most frequently prescribed. This result imply the real world's combination of prescription status that was different from result of National health insurance corporation database. Senior patients in rural area take medicine long period and have various underlying disease. We call for some attention about senior and rural area patients' prescription status in interaction studies of Korean medicine and Western medicine.

• 대한임상검사과학회지
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• 제49권2호
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• pp.88-98
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• 2017

비 스테로이드성 항염증제에 대한 개별적 독성증상을 예방하기 위해 로박스 플라티넘(Robax Platinum), 로박스아세트(Robaxacet), 나프록센(Naproxen) 그리고 재활치료를 선택적으로 처방하여 비 스테로이드 진통소염제(Non-Steroidal Anti-Inflammatory Drugs)에 대한 독성증상을 예방을 위한 효과 비교 연구를 진행하였다. 이 연구에서는 로박스 플라티넘(Robax platinum), 로박스아세트(Robaxacet), 나프록센(Naproxen)을 주한미군 처방전(Annex A-Over-The-Counter Prescription)을 기준으로 하여 처방하였고, 앨리스 리치의 통증 척도(Alice Rich's Pain Scale)를 사용하여 통증 경과를 비교하고 그 결과를 IBM SPSS statics 24 버전을 사용하여 데이를 계산했다. 결합된 메토카바몰(Methocarbamol, 500 mg), 아세트아미노펜(Acetaminophen, 325 mg), 이부프로펜(Ibuprofen, 200 mg) 정제는 결합된 메토카바몰(Methocarbamol, 500 mg) 정제와 함께 사용할 수 있다. 아세트아미노펜 (Acetaminophen, 325 mg)의 알약이 통증을 조절하는 방법으로 사용되었다. 메도카바몰 500mg, 아세트아미토펜 325 mg 및 이부프로펜 200 mg 정제의 약물 조합은 메도카바몰 500 mg 및 아세트아미노펜 325 mg 정제가 전반적인 통증 조절과 관련하여 물리적인 스트레칭 운동과 쌍을 이룬 것과 유사한 통증 완화효과를 나타내었다.