The purpose of this study was to provide basic data for improving health promotion behavior by identifying the effects of life stress and coping with stress among nursing college students on health promotion behavior. The data was collected from 352 nursing students in 6 colleges in B and K city, and the data was analyzed with SPSS/Win 23.0. Factors influencing health promotion behavior were school life satisfaction (F=9.18, p<.001), happiness score (F=20.64, p<.001), health status (F=12.40, p<.001), eating breakfast (t=-3.31, p=.001), unbalanced diet (t=-4.20, p<.001), time spent sleeping (F=2.64, p=.049), and exercise (t=5.20, p<.001). In the correlations, health promotion behavior was negatively correlated with life stress (r=-.289, p<.001), but it was positively correlated with coping with stress (r=.539, p<.001). The factors influencing health promotion behavior were stress coping (β=.439, p<.001), happiness score (β=.251, p<.001), exercise (β=.172, p<.001), unbalanced diet (β=.125, p=.002), life stress (β=-.121, p=.005), and eating breakfast (β=.083, p=.046). The above variables explained 46.0% for the health promotion behavior. Thus, in order to improve the health promotion behavior of nursing college students, integrated nursing interventions need to be developed through improving coping with stress, creating a sense of happiness, reducing life stress, and maintaining exercise and good eating habits.