• Title/Summary/Keyword: Combination Approach

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Fingertip reconstruction with a subcutaneous flap and composite graft composed of nail bed and volar pulp skin

  • Koh, Sung Hoon;Park, Ilou;Kim, Jin Soo;Lee, Dong Chul;Roh, Si Young;Lee, Kyung Jin;Hong, Min Ki
    • Archives of Plastic Surgery
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    • v.49 no.1
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    • pp.70-75
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    • 2022
  • Background Fingertip injuries are very common; however, the reconstruction of volar pulp defects with nail bed defects is challenging in the absence of the amputated segment. We reconstructed fingertip amputations with nail bed defects using a new surgical approach: a subcutaneous flap and composite graft. Methods We treated 10 fingertip amputation patients without an amputated segment, with exposed distal phalangeal bone and full-thickness nail bed defects between February 2018 and December 2020. All patients underwent two-stage surgery: in the first stage, a subcutaneous flap was performed to cover the exposed distal phalanx, and in the second stage, a composite graft, consisting of nail bed, hyponychium, and volar pulp skin, was applied over the subcutaneous flap. Results All flaps survived and all composite grafts were successful. The wounds healed without any significant complications, including the donor site. The average follow-up duration was 11.2 months (range, 3-27 months). The new nail and the shape of the volar pulp were evaluated during follow-up. All patients were satisfied with their natural fingertip shapes and the new nails did not have any serious deformities. Conclusions A subcutaneous flap in combination with a composite graft fitting the shape of the defect could be another option for fingertip injuries without amputated segments.

Combination of multiplex reverse transcription recombinase polymerase amplification assay and capillary electrophoresis provides high sensitive and high-throughput simultaneous detection of avian influenza virus subtypes

  • Tsai, Shou-Kuan;Chen, Chen-Chih;Lin, Han-Jia;Lin, Han-You;Chen, Ting-Tzu;Wang, Lih-Chiann
    • Journal of Veterinary Science
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    • v.21 no.2
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    • pp.24.1-24.11
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    • 2020
  • The pandemic of avian influenza viruses (AIVs) in Asia has caused enormous economic loss in poultry industry and human health threat, especially clade 2.3.4.4 H5 and H7 subtypes in recent years. The endemic chicken H6 virus in Taiwan has also brought about human and dog infections. Since wild waterfowls is the major AIV reservoir, it is important to monitor the diversified subtypes in wildfowl flocks in early stage to prevent viral reassortment and transmission. To develop a more efficient and sensitive approach is a key issue in epidemic control. In this study, we integrate multiplex reverse transcription recombinase polymerase amplification (RT-RPA) and capillary electrophoresis (CE) for high-throughput detection and differentiation of AIVs in wild waterfowls in Taiwan. Four viral genes were detected simultaneously, including nucleoprotein (NP) gene of all AIVs, hemagglutinin (HA) gene of clade 2.3.4.4 H5, H6 and H7 subtypes. The detection limit of the developed detection system could achieve as low as one copy number for each of the four viral gene targets. Sixty wild waterfowl field samples were tested and all of the four gene signals were unambiguously identified within 6 h, including the initial sample processing and the final CE data analysis. The results indicated that multiplex RT-RPA combined with CE was an excellent alternative for instant simultaneous AIV detection and subtype differentiation. The high efficiency and sensitivity of the proposed method could greatly assist in wild bird monitoring and epidemic control of poultry.

Derivation of endothelial cells from porcine induced pluripotent stem cells by optimized single layer culture system

  • Wei, Renyue;Lv, Jiawei;Li, Xuechun;Li, Yan;Xu, Qianqian;Jin, Junxue;Zhang, Yu;Liu, Zhonghua
    • Journal of Veterinary Science
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    • v.21 no.1
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    • pp.9.1-9.15
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    • 2020
  • Regenerative therapy holds great promise in the development of cures of some untreatable diseases such as cardiovascular diseases, and pluripotent stem cells (PSCs) including induced PSCs (iPSCs) are the most important regenerative seed cells. Recently, differentiation of human PSCs into functional tissues and cells in vitro has been widely reported. However, although porcine reports are rare they are quite essential, as the pig is an important animal model for the in vitro generation of human organs. In this study, we reprogramed porcine embryonic fibroblasts into porcine iPSCs (piPSCs), and differentiated them into cluster of differentiation 31 (CD31)-positive endothelial cells (ECs) (piPSC-derived ECs, piPS-ECs) using an optimized single-layer culture method. During differentiation, we observed that a combination of GSK3β inhibitor (CHIR99021) and bone morphogenetic protein 4 (BMP4) promoted mesodermal differentiation, resulting in higher proportions of CD31-positive cells than those from separate CHIR99021 or BMP4 treatment. Importantly, the piPS-ECs showed comparable morphological and functional properties to immortalized porcine aortic ECs, which are capable of taking up low-density lipoprotein and forming network structures on Matrigel. Our study, which is the first trial on a species other than human and mouse, has provided an optimized single-layer culture method for obtaining ECs from porcine PSCs. Our approach can be beneficial when evaluating autologous EC transplantation in pig models.

