• 혜화의학회지
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• 제23권1호
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• pp.13-20
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• 2014

Objectives : Clinical data in traditional medicine, such as Korean medicine, traditional Chinese medicine have a long history of accumulating evidence and these rich data are recorded in classic literature. We have conducted a study of developing an algorithm that support clinical diagnosis with composing both users knowledge and data obtained from literature. In order to define necessary information and required steps in diagnosis procedure, we have established a clinical diagnostic procedure including a step of collecting patients symptoms, a step of determining candidates, a step of diagnostic decisions, a step of deciding of treatment and a step of adjusting medicinal treatment. Methods : Our study have been based on the following premises. 1. Using data obtained from literature contributes to accurate diagnosis 2. Displaying the data before users request contributes to accurate conclusion. Displaying before users request enable users to recognize their overlooking a fact on purpose or not. 3. Checking symptoms that are commonly accompanied with a group of diseases that accompany symptoms appealed by a patient contributes to accurate conclusion. These symptoms are worthy of checking. 4. Comparing more than two candidates contributes to accurate conclusion. Users can compare their accompanied symptoms with patients symptoms and this helps users to make a decision. Results : Based on the above premises, we have developed an literature based algorithm to provide various functions, such as recommending symptoms to check, comparing groups of symptoms, differential diagnosis, recommending medicinal materials to prescribe, and more. Conclusions : By the results of simulation with virtual diagnostic scenario, we concluded this algorithm is useful helping clinician in diagnosis procedure.

• 한국임상약학회지
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• 제25권4호
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• pp.280-285
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• 2015

Objectives: To suggest direction for improving policies by understanding current management of narcotics or psychotropic drugs and analyzing their distributions and usage. Method: We conducted a comparison analysis between health insurance claims and the amount supplied to health care institutions for narcotics or psychotropic drugs through health insurance claims data and drug distribution supply data from 2010 to 2012 collected from Korea Pharmaceutical Information Service Center (KPIS). Furthermore, we carried out literature investigation and online search to comprehend the current management of narcotics drugs in Korea. Results: The amount supplied to medical institutions for all drugs in 2012 was 19.4 trillion won, which increased from 19.5 trillion in 2011 by 0.54%. For narcotic drugs, the amount supplied was 318.4 billion won in 2011 and increased to 335.1 billion won by 5.3% in 2012, which exceeded the rate of increase for the amount supplied for all drugs. The proportion of amount claimed in the total amount supplied to medical institutions for all drugs was 60.5% in 2012, whereas the proportion of amount claimed for narcotic drugs was 55.6%, which showed that narcotic drugs were used relatively less within health insurance. Furthermore, management of the current domestic distribution supply data focuses on manufacturing and medical institution supply stages. Conclusion: Hereafter, the management of narcotics or psychotropic drugs needs to be improved by reinforcing active monitoring in optimal prescription and usage in patients by collecting and analyzing information on drug usage of patients.

• International Journal of Industrial Entomology and Biomaterials
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• 제31권2호
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• pp.70-74
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• 2015

The current market size of insect industry in Korea is estimated at 300 million dollars and more than 500 local farms are related to many insect industry. One of the strong candidates for insect industry is Korean horn beetle, Allomyrina dichotoma. Early this year, we reported a viral disease extremely fatal to A. dichotoma larvae. While we were proceeding a nationwide investigation of this disease, it was informed that similar disease symptom has been occurred occasionally during past over 10 years. The symptom can be easily confused with early stage of bacterial infection or physiological damage such as low temperature and high humidity. A peroral infection with the purified virus to healthy larvae produced a result that only 21% of larvae survived and became pupae. Although some of the survived adult beetle was deformational, many of them had no abnormal appearance and even succeeded in mating. Later, these beetles were examined if they were carrying the virus, and all except one were confirmed as live virus carrier. This implies that these beetles may fly out and spread the disease to the nature. We found the evidence for this possibility by collecting a few wild A. dichotoma larvae which were virus infected, near two local farms rearing A. dichotoma larvae. So far, transovarial transmission of this virus to the eggs, or horizontal transmission to other commercially reared insects is not known yet.

• Environmental Analysis Health and Toxicology
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• 제30권sup호
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• pp.7.1-7.10
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• 2015

Objectives For successful adoption of legislation controlling registration and assessment of chemical substances, it is important to obtain sufficient toxicological experimental evidence and other related information. It is also essential to obtain a sufficient number of predicted risk and toxicity results. Particularly, methods used in predicting toxicities of chemical substances during acquisition of required data, ultimately become an economic method for future dealings with new substances. Although the need for such methods is gradually increasing, the-required information about reliability and applicability range has not been systematically provided. Methods There are various representative environmental and human toxicity models based on quantitative structure-activity relationships (QSAR). Here, we secured the 10 representative QSAR-based prediction models and its information that can make predictions about substances that are expected to be regulated. We used models that predict and confirm usability of the information expected to be collected and submitted according to the legislation. After collecting and evaluating each predictive model and relevant data, we prepared methods quantifying the scientific validity and reliability, which are essential conditions for using predictive models. Results We calculated predicted values for the models. Furthermore, we deduced and compared adequacies of the models using the Alternative non-testing method assessed for Registration, Evaluation, Authorization, and Restriction of Chemicals Substances scoring system, and deduced the applicability domains for each model. Additionally, we calculated and compared inclusion rates of substances expected to be regulated, to confirm the applicability. Conclusions We evaluated and compared the data, adequacy, and applicability of our selected QSAR-based toxicity prediction models, and included them in a database. Based on this data, we aimed to construct a system that can be used with predicted toxicity results. Furthermore, by presenting the suitability of individual predicted results, we aimed to provide a foundation that could be used in actual assessments and regulations.

• 한국콘텐츠학회논문지
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• 제17권11호
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• pp.331-341
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• 2017

최근 과학기술정보 콘텐츠 분석 기반의 R&D 전략 수립이 중요시됨에 따라 국내 외 과학기술 통계 정보를 수집, 범주화하여 DB를 구축하고 이를 증거 기반의 기초연구정책을 수립하는데 활용하고자 하였다. 국내 외 49종의 과학기술 관련 보고서 등 자료를 수집하여 6,446개 지표 추출, 877개 통계 정보로 범주화, 이중 208개를 집중 관리 통계로 도출하였다. 이렇게 구축된 DB의 활용성 제시를 위해 논문정보 관련 심층분석을 통해 제한적으로나마 우리나라 기초연구의 효과성을 보여주고자 하였다. 이를 위해, 고피인용 논문창출과 R&D 투자 간의 통계기반 분석과 고피인용 논문의 국내 외 지식맵 비교 분석을 실시하였다. 그 결과, 기초연구비 증가가 우리나라의 보편적 연구활동도와 세계적 연구성과 창출에 긍정적 영향을 미친 것으로 나타났다. 또한 순수기초연구분야로 간주되어온 수학, 물리, 화학이 신성장동력이라 불리는 AI, 청정에너지 등 기술 발전의 기반이 되어왔음을 알 수 있었다.

• 한국컴퓨터정보학회논문지
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• 제17권11호
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• pp.101-105
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• 2012

최근 스마트폰의 급격한 보급으로 개인정보 침해사고 및 프라이버시 침해를 통한 여러 가지 사회문제가 급속도로 증가하고 있으며, 이에 따라 개인 정보보호를 위한 다양한 연구 및 기술 개발이 이루어지고 있다. 개인의 모든 정보가 거의 들어 있다고 해도 과언이 아닌 스마트폰의 정보유출은 우리의 일상에서 쉽고 빈번하게 발생할 수 있는데, 포렌식 분석 툴을 이용하여 증거를 수집하거나 분석하기란 쉽지 않은 일이다. 현재 안드로이드 포렌식 연구는 비휘발성 메모리로부터 데이터를 수집하여 분석하는 기법에 집중되어 왔으며, 휘발성 데이터에 대한 연구는 미미한 실정이다. 안드로이드 로그는 휘발성 저장매체로부터 수집될 수 있는 휘발성 데이터이다. 안드로이드 로그는 안드로이드 시스템에서부터 애플리케이션에 이르기까지 최근의 모든 구동내역과 관련한 기록이 로그로 저장되기 때문에 안드로이드폰 사용을 추적할 수 있는 자료로 활용이 충분하다. 본 논문에서는 포렌식 분석 툴을 이용하지 않고 로그를 필터링하여 개인의 정보 유출 유무를 판단하여 대응할 수 있는 방법을 제시한다.

• 한국컴퓨터정보학회논문지
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• 제19권12호
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• pp.161-169
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• 2014

디지털포렌식은 범죄와 관련된 디지털 증거를 수집, 분석하여 범죄혐의를 입증하는 과정으로 범죄수사에서 중요한 역할을 한다. 지금까지의 디지털포렌식 온톨로지에 대한 연구는 디지털포렌식을 사이버 관련 범죄에만 적용하였거나 디지털포렌식 자체의 절차와 기법에 관한 것으로 한정되었다. 본 연구에서는 다양한 유형의 범죄수사에서 디지털포렌식을 효과적으로 활용하기 위해 전반적인 수사절차와 디지털포렌식의 연관성을 분석하여 연계 모델을 설계하고 이를 바탕으로 디지털포렌식 온톨로지를 구축하였다. 온톨로지 구축시 포렌식 분석결과의 구체적인 활용 분야를 도출하여 반영하였고, 디지털포렌식의 절차 검증과 관련된 적법성 규칙, 분석 결과 활용과 관련된 적절성 규칙을 적용하여 의사결정지원이 가능하도록 하였다. 구축된 디지털포렌식 온톨로지는 다양한 범죄 유형에 적용 가능한 지능형 범죄수사 시스템 구축시 중요한 기반을 제공하게 될 것이다.

