• Structural Engineering and Mechanics
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• v.77 no.5
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• pp.691-703
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• 2021

Reinforced concrete (RC) beams can be subjected to a complex combination of shear forces (V), torsional moments (T), flexural moments (M) and axial loads (N). This paper proposes a unified approach for the analysis of these elements. An existing model for the analysis of orthogonally reinforced concrete membrane elements subjected to in-plane shear and normal stresses is generalized to apply to the case of beams subjected to the complex loading. The combination of V and T can be critical. Torsion is modelled using the hollow-tube analogy. A direct equation for the calculation of the thickness of the equivalent hollow tube is proposed, and the shear stresses caused by V and T are combined using a simple approach. The development and the evaluation of the model are described. The calculations of the model are compared to experimental data from 350 beams subjected to various combinations of stress-resultants and to the calculations of the ACI and the CSA codes. The proposed model provides the most favorable results. It is also shown that it can accurately model the interaction between V and T. The proposed model provides a unified treatment of shear in beams subjected to complex stress-resultants and in thin membrane elements subjected to in-plane stresses.

• Archives of Plastic Surgery
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• v.41 no.6
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• pp.686-692
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• 2014

Background Restoring orbital volume in large blowout fractures is still a technically challenge to the orbital surgeon. In this study, we restored the orbital wall using the combination of transorbital and transnasal approach with additional supports from the paranasal sinuses, and we compared the surgical outcome to that of a conventional transorbital method. Methods A retrospective review of all patients with pure unilateral blowout fractures between March 2007 and March 2013 was conducted. 150 patients were classified into two groups according to the surgical method: conventional transorbital method (group A, 75 patients, control group), and the combination of transorbital and transnasal approach with additional supports from the paranasal sinuses (group B, 75 patients, experimental group). Each group was subdivided depending on fracture location: group I (inferior wall), group IM (inferomedial wall), and group M (medial wall). The surgical results were assessed by the Hertel scale and a comparison of preoperative and postoperative orbital volume ratio (OVR) values. Results In the volumetric analysis, the OVR decreased more by the experimental groups than each corresponding control groups (P<0.05). Upon ophthalmic examination, neither the differences among the groups in the perioperative Hertel scale nor the preoperative and postoperative Hertel scales were statistically significant (P>0.05). Conclusions Our surgical results suggest that orbital volume was more effectively restored by the combination of transorbital and transnasal approach with additional supports from the paranasal sinuses than the conventional method, regardless of the type of fracture.

• Journal of Korea Water Resources Association
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• v.49 no.2
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• pp.165-175
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• 2016

In order to examine the applicability, the evaporation estimation approaches based on solar radiation are classified into 3 different model groups (Model groups A, B, and C) in this study. Each group is tested in the 6 study stations (Seoul, Daejeon, Jeonju, Busan, Mokpo, and Jeju). The model parameters of each model group are estimated and verified with measured pan evaporation data. The applicability of verified model groups are compared with results of Penman (1948) combination approach. Nash-Sutcliffe (N-S) efficiency coefficients greater than 0.663 in all study stations indicate satisfactory estimates of evaporation. On the other hand, in the model verification process, N-S efficiency coefficients greater than 0.526 in all study stations indicate also satisfactory estimates of evaporation. However, N-S efficiency coefficients in all study cases except Model groups B and C in Busan are less than those of Penman (1948) combination approach. Therefore, it is concluded in this study that the evaporation estimation approaches based on solar radiation have capability to replace Penman (1948) combination approach for the estimation of evaporation in case that some meteorological data (wind speed, relative humidity) are missing or not measured.

• Journal of Korea Water Resources Association
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• v.56 no.spc1
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• pp.1007-1014
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• 2023

Two-dimensional flow analysis, a fundamental component of hydrodynamics, plays a pivotal role in numerically simulating fluid behavior in rivers and waterways. This modeling approach heavily relies on parameters such as eddy viscosity and roughness coefficient to accurately represent flow characteristics. Therefore, combination of appropriate parameters is very important to accurately simulate flow characteristics. In this study, an automation algorithm was developed and applied to find the optimal combination of parameters. Previously, when applying a two-dimensional flow analysis model, former researchers usually depend on the empirical approach, which causes many difficulties in finding optimal variable values. Using the experimental data, we tracked errors according to the combination of various parameters and applied the algorithm that can determine the optimal combination of parameters with the Python language. The automation algorithm can easily determine the most accurate combination by comparing the flow velocity error values among the two-dimensional flow analysis results among the combinations of 121 (11×11) parameters. In the perspective of utilizing automation algorithm, there is an expected high utility in promptly and straightforwardly determining the optimal combination of parameters with the smallest error.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.473-481
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• 2020