A Multi-step Time Series Forecasting Model for Mid-to-Long Term Agricultural Price Prediction

  • Jonghyun, Park;Yeong-Woo, Lim;Do Hyun, Lim;Yunsung, Choi;Hyunchul, Ahn
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.2
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    • pp.201-207
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    • 2023
  • In this paper, we propose an optimal model for mid to long-term price prediction of agricultural products using LGBM, MLP, LSTM, and GRU to compare and analyze the three strategies of the Multi-Step Time Series. The proposed model is designed to find the optimal combination between the models by selecting methods from various angles. Prior agricultural product price prediction studies have mainly adopted traditional econometric models such as ARIMA and LSTM-type models. In contrast, agricultural product price prediction studies related to Multi-Step Time Series were minimal. In this study, the experiment was conducted by dividing it into two periods according to the degree of volatility of agricultural product prices. As a result of the mid-to-long-term price prediction of three strategies, namely direct, hybrid, and multiple outputs, the hybrid approach showed relatively superior performance. This study academically and practically contributes to mid-to-long term daily price prediction by proposing an effective alternative.

Lifetime Escalation and Clone Detection in Wireless Sensor Networks using Snowball Endurance Algorithm(SBEA)

  • Sathya, V.;Kannan, Dr. S.
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.16 no.4
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    • pp.1224-1248
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    • 2022
  • In various sensor network applications, such as climate observation organizations, sensor nodes need to collect information from time to time and pass it on to the recipient of information through multiple bounces. According to field tests, this information corresponds to most of the energy use of the sensor hub. Decreasing the measurement of information transmission in sensor networks becomes an important issue.Compression sensing (CS) can reduce the amount of information delivered to the network and reduce traffic load. However, the total number of classification of information delivered using pure CS is still enormous. The hybrid technique for utilizing CS was proposed to diminish the quantity of transmissions in sensor networks.Further the energy productivity is a test task for the sensor nodes. However, in previous studies, a clustering approach using hybrid CS for a sensor network and an explanatory model was used to investigate the relationship between beam size and number of transmissions of hybrid CS technology. It uses efficient data integration techniques for large networks, but leads to clone attacks or attacks. Here, a new algorithm called SBEA (Snowball Endurance Algorithm) was proposed and tested with a bow. Thus, you can extend the battery life of your WSN by running effective copy detection. Often, multiple nodes, called observers, are selected to verify the reliability of the nodes within the network. Personal data from the source centre (e.g. personality and geographical data) is provided to the observer at the optional witness stage. The trust and reputation system is used to find the reliability of data aggregation across the cluster head and cluster nodes. It is also possible to obtain a mechanism to perform sleep and standby procedures to improve the life of the sensor node. The sniffers have been implemented to monitor the energy of the sensor nodes periodically in the sink. The proposed algorithm SBEA (Snowball Endurance Algorithm) is a combination of ERCD protocol and a combined mobility and routing algorithm that can identify the cluster head and adjacent cluster head nodes.This algorithm is used to yield the network life time and the performance of the sensor nodes can be increased.

Optimization of Gate and Process Design Factors for Injection Molding of Automotive Door Cover Housing (자동차 도어용 커버 하우징의 사출성형을 위한 게이트 및 공정 설계인자의 최적화)

  • Yu, Man-Jun;Park, Jong-Cheon
    • Journal of the Korean Society of Manufacturing Process Engineers
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    • v.21 no.7
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    • pp.84-90
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    • 2022
  • The purpose of the cover housing component of a car door is to protect the terminals of the plug housing that connects the electric control unit on the door side to the car body. Therefore, for a smooth assembly with the plug housing and to prevent contaminants from penetrating into the gaps that occur after assembly, the warpage of the cover housing should be minimized. In this study, to minimize the warpage of the cover housing, optimization was performed for design factors related to the mold and processes based on the injection molding simulation. These design factors include gate location, gate diameter, injection time, resin temperature, mold temperature, and packing pressure. To optimize the design factors, Taguchi's approach to the design of experiments was adopted. The optimal combination of the design factors and levels that minimize warpage was predicted through L18-orthogonal array experiments and main effects analysis. Moreover, the warpage under the optimal design was estimated by the additive model, and it was confirmed through the simulation experiment that the estimated result was quite consistent with the experimental result. Additionally, it was found that the warpage under the optimal design was significantly improved compared to both the warpage under the initial design and the best warpage among the orthogonal array experimental results, which numerically decreased by 36.9% and 23.4%, respectively.

