• Biomolecules & Therapeutics
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• v.4 no.3
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• pp.280-284
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• 1996

Licorice has been widely used in combination with other herbs or synthetic drugs for various disorders. In an effort to study the effect of licorice roots (Glycyrrhizae Radix, GR) and glycyrrhizin on the hepatic glucuronidation, we have previously found that the pretreatment of GR or glycyrrhizin for 6 days resulted in a marked increase in the enzymatic activity of 3-methylcholanthrene (3-MC)-inducible hepatic UDP-glucuronosyltransferase (UGT) isozyme that has high affinity toward phenolic substrates (p-nitrophenol form, UGTIA) in Sprague-Dawley rats. As an approach to elucidate the mechanism for the enzyme activation by licorice in rat liver, we examined the levels of hepatocellular mRNAs for UGTIA upon the treatment of GR or glycyrrhizin. The hepatic mRNAs were extracted from Sprague-Dawley rats and Wistar rats after the treatment of the methanol extract of GR (1 g/kg, p.o.), glycyrrhizin (23 mg/kg, p.o.) for 6 days, or 3-MC (40 mg/kg, i.p.) for 3 days. Using the UGT1A1 CDNA as a probe, we found that the mRNAs for the enzyme were induced by 3-MC treatment while those were influenced neither by GR nor by glycyrrhizin in both strains of rats. These results indicate that the activation of rat liver UGTI A by licorice and glycyrrhizin was not due to the induction of mRNAs for the enzyme.

• Wind and Structures
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• v.7 no.6
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• pp.373-392
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• 2004

This paper presents a methodology for spatial extrapolation of wind-induced pressure time series from a corner bay to roof locations on a low building away from the corner through the application of proper orthogonal decomposition (POD). The approach is based on the concept that pressure time series in the far field can be approximated as a linear combination of a series of modes and principal coordinates, where the modes are extracted from the full roof pressure field of an aerodynamically similar building and the principal coordinates are calculated from data at the leading corner bay only. The reliability of the extrapolation for uplift time series in nine bays for a cornering wind direction was examined. It is shown that POD can extrapolate reasonably accurately to bays near the leading corner, given the first three modes, but the extrapolation degrades further from the corner bay as the spatial correlations decrease.

• Steel and Composite Structures
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• v.19 no.3
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• pp.615-633
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• 2015

Composite steel-concrete beams are used frequently in situations where axial forces are introduced. Some examples include the use in cable-stayed bridges or inclined members in stadia and bridge approach spans. In these situations, the beam may be subjected to any combination of flexure and axial load. However, modern steel and composite construction codes currently do not address the effects of these combined actions. This study presents an analysis of composite beams subjected to combined loadings. An analytical model is developed based on a cross-sectional analysis method using a strategy of successive iterations. Results derived from the model show an excellent agreement with existing experimental results. A parametric study is conducted to investigate the effect of axial load on the flexural strength of composite beams. The parametric study is then extended to a number of section sizes and employs various degrees of shear connection. Design models are proposed for estimating the flexural strength of an axially loaded member with full and partial shear connection.

• Macromolecular Research
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• v.14 no.5
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• pp.499-503
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• 2006

This report presents a new technical approach for evaluating the fiber orientation of composites using small-angle light scattering (SALS). Glass fiber (GF)/polypropylene (PP) composites with different fiber orientations were prepared by drawing compression-molded specimens. The drawn samples were remelted and then annealed at $150^{\circ}C$ in order to induce a crystalline structure on the fiber surface, and then underwent SALS analysis. The samples showed a combination of circular and streak patterns. The model calculations demonstrated that the number of nuclei on the fiber surface and the thickness of the transcrystalline layer affected the sharpness and intensity of the streak pattern. In addition, the azimuthal angle of the streak pattern was found to be dependent on the direction of the transcrystalline layer, which correlated with the fiber direction. This correlation suggests that the fiber orientation in the composites can be easily evaluated using SALS.

• Korean Journal of Bronchoesophagology
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• v.17 no.1
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• pp.46-49
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• 2011

Background and Objectives Cervical necrotizing fasciitis is a fulminant disease associated with necrosis of connective tissue, spread along the fascial plane, and high mortality. We analyzed the clinical characteristics and treatment outcome of this rare fatal disease. Materials and Methods We retrospectively reviewed the medical records of 19 patients treated for cervical necrotizing fasciitis from January 1999 to January 2009. Mean age was 53.7 years. Results The most common predisposing illness was tonsillitis (36.8%), followed by odontogenic infection (15.7%). Diabetes mellitus was most common underlying disease. Liver cirrhosis and chronic renal failure were found in 2 patients each. All patients were treated with combination of parenteral antibiotics and wide surgical debridement by transcervical and/or thoracotomy approach. Multiple surgical debridements were performed in 7 patients. Tracheotomy was performed in most of the patients (88.8%). Period of total hospitalization and Intensive care unit was 23 days and 10.1 days. Two patients died of disease and overall survival rate was 89.4%. Conclusion Early surgical management and care in intensive care unit are essential for cervical necrotizing fasciitis. Possible complications such as respiratory failure, mediastinitis or sepsis should be carefully evaluated.