Axl receptor tyrosine kinase has been implicated in cancer progression, invasion, and metastasis in various cancer types. Axl overexpression has been observed in many cancers, and selective inhibitors of Axl, including R428, may be promising therapeutic agents for several human cancers, such as breast, lung, and pancreatic cancers. Here, we examined the cell growth inhibition mediated by R428 and auranofin individually as well as in combination in the human breast cancer cell lines MCF-7 and MDA-MB-231 to identify new advanced combination treatments for human breast cancer. Our data showed that combination therapy with R428 and auranofin markedly inhibited cancer cell proliferation. Isobologram analyses of these cells indicated a clear synergism between R428 and auranofin with a combination index value of 0.73. The combination treatment promoted apoptosis as indicated by caspase 3 activation and poly (ADP-ribose) polymerase cleavage. Cancer cell migration was also significantly inhibited by this combination treatment. Moreover, we found that combination therapy significantly increased the expression level of Bax, a mitochondrial proapoptotic factor, but decreased that of the X-linked inhibitor of apoptosis protein. Furthermore, the suppression of cell viability and induction of Bax expression by the combination treatment were recovered by treatment with N-acetylcysteine. In conclusion, our data demonstrated that combined treatment with R428 and auranofin synergistically induced apoptosis in human breast cancer cells and may thus serve as a novel and valuable approach for cancer therapy.

• Journal of Pharmacopuncture
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• v.19 no.4
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• pp.312-318
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• 2016

Objectives: Bacterial resistant infections have become a global health challenge and threaten the society's health. Thus, an urgent need exists to find ways to combat resistant pathogens. One promising approach to overcoming bacterial resistance is the use of herbal products. Green tea catechins, the major green tea polyphenols, show antimicrobial activity against resistant pathogens. The present study aimed to investigate the effect of catechins, green tea extract, and methylxanthines in combination with gentamicin against standard and clinical isolates of Staphylococcus aureus (S. aureus) and the standard strain of Pseudomonas aeruginosa (P. aeruginosa). Methods: The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) values of different agents against bacterial strains were determined. The interactions of green tea extract, epigallate catechin, epigallocatechin gallate, two types of methylxanthine, caffeine, and theophylline with gentamicin were studied in vitro by using a checkerboard method and calculating the fraction inhibitory concentration index (FICI). Results: The MICs of gentamicin against bacterial strains were in the range of $0.312-320{\mu}g/mL$. The MIC values of both types of catechins were $62.5-250{\mu}g/mL$. Green tea extract showed insufficient antibacterial activity when used alone. Methylxanthines had no intrinsic inhibitory activity against any of the bacterial strains tested. When green tea extract and catechins were combined with gentamicin, the MIC values of gentamicin against the standard strains and a clinical isolate were reduced, and synergistic activities were observed (FICI < 1). A combination of caffeine with gentamicin did not alter the MIC values of gentamicin. Conclusion: The results of the present study revealed that green tea extract and catechins potentiated the antimicrobial action of gentamicin against some clinical isolates of S. aureus and standard P. aeruginosa strains. Therefore, combinations of gentamicin with these natural compounds might be a promising approach to combat microbial resistance.

• Journal of Information Processing Systems
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• v.18 no.2
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• pp.268-281
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• 2022

The development of information technology is bringing many changes to everyday life, and machine learning can be used as a technique to solve a wide range of real-world problems. Analysis and utilization of data are essential processes in applying machine learning to real-world problems. As a method of processing data in machine learning, we propose an approach based on applying multiple linear regression models by interlacing data to the task of classifying similar software. Linear regression is widely used in estimation problems to model the relationship between input and output data. In our approach, multiple linear regression models are generated by training on interlaced feature data. A combination of these multiple models is then used as the prediction model for classifying similar software. Experiments are performed to evaluate the proposed approach as compared to conventional linear regression, and the experimental results show that the proposed method classifies similar software more accurately than the conventional model. We anticipate the proposed approach to be applied to various kinds of classification problems to improve the accuracy of conventional linear regression.

• Proceedings of the IEEK Conference
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• 2001.06c
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• pp.21-24
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• 2001

In this paper, we Propose a new computational approach to stability analysis of the linguistic control system. The FLC is assumed to be modeled as a combination of affine system. Stability is tested via the LMI. Computer simulation result is given to illustrate the validity of the suggested methodology.

• Proceedings of the IEEK Conference
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• 2001.06c
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• pp.169-172
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• 2001

In recent years, many studies regarding the modeling of fuzzy system have been conducted. In this paper, a new computational approach to modeling of linguistic fuzzy system is proposed The fuzzy system is modeled as a combination of affine systems, The proposed method can be used in a rigorous stability analysis of fuzzy system including the linguistic fuzzy controller.

• 제어로봇시스템학회:학술대회논문집
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• 1989.10a
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• pp.489-493
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• 1989

In this paper a new approach to adaptive control using a combination of both direct and indirect methods has been proposed. Based on the estimates of the plant parameters and the current values of the control parameters, closed-loop estimation errors .epsilon.$_{\theta}$(t) and .epsilon.$_{k}$(t) are defined. These in turn are used in the adaptive laws for updating both identification as well as control parameters. The global uniform stability of the overall system is shown by constructing a Lyapunov function.n.