• 환경위생공학
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• 제19권4호
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• pp.34-47
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• 2004

Although Environmental Impact Assessment(EIA) in Korea has been improved markedly over the past two decades, by enlarging the range of projects for assessment, instituting pub lic participation and environmental monitoring, and similar measures, it remains deficient in its coverage of human health in Environmental Impact Statements(EISs). Health Impact Assessment(HIA) can supply the necessary correctives. HIA is a combination of procedures, methods and tools by which a policy, programme, projects or legislative procedure may be judged for its potential effects on the health of a population, and the distribution of these effects within it. The principle of health protection is, however, established as a primary concern in EIA processes, in practice health is scarcely mentioned or the discussion is limited to a description of effects through the biophysical environment. The whole range of possible effects on health, including those mediated by socio-economic factors is often ignored, and no effective mechanism are in place to successfully incorporating health criteria and expertise into environmental, assessment(EA) that include ElA, SEA. These are foremost among the current issues facing EIA in Korea.

• International Journal of Concrete Structures and Materials
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• 제5권1호
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• pp.65-73
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• 2011

Corrosion of steel bars embedded in concrete admixed with 0%, 2% and 4% calcium nitrite (CN), having compressive strengths of 20 and 46 MPa was investigated. Reinforced concrete specimens were immersed in 3% NaCl solutions for 1, 7 and 15 days where 0.4A external current was applied to accelerate the chemical reactions. Corrosion rate was measured by retrieving electrochemical data via potentiodynamic polarization technique. Pull-out tests of reinforced concrete specimens were then conducted to assess the corroded steel-concrete bond characteristics. Experimental results showed that corrosion rate of steel bars and steel-concrete bond strength were dependent on concrete strength, amount of CN added and accelerated corrosion period. As concrete strength increased from 20 to 46 MPa, corrosion rate of embedded steel decreased. The addition of 2% CN to concrete of 20 MPa was not effective in retarding corrosion of steel at long time of exposure. However, the combination of higher strength concrete and 2% or 4% CN appear to be a desirable approach to reduce the effect of chloride-induced corrosion of steel reinforcement. After 1 day of corrosion acceleration, specimens without CN showed higher bond strength in both concrete mixes than those with CN. After 7 and 15 days of exposure, the higher concentration of CN, the higher bond strength in both concrete mixes achieved, except for the concrete specimen of 20 MPa compressive strength with 2% CN that recorded the highest deterioration in bond strength at 15 days of exposure.

• Smart Structures and Systems
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• 제13권4호
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• pp.615-636
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• 2014

Aluminium Foam Sandwich (AFS) panels are becoming always more attractive in transportation applications thanks to the excellent combination of mechanical properties, high strength and stiffness, with functional ones, thermo-acoustic isolation and vibration damping. These properties strongly depend on the density of the foam, the morphology of the pores, the type (open or closed cells) and the size of the gas bubbles enclosed in the solid material. In this paper, the vibrational performances of two classes of sandwich panels with an Alulight(R) foam core are studied. Experimental tests, in terms of frequency response function and modal analysis, are performed in order to investigate the effect of different percentage of porosity in the foam, as well as the effect of the random distribution of the gas bubbles. Experimental results are used as a reference for developing numerical models using finite element approach. Firstly, a sensitivity analysis is performed in order to obtain a limit-but-bounded dynamic response, modelling the foam core as a homogeneous one. The experimental-numerical correlation is evaluated in terms of natural frequencies and mode shapes. Afterwards, an update of the previous numerical model is presented, in which the core is not longer modelled as homogeneous. Mass and stiffness are randomly distributed in the core volume, exploring the space of the eigenvectors.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8603-8605
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• 2014

Objective: To assess the safety of Brucea javanica and Cantharidin combined with chemotherapy in treating patients with non-small-cell lung carcinoma. Method: A consecutive cohort of patients with NSCLC were divided into four groups: experimental group A treated with Brucea javanica injection combined with chemotherapy; experimental group B with Cantharidin injection combined with chemotherapy; experimental group C treated with Brucea javanica and Cantharidin injection combined with chemotherapy; and the control group receiving only chemotherapy. After more than two courses of treatment, safety, quality of life and side effects were evaluated. Results: The incidences of myelosuppression in groups A, B and C were lower than that in Control group (p<0.05), but without significant differences among A, B and C. Adverse effects on the gastrointestinal tract also were lower than in controls (p<0.05) without variation amnog the combined treatment groups. Conclusions: Brucea javanica or Cantharidin combined with chemotherapy could in both cases improve quality of life in our cohort of NSCLC patients without any increase in toxicity. However, further clinical experiments should be conducted to evaluate the efficacy of Brucea javanica and Cantharidin combined with chemotherapy for patients with NSCLC.