• Geophysics and Geophysical Exploration
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• v.7 no.1
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• pp.99-104
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• 2004

A combination of drilling, geophysical well logging, and electrical soundings was performed to evaluate seawater intrusion in Baeksu-eup, Youngkwang-gun, Korea. The survey area extends for over 24 $km^2$. To delineate the extent of seawater intrusion, 60 vertical electrical soundings (VES) have been carried out. Twelve wells were also drilled for the collection of hydrogeological, geochemical, and geophysical well logging data, to delineate the degree and vertical extent of seawater intrusion. To map the spatial distribution of seawater in this coastal aquifer, geophysical data and hydrogeochemical results were used, and the relation between the resistivity of groundwater and equivalent NaCl concentration was found. Layer parameters derived from VES data, various in-situ physical properties from geophysical well logging, and the estimated equivalent NaCl concentration were very useful for quantitative evaluation of seawater intrusion. Our approach for evaluating seawater intrusion can be considered a valuable attempt at enhancing the use of geophysical data.

• YAKHAK HOEJI
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• v.17 no.3
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• pp.129-136
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• 1973

In order to establish the chemical standards for the quality control of ginsentgextract, an approach for the assay of sapogenin contents in the part of main roots and fibrous side roots was performed by combination of preparative thin layer chromotographic procedure and vanillin-$H_{2}SO_{4}$ color reaction. The contents of dammarane aglycones as funcction of dammarane glycosides in 80%-EtOH extracts were analyzed by the method from the main roots and fibrous side roots of Korean ginseng grown for 4-6 years. The differences by their grown ages in the contents of dammarane glycosides, in the ratio of panaxadiol to panaxatriol contents, and in the mounts of 80% EtOH extract were not significant in the parts of main roots and fibrous side roots of Korean gingeng. Differences due to the part for medicinal uses were highly significant in all parameters mentioned, showing following results ; in the main roots ; 80% EtOH extract, 12.7-15.7 % : the ratio of aglycone composition, 0.955-1.012 : dammarane glycoside (as diglucoside bases), 1.537-1.863 ; in fibrous isde roots ; 80% EtOH extract, 26.0-26.02% : dammarane glycoside, 4.767-5.641 : the ratio, 1.456-1.50.

• Nuclear Engineering and Technology
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• v.52 no.11
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• pp.2522-2534
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• 2020

It is well known that the model of nuclear reactors features natural nonlinearity, and variable parameters during power tracking operation. In this paper, a disturbance observer-based adaptive sliding mode control (DOB-ASMC) strategy is proposed for power tracking of the pressurized-water reactor (PWR) in the presence of lumped disturbances. The nuclear reactor model is firstly established based on point-reactor kinetics equations with six delayed neutron groups. Then, a new sliding mode disturbance observer is designed to estimate the lumped disturbance, and its stability is discussed. On the basis of the developed DOB, an adaptive sliding mode control scheme is proposed, which is a combination of backstepping technique and integral sliding mode control approach. In addition, an adaptive law is introduced to enhance the robustness of a PWR with disturbances. The asymptotic stability of the overall control system is verified by Lyapunov stability theory. Simulation results are provided to demonstrate that the proposed DOB-ASMC strategy has better power tracking performance than conventional sliding mode controller and PID control method as well as conventional backstepping controller.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.1
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• pp.45-60
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• 1995

It is attempted to estimate excitation force of a linear vibratory system using measured vibration responses. The excitation force is estimated from the relationship between the vibration response and system characteristic matrices which are extracted from both the mathematical model of the system and actual response in contrast to the usual approach of inverting the frequency response matrices. This extraction scheme is based on the fact that the vibration response can be expressed in term of linear combination of frequency domain modal vectors defined as mutually orthonormal basis vectors in frequency domain. The extracted frequency domain basis vectors are very stable in computational manipulation. It is found that the estimated excitation force is in good agreement with actually measured force except at the natural frequencies the structure, which is the common feature still to be overcome by the research efforts in this area. From the results of this paper, this disagreement is considered to come from the discrepancy between the model and actual value of the mass, damping and stiffness of the structure.

• The Journal of Korean Society for Radiation Therapy
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• v.7 no.1
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• pp.15-31
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• 1995

The radiosurgery treatment is one time, non surgical approach to the treatment of patients with intracranial disorders whose conditions would be difficult or dangerous to treat with conventional sugical procedures. The LINAC based radiosurgery is based on the combination of multiple isocentric arc irradiation with small fields centered in the stereotactic target. The absorption of the beam in a tissue equivalent medium, such as water, as well as the uniformity, or profile, of the beam must be precisely documented. The beam characteristics and dosimetric measurememts of the 6MV X-ray beam from a ML-6M linear accelerator are examined. The percent depth dose (PDD) and beam profile (including flatness, symmetry and penumbra) is calibrated with the radiosurgery cone in water phantom. The cone is made of lead which size is from $10{\times}10mm{\phi}$ to $30{\times}30mm{\phi}$ All of these dosimetric measurements sufficiently characterized the beam to permit safe clinical use.