Gluteal Region Reshaping of Massive Weight Loss Patients-A Decision-Making Strategy

  • Mahgoub, Mohamed Ali;Zeina, Ahmed Mahmoud;El-Din, Ahmed Mohamed Bahaa;El-Sabbagh, Ahmed Hassan;Bassetto, Franco;Vindigni, Vincenzo
    • Archives of Plastic Surgery
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    • v.49 no.3
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    • pp.289-295
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    • 2022
  • Background Massive weight loss (MWL) is a very common presentation that you may face as a plastic surgeon. Each patient has his own individual criteria, so, you should work according to a well-organized plan, especially when such cases have concerns about their gluteal area contour that were neglected before by many surgeons. A decision-making strategy was used to give a personalized treatment for targeting gluteal region reshaping of MWL patients. Methods This study considered all patients with MWL subjected to buttock reshaping. There was no randomization in treatment; there was a case-by-case assessment. We analyzed the features of the buttocks, the type of surgery performed, the outcomes, and the complications. Results Fifty two patients were included (41 females and 11 males), ages ranged between 21 and 66 years. Demographic data, preoperative body mass index (BMI), duration of surgery, type of surgery, and postoperative complications were collected. Statistically significant improvements were observed in gluteal ptosis and patient satisfaction grades. Conclusion Aesthetic improvement of the buttocks involves either augmentation or contouring that may be obtained by liposculpture, surgical lifting, or combination. Patients with MWL have high expectations and are often treated with multiple procedures. Thus, an easy strategic approach personalized on each patient to treat multiple adjacent areas in one operation is necessary. Adipose tissue distribution, gluteal skin status, and BMI were the main factors that can forcefully affect our plan to guarantee reduction of unpleasant results and complications and improve patient satisfaction.

Bi-directional Maximal Matching Algorithm to Segment Khmer Words in Sentence

  • Mao, Makara;Peng, Sony;Yang, Yixuan;Park, Doo-Soon
    • Journal of Information Processing Systems
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    • v.18 no.4
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    • pp.549-561
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    • 2022
  • In the Khmer writing system, the Khmer script is the official letter of Cambodia, written from left to right without a space separator; it is complicated and requires more analysis studies. Without clear standard guidelines, a space separator in the Khmer language is used inconsistently and informally to separate words in sentences. Therefore, a segmented method should be discussed with the combination of the future Khmer natural language processing (NLP) to define the appropriate rule for Khmer sentences. The critical process in NLP with the capability of extensive data language analysis necessitates applying in this scenario. One of the essential components in Khmer language processing is how to split the word into a series of sentences and count the words used in the sentences. Currently, Microsoft Word cannot count Khmer words correctly. So, this study presents a systematic library to segment Khmer phrases using the bi-directional maximal matching (BiMM) method to address these problematic constraints. In the BiMM algorithm, the paper focuses on the Bidirectional implementation of forward maximal matching (FMM) and backward maximal matching (BMM) to improve word segmentation accuracy. A digital or prefix tree of data structure algorithm, also known as a trie, enhances the segmentation accuracy procedure by finding the children of each word parent node. The accuracy of BiMM is higher than using FMM or BMM independently; moreover, the proposed approach improves dictionary structures and reduces the number of errors. The result of this study can reduce the error by 8.57% compared to FMM and BFF algorithms with 94,807 Khmer words.

Meaning Making for the Experience of Retaking College Entrance Examination (대학입시 재수경험에 대한 의미화작업)

  • Sanghun Lee;Taeyun Jung
    • Korean Journal of Culture and Social Issue
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    • v.20 no.4
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    • pp.365-389
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    • 2014
  • The present study aimed at investigating how those students who retook college entrance examination(or RCEE) appreciate the experience. For this purpose, three persons from each cell at the 2(satisfaction with college life: high vs. low) by 2 (evaluation of RCEE: positive vs. negative) combination among those who participated in Lee and Jung study (2014) were selected and were interviewed. Qualitative data analysis based on phenomenological approach produced seven categories and 19 subcategories, which were grouped on the temporal dimension. First, when they were at the midst of this RCEE experience, the college students saw this as adversity that should be overcome while they underwent a limit of pain they could bear. Second, the college students evaluated this experience as upgrading my life with wound left unseen. Finally, they assigned to both of the positive and negative aspects of RCEE experience the meaning that the experience made them accept themselves as they were. Given these results, implications, limitations of this study were discussed.

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A Study on the Production of Supporting Ring Using Casting for Public Environmental Vehicles (대중적 환경차를 위한 주조를 이용한 서포트링 제작에 관한 연구)

  • Jeongick Lee
    • Journal of Advanced Technology Convergence
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    • v.2 no.3
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    • pp.17-24
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    • 2023
  • I am designing a research paper with the aim of studying hybrid vehicles. Hybrid vehicles, as the next-generation automobiles, feature a combination of internal combustion engines and battery engines, resulting in a revolutionary reduction in fuel consumption and harmful gas emissions compared to conventional vehicles. The electric motor in hybrid cars derives power from a high-voltage battery installed within the vehicle, which is recharged during vehicle motion. In contrast to traditional cars, which often experience energy losses due to idling caused by traffic congestion, hybrid systems optimize efficiency by skillfully managing the interplay between the internal combustion engine and the electric motor. This approach effectively addresses the inherent drawbacks of gasoline or diesel engines.Hybrid cars offer an array of benefits, including improved fuel efficiency, environmental friendliness, cost-effectiveness, and reduced noise emission. Consequently, they are progressively becoming a favored alternative among a growing number of individuals. This research endeavor has the potential to contribute towards curbing environmental pollution and dedicating efforts to future automotive research.