• 한국의류산업학회지
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• 제16권5호
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• pp.730-744
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• 2014

With advances in QR code, mobile is becoming one of important channels in the fashion retail industries. This study attempts to understand the importance of QR code utilization in creating multi-channel business model. Study objectives are to classify types of multi-channel retailing by QR code utilization and to explore the role of QR code technology in strategic marketing elements for types of multichannel retailer. As an exploratory approach, a total of 78 news articles regarding QR code issues were reviewed and analyzed by focusing on 48retailers seleted in this study. The results found seven dimensions of QR code marketing strategies: abundant product information, additional information contents, transaction accessibility, connectedness to channels, location based service, loyalty program and multimedia advertising. Based a combination of channels and level of mobile apps' activation, multichannel retailers utilizing QR code technology were classified into four types; bricks-click-active mobile model, bricks-click-inactive mobile model, bricks-click model, and click-active mobile model. There were differences of using QR code marketing strategies among multichannel models. According to results, for bricks-and-mortar retailers, QR code was critical to integrate shopping experience with merchandise or sales promotions across channels. In addition, for non-store retailers, the QR code utilization was successful in expanding mobile channels, which can promote retail sales by a two-way interaction with customers via the mobile apps.

• 대한기계학회논문집A
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• 제32권6호
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• pp.488-495
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• 2008

In order to achieve long fatigue lifetimes for cyclically pressurized thick cylinders, multi-layered compound cylinder has been proposed. Such compound cylinder involves a shrink-fit procedure incorporating a monobloc tube which has previously undergone autofrettage. The basic autofrettage theory assumes elastic-perfectly plastic behaviour. Because of the Bauschinger effect and strain-hardening, most materials do not display elastic-perfectly plastic properties and consequently various autofrettage mo dels are based on different simplified material strain-hardening models, which is assumed that combination of linear strain-hardenig and power strain-hardening model. This approach gives a more accurate prediction than the elastic-perfectly plastic model and is suitable for different strain-hardening materials. In this paper, a general autofrettage model that incorporates the material strain-hardening relationship and the Bauschinger effect, based upon the actual tensile-compressive stress-strain curve of a material was proposed. The model was obtained using the von Mises yield criterion and plane strain condition. The tensile-compressive stress-strain curve was obtained by experiment. The parameters needed in the model were determined by fitting the actual tensile-compressive curve of the material. Finally, strain- hardening model was compared with elastic-perfectly plastic model.

• 대한기계학회논문집A
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• 제39권6호
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• pp.583-588
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• 2015

완전접촉 문제를 이론적으로 해석하기 위해서 점근해법이 많이 사용된다. 점근해로서의 응력장은 특이항 만으로 구성되므로 접촉경계로부터 멀어질수록 정확도가 감소한다. 이에 반해 유한요소해석 방법은 요소크기의 제한으로 인해 완전접촉 문제에서의 응력특이성을 엄밀히 표현할 수 없다. 따라서 본 연구에서는 이론적 해법을 보조하고 또 그와 비교하기 위해 응착접촉 상태에 있는 완전접촉 문제를 이론적으로 해석한 후, 모아레 실험 및 유한요소해석 방법으로 접촉부 부근의 응력장을 분석하였다. 실험은 알루미늄과 구리 합금을 접촉각 $120^{\circ}$, $135^{\circ}C$로 가공하여 수행하였으며 모아레 무늬로부터 얻은 변위장과 유한요소해석을 수행한 결과와 비교하였다. 이로부터 타당성이 확보된 수치적 방법을 이용하여 실험조건에서의 일반화 응력확대계수와 접촉부 응력장을 구하여 이론 해와 비교하였으며, 접촉경계로부터 멀어질 때 나타나는 이론과 수치 해의 차이를 분석하였다.

• Steel and Composite Structures
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• 제28권3호
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• pp.363-380
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• 2018

This paper presented an integral design procedure for demountable bolted composite frames with semi-rigid joints. Moment-rotation relationships of beam-to-column joints were predicted with analytical models aiming to provide accurate and reliable analytical solutions. Among this, initial stiffness of beam-to-column joints was derived on the basis of Timoshenko's plate theory, and moment capacity was derived in accordance with Eurocodes. The predictions were validated with relevant test results prior to further applications. Frame analysis was conducted by using Abaqus software with material and geometrical nonlinearity considered. Variable lateral loads incorporating wind actions and earthquake actions in accordance with Australian Standards were adopted to evaluate the flexural behaviour of the composite frames. Strength and serviceability limit state criteria were utilized to verify configurations of designed models. A wide range of frames with the varied number of storeys and bays were thereafter programmed to ascertain bending moment envelopes under various load combinations. The analytical results suggest that the proposed approach is capable of predicting the moment-rotation performance of the semi-rigid joints reasonably well. Outcomes of the frame analysis indicate that the load combination with dead loads and live loads only leads to maximum sagging and hogging moment magnitudes in beams. As for lateral loads, wind actions are more crucial to dominate the design of the demountable composite frames than earthquake actions. No hogging moment reversal is expected in the composite beams given that the frames are designed properly. The proposed analysis procedure is demonstrated to be a simple and efficient method, which can be applied into engineering practice.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.899-904
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• 2014

Concurrent chemo-radiation (CRT) has been established as the standard of care for non-metastatic loco-regionally advanced nasopharyngeal carcinoma (NPC) but recently the addition of induction chemotherapy in the already established regimen has presented an attractive multidisciplinary approach. This retrospective study was carried out to evaluate the efficacy of induction chemotherapy (IC) followed by CRT for the management of loco-regionally advanced NPC. Between July 2005 and September 2010, 99 patients were treated with cisplatin based IC followed by CRT. Induction chemotherapy included a 2 drug combination; intravenous gemcitabine $1000mg/m^2$ on day 1 and 8 and cisplatin $75mg/m^2$ on day 1 only. Radiotherapy (RT) was given as a phase treatment to a total dose of 70 Gy in 35 fractions. Concurrent cisplatin ($75mg/m^2$) was administered to all patients on days 1, 22 and 43. All patients were evaluated for tumor response and adverse effects after IC and 6 weeks after the completion of the treatment protocol. Statistical analysis was performed using SPSS version 17 and Kaplan Meier estimates were applied to project survival. Median follow-up duration was 20 months. The 5-year overall survival (OS), loco regional control (LRC) and relapse free survival (RFS) rates were 71%, 73% and 50%respectively. Acute grade 4 toxicity related to induction chemotherapy and concurrent chemo-radiation was 4% and 2% respectively, with only 3 toxicity-related hospital admissions. We conclude that induction gemcitabine and cisplatin followed by chemo-radiation is a safe and effective regimen in management of nasopharyngeal carcinoma, meriting further investigation in randomized clinical trials.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.629-635
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• 2014

Background: Acute myeloid leukemia (AML) is a fatal hematological malignancy which is resistant to a variety of chemotherapy drugs. Myeloid cell leukemia-1 (Mcl-1), a death-inhibiting protein that regulates apoptosis, has been shown to be overexpressed in numerous malignancies. In addition, it has been demonstrated that the expression level of the Mcl-1 gene increases at the time of leukemic relapse following chemotherapy. The aim of this study was to target Mcl-1 by small interference RNA (siRNA) and analyze its effects on survival and chemosensitivity of acute myeloid leukemia cell line HL-60. Materials and Methods: siRNA transfection was performed with a liposome approach. The expression levels of mRNA and protein were measured by real-time quantitative PCR and Western blot analysis, respectively. Trypan blue assays were performed to evaluate tumor cell growth after siRNA transfection. The cytotoxic effects of Mcl-1 siRNA (siMcl-1) and etoposide were determined using MTT assay on their own and in combination. Apoptosis was quantified using a DNA-histone ELISA assay. Results: Transfection with siMcl-1 significantly suppressed the expression of Mcl-1 mRNA and protein in a time-dependent manner, resulting in strong growth inhibition and spontaneous apoptosis. Surprisingly, pretreatment with siMcl-1 synergistically enhanced the cytotoxic effect of etoposide. Furthermore, Mcl-1 down-regulation significantly increased apoptosis sensitivity to etoposide. No significant biological effects were observed with negative control siRNA treatment. Conclusions: Our results suggest that specific suppression of Mcl-1 by siRNA can effectively induce apoptosis and overcome chemoresistance of leukemic cells. Therefore, siMcl-1 may be a potent adjuvant in leukemia chemotherapy.