This study examined the relationship between depression, anxiety, stress, and adaptation to college life of international students living in South Korea during the COVID-19 pandemic and the factors affecting the adaptation to college life. This study was carried out between December 3, 2021, to January 25, 2022, on international students living in South Korea. The questionnaires were composed of self-reported questionnaires, and the survey URL was sent as text messages to international students who understood the purpose and rationale of this study and consented to participate in the survey. The data were analyzed using SPSS WIN 22.0, and t-test, ANOVA, Pearson's Correlation Coefficient, and hierarchical regression were performed. As a result of the study, the average score of the study subjects was 8.44 points for depression, 8.28 points for anxiety, and 9. 28 points for stress. factors with significant differences in adaptation to college life according to general characteristics were living means and smoking. The relationship between the main variables, it was significant with depression (r=-.785, p<.001), anxiety (r=-.593, p<.001), and stress (r=-.726, p<.001). There was one negative correlation. It was found that the higher the depression, anxiety, and stress, the lower the college life adaptation. Lastly, depression (β=-.666, p<.001) was the factor affecting foreign students' adaptation to college life, and the explanatory power was 62%. Therefore, for international students to adapt to college life, it is necessary to establish an institutional strategy to detect depression, a negative psychological emotion, at an early stage and to systematically manage it. Also, it is necessary to find an intervention plan to relieve depression that can be applied in social isolation situations due to the spread of infectious diseases. Research confirming the intervention effect should be upgraded.