• 대한유전성대사질환학회지
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• 제11권1호
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• pp.52-73
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• 2011

Since we have started organic acid analysis on Jul. 1997, we have been collecting data about organic acidemias in Korea. The data presented here is our 3 years experience in organic acid analysis. We have collected 712 samples from major university hospitals all over the Korea, large enough for relatively accurate incidence of organic acid disorders. We are using solvent extraction method with ethylacetate, MSTFA for derivatization and quantitation of 83 organic acids simultaneously. Out of 712 patients sample, 498 patients sample (70%) showed no evidence of organic acid abnormalities. Out of 214 remaining samples we have found very diverse disorders such as methylmalonic aciduria(6), propionic aciduria (10), biotinidase deficiency (6), maple syrup urine disease (3), isovaleric aciduria (4), tyrosinemia type II (4), tyrosinemia type IV (1), glutaric aciduria type I (1), glutaric aciduria type II (22), 3-methylglutaconic aciduria type I (3), 3-methylglutaconic aciduria type III (7), HMG-CoA lyase deficiency (1), hyperglyceroluria (2), cytosolic 3-ketothiolase deficiency (55), mitochondrial 3-ketothiolase deficiency (3), 3-hydroxyisobutyric aciduria (2), L-2-hydroxyglutaric aciduria (2), fumaric aciduria (2), lactic aciduria with combined elevation of pyruvate (most likely PDHC deficiency) (28), lactic aciduria without combined elevation of pyruvate (most likely mitochondrial respiratory chain disorders) (35), SCAD deficiency (3), MCAD deficiency (1), 3-methylcrotonylglycineuria (1), orotic aciduria (most likely urea cycle disorders) (7) and 2-methylbranched chain acyl-CoA dehydrogenase deficiency (1). In conclusion, though the incidence of indivisual organic acidemia is low, the incidence of overall organic acidemia is relatively high in Korea. Most of the patients showed some signs of neurological dysfunction. In other words, organic acid analysis should be included in the diagnostic work up of all neurological dysfunctions.

• 대한한의학회지
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• 제30권1호
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• pp.40-50
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• 2009

Objectives: The clinical document forms, a format for collecting clinical data, is the most fundamental object of standardization. Doctors must have a mutual understanding of the clinical chart. Methods: Clinical document forms were developed by investigating existing conditions in hospitals and conducting demand surveys, doing literature research, and seeking expert advice for the improvement of version 1.0. In addition, an organization of a network of 19 Oriental medical doctors and nurses, 190 patients, and users of collected and assessed data was formed to come up with version 2.0. Results: The overall format was divided into different portions that the patient, nurse, and doctor must fill out, respectively. The patient's section consists of demographic data, lifestyle details, history, and symptoms. The data to be supplied by the nurse include the patient's vital signs and anthropometric parameters. As for the doctors, they are to supply data regarding the patient's palpitation, the detailed symptoms of the patient's head, ophthalmological and otorhinolaryngological symptoms (mouth), respiration, circulatory organ and chest conditions, digestive-organ conditions (thirst), neuropsychiatric conditions, reproductive system, musculoskeletal system, skin (depilation), etc. Conclusions: Common clinical chart development is the prior question to Traditional Korean Medicine standardization. A web-based clinical document format should be developed to support diagnosis and treatment, and furthermore EMR (electronic medical record system) and EHR (electronic health record) developed. Clinical information could be shared through a network of medical institutions and be useful Traditional Korean Medicine for evidence-based medicine.

• 한국안전학회지
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• 제29권3호
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• pp.98-106
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• 2014

This study proposes severity analysis for pedestrian accidents by improving variables which were used for general severity analysis. The existing variables were collected based on the interviews with policeman or witnesses and evidence of accidents. Therefore, existing variables were subjective and had several measurement errors. In order to improve such problems, this study collected variables from vehicle recorder of taxi which recorded the moment of accidents. As a result, explanatory power of independent variables was enhanced and the complete objective variables could be collected. After collecting variables, ordered probit model was developed by utilizing vehicle recorder database. Fitness of ordered probit model was 0.23. Vehicle speed and pedestrian's eye direction variables were the most critical factors for severity of pedestrian accident. In addition, severity analysis for vulnerable pedestrian was carried out. As a result, it was revealed that vehicle speed, pedestrian's eye direction and safety zone variables affected the severity of pedestrian accidents most. Particularly, vehicle speed variable is the most important factor. Consequently, driver's defensive driving and compliance to the regulations are the priority to reduce severity of pedestrian accidents and prevent pedestrian